G Pawelec

Summary

Country: Germany

Publications

  1. ncbi request reprint Immunosenescence and human longevity
    Graham Pawelec
    Center for Medical Research, University of Tubingen, Waldhornlestr 22, D 72072 Tubingen, Germany
    Biogerontology 4:167-70. 2003
  2. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
  3. pmc A novel series of conferences tackling the hurdles confronting the translation of novel cancer immunotherapies
    Adrian Bot
    Kite Pharma Inc, Los Angeles, CA, USA
    J Transl Med 10:218. 2012
  4. pmc Immunosenescence in vertebrates and invertebrates
    Ludmila Muller
    Max Planck Institute for Human Development, Berlin, Germany
    Immun Ageing 10:12. 2013
  5. pmc An investigation of the effects of the antioxidants, ebselen or N-acetyl cysteine on human peripheral blood mononuclear cells and T cells
    Shiva Marthandan
    School of Science and Technology, College of Arts and Science, Nottingham Trent University, Clifton Lane, Nottingham, England, NG11 8NS, UK
    Immun Ageing 10:7. 2013
  6. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
  7. pmc Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
    Sijia Chen
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands
    Immun Ageing 9:18. 2012
  8. pmc Nutritional status influences peripheral immune cell phenotypes in healthy men in rural Pakistan
    Iftikhar Alam
    Tubingen Ageing and Tumour Immunology Group, Zentrum für Medizinische Forschung, University of Tubingen, Waldhörnlestraße 22, D 72072, Tubingen, Germany
    Immun Ageing 9:16. 2012
  9. pmc Hallmarks of human "immunosenescence": adaptation or dysregulation?
    Graham Pawelec
    Center for Medical Research, University of Tubingen Medical School, Waldhörnlestr, 22, Tubingen, D 72072, Germany
    Immun Ageing 9:15. 2012
  10. pmc Defining the critical hurdles in cancer immunotherapy
    Bernard A Fox
    Earle A, Chiles Research Institute, Robert W, Franz Research Center, Providence Cancer Center, Providence Portland Medical Center, Portland, OR, USA
    J Transl Med 9:214. 2011

Detail Information

Publications121 found, 100 shown here

  1. ncbi request reprint Immunosenescence and human longevity
    Graham Pawelec
    Center for Medical Research, University of Tubingen, Waldhornlestr 22, D 72072 Tubingen, Germany
    Biogerontology 4:167-70. 2003
    ....
  2. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
    ..The results of this international validation may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune)...
  3. pmc A novel series of conferences tackling the hurdles confronting the translation of novel cancer immunotherapies
    Adrian Bot
    Kite Pharma Inc, Los Angeles, CA, USA
    J Transl Med 10:218. 2012
    ..This Editorial provides highlights of the first event held earlier this year and outlines the focus of the second meeting to be held in 2013 that will be dedicated to stem cells and immunotherapy...
  4. pmc Immunosenescence in vertebrates and invertebrates
    Ludmila Muller
    Max Planck Institute for Human Development, Berlin, Germany
    Immun Ageing 10:12. 2013
    ..is not necessarily "senescence" if it is not deleterious). Indeed, under certain circumstances, or potentially even as a rule, this adaptation to the individual host environment may confer an actual survival advantage...
  5. pmc An investigation of the effects of the antioxidants, ebselen or N-acetyl cysteine on human peripheral blood mononuclear cells and T cells
    Shiva Marthandan
    School of Science and Technology, College of Arts and Science, Nottingham Trent University, Clifton Lane, Nottingham, England, NG11 8NS, UK
    Immun Ageing 10:7. 2013
    ..Such damage has the potential to interfere with the ability of the T cells to proliferate at times when they need to, such as when antigen challenged. The consequence of this could be a sub-optimal immune response in vivo...
  6. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
    ..Here we summarize the major findings of this workshop...
  7. pmc Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
    Sijia Chen
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands
    Immun Ageing 9:18. 2012
    ..abstract:..
  8. pmc Nutritional status influences peripheral immune cell phenotypes in healthy men in rural Pakistan
    Iftikhar Alam
    Tubingen Ageing and Tumour Immunology Group, Zentrum für Medizinische Forschung, University of Tubingen, Waldhörnlestraße 22, D 72072, Tubingen, Germany
    Immun Ageing 9:16. 2012
    ....
  9. pmc Hallmarks of human "immunosenescence": adaptation or dysregulation?
    Graham Pawelec
    Center for Medical Research, University of Tubingen Medical School, Waldhörnlestr, 22, Tubingen, D 72072, Germany
    Immun Ageing 9:15. 2012
    ..Here, I discuss some of the available data bearing on this prediction...
  10. pmc Defining the critical hurdles in cancer immunotherapy
    Bernard A Fox
    Earle A, Chiles Research Institute, Robert W, Franz Research Center, Providence Cancer Center, Providence Portland Medical Center, Portland, OR, USA
    J Transl Med 9:214. 2011
    ..Each of these hurdles can significantly delay clinical translation of promising advances in immunotherapy yet if overcome, have the potential to improve outcomes of patients with cancer...
  11. pmc Relationship between anthropometric variables and nutrient intake in apparently healthy male elderly individuals: a study from Pakistan
    Iftikhar Alam
    Tübingen Aging and Tumour Immunology Group, Sektion für Transplantationsimmunologie und Immunohämatologie, University of Tubingen, Zentrum für MedizinischeForschung, Waldhörnlestraße 22, 72072 Tubingen, Germany
    Nutr J 10:111. 2011
    ..The elderly population is increasing worldwide, which warrants their nutritional status assessment more important. The present study was undertaken to establish the nutritional status of the least-studied elderly population in Pakistan...
  12. pmc Mechanisms of immunosenescence
    Calogero Caruso
    Immunosenescence Unit, Department of Pathobiology and Biomedical Methodologies, University of Palermo, Italy
    Immun Ageing 6:10. 2009
    ..A better understanding of immunosenescence and mechanisms responsible for proven deleterious changes is needed to maintain a healthy state in later life and to design possible therapeutic interventions...
  13. ncbi request reprint Immunity and ageing in man
    Graham Pawelec
    University of Tübingen Center for Medical Research, Waldhornlestr 22, D 72072 Tubingen, Germany
    Exp Gerontol 41:1239-42. 2006
    ..The past year has seen many significant advances in our knowledge of age-associated alterations to immunity in elderly people, only some of which can be briefly reviewed here...
  14. ncbi request reprint When T cells get old
    Graham Pawelec
    Center for Medical Research, University of Tuebingen, D 72072 Tuebingen, Germany
    Sci Aging Knowledge Environ 2005:pe39. 2005
    ..Presentations from a recent workshop, which are summarized here, examined these questions and provided some insights from the perspective of improving vaccination strategies among the elderly...
  15. ncbi request reprint ESTDAB: a collection of immunologically characterised melanoma cell lines and searchable databank
    Graham Pawelec
    University of Tübingen Center for Medical Research, ZMF, Waldhornlestr 22, 72072 Tubingen, Germany
    Cancer Immunol Immunother 55:623-7. 2006
    ..This European Searchable Tumour Cell Line and Data Bank (ESTDAB) was established as a Research Infrastructure of the European Commission. For access to the databank and further details, please go to http://www.ebi.ac.uk/ipd/estdab/ ...
  16. ncbi request reprint Immunosenescence in Montecatini
    Graham Pawelec
    Center for Medical Research, University of Tubingen, Waldhornlestr 22, 720272 Tübingen, Germany Author for correspondence e mail fax 49 7071 294677
    Biogerontology 4:121-3. 2003
  17. doi request reprint Translating immunity into cancer therapy: new findings from the first conference of the European Society for Cancer Immunology and Immunotherapy, an ESMO-EIS held in Athens, 15-17 November 2007
    Graham Pawelec
    Center for Medical Research, Tubingen, Germany
    Cancer Immunol Immunother 57:1505-9. 2008
  18. ncbi request reprint Immunorejuvenation in the elderly
    Graham Pawelec
    Center for Medical Research, University of Tubingen, Tubingen, Germany
    Rejuvenation Res 9:111-6. 2006
    ....
  19. ncbi request reprint Immunity and ageing in man: Annual Review 2006/2007
    Graham Pawelec
    University of Tübingen Center for Medical Research, Waldhornlestr 22, D 72072, Tubingen, Germany
    Exp Gerontol 43:34-8. 2008
    ..Here, we summarise some of the developments in this area and in other important areas of immunosenescence research over the past year...
  20. ncbi request reprint T-cell dysregulation caused by chronic antigenic stress: the role of CMV in immunosenescence?
    Graham Pawelec
    Center for Medical Research, University of Tubingen, Germany
    Aging Clin Exp Res 18:171-3. 2006
    ....
  21. ncbi request reprint Pathways to a robust immune response in the elderly
    Graham Pawelec
    Second Department of Internal Medicine, University of Tubingen Medical School, Waldhornlestr 22, D 72076 Tubingen, Germany
    Immunol Allergy Clin North Am 23:1-13. 2003
    ....
  22. ncbi request reprint Human immunosenescence: does it have an infectious component?
    G Pawelec
    University of Tubingen Medical School, Center for Medical Research, ZMF, Germany
    Ann N Y Acad Sci 1067:56-65. 2006
    ..In this respect, immunosenescence is infectious...
  23. ncbi request reprint Immunosenescence, suppression and tumour progression
    G Pawelec
    Center for Medical Research and Department of Immunology, University of Tubingen, Tubingen, Germany
    Cancer Immunol Immunother 55:981-6. 2006
    ..by antigen which is not or cannot be eliminated? What are the similarities and differences between chronic antigenic stimulation by tumour antigen versus CMV antigen? What can we learn in one system which may illuminate the other?..
  24. doi request reprint Role of CMV in immune senescence
    Graham Pawelec
    Section for Transplantation Immunology, 2nd Dept of Internal Medicine, University of Tübingen Center for Medical Research, Tubingen Ageing and Tumour Immunology Group, Waldhornlestr 22, D 72072 Tubingen, Germany
    Virus Res 157:175-9. 2011
    ..Here we review the impact of CMV on "immune senescence" in humans...
  25. ncbi request reprint Human immunosenescence: is it infectious?
    Graham Pawelec
    University of Tubingen Medical School, Center for Medical Research, ZMF, Germany
    Immunol Rev 205:257-68. 2005
    ..In this sense, then, we suggest that immunosenescence is contagious...
  26. ncbi request reprint Is immunosenescence infectious?
    Graham Pawelec
    University of Tubingen Medical School, Center for Medical Research, ZMF, Waldhornlestrasse 22, D 72072 Tubingen, Germany
    Trends Immunol 25:406-10. 2004
  27. ncbi request reprint Immunosenescence: what is it and what can be done about it? Session 20 of the BSI Annual Congress, Harrogate, December, 2003
    Graham Pawelec
    Centre for Medical Research, University of Tubingen Medical School, Germany
    Rejuvenation Res 7:61-4. 2004
  28. ncbi request reprint Engineering anticancer T cells for extended functional longevity
    Graham Pawelec
    Center for Medical Research, ZMF, University of Tubingen Medical School, Waldhornlestrasse 22, D 72072 Tuebingen, Germany
    Ann N Y Acad Sci 1019:178-85. 2004
    ....
  29. ncbi request reprint Immunotherapy and immunoselection -- tumour escape as the final hurdle
    Graham Pawelec
    Section for Transplantation Immunology and Immunohaematology, Center for Medical Research, University of Tubingen Medical School, ZMF, Waldhornlestr 22, D 72072 Tubingen, Germany
    FEBS Lett 567:63-6. 2004
    ..Prevention or reversal of tumour escape from the immune response therefore offers the possibility of reconstituting effective anti-tumour immunity and remains the major challenge for 21st century tumour immunology...
  30. doi request reprint Cytomegalovirus and human immunosenescence
    Graham Pawelec
    Center for Medical Research, University of Tubingen Medical School, Tubingen, Germany
    Rev Med Virol 19:47-56. 2009
    ..Whether the IRP is informative in younger individuals and the mechanism of the CMV effect is discussed in this review...
  31. ncbi request reprint Strategies for immune therapy: Würzburg, Germany, 29 February-3 March 2004
    G Pawelec
    Center for Medical Research ZMF, University of Tubingen, Waldhornlestr 22, 72072, Germany
    Cancer Immunol Immunother 53:755-8. 2004
  32. doi request reprint Senescence of the human immune system
    G Pawelec
    Centre for Medical Research, ZMF, University of Tubingen Medical School, Tubingen, Germany
    J Comp Pathol 142:S39-44. 2010
    ....
  33. ncbi request reprint Tumour escape: antitumour effectors too much of a good thing?
    Graham Pawelec
    Center for Medical Research ZMF, University of Tubingen, Waldhornlestr 22, 72072, Tubingen, Germany
    Cancer Immunol Immunother 53:262-74. 2004
    ....
  34. doi request reprint Immunosenescence and cancer
    Graham Pawelec
    Tubingen Ageing and Tumour Immunology Group, Center for Medical Research, University of Tübingen Clinical School, Waldhornlestr 22, D 72072 Tubingen, Germany
    Crit Rev Oncol Hematol 75:165-72. 2010
    ..This review weighs some of the evidence for and against this possibility...
  35. pmc Immunosenescence comes of age. Symposium on Aging Research in Immunology: The Impact of Genomics
    Graham Pawelec
    Centre for Medical Research, University of Tübingen Clinical School, Waldhornlestrasse 22, D 72072 Tubingen, Germany
    EMBO Rep 8:220-3. 2007
  36. ncbi request reprint Altered T cell signalling in ageing
    G Pawelec
    Tubingen Ageing and Tumour Immunology Group, Second Department of Internal Medicine, University of Tubingen Medical School, Zentrum für Medizinsche Forschung, Waldhornlestr 22, D 72072, Tubingen, Germany
    Mech Ageing Dev 122:1613-37. 2001
    ....
  37. ncbi request reprint Escape mechanisms in tumor immunity: a year 2000 update
    G Pawelec
    Section for Transplantation Immunology, University of Tubingen, Germany
    Crit Rev Oncog 11:97-133. 2000
    ..Therefore, it focuses mostly on publications that have appeared since then, illustrating the impressive accumulation of new data since that time and the importance currently attributed to studies of tumor escape from the immune response...
  38. ncbi request reprint Hypothesis: loss of telomerase inducibility and subsequent replicative senescence in cultured human T cells is a result of altered costimulation
    G Pawelec
    Section for Transplantation Immunology and Immunohaematology, Tübingen Ageing and Tumour Immunology Group TATI, University of Tubingen, ZMF, Room UG 25, Waldhornlestr 22, D 72072 Tubingen, Germany
    Mech Ageing Dev 121:181-5. 2000
    ..The balance of these positive and negative signals at each encounter with antigen will determine T cell fate by regulating activation and telomerase induction...
  39. pmc Are cancer and ageing different sides of the same coin? Conference on Cancer and Ageing
    Graham Pawelec
    Center for Medical Research, University of Tubingen Medical School, Waldörnlestr 22, D 72072 Tubingen, Germany
    EMBO Rep 9:234-8. 2008
  40. ncbi request reprint Escape from host-antitumor immunity
    G Pawelec
    Tubingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology, Medizinische Universitatsklinik, Germany
    Crit Rev Oncog 8:111-41. 1997
    ..The purpose of this review is to consider the current status of knowledge concerning these different tumor escape strategies...
  41. ncbi request reprint Human T-cell clones in long-term culture as a model of immunosenescence
    G Pawelec
    Department of Internal Medicine II, University of Tubingen Medical School, Germany
    Immunol Rev 160:31-42. 1997
    ..They may also provide a model system for studying ways of modulating the ageing process to delay or prevent immunosenescence in the elderly and the chronically infected or possibly to accelerate immunosenescence in organ transplantation...
  42. ncbi request reprint Interleukin 10 protects activated human T lymphocytes against growth factor withdrawal-induced cell death but only anti-fas antibody can prevent activation-induced cell death
    G Pawelec
    Second Department of Internal Medicine, University of Tübingen MedicalSchool, Federal Republic of Germany
    Cytokine 8:877-81. 1996
    ....
  43. ncbi request reprint Longevity in vitro of human CD4+ T helper cell clones derived from young donors and elderly donors, or from progenitor cells: age-associated differences in cell surface molecule expression and cytokine secretion
    G Pawelec
    Tubingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology and Immunohaematology, Zentrum für Medizinische Forschung, Waldhornlestr 22, D 72072 Tubingen, Germany
    Biogerontology 1:247-54. 2000
    ..Conversely, the frequency of clones secreting IL-6 and the amount secreted per clone was higher in the young...
  44. ncbi request reprint Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human CD4+ TCR2+ cultured T cell clones
    G Pawelec
    Second Department of Internal Medicine, University of Tubingen Medical School, Germany
    Exp Gerontol 31:655-68. 1996
    ..This may contribute to an improved understanding of the mechanisms underlying depressed T cell function in old age...
  45. ncbi request reprint Cancer vaccination progress
    Graham Pawelec
    University of Tuebingen Medical School, Center for Medical Research ZMF, Germany
    Trends Mol Med 8:545-6. 2002
    ....
  46. ncbi request reprint Is human immunosenescence clinically relevant? Looking for 'immunological risk phenotypes'
    Graham Pawelec
    Tubingen Ageing and Tumour Immunology Group, Center for Medical Research, Waldhornlestrasse 22, D 72072 Tubingen, Germany
    Trends Immunol 23:330-2. 2002
  47. ncbi request reprint New methods to approach immunotherapy of cancer--and strategies of tumours to avoid elimination. Conference report, on behalf of EUCAPS. European Cancer Research Consortium
    G Pawelec
    University of Tubingen, Section for Transplantation Immunology and Immunohaematology, Germany
    Cancer Immunol Immunother 49:276-80. 2000
    ..This conference was the second of a series, the first of which was summarised previously in this journal [Pawelec G et al. (1999) Cancer Immunol Immunother 48: 214]...
  48. ncbi request reprint T cells and aging, January 2002 update
    Graham Pawelec
    University of Tubingen, Center for Medical Research, ZMF, Waldhornlestr 22, D 72072 Tubingen, Germany
    Front Biosci 7:d1056-183. 2002
    ....
  49. ncbi request reprint Human CD4+ T cell clone longevity in tissue culture: lack of influence of donor age or cell origin
    Graham Pawelec
    Tubingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology and Immunohaematology, Center for Medical Research, ZMF, University of Tubingen, Waldhornlestrasse 22, D 72072 Tubingen, Germany
    Exp Gerontol 37:265-9. 2002
    ..These results imply that the longevity of T cells in culture is more likely to be dictated by cloning conditions than any intrinsic differences between the cells studied...
  50. ncbi request reprint The T cell in the ageing individual
    G Pawelec
    Second Department of Internal Medicine, University of Tubingen Medical School, Germany
    Mech Ageing Dev 93:35-45. 1997
    ....
  51. ncbi request reprint The self peptide annexin II (208-223) presented by dendritic cells sensitizes autologous CD4+ T lymphocytes to recognize melanoma cells
    S Heinzel
    , Second Department of Internal Medicine, , Germany
    Cancer Immunol Immunother 49:671-8. 2001
    ..This peptide may therefore be useful in immunotherapy for recruiting CD4+ type 1 helper cells active locally in the tumour environment...
  52. ncbi request reprint T cell immunosenescence in vitro and in vivo
    G Pawelec
    Tubingen Ageing and Tumour Immunology Group, Second Department of Internal Medicine, Medizinische Universitätsklinik und Poliklinik, Germany
    Exp Gerontol 34:419-29. 1999
    ..The use of culture models to screen for ways of manipulating immunosenescence in vitro may provide a basis for intervention to ameliorate immunosenescence in vivo...
  53. ncbi request reprint In vitro senescence models for human T lymphocytes
    G Pawelec
    Tübingen Ageing and Tumour Immunology TATI Group, Second Department of Internal Medicine, Medizinische Universitätsklinik und Poliklinik, Otfried Muller Str 10, D 72076, Tubingen, Germany
    Vaccine 18:1666-74. 2000
    ..It will be argued that parallels between this in vitro model and T cell senescence in vivo suggest the use of such models to screen for interventions ameliorating immunosenescence in vivo...
  54. ncbi request reprint Prediction of an HLA-DR-binding peptide derived from Wilms' tumour 1 protein and demonstration of in vitro immunogenicity of WT1(124-138)-pulsed dendritic cells generated according to an optimised protocol
    Ashley John Knights
    University of Tubingen, Section for Transplantation Immunology and Immunohaematology, Second Department of Internal Medicine, Zentrum für Medizinische Forschung ZMF, Waldhornlestrasse 22, 72072 Tubingen, Germany
    Cancer Immunol Immunother 51:271-81. 2002
    ..These results suggest that the WT1 protein may yield epitopes immunogenic to CD4 as well as CD8 T cells, and therefore constitute a novel potential target for specific immunotherapy...
  55. ncbi request reprint T cells and aging (update february 1999)
    G Pawelec
    University of Tubingen, Tubingen, FRG
    Front Biosci 4:D216-69. 1999
    ..This review aims to consider the current state of knowledge on the scientific basis for and potential clinical relevance of those factors in immunosenescence...
  56. ncbi request reprint Recognition of chronic myelogenous leukaemia cells by autologous T lymphocytes primed in vitro against the patient's dendritic cells
    L Muller
    Tübingen Ageing and Tumour Immunology Group TATI, Section for Transplantation Immunology, University of Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Br J Haematol 112:740-8. 2001
    ..This approach allows sensitization of patients' T cells by their own particular tumour without the need to identify the exact leukaemia antigens involved, and may find application in immunotherapy of CML...
  57. ncbi request reprint Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)
    Qin Ouyang
    Section for Transplantation Immunology and Immunohematology, University of Tubingen, Germany
    Exp Gerontol 38:911-20. 2003
    ..The presence of clonal expansions of such virus-specific cells may shrink the available repertoire for other antigens and contribute to the increased incidence of infectious disease in the elderly...
  58. ncbi request reprint Cytokine modulation of TH1/TH2 phenotype differentiation in directly alloresponsive CD4+ human T cells
    G Pawelec
    Section for Transplantation Immunology, Medizinische Universitatsklinik, Tubingen, Germany
    Transplantation 62:1095-101. 1996
    ..These findings may have implications for manipulating the direct pathway of alloantigen recognition in human organ transplantation...
  59. ncbi request reprint T cells and aging
    G Pawelec
    University of Tubingen, Tubingen, Federal Republic of Germany
    Front Biosci 3:d59-99. 1998
    ..This review aims to consider the current state of knowledge on the scientific basis for and potential clinical relevance of those factors in immunosenescence...
  60. ncbi request reprint Finite lifespans of T cell clones derived from CD34+ human haematopoietic stem cells in vitro
    G Pawelec
    Tubingen Ageing and Tumour Immunology Group, Department of Hematology, Oncology, Immunology and Rheumatology, Tübingen University Medical School, Germany
    Exp Gerontol 34:69-77. 1999
    ..We show here that T cell clones derived under these circumstances also manifest variable finite life expectancies, for which the only uncontrolled (nonstochastic) effects of aging must already have occurred at the stem cell level...
  61. ncbi request reprint Prerequisites for the immunotherapy of cancer
    G Pawelec
    Tubingen Ageing and Tumour Immunology Group, Second Department of Internal Medicine, University of Tubingen Medical School, Germany
    Cancer Immunol Immunother 48:214-7. 1999
    ....
  62. ncbi request reprint Generation of chronic myelogenous leukemia-specific T cells in cytokine-modified autologous mixed lymphocyte/tumor cell cultures
    L Muller
    Section for Transplantation Immunology, Second Department of Internal Medicine, University of Tubingen Medical School, Germany
    J Immunother 24:482-92. 2001
    ....
  63. ncbi request reprint IFN-alpha regulates IL 10 production by CML cells in vitro
    G Pawelec
    Tubingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology, Second Department of Internal Medicine, Tübingen University Medical School, Tubingen, Germany
    Cancer Immunol Immunother 48:430-4. 1999
    ....
  64. ncbi request reprint Escape mechanisms in tumor immunity: an update
    Ludmila Muller
    Tübingen Aging and Tumour Immunology Group TATI, Section for Transplantation Immunology, Med izinische Universitätsklinik, D 72076 Tubingen, Germany
    J Environ Pathol Toxicol Oncol 21:277-330. 2002
    ..The purpose of this review is to consider the current status of knowledge concerning these different tumor-escape strategies, in the form of an update of previous publications in this journal...
  65. ncbi request reprint Dysfunctional CMV-specific CD8(+) T cells accumulate in the elderly
    Qin Ouyang
    Tubingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology and Immunohematology, University of Tubingen, Tubingen, Germany
    Exp Gerontol 39:607-13. 2004
    ..This might account for the increased incidence of many infectious diseases in the elderly...
  66. ncbi request reprint Impact of aging on innate immunity
    G Pawelec
    Second Department of Internal Medicine, University of Tubingen Medical School, Germany
    J Leukoc Biol 64:703-12. 1998
    ....
  67. ncbi request reprint High frequencies of functionally impaired cytokeratin 18-specific CD8+ T cells in healthy HLA-A2+ donors
    Steffen Walter
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University, Tubingen, Germany
    Eur J Immunol 35:2876-85. 2005
    ..Thus, cytokeratin 18-specific cells constitute a frequently encountered, new CD8+ T lymphocyte subpopulation without classical effector status and with so far unknown function...
  68. doi request reprint Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas
    Sebastian Attig
    Department of Immunology, Institute for Cell Biology, Eberhard Karls University, Tubingen, Germany
    Cancer Res 69:8412-9. 2009
    ..Additionally, several populations of CD4(+) and CD8(+) regulatory T cells were identified that may synergize to locally dampen antitumor T-cell responses...
  69. ncbi request reprint T-CIA: investigating T cells in aging
    Sven Koch
    Center for Medical Research, University of Tuebingen, D 72072 Tuebingen, Germany
    Sci Aging Knowledge Environ 2005:pe21. 2005
    ....
  70. ncbi request reprint Senescence: the cost of being young and healthy?
    Graham Pawelec
    Tubingen Ageing and Tumour Immunology Group, ZMF, University of Tubingen, Germany
    Eur Cytokine Netw 13:387-8. 2002
  71. ncbi request reprint Extrathymic T cell differentiation in vitro from human CD34+ stem cells
    G Pawelec
    Department of Hematology, Oncology, Immunology and Rheumatology, Tübingen University Medical School, Germany
    J Leukoc Biol 64:733-9. 1998
    ..This culture system therefore supports human T lymphopoiesis in the absence of any thymic influence and may prove useful for the evaluation of extrathymic T cell differentiation in vitro...
  72. doi request reprint Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation
    Anis Larbi
    Center for Medical Research, Tübingen Aging and Tumor Immunology Group, University of Tubingen, 72072 Tubingen, Germany
    Free Radic Biol Med 48:26-34. 2010
    ..Altogether, this study highlights the importance of controlling oxygen levels in culture when investigating oxygen-dependent phenomena such as oxidative stress...
  73. ncbi request reprint Oxidative stress modulation and T cell activation
    Anis Larbi
    Center for Medical Research, Tuebingen Ageing and Tumor Immunology group, University of Tuebingen, Waldhornlestrasse 22, 72072 Tuebingen, Germany
    Exp Gerontol 42:852-8. 2007
    ..Here, we discuss the relevance of oxidative stress modulation to prevent T cell dysfunction. We draw attention to some technical, but critical, aspects of T cell culture under hyperoxic conditions...
  74. doi request reprint Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients
    Benjamin Weide
    Department of Dermatology, Division of Dermatooncology, University of Tubingen, Tubingen, Germany
    J Immunother 32:498-507. 2009
    ....
  75. ncbi request reprint A satellite symposium of the 1st European Congress of Immunology Paris, France, September 2006, Aging Research in Immunology: the genomic facet in Paris
    Anis Larbi
    Center for Medical Research, Tuebingen Aging and Tumor Immunology group Waldhornlestrasse 22, 72072, University of Tuebingen, Tuebingen, Germany
    Exp Gerontol 42:379-84. 2007
  76. doi request reprint Aging of the immune system as a prognostic factor for human longevity
    Anis Larbi
    University of Tubingen, Center for Medical Research, Tubingen, Germany
    Physiology (Bethesda) 23:64-74. 2008
    ..The mechanisms and consequences of age-associated immune alterations, designated immunosenescence, are briefly reviewed here...
  77. doi request reprint Immune receptor signaling, aging and autoimmunity
    Anis Larbi
    Center for Medical Research ZMF, Tübingen Aging and Tumour Immunology Group, Section for Transplantation Immunology and Immunohematology, University of Tubingen, Waldhornlestrasse 22, D 72072 Tubingen, Germany
    Adv Exp Med Biol 640:312-24. 2008
    ..g., rheumatoid arthritis, systemic lupus erythematosus and cancer. In this chapter, we will summarize our knowledge about multichain immune recognition receptor signaling, mainly the TCR, in aging and autoimmune diseases...
  78. ncbi request reprint Cytomegalovirus infection: a driving force in human T cell immunosenescence
    Sven Koch
    Department of Immunology, University of Tubingen, Auf der Morgenstelle 15, D 72076, Tubingen, Germany
    Ann N Y Acad Sci 1114:23-35. 2007
    ..These findings support the hypothesis that persistent herpesviruses, especially CMV, act as chronic antigenic stressors and play a major causative role in immunosenescence and associated mortality...
  79. doi request reprint Hallmark features of immunosenescence are absent in familial longevity
    Evelyna Derhovanessian
    Department of Internal Medicine II, Center for Medical Research, University of Tubingen, Tubingen, Germany
    J Immunol 185:4618-24. 2010
    ....
  80. doi request reprint High response rate after intratumoral treatment with interleukin-2: results from a phase 2 study in 51 patients with metastasized melanoma
    Benjamin Weide
    Department of Dermatology, Center of Dermato Oncology, University of Tuebingen, Tuebingen, Germany
    Cancer 116:4139-46. 2010
    ..The objectives of the current study were to confirm those results in a larger cohort and to identify patient or regimen characteristics associated with response...
  81. doi request reprint Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients
    Evelyna Derhovanessian
    Department of Internal Medicine II, Center for Medical Research, University of Tubingen, Tubingen, Germany
    Int J Cancer 125:1372-9. 2009
    ....
  82. ncbi request reprint The heat shock proteins in cellular aging: is zinc the missing link?
    Anis Larbi
    Center for Medical Research, Tüebingen Aging and Tumor Immunology group, University of Tuebingen, Waldhornlestrasse 22, 72072, Tuebingen, Germany
    Biogerontology 7:399-408. 2006
    ..In this short review we will briefly outline the role of heat-shock proteins and zinc deficiency in aging in order to finally discuss our own results in the context of a link between HSPs, aging and zinc...
  83. ncbi request reprint Basic biology and clinical impact of immunosenescence
    Wolfgang M Wagner
    Zentrum für Medizinische Forschung, Universitätsklinik Tübingen, Waldhornlestrasse 22, 72072, Tubingen, Germany
    Biogerontology 5:63-6. 2004
  84. doi request reprint Induction of HIF-1alpha and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells
    Anis Larbi
    Center for Medical Research ZMF, Tübingen Aging and Tumor Immunology Group Sektion für Transplantationsimmunologie und Immunhämatologie, Waldhornlestrasse 22, 72072 Tubingen, Germany
    J Leukoc Biol 87:265-73. 2010
    ....
  85. ncbi request reprint Development of an MHC-class I peptide selection assay combining nanoparticle technology and matrix-assisted laser desorption/ionisation mass spectrometry
    Thomas Flad
    Section for Transplantation Immunology and Immunohematology, University of Tuebingen, Germany
    J Immunol Methods 283:205-13. 2003
    ..The advantage of the system is that the bound peptides can be unambiguously identified without any prior modification (e.g. radioactive or fluorescence labelling), even from complex peptide mixtures...
  86. ncbi request reprint T Cell Immunity and Aging
    Sven Dominik Koch
    Center for Medical Research, University of Tuebingen, D 72072 Tuebingen, Germany
    Sci Aging Knowledge Environ 2005:pe37. 2005
    ..This Perspective discusses some of the outcomes of a recent conference that considered progress toward resolving these questions in humans...
  87. ncbi request reprint Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old
    Qin Ouyang
    Tuebingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology and Immunohematology, University of Tubingen, Tubingen, Germany
    J Clin Immunol 23:247-57. 2003
    ....
  88. ncbi request reprint Cytokines and antitumor immunity
    Ludmila Muller
    Tubingen Ageing and Tumor Immunology Group, Centre for Medical Research, Section for Transplantation Immunology, University of Tubingen Medical School, Waldhornlestr 22, D 72072 Tubingen, Germany
    Technol Cancer Res Treat 2:183-94. 2003
    ..Clearly, encouraging the former but preventing the latter will be the key to the effective clinical application of cancer immunotherapy...
  89. ncbi request reprint An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness
    Qin Ouyang
    Tuebingen Ageing and Tumour Immunology Group, Center for Medical Research, ZMF, Waldhoernlestr 22, 72072, Tuebingen, Germany
    Mech Ageing Dev 124:477-85. 2003
    ..This may help to explain the increased incidence and case-fatality caused by viruses and intracellular pathogens in the elderly...
  90. ncbi request reprint Synthetic peptides derived from the Wilms' tumor 1 protein sensitize human T lymphocytes to recognize chronic myelogenous leukemia cells
    Ludmila Muller
    Tubingen Ageing and Tumor Immunology Group, Second Department of Internal Medicine, University of Tubingen Medical School, Germany
    Hematol J 4:57-66. 2003
    ..These results suggest that WT1 peptides can be selected that are immunogenic for class II-restricted T-cell responses to native tumor cells, and indicate that they may find application in active immunotherapy of CML...
  91. ncbi request reprint The abl/bcr gene product as a novel leukemia-specific antigen: peptides spanning the fusion region of abl/bcr can be recognized by both CD4+ and CD8+ T lymphocytes
    Wolfgang M Wagner
    Section for Transplantation Immunology and Immunohaematology, Second Department of Internal Medicine, Tübingen University Medical School, Tubingen, Germany
    Cancer Immunol Immunother 52:89-96. 2003
    ..Because abl/bcr is expressed in the majority of CML patients, it may represent a highly leukemia-specific antigen with potential use in immunotherapy...
  92. ncbi request reprint Chronic phase CML patients possess T cells capable of recognising autologous tumour cells
    Ludmila Muller
    Second Department of Internal Medicine, University of Tubingen Medical School, Germany
    Leuk Lymphoma 43:943-51. 2002
    ..These results could be exploited for adoptive immunotherapy, and possibly, after identification of the antigens recognised, also for active immunotherapy, i.e. including therapeutic vaccination...
  93. ncbi request reprint Compromised interferon gamma (IFN-gamma) production in the elderly to both acute and latent viral antigen stimulation: contribution to the immune risk phenotype?
    Qin Ouyang
    Tubingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology and Immunohaematology, Center for Medical Research, ZMF, University of Tubingen, Germany
    Eur Cytokine Netw 13:392-4. 2002
    ..Further longitudinal studies are needed to demonstrate whether cytokines such as IFN-g are also part of the IRP. Improving the definition of the IRP will help to understand and thus prevent or reverse age-associated immune dysfunction...
  94. ncbi request reprint A novel MHC-associated proteinase 3 peptide isolated from primary chronic myeloid leukaemia cells further supports the significance of this antigen for the immunotherapy of myeloid leukaemias
    A J Knights
    Section for Transplantation Immunology and Immunohaematology, University Hospital Tubingen, ZMF, Waldhornlestrasse 22, Tubingen, Germany
    Leukemia 20:1067-72. 2006
    ..Taken in conjunction with clinical observations of functional Proteinase 3 specific CTL in patients', these data further support the application of this antigen as an immunotherapeutical target for myelogenous leukaemias...
  95. ncbi request reprint CIMT meets strategies for immune therapy. Report and abstracts of the 4th International Meeting of the Association for Immunotherapy of Cancer, Mainz, Germany, 4-5 May 2006
    C Gouttefangeas
    Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Cancer Immunol Immunother 56:397-427. 2007
  96. ncbi request reprint Myelopoiesis in vitro is suppressed by hepatitis A virus
    F W Busch
    Medizinische Universitatsklinik, Tubingen, Federal Republic of Germany
    Ann Hematol 64:A132-6. 1992
    ..These findings argue for a direct suppression of (pre-) CFU-GM by HAV in a model system (LTBMC) lacking an immune defense which would limit viral replication...
  97. doi request reprint Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
    Evelyna Derhovanessian
    Center for Medical Research, ZMF, University of Tubingen Medical School, Tubingen, Germany
    Curr Opin Immunol 21:440-5. 2009
    ....
  98. doi request reprint Dramatic shifts in circulating CD4 but not CD8 T cell subsets in mild Alzheimer's disease
    Anis Larbi
    Center for Medical Research, University of Tubingen, Tubingen, Germany
    J Alzheimers Dis 17:91-103. 2009
    ....
  99. ncbi request reprint Human cytomegalovirus infection and T cell immunosenescence: a mini review
    Sven Koch
    Center for Medical Research ZMF, University of Tubingen, Waldhornlestr 22, D 72072 Tubingen, Germany
    Mech Ageing Dev 127:538-43. 2006
    ..Taken together, these findings suggest the hypothesis that persistence of CMV as a chronic antigenic stressor is a major contributor to immunosenescence and associated mortality...
  100. ncbi request reprint The concept of telomeric non-reciprocal recombination (TENOR) applied to human fibroblasts grown in serial cultures: concordance with genealogical data
    Stefan Hasenmaile
    Tubingen Ageing and Tumour Immunology Group, Center for Medical Research, University of Tubingen Medical School, Tubingen, Germany
    Rejuvenation Res 8:154-71. 2005
    ..Here we discuss genealogical data collected over the last decades as well as more recent findings on the telomere-driven replicative senescence process, and we summarize both to give an integrated picture...
  101. ncbi request reprint A lack of telomeric non-reciprocal recombination (TENOR) may account for the premature proliferation blockade of Werner's syndrome fibroblasts
    Stefan Hasenmaile
    Tubingen Ageing and Tumour Immunology Group, Section for Transplantation Immunology and Immunohaematology, Zentrum für Medizinische Forschung, University of Tubingen, 72072 Tubingen, Germany
    Biogerontology 4:253-73. 2003
    ..If it is stipulated that WF are defective for TENOR because of their defective WRNp, a simple model emerges as to how they become prematurely senescent...