Natalia S Pellegata

Summary

Country: Germany

Publications

  1. pmc MENX and MEN4
    Natalia S Pellegata
    Institute of Pathology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Clinics (Sao Paulo) 67:13-8. 2012
  2. doi request reprint MENX
    Natalia S Pellegata
    Institute of Pathology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Ann Endocrinol (Paris) 73:65-70. 2012
  3. pmc Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans
    Natalia S Pellegata
    Institutes of Pathology, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 103:15558-63. 2006
  4. pmc Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Acta Neuropathol 126:137-50. 2013
  5. doi request reprint Allelic loss of chromosomes 8 and 19 in MENX-associated rat pheochromocytoma
    Alena Shyla
    Institute of Pathology, Helmholtz Zentrum München German Research Center for Environment and Health, Neuherberg, Germany
    Int J Cancer 126:2362-72. 2010
  6. ncbi request reprint Human pheochromocytomas show reduced p27Kip1 expression that is not associated with somatic gene mutations and rarely with deletions
    Natalia S Pellegata
    Institute of Pathology, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Virchows Arch 451:37-46. 2007
  7. doi request reprint Multiple endocrine neoplasia type 4
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Front Horm Res 41:63-78. 2013
  8. doi request reprint Secretin receptor promotes the proliferation of endocrine tumor cells via the PI3K/AKT pathway
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Mol Endocrinol 26:1394-405. 2012
  9. doi request reprint The MENX syndrome and p27: relationships with multiple endocrine neoplasia
    Sara Molatore
    Institute of Pathology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Prog Brain Res 182:295-320. 2010
  10. doi request reprint Levels of p27 sensitize to dual PI3K/mTOR inhibition
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Cancer Ther 10:1450-9. 2011

Collaborators

Detail Information

Publications15

  1. pmc MENX and MEN4
    Natalia S Pellegata
    Institute of Pathology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Clinics (Sao Paulo) 67:13-8. 2012
    ..Here we review the characteristics of the MENX and MEN4 syndromes and we briefly address the main function of p27 and how they are affected by MENX/4-associated mutations...
  2. doi request reprint MENX
    Natalia S Pellegata
    Institute of Pathology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Ann Endocrinol (Paris) 73:65-70. 2012
    ..Finally, I present examples of how this animal model might be exploited as a translational platform for preclinical studies of pituitary adenomas...
  3. pmc Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans
    Natalia S Pellegata
    Institutes of Pathology, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 103:15558-63. 2006
    ..Our findings demonstrate that germ-line mutations in p27(Kip1) can predispose to the development of multiple endocrine tumors in both rats and humans...
  4. pmc Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Acta Neuropathol 126:137-50. 2013
    ..Our studies reveal clues about the molecular mechanisms driving rat and human gonadotroph adenomas development, and may help identify previously unexplored biomarkers for clinical use...
  5. doi request reprint Allelic loss of chromosomes 8 and 19 in MENX-associated rat pheochromocytoma
    Alena Shyla
    Institute of Pathology, Helmholtz Zentrum München German Research Center for Environment and Health, Neuherberg, Germany
    Int J Cancer 126:2362-72. 2010
    ..Because of the high concordance of affected loci between rat and human tumors, studies of the MENX-associated pheochromocytomas should facilitate the identification of novel candidate genes implicated in their human counterpart...
  6. ncbi request reprint Human pheochromocytomas show reduced p27Kip1 expression that is not associated with somatic gene mutations and rarely with deletions
    Natalia S Pellegata
    Institute of Pathology, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Virchows Arch 451:37-46. 2007
    ..Three cases had allelic imbalance but none had mutations. In conclusion, pheochromocytomas display extreme reduction/loss of p27Kip1 expression at high frequency...
  7. doi request reprint Multiple endocrine neoplasia type 4
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Front Horm Res 41:63-78. 2013
    ..Here, we review the clinical characteristics of the MEN4 syndrome and the molecular phenotype of the associated p27Kip1 mutations...
  8. doi request reprint Secretin receptor promotes the proliferation of endocrine tumor cells via the PI3K/AKT pathway
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Mol Endocrinol 26:1394-405. 2012
    ..The association between SR levels and response to PI3K inhibition might open new avenues for the treatment of tumors overexpressing this receptor...
  9. doi request reprint The MENX syndrome and p27: relationships with multiple endocrine neoplasia
    Sara Molatore
    Institute of Pathology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Prog Brain Res 182:295-320. 2010
    ..These findings are placed in the broader context of how p27 dysregulation might affect neuroendocrine cell function and trigger tumorigenesis...
  10. doi request reprint Levels of p27 sensitize to dual PI3K/mTOR inhibition
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Cancer Ther 10:1450-9. 2011
    ..Our data suggest that NVP-BEZ235 may represent an effective therapeutic modality for pituitary adenomas and that p27Kip1 levels represent a potential predictor of response to dual PI3K/mTOR inhibition...
  11. pmc Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma
    Sara Molatore
    Department of Pathology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 107:18493-8. 2010
    ..These studies reveal clues to the molecular pathways involved in rat and human pheochromocytoma and identify previously unexplored biomarkers for clinical use...
  12. pmc Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors
    Sara Molatore
    Institute of Pathology, Helmholtz Zentrum Munchen, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Mol Cancer 9:116. 2010
    ....
  13. doi request reprint p27kip1: a new multiple endocrine neoplasia gene?
    Ilaria Marinoni
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Neuroendocrinology 93:19-28. 2011
    ..Here, we review the clinical and molecular characteristics of the MEN4 syndrome and summarize the main functions of p27 to better comprehend how their alteration can predispose to neuroendocrine tumors...
  14. pmc A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization
    Sara Molatore
    Institute of Pathology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Hum Mutat 31:E1825-35. 2010
    ..Our results extend previous findings of CDKN1B mutations in patients with MEN1-related states and support the hypothesis of a tumor suppressor role for p27 in neuroendocrine cells...
  15. ncbi request reprint Mapping of a novel MEN-like syndrome locus to rat chromosome 4
    Kamilla Piotrowska
    Institute of Pathology, GSF National Research Center for Environment and Health, D 85764 Neuherberg, Germany
    Mamm Genome 15:135-41. 2004
    ..The identification of the MENX gene should contribute to our understanding of the genetic mechanisms of neuroendocrine tissue tumorigenesis and may assist in developing new and more appropriate therapeutic strategies for these diseases...