Walter Paulus

Summary

Country: Germany

Publications

  1. ncbi Modulation of cortical excitability by weak direct current stimulation--technical, safety and functional aspects
    Michael A Nitsche
    Department of Clinical Neurophysiology, , Robert Koch Strasse 40, , Germany
    Suppl Clin Neurophysiol 56:255-76. 2003
  2. ncbi Facilitation of visuo-motor learning by transcranial direct current stimulation of the motor and extrastriate visual areas in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, 37075 Goettingen, Germany
    Eur J Neurosci 19:2888-92. 2004
  3. ncbi Outlasting excitability shifts induced by direct current stimulation of the human brain
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Suppl Clin Neurophysiol 57:708-14. 2004
  4. ncbi Dopamine and the spinal cord in restless legs syndrome: does spinal cord physiology reveal a basis for augmentation?
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Sleep Med Rev 10:185-96. 2006
  5. ncbi Normal interhemispheric inhibition in persistent developmental stuttering
    Martin Sommer
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 24:769-73. 2009
  6. ncbi Less is more: pathophysiology of dopaminergic-therapy-related augmentation in restless legs syndrome
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Lancet Neurol 5:878-86. 2006
  7. ncbi [Therapy and prophylaxis of facial neuralgias and other forms of facial pain syndromes -- revised recommendations of the German Society of Migraine and Headache]
    W Paulus
    Abteilung Klinische Neurophysiologie der Universität Göttingen
    Schmerz 17:74-91. 2003
  8. ncbi Update of the pathophysiology of the restless-legs-syndrome
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 22:S431-9. 2007
  9. ncbi Transcranial electrical stimulation (tES - tDCS; tRNS, tACS) methods
    Walter Paulus
    Department of Clinical Neurophysiology, University Medical Faculty Göttingen, Gottingen, Germany
    Neuropsychol Rehabil 21:602-17. 2011
  10. ncbi Pathophysiological concepts of restless legs syndrome
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 22:1451-6. 2007

Detail Information

Publications114 found, 100 shown here

  1. ncbi Modulation of cortical excitability by weak direct current stimulation--technical, safety and functional aspects
    Michael A Nitsche
    Department of Clinical Neurophysiology, , Robert Koch Strasse 40, , Germany
    Suppl Clin Neurophysiol 56:255-76. 2003
  2. ncbi Facilitation of visuo-motor learning by transcranial direct current stimulation of the motor and extrastriate visual areas in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, 37075 Goettingen, Germany
    Eur J Neurosci 19:2888-92. 2004
    ..Also, stimulation of the primary visual cortex was not effective for this kind of task. Our data suggest that the areas V5 and M1 are involved in the early phase of learning of visuo-motor coordination...
  3. ncbi Outlasting excitability shifts induced by direct current stimulation of the human brain
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Suppl Clin Neurophysiol 57:708-14. 2004
    ..Thus, this technique is a promising method in the field of neuroplastic research in animals and humans and could evolve as a therapeutic tool in some neuro-psychiatric disorders which benefit from modulation of cortical excitability...
  4. ncbi Dopamine and the spinal cord in restless legs syndrome: does spinal cord physiology reveal a basis for augmentation?
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Sleep Med Rev 10:185-96. 2006
    ..In particular, we propose that the differential effects of l-DOPA and opioids on early and late flexor reflexes may be linked to the phenomenon of augmentation...
  5. ncbi Normal interhemispheric inhibition in persistent developmental stuttering
    Martin Sommer
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 24:769-73. 2009
    ..The abnormal right motor and premotor activity observed in functional imaging studies on PDS are not likely to reflect altered primary motor cortex excitability, but are likely to have a different origin...
  6. ncbi Less is more: pathophysiology of dopaminergic-therapy-related augmentation in restless legs syndrome
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Lancet Neurol 5:878-86. 2006
    ....
  7. ncbi [Therapy and prophylaxis of facial neuralgias and other forms of facial pain syndromes -- revised recommendations of the German Society of Migraine and Headache]
    W Paulus
    Abteilung Klinische Neurophysiologie der Universität Göttingen
    Schmerz 17:74-91. 2003
    ..Therapeutic recommendations are based on evidence based medicine criteria (EBM)...
  8. ncbi Update of the pathophysiology of the restless-legs-syndrome
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 22:S431-9. 2007
    ..Furthermore, this may create a framework to help understand why dopamine, opioid, and some anticonvulsant therapies are effective in RLS patients...
  9. ncbi Transcranial electrical stimulation (tES - tDCS; tRNS, tACS) methods
    Walter Paulus
    Department of Clinical Neurophysiology, University Medical Faculty Göttingen, Gottingen, Germany
    Neuropsychol Rehabil 21:602-17. 2011
    ..Transcranial alternating stimulation (tACS) and random noise stimulation (tRNS) are used to interfere with ongoing neuronal oscillations and also finally produce neuroplastic effects if applied with appropriate parameters...
  10. ncbi Pathophysiological concepts of restless legs syndrome
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 22:1451-6. 2007
    ..Neurophysiologically excitability alterations can be measured by a variety of methods such as determination of pain thresholds, H-reflex testing, and quantitative sensory testing...
  11. ncbi Modulatory effects of transcranial direct current stimulation on laser-evoked potentials
    Gabor Csifcsak
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Pain Med 10:122-32. 2009
    ..In a separate experiment subjective, pain rating scores of 16 healthy subjects in two perceptual categories (warm sensation, mild pain) were also analyzed...
  12. ncbi Cortical hypoexcitability in chronic smokers? A transcranial magnetic stimulation study
    Nicolas Lang
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Neuropsychopharmacology 33:2517-23. 2008
    ..These changes may form a physiological basis for neurobiological and behavioral variations associated with chronic smoking...
  13. ncbi Fate of pre-differentiated mouse embryonic stem cells transplanted in unilaterally 6-hydroxydopamine lesioned rats: histological characterization of the grafted cells
    Keneuoe Thinyane
    Department of Clinical Neurophysiology, , , Germany
    Brain Res 1045:80-7. 2005
    ..After 5 weeks, two out of fifteen graft recipients had tumors indicating that pre-differentiation of mouse embryonic stem cells using this differentiation protocol is not sufficient to prevent tumor formation...
  14. ncbi Neuroplasticity in cigarette smokers is altered under withdrawal and partially restituted by nicotine exposition
    Jessica Grundey
    Georg August University, Department of Clinical Neurophysiology, Gottingen, Germany
    J Neurosci 32:4156-62. 2012
    ..These results might shed further light on the proposed mechanism of nicotine on cognition and attention, which might be connected to nicotine addiction and probability of relapse in smokers...
  15. ncbi Modulation of motor consolidation by external DC stimulation
    Nicolas Lang
    Department of Clinical Neurophysiology, , Robert-Koch-Strasse 40, , Germany
    Suppl Clin Neurophysiol 56:277-81. 2003
  16. ncbi Dopaminergic modulation of long-lasting direct current-induced cortical excitability changes in the human motor cortex
    Michael A Nitsche
    Georg August University, Department for Clinical Neurophysiology, Robert Koch Str 40, 37099 Goettingen, Germany
    Eur J Neurosci 23:1651-7. 2006
    ..g. migraine and epilepsy...
  17. ncbi Limited impact of homeostatic plasticity on motor learning in humans
    Min Fang Kuo
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37099 Goettingen, Germany
    Neuropsychologia 46:2122-8. 2008
    ..We conclude that homeostatic plasticity, as tested here, has a limited influence on implicit sequential motor learning...
  18. ncbi Effects of transcranial direct current stimulation of the primary sensory cortex on somatosensory perception
    Lisa Grundmann
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Brain Stimul 4:253-60. 2011
    ..Transcranial direct current stimulation (tDCS) is able to modify cortical excitability and activity in humans...
  19. ncbi Half sine, monophasic and biphasic transcranial magnetic stimulation of the human motor cortex
    Martin Sommer
    Department of Clinical Neurophysiology, , Robert-Koch-Street 40, , Germany
    Clin Neurophysiol 117:838-44. 2006
    ..SIGNIFICANCE: This systematic comparison of 3 waveforms and two current directions allows a better understanding of the mechanisms of TMS...
  20. ncbi Transcranial direct current stimulation of the motor cortex induces distinct changes in thermal and mechanical sensory percepts
    Cornelius G Bachmann
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Clin Neurophysiol 121:2083-9. 2010
    ..The aim of this single-blinded, complete crossover study was to evaluate the effects of tDCS on thermal and mechanical perception, as assessed by quantitative sensory testing (QST)...
  21. ncbi Anodal transcranial direct current stimulation of the motor cortex ameliorates chronic pain and reduces short intracortical inhibition
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, 37075 Gottingen, Germany
    J Pain Symptom Manage 39:890-903. 2010
    ..Consecutive sessions of transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) may be a suitable therapy to treat chronic pain, as it can modulate neural activities in the stimulated and interconnected regions...
  22. ncbi D1-receptor impact on neuroplasticity in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, Georg August University, 37099 Gottingen, Germany
    J Neurosci 29:2648-53. 2009
    ..However, comparison with former results show that an appropriate balance of D(1) and D(2) activity seems necessary to (1) consolidate the respective excitability modifications and (2) to elicit a focusing effect...
  23. ncbi No correlation between moving phosphene and motor thresholds: a transcranial magnetic stimulation study
    Andrea Antal
    Department of Clinical Neurophysiology, George August University of Göttingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neuroreport 15:297-302. 2004
    ..Thus, we propose specific measures for cortices of interest: PT for visual experiments and MT for motor experiments...
  24. ncbi Towards unravelling task-related modulations of neuroplastic changes induced in the human motor cortex
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Eur J Neurosci 26:2687-91. 2007
    ..Our results show that transcranial direct current stimulation-induced plasticity is highly dependent on the state of the subject during stimulation...
  25. ncbi Theta burst stimulation of the motor cortex reduces laser-evoked pain perception
    Csaba Poreisz
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Neuroreport 19:193-6. 2008
    ..Further studies are needed using motor cortex TBS in chronic pain to pave the way towards a therapeutic tool...
  26. ncbi Dopamine D3 receptor specifically modulates motor and sensory symptoms in iron-deficient mice
    Pascal Dowling
    Department of Clinical Neurophysiology, University Medical Centre Göttingen, 37075 Gottingen, Germany
    J Neurosci 31:70-7. 2011
    ..Furthermore this study suggests an increase of ID-related sensory symptoms and modification of ID-related motor symptoms by D3R-/-...
  27. ncbi Transcranial magnetic and direct current stimulation of the visual cortex
    Andrea Antal
    Department of Clinical Neurophysiology, Georg-August University, Robert Koch Strasse 40, , Germany
    Suppl Clin Neurophysiol 56:291-304. 2003
  28. ncbi Introducing graph theory to track for neuroplastic alterations in the resting human brain: a transcranial direct current stimulation study
    Rafael Polania
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Gottingen, Germany
    Neuroimage 54:2287-96. 2011
    ..Additionally, we propose our approach as a powerful method to track for neuroplastic changes in the human brain...
  29. ncbi Pergolide increases the efficacy of cathodal direct current stimulation to reduce the amplitude of laser-evoked potentials in humans
    Daniella Terney
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    J Pain Symptom Manage 36:79-91. 2008
    ..Furthermore, it demonstrates the potential for repetitive daily stimulation therapy for pain patients...
  30. ncbi Circadian distribution of motor-activity in unilaterally 6-hydroxy-dopamine lesioned rats
    Paul Christian Baier
    Department of Clinical Neurophysiology, Georg August University Gottingen, Robert Koch Str 40, 37075, Gottingen, Germany
    Exp Brain Res 169:283-8. 2006
    ..In order to further elucidate the described phenomena, it will be necessary to perform studies combining sleep recordings with locomotor activity measurements...
  31. ncbi Transcranial direct current stimulation over somatosensory cortex decreases experimentally induced acute pain perception
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Clin J Pain 24:56-63. 2008
    ....
  32. ncbi Electrophysiological correlates of reduced pain perception after theta-burst stimulation
    Gabor Csifcsak
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Neuroreport 20:1051-5. 2009
    ..When compared with sham stimulation, cTBS resulted in a significantly greater diminution of pain ratings and N2-P2 amplitudes on the hand contralateral to the site of motor cortex stimulation...
  33. ncbi Training effects outweigh effects of single-session conventional rTMS and theta burst stimulation in PD patients
    Holger Rothkegel
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Neurorehabil Neural Repair 23:373-81. 2009
    ..Focal single-session repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex has been claimed to be capable of improving motor function in Parkinson's disease...
  34. ncbi GABAergic modulation of DC stimulation-induced motor cortex excitability shifts in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str. 40, 37075 Goettingen, Germany
    Eur J Neurosci 19:2720-6. 2004
    ..Because intracortical inhibition and facilitation are not changed in this phase compared with pre-tDCS values, excitability changes originating from remote cortical or subcortical areas could be involved...
  35. ncbi Transcranial direct current stimulation and visual perception
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Perception 37:367-74. 2008
    ..Up- and down-regulation of different cortical areas by tDCS is likely to open a new branch in the field of visual psychophysics...
  36. ncbi Bidirectional modulation of primary visual cortex excitability: a combined tDCS and rTMS study
    Nicolas Lang
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Invest Ophthalmol Vis Sci 48:5782-7. 2007
    ..The authors examined whether tDCS can also prime the cortical response to rTMS in the human visual cortex...
  37. ncbi Direct current stimulation over V5 enhances visuomotor coordination by improving motion perception in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Goettingen, Germany
    J Cogn Neurosci 16:521-7. 2004
    ..The results also raise the possibility of the usefulness of tDCS in rehabilitation strategies for neurological patients with visuomotor disorders...
  38. ncbi Thermal hypoaesthesia differentiates secondary restless legs syndrome associated with small fibre neuropathy from primary restless legs syndrome
    Cornelius G Bachmann
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, D 37075 Goettingen, Germany
    Brain 133:762-70. 2010
    ....
  39. ncbi Anticonvulsant effects of transcranial direct-current stimulation (tDCS) in the rat cortical ramp model of focal epilepsy
    David Liebetanz
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Epilepsia 47:1216-24. 2006
    ..To evaluate its anticonvulsant potential, transcranial direct current stimulation (tDCS) was tested in a modified cortical ramp-stimulation model of focal epilepsy...
  40. ncbi The enhancement of cortical excitability over the DLPFC before and during training impairs categorization in the prototype distortion task
    Géza Gergely Ambrus
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Straße 40, 37075 Gottingen, Germany
    Neuropsychologia 49:1974-80. 2011
    ..The prototype-effect, observable in the case of the sham stimulation group, was severed in all active stimulation conditions...
  41. ncbi Normal intracortical excitability in developmental stuttering
    Martin Sommer
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 18:826-30. 2003
    ..Normal intracortical excitability makes a pathophysiological analogy between focal dystonia and PDS less likely. The enhanced motor threshold suggests reduced motor cortical neuronal membrane excitability in PDS...
  42. ncbi Facilitation of probabilistic classification learning by transcranial direct current stimulation of the prefrontal cortex in the human
    Tamas Z Kincses
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neuropsychologia 42:113-7. 2004
    ..Our results suggest that further studies on the facilitation of learning and memory processes by tDCS are warranted...
  43. ncbi Dose-dependent nonlinear effect of L-DOPA on paired associative stimulation-induced neuroplasticity in humans
    Nivethida Thirugnanasambandam
    Department of Clinical Neurophysiology, Georg August University Goettingen, 37075 Goettingen, Germany
    J Neurosci 31:5294-9. 2011
    ..This might help to explain dopaminergic effect on cognition and could be relevant for understanding the pathophysiology and treatment of neuropsychiatric diseases accompanied by alterations of the dopaminergic system...
  44. ncbi Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Gottingen, Germany
    Brain Stimul 3:230-7. 2010
    ..Plasticity induced in the human motor cortex by intermittent theta-burst stimulation (iTBS) was impaired in individuals expressing the Val66Met polymorphism...
  45. ncbi Growth hormone response to low-dose apomorphine in restless legs syndrome
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Growth Horm IGF Res 17:323-7. 2007
    ..It is therefore the aim of this study to determine whether the GH response to subcutaneously applied low-dose apomorphine is generally altered in patients with RLS as compared to healthy controls...
  46. ncbi Short-duration transcranial random noise stimulation induces blood oxygenation level dependent response attenuation in the human motor cortex
    Leila Chaieb
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    Exp Brain Res 198:439-44. 2009
    ..TRNS also provides a qualitatively new way of producing and interfering with brain plasticity, although, further research is required to optimise stimulation parameters and efficacy...
  47. ncbi Contribution of the premotor cortex to consolidation of motor sequence learning in humans during sleep
    Michael A Nitsche
    Georg August University, Department of Clinical Neurophysiology, Gottingen, Germany
    J Neurophysiol 104:2603-14. 2010
    ..In the control experiments, tDCS did not improve performance. We conclude that the premotor cortex is involved in motor memory consolidation during REM sleep...
  48. ncbi Orientation-specific fast rTMS maximizes corticospinal inhibition and facilitation
    Tobias Tings
    Department of Clinical Neurophysiology, , Robert-Koch-Str. 40, 37075, , Germany
    Exp Brain Res 164:323-33. 2005
    ..In any case biphasic rTMS results can be explained by a mixture of monophasic opposite stimulations. We propose the use of monophasic pulses for maximizing effects during rTMS...
  49. ncbi H-coil: Induced electric field properties and input/output curves on healthy volunteers, comparison with a standard figure-of-eight coil
    Tommaso Fadini
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Clin Neurophysiol 120:1174-82. 2009
    ..To acquire information about the physical properties and physiological effects of the H-coil...
  50. ncbi Electrode-distance dependent after-effects of transcranial direct and random noise stimulation with extracephalic reference electrodes
    Vera Moliadze
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, Gottingen, Germany
    Clin Neurophysiol 121:2165-71. 2010
    ..To evaluate the importance of the distance between stimulation electrodes, in various montages, on the ability to induce sustained cortical excitability changes using transcranial direct and random noise stimulation...
  51. ncbi Transcranial magnetic stimulation and PAS-induced cortical neuroplasticity in the awake rhesus monkey
    Franco Amaya
    Department of Clinical Neurophysiology, Georg August University, 37075 Gottingen, Germany
    Clin Neurophysiol 121:2143-51. 2010
    ....
  52. ncbi Oscillatory brain activity and transcranial direct current stimulation in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neuroreport 15:1307-10. 2004
    ..Since gamma activity is also related to a higher level of information processing, tDCS might be a suitable method to affect higher order cognitive processes...
  53. ncbi Increasing human brain excitability by transcranial high-frequency random noise stimulation
    Daniella Terney
    Department of Clinical Neurophysiology, Georg August University, 37075 Gottingen, Germany
    J Neurosci 28:14147-55. 2008
    ..In terms of efficacy tRNS appears to possess at least the same therapeutic potential as rTMS/tDCS in diseases such as depression, while furthermore avoiding the constraint of current flow direction sensitivity characteristic of tDCS...
  54. ncbi Comparatively weak after-effects of transcranial alternating current stimulation (tACS) on cortical excitability in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Brain Stimul 1:97-105. 2008
    ..Here, we aim to extend transcranial direct current stimulation (tDCS) techniques to transcranial alternating current stimulation (tACS)...
  55. ncbi Gender-specific modulation of short-term neuroplasticity in the visual cortex induced by transcranial direct current stimulation
    Leila Chaieb
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Vis Neurosci 25:77-81. 2008
    ..These results indicate that sex differences exist within the visual cortex of humans, and may be subject to the influences of modulatory neurotransmitters or gonadal hormones which mirror short-term neuroplastic effects...
  56. ncbi Transcranial alternating stimulation in a high gamma frequency range applied over V1 improves contrast perception but does not modulate spatial attention
    Bence Laczo
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Gottingen, Germany
    Brain Stimul 5:484-91. 2012
    ..These results suggest that attention plays an important role in contrast discrimination based on V1 activities that are influences by gamma range tACS stimulation...
  57. ncbi Cathodal stimulation of human MT+ leads to elevated fMRI signal: a tDCS-fMRI study
    Andrea Antal
    Department of Clinical Neurophysiology, University Medical Center, Georg August University of Gottingen, Gottingen, Germany
    Restor Neurol Neurosci 30:255-63. 2012
    ..Here, we tested the effect of tDCS on the blood-oxygen level dependent (BOLD) signal evoked by coherent visual motion using functional magnetic resonance imaging (fMRI)...
  58. ncbi The importance of timing in segregated theta phase-coupling for cognitive performance
    Rafael Polania
    Department of Clinical Neurophysiology, Georg August University of Gottingen, 37075 Gottingen, Germany
    Curr Biol 22:1314-8. 2012
    ..Moreover, the results demonstrate the suitability of transcranial alternating current stimulation to artificially induce coupling or decoupling of behaviorally relevant brain rhythms between segregated cortical regions...
  59. ncbi D2 receptor block abolishes θ burst stimulation-induced neuroplasticity in the human motor cortex
    Katia Monte-Silva
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Neuropsychopharmacology 36:2097-102. 2011
    ..As the reduced response to TBS following SULP resembles its effect on tDCS, the results support an effect of DA on plasticity, which might be related to the focality and associativity of the plasticity induced...
  60. ncbi Does a single session of theta-burst transcranial magnetic stimulation of inferior temporal cortex affect tinnitus perception?
    Csaba Poreisz
    Department of Clinical Neurophysiology Georg August University, Gottingen, Germany
    BMC Neurosci 10:54. 2009
    ..Changes in subjective tinnitus perception were measured with a numerical rating scale (NRS)...
  61. ncbi Transcranial direct current stimulation and the visual cortex
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, 37075 Gottingen, Germany
    Brain Res Bull 68:459-63. 2006
    ..Most likely that up- or downregulation of different cortical areas by tDCS will open a new branch in the area of visual psychophysics...
  62. ncbi Levodopa treatment does not affect low-dose apomorphine test in patients with Parkinson's disease
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Mov Disord 19:1511-5. 2004
    ..Thus, the low-dose apomorphine test may also be a useful biological marker in the early differential diagnosis of PD patients who have already received levodopa treatment...
  63. ncbi Nicotinergic impact on focal and non-focal neuroplasticity induced by non-invasive brain stimulation in non-smoking humans
    Nivethida Thirugnanasambandam
    Department of Clinical Neurophysiology, Georg August University Goettingen, Goettingen, Germany
    Neuropsychopharmacology 36:879-86. 2011
    ..Therefore, activating nicotinic receptors has clearly discernable effects from global cholinergic activation. These nicotine-generated plasticity alterations might be important for the effects of the drug on cognitive function...
  64. ncbi Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Physiol 568:291-303. 2005
    ..In contrast, the after-effects of tDCS are due to shifts in intracortical inhibition and facilitation, and at least partly also to facilitatory I-wave interaction, which is controlled by synaptic activity...
  65. ncbi Dose-dependent inverted U-shaped effect of dopamine (D2-like) receptor activation on focal and nonfocal plasticity in humans
    Katia Monte-Silva
    Department of Clinical Neurophysiology, Georg August University, 37075 Gottingen, Germany
    J Neurosci 29:6124-31. 2009
    ....
  66. ncbi Simply longer is not better: reversal of theta burst after-effect with prolonged stimulation
    Olga Lucia Gamboa
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Exp Brain Res 204:181-7. 2010
    ..It is relevant for clinical applications for which an ongoing need for further protocol improvement is imminent...
  67. ncbi Direct current stimulation over MT+/V5 modulates motion aftereffect in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, 37075 Gottingen, Germany
    Neuroreport 15:2491-4. 2004
    ..These results provide evidence that external modulation of neural excitability in human MT+/V5 affects the strength of perceived motion after-effect and support the involvement of MT+/V5 in motion adaptation processes...
  68. ncbi Level of action of cathodal DC polarisation induced inhibition of the human motor cortex
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075, Goettingen, Germany
    Clin Neurophysiol 114:600-4. 2003
    ..To induce prolonged motor cortical excitability reductions by transcranial direct current stimulation in the human...
  69. ncbi Modulation of moving phosphene thresholds by transcranial direct current stimulation of V1 in human
    Andrea Antal
    Department of Clinical Neurophysiology, George August University of Göttingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neuropsychologia 41:1802-7. 2003
    ..Our results show that the excitability shifts induced by V1 stimulation can modulate moving phosphene perception. tDCS elicits transient, but yet reversible effects, thus presenting a promising tool for neuroplasticity research...
  70. ncbi Comparative assessment of best conventional with best theta burst repetitive transcranial magnetic stimulation protocols on human motor cortex excitability
    Noman Zafar
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Street 40, 37075 Gottingen, Germany
    Clin Neurophysiol 119:1393-9. 2008
    ..Comparative assessment of best conventional with best theta burst repetitive transcranial magnetic stimulation (rTMS) protocols on human motor cortex excitability...
  71. ncbi Effects of transcranial theta-burst stimulation on acute pain perception
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Restor Neurol Neurosci 28:477-84. 2010
    ..Nevertheless, the effectiveness of other types of TBS paradigms should also be tested...
  72. ncbi Impact of regular LDL apheresis on the development of restless legs syndrome
    Tobias Tings
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Mov Disord 19:1072-5. 2004
    ..Substitution of iron therefore may be a promising line of treatment for LA-induced RLS...
  73. ncbi Individual voxel-based subtype prediction can differentiate progressive supranuclear palsy from idiopathic Parkinson syndrome and healthy controls
    Niels K Focke
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Hum Brain Mapp 32:1905-15. 2011
    ..In summary, a voxel-based SVM analysis allows for a reliable classification of individual cases in PSP that can be directly clinically useful. For patients with MSA and IPS, further developments like quantitative MRI are needed...
  74. ncbi Botulinum toxin-induced focal paresis in mice is unaffected by muscle activity
    Anna Kutschenko
    Department of Clinical Neurophysiology, University Medical Centre Göttingen, Gottingen, Germany
    Muscle Nerve 44:930-6. 2011
    ....
  75. ncbi Automated MR image classification in temporal lobe epilepsy
    Niels K Focke
    Department of Clinical Neurophysiology, Georg August University Gottingen, Gottingen, Germany
    Neuroimage 59:356-62. 2012
    ..This could be helpful for screening assessments of MRI scans in patients with epilepsy and when no lesion is detected on visual evaluation...
  76. ncbi Inverse correlation of intracortical inhibition and brain-stem inhibition in humans
    Martin Sommer
    Department of Clinical Neurology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Clin Neurophysiol 113:120-3. 2002
    ..To determine whether intracortical inhibition and the conditioned blink reflex R2 inhibition correlate in healthy subjects...
  77. ncbi Evaluating aftereffects of short-duration transcranial random noise stimulation on cortical excitability
    Leila Chaieb
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Stra β e 40, 37075 Gottingen, Germany
    Neural Plast 2011:105927. 2011
    ....
  78. ncbi Modulating functional connectivity patterns and topological functional organization of the human brain with transcranial direct current stimulation
    Rafael Polania
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Strasse 40, Gottingen, Germany
    Hum Brain Mapp 32:1236-49. 2011
    ..In summary, we show for the first time evidence for tDCS-induced changes in brain synchronization and topological functional organization...
  79. ncbi Can epilepsies be improved by repetitive transcranial magnetic stimulation?--interim analysis of a controlled study
    Frithjof Tergau
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Suppl Clin Neurophysiol 56:400-5. 2003
  80. ncbi Boosting brain excitability by transcranial high frequency stimulation in the ripple range
    Vera Moliadze
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Straße 40, 37075, Gottingen, Germany
    J Physiol 588:4891-904. 2010
    ..High frequency stimulation in the ripple range is a new promising non-invasive brain stimulation protocol to increase human cortical excitability during and after the end of stimulation...
  81. ncbi Impact of repetitive theta burst stimulation on motor cortex excitability
    Olga Lucia Gamboa
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Brain Stimul 4:145-51. 2011
    ..These results might be relevant for clinical applications of TBS, when long-lasting excitability alterations are needed...
  82. ncbi Transcranial alternating current stimulation in the low kHz range increases motor cortex excitability
    Leila Chaieb
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Restor Neurol Neurosci 29:167-75. 2011
    ....
  83. ncbi Relationship between lamotrigine oral dose, serum level and its inhibitory effect on CNS: insights from transcranial magnetic stimulation
    Frithjof Tergau
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Goettingen, Germany
    Epilepsy Res 56:67-77. 2003
    ....
  84. ncbi Robot-assisted image-guided transcranial magnetic stimulation for somatotopic mapping of the motor cortex: a clinical pilot study
    Sven Rainer Kantelhardt
    Department of Neurosurgery, Georg August University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Acta Neurochir (Wien) 152:333-43. 2010
    ..In this study, we have used robot-assisted image-guided transcranial magnetic stimulation (Ri-TMS) to elicit MEP response recorded for individual muscles and reconstruct functional motor maps of the primary motor cortex...
  85. ncbi Premotor transcranial direct current stimulation (tDCS) affects primary motor excitability in humans
    Klara Boros
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Eur J Neurosci 27:1292-300. 2008
    ..Moreover, this finding indirectly substantiates the efficacy of tDCS to modulate premotor excitability, which might be of interest for applications in diseases accompanied by pathological premotor activity...
  86. ncbi Boosting focally-induced brain plasticity by dopamine
    Min Fang Kuo
    Department of Clinical Neurophysiology, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Cereb Cortex 18:648-51. 2008
    ..Most importantly, it prolongs all of these aftereffects by a factor of about 20. Hereby, DA focuses synapse-specific excitability-enhancing neuroplasticity in human cortical networks...
  87. ncbi Attenuation of N2 amplitude of laser-evoked potentials by theta burst stimulation of primary somatosensory cortex
    Csaba Poreisz
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Exp Brain Res 185:611-21. 2008
    ..Furthermore, imTBS produced responses similar to those observed by other forms of TBS induced excitability changes in the SI...
  88. ncbi Focusing effect of acetylcholine on neuroplasticity in the human motor cortex
    Min Fang Kuo
    Department of Clinical Neurophysiology, Georg August University Gottingen, 37075 Gottingen, Germany
    J Neurosci 27:14442-7. 2007
    ..These findings are in line with a cholinergic focusing effect that optimizes the detection of relevant signals during information processing in humans...
  89. ncbi Pregabalin exerts oppositional effects on different inhibitory circuits in human motor cortex: a double-blind, placebo-controlled transcranial magnetic stimulation study
    Nicolas Lang
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Epilepsia 47:813-9. 2006
    ..To explore acute effects of pregabalin (PGB) on human motor cortex excitability with transcranial magnetic stimulation (TMS)...
  90. ncbi Serotonin affects transcranial direct current-induced neuroplasticity in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, Göttingen 37099, Germany
    Biol Psychiatry 66:503-8. 2009
    ..Here we explore the impact of the serotonin reuptake blocker citalopram on plasticity induced by transcranial direct current stimulation (tDCS) in humans in a single-blinded, placebo-controlled, randomized crossover study...
  91. ncbi Toward establishing a therapeutic window for rTMS by theta burst stimulation
    Walter Paulus
    Department of Clinical Neurophysiology, University of Goettingen, D-37075 Goettingen, Germany
    Neuron 45:181-3. 2005
    ..These results may have important implications for the development of clinical applications of rTMS in the treatment of depression, epilepsy, Parkinson's, and other diseases...
  92. ncbi Propagation of spreading depression inversely correlates with cortical myelin content
    Doron Merkler
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    Ann Neurol 66:355-65. 2009
    ..However, the functional implication of cortical demyelination remains elusive. In this study, we investigated whether cortical myelin influences cortical spreading depression (CSD)...
  93. ncbi Neuronal tissue polarization induced by repetitive transcranial magnetic stimulation?
    Martin Sommer
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Neuroreport 13:809-11. 2002
    ..d.). We propose that the current flow in the coil plays a significant role in optimising after effects, and asymmetric current flow may be particularly efficient in building up tissue polarization...
  94. ncbi Temporal pattern of source activities evoked by different types of motion onset stimuli
    Chantal Delon-Martin
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Str 40, D 37075 Gottingen, Germany
    Neuroimage 31:1567-79. 2006
    ..v) The rotation condition evoked a novel component P180, concomitant with an increased activity in the left middle temporal gyrus...
  95. ncbi Iron-deficiency sensitizes mice to acute pain stimuli and formalin-induced nociception
    Pascal Dowling
    Department of Clinical Neurophysiology, Georg August University Gottingen, 37075 Gottingen, Germany
    J Nutr 139:2087-92. 2009
    ..These results demonstrate that iron deficiency increases acute and chronic pain responses in mice and may cause similar alterations to the acute pain threshold and sensitivity to C-fiber-mediated chronic pain in ID RLS patients...
  96. ncbi Catecholaminergic consolidation of motor cortical neuroplasticity in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Str 40, 37075 Goettingen, Germany
    Cereb Cortex 14:1240-5. 2004
    ..This result may enable researchers to optimize neuroplastic processes in the human brain on the rational basis of purpose-designed pharmacological interventions...
  97. ncbi Timing-dependent modulation of associative plasticity by general network excitability in the human motor cortex
    Michael A Nitsche
    Georg August University, Department for Clinical Neurophysiology, 37075 Goettingen, Germany
    J Neurosci 27:3807-12. 2007
    ..These findings might be of importance for the development of plasticity-inducing stimulation protocols supporting information processing in humans...
  98. ncbi The effect of rTMS over left and right dorsolateral premotor cortex on movement timing of either hand
    Bettina Pollok
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Eur J Neurosci 27:757-64. 2008
    ..Additionally, they reveal a piece of evidence that the left dPMC affects the left hand not via a direct left dPMC-right M1 connection...
  99. ncbi Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute
    Diego Garcia-Borreguero
    Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
    Sleep Med 8:520-30. 2007
    ..The Consensus Conference sought to develop a better understanding of augmentation and generate a better operational definition for its clinical identification...
  100. ncbi Focal reduction of intracortical inhibition in the motor cortex by selective proprioceptive stimulation
    Karin Rosenkranz
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square 8 11, London, WC1N 3BG, UK
    Exp Brain Res 149:9-16. 2003
    ..We suggest that MV induces a focused motorcortical activation which relies on a reduced activity of intracortical inhibitory interneuronal circuits targeting selectively the motorcortical representation of the vibrated muscle...
  101. ncbi Pulse configuration-dependent effects of repetitive transcranial magnetic stimulation on visual perception
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Strasse 40, 37070 Gottingen, Germany
    Neuroreport 13:2229-33. 2002
    ..However the effect of modulation significantly depends on the current waveform and direction...