Research Topics
| W PaulusSummaryCountry: Germany Publications
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Detail Information
Publications
Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotypeK A Jellinger
L Boltzmann Institute of Clinical Neurobiology, Baumgartner Hoehe 1, B Bldg, A 1140 Vienna, Austria
BMC Neurol 1:3. 2001..The impact of traumatic brain injury (TBI) on the pathogenesis of Alzheimer disease (AD) is still controversial. The aim of our retrospective autopsy study was to assess the impact of TBE and ApoE allele frequency on the development of AD...
Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastomaSonja Mertsch
Institute of Neuropathology, University Hospital Munster, Munster, Germany
BMC Cancer 9:302. 2009....
Variability of transcriptional regulation after gene transfer with the retroviral tetracycline systemW Paulus
Institute of Neuropathology, University of Munster, Domagkstr 19, D 48129, Munster, Germany
J Biotechnol 81:159-65. 2000....
Middle ear adenocarcinoma with intracranial extension. Case reportW Paulus
Department of Neuropathology, University of Erlangen Medical School, Germany
J Neurosurg 90:555-8. 1999..The authors conclude that middle ear adenocarcinoma belongs to the spectrum of extracranial tumors that have possible local extension to the brain...
Xanthogranuloma of the sellar region: a clinicopathological entity different from adamantinomatous craniopharyngiomaW Paulus
Department of Neuropathology, University of Erlangen, Germany
Acta Neuropathol 97:377-82. 1999..We suggest that xanthogranuloma (cholesterol granuloma) of the sellar region is clinically and pathologically distinct from the classical adamantinomatous craniopharyngioma...
Classification, pathogenesis and molecular pathology of primary CNS lymphomasW Paulus
Institute of Neuropathology, University of Munster, Germany
J Neurooncol 43:203-8. 1999....
Evaluation of the extension of cerebral gliomas by scintigraphyM Weckesser
Department of Nuclear Medicine, University of Munster, Germany
Strahlenther Onkol 176:180-5. 2000..123I-IMT transport across the blood brain barrier is mediated by an amino acid carrier, 201Tl accumulation is analogous to cerebral potassium uptake...
Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult casesC H Rickert
Institute of Neuropathology, Westfalische Wilhelms Universitat Munster, Domagkstr 19, D 48129, Munster, Germany
Am J Pathol 158:1525-32. 2001..Furthermore, gains of chromosomal material on 1q might be correlated with a worse prognosis in pediatric anaplastic astrocytomas...
BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adultsM Hasselblatt
Institute of Neuropathology, University Hospital Munster, Munster, Germany
Neuropathol Appl Neurobiol 37:803-6. 2011..As data on BRAF-KIAA1549 fusion transcript status remain mainly limited to children, we aimed to examine the diagnostic value of BRAF-KIAA1549 fusion transcripts across all age groups...
Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal regionM Hasselblatt
Institute of Neuropathology, University Hospital Munster, Munster, Germany
Neuropathol Appl Neurobiol 32:278-83. 2006..Antibodies directed against these antigens are thus expected to be valuable markers in the diagnosis of papillary tumours located in the vicinity of the third ventricle...
Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migrationS Mertsch
Institute of Neuropathology, University Hospital Muenster, Muenster, Germany
Neuropathol Appl Neurobiol 35:342-52. 2009..After identifying vesicle amine transport protein-1 (VAT-1) as being upregulated in invasive human gliomas, we study its possible function in glioblastoma cell migration...
Increased chromosomal imbalances in recurrent pituitary adenomasC H Rickert
Institute of Neuropathology, University Clinics Münster, Domagkstr 19, 48129 Munster, Germany
Acta Neuropathol 102:615-20. 2001..The average MIB-1 proliferation indices were 1.2% for primary and 1.9% for recurrent adenomas (P < 0.005). Our findings suggest that acquisition of certain chromosomal imbalances is related to and may underlie adenoma recurrence...
Comparative genomic hybridization in pineal parenchymal tumorsC H Rickert
Institute of Neuropathology, Westfalische Wilhelms Universitat, Munster, Germany
Genes Chromosomes Cancer 30:99-104. 2001..Furthermore, imbalances in higher-grade pineal parenchymal tumors mainly affect gains of 12q and losses of chromosome 22...
Knockdown of annexin 2 decreases migration of human glioma cells in vitroL Tatenhorst
Institute of Neuropathology, University Hospital Muenster, Muenster, Germany
Neuropathol Appl Neurobiol 32:271-7. 2006..Our findings identify annexin 2 as a potential candidate involved in glioma invasion and support the potential of RNA interference as powerful tool in the decryption of glioma invasion mechanisms...
[Hypermethylation as a potential prognostic factor and a clue to a better understanding of the molecular pathogenesis of medulloblastoma--results of a genomewide methylation scan]M C Frühwald
Westfalische Wilhelms Universitat Munster, Klinik und Poliklinik für Kinderheilkunde, Pädiatrische Hämatologie Onkologie, Munster, Germany
Klin Padiatr 213:197-203. 2001..The molecular mechanisms controlling initiation and progression of medulloblastomas are largely unclear. Changes in DNA methylation of promoter regions have been shown to disturb the expression of growth regulatory genes...
Chromosomal aberrations in pituitary carcinoma metastasesC H Rickert
Institute of Neuropathology, University Clinics Münster, Germany
Acta Neuropathol 102:117-20. 2001..To date, gains of chromosome 14q have not been reported among pituitary tumors. It remains to be shown whether gain of 14q is associated with malignant progression and metastatic dissemination of pituitary carcinomas...
Regulated gene expression in glioma cells: a comparison of three inducible systemsV Senner
Institute of Neuropathology, , Germany
Neurochem Res 26:521-4. 2001..Our data suggest that the most appropriate system depends on the experimental procedures, the application and the gene to be regulated...
Chromosomal imbalances in primary lymphomas of the central nervous systemC H Rickert
Institute of Neuropathology, Gerhard Domagk Institute of Pathology, University of Munster, Munster, Germany
Am J Pathol 155:1445-51. 1999....
CDKN2A/p16 inactivation is related to pituitary adenoma type and sizeN Seemann
Institute of Neuropathology, , Domagkstrasse 19, , Germany
J Pathol 193:491-7. 2001..These findings also suggest that p16 down-regulation is usually not an initial event, but is acquired during adenoma progression...
Sequential scintigraphic strategy for the differentiation of brain tumoursP Matheja
Department of Nuclear Medicine, University of Munster, Germany
Eur J Nucl Med 27:550-8. 2000..Based on these preliminary results, a sequential strategy is proposed involving an initial 201Tl SPET study and an additional 123I-IMT SPET study in the event of positive 201Tl uptake...
Tumors of the choroid plexusC H Rickert
Institute of Neuropathology, Westfalische Wilhelms Universitat, Domagkstrasse 19, Munster, Germany
Microsc Res Tech 52:104-11. 2001....
Serum S100beta increases in marathon runners reflect extracranial release rather than glial damageM Hasselblatt
Institutes of Neuropathology, University Hospital Munster, Germany
Neurology 62:1634-6. 2004..001). To conclude, serum S100beta increases after running originate from extracranial sources. CK determination may improve specificity of S100beta as a marker of brain tissue damage in acute trauma...
Mycotic cerebral vasculitis in a paediatric cardiac transplant patient excludes misadventureC H Rickert
Institute of Neuropathology, University Hospital Munster, Germany
Int J Legal Med 116:233-7. 2002..This case illustrates that it is of paramount importance to copiously sample and investigate the basal cerebral arteries in cases of subarachnoid haemorrhage of unknown origin, in particular in a medico-legal context...
High uptake of L-3-[123I]iodo-alpha-methyl tyrosine in pilocytic astrocytomasM Weckesser
Department of Nuclear Medicine, Munster University, Albert Schweitzer Strasse 33, 48149 Munster, Germany
Eur J Nucl Med 28:273-81. 2001..7, n = 6) did not attain statistical significance. IMT SPET results indicative of malignancy are regularly found in pilocytic astrocytomas, despite their good prognosis. No uptake may be detected in largely cystic or in small tumours...
Complete inhibition of in vivo glioma growth by oncostatin MM Friedrich
Department of Neurology, , , Germany
J Neurochem 76:1589-92. 2001..Our results suggest that OSM exerts pronounced antitumorigenic effects on glioblastoma cells in vivo and provide arguments for a therapeutic application of OSM in humans...
Sudden unexpected death in young adults with chronic hydrocephalusC H Rickert
Institute of Neuropathology, University of Munster, Germany
Int J Legal Med 114:331-7. 2001....
AMOG/beta2 and glioma invasion: does loss of AMOG make tumour cells run amok?V Senner
Institute of Neuropathology, University Hospital, Munster, Germany
Neuropathol Appl Neurobiol 29:370-7. 2003..We conclude that increasing loss of AMOG/beta2 during malignant progression parallels and may underlie the extensive invasion pattern of malignant gliomas...
Rosetted glioneuronal tumor: a case with proliferating neuronal nodulesK Keyvani
Institute of Neuropathology, Westfalische Wilhelms Universitat Munster, Germany
Acta Neuropathol 101:525-8. 2001..Remarkably, highest proliferative activity was observed within the neuronal nodules. Comparative genomic hybridization revealed a gain of chromosome 7q and a loss on chromosome 9p...
Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classificationC H Rickert
Institute of Neuropathology, University Clinics Münster, Germany
Childs Nerv Syst 17:503-11. 2001..The topography, sex distribution and histology of 340 primary CNS tumors in children up to 17 years of age were investigated and (re-)classified according to the latest WHO classification of nervous system tumors...
Familial occurrence of dysembryoplastic neuroepithelial tumorM Hasselblatt
Institute of Neuropathology, Gerhard-Domagk-Institute of Pathology, University Hospital, , Germany
Neurology 62:1020-1. 2004
Cerebral malakoplakia associated with Escherichia coli infectionC H Rickert
Institute of Neuropathology, Westfalische Wilhelms Universitat, Munster, Germany
Acta Neuropathol 99:595-8. 2000..coli-associated abscess. This case indicates that malakoplakia of the brain might also be a histiocytic reaction against bacterial antigens of the E. coli family...
Radiation therapy approach in gliomatosis cerebri--case reports and literature reviewE Horst
Department of Radiation Oncology, University of Munster, School of Medicine, Germany
Acta Oncol 39:747-51. 2000..Survival from onset of symptoms was 23.8 months (range 8-42). Considerable variation in the natural course of the disease precludes conclusions regarding the impact of radiation therapy on survival...
Neglect-associated fatal Marchiafava-Bignami disease in a non-alcoholic womanC H Rickert
Institute of Neuropathology, University Clinics Münster, Germany
Int J Legal Med 115:90-3. 2001..This is the first known case of Marchiafava-Bignami disease in a non-alcoholic woman and the first case in the forensic setting of neglect...
Cellular and reticular variants of haemangioblastoma revisited: a clinicopathologic study of 88 casesM Hasselblatt
Institute of Neuropathology, University Hospital Munster, Germany
Neuropathol Appl Neurobiol 31:618-22. 2005..To conclude, the results from this retrospective study suggest that histological subtyping of haemangioblastomas has prognostic implications and might contribute to identify patients at risk for recurrence...
Chromosomal imbalances and NF2 mutational analysis in a series of 10 spinal nerve sheath myxomasC H Rickert
Institute of Neuropathology, University Hospital Munster, Munster, Germany
Histopathology 50:252-7. 2007..Nerve sheath myxomas are diagnostically challenging, mainly cutaneous spindle cell neoplasms exhibiting Schwann cell differentiation. They are frequently mistaken for neurothekeomas and their genetic features are essentially unknown...
Sudden death due to subarachnoid bleeding from ecchordosis physaliphoraT Fracasso
Institute of Legal Medicine, University of Munster, Röntgenstrasse 23, 48149 Munster, Germany
Int J Legal Med 122:225-7. 2008..Further histological and immunohistochemical investigations allowed the diagnosis of EP...
Does breastfeeding reduce the risk of sudden infant death syndrome?M M Vennemann
PD, University of Munster, Institute of Legal Medicine, Röntgenstrasse 23, D 48149 Munster, Germany
Pediatrics 123:e406-10. 2009..In the last 20 years, the prevention campaigns to reduce the risk of sudden infant death syndrome were very successful. In some countries the advice to breastfeed is included in the campaigns' messages, but in other countries it is not...
No evidence of tumour cells in blood of patients with gliomaC Bohm
Institute of Neuropathology, University Hospital, Domagkstr 19, 48149 Munster, Germany
Mol Pathol 56:187-9. 2003..Although clinically apparent systemic metastases of gliomas are very rare, reports of gliomas developing in recipient's transplanted organs have suggested that haematogenous spread might be more common...
Postlesional transcriptional regulation of metabotropic glutamate receptors: implications for plasticity and excitotoxicityK Keyvani
Institute of Neuropathology, Westfälische Wilhelms University Münster, Germany
Acta Neuropathol 101:79-84. 2001....
Corticobasal degeneration presenting with progressive spasticityM Hasselblatt
Institute of Neuropathology, , Domagkstr. 19, , Germany
Neurology 68:791-2. 2007
Lack of chromosomal imbalances in adamantinomatous and papillary craniopharyngiomasC H Rickert
Institute of Neuropathology, University Hospital Munster, Gerhard Domagk Institute of Pathology, Domagkstrasse 17, D 48149 Munster, Germany
J Neurol Neurosurg Psychiatry 74:260-1. 2003..These data suggest that chromosomal imbalances are a rare event in both adamantinomatous and papillary craniopharyngiomas...
Effects of closed traumatic brain injury and genetic factors on the development of Alzheimer's diseaseK A Jellinger
L Boltzmann Institute of Clinical Neurobiology, Vienna, Austria, Institute of Neuropathology, University of Münster School of Medicine, Munster, Germany
Eur J Neurol 8:707-10. 2001..The results of this first retrospective autopsy study of TBI, ApoE allele frequency, and AD confirms clinical studies suggesting severe TBI to be a risk factor for the development of AD particularly in subjects lacking ApoEepsilon4...
No evidence of hSNF5/INI1 point mutations in choroid plexus papillomaW Mueller
Institute of Neuropathology, Charite, Humboldt University, Berlin, Germany
Neuropathol Appl Neurobiol 30:304-7. 2004..No alterations in migratory patterns were detected. These data indicate that somatic point mutations of hSNF5/INI1 do not play a role in the pathogenesis of CPP and that CPP and CPC may arise by two different molecular pathways...
Sleep environment risk factors for sudden infant death syndrome: the German Sudden Infant Death Syndrome StudyMechtild M Vennemann
Institute of Legal Medicine, University of Munster, Röntgenstrasse 23, D 48149 Munster, Germany
Pediatrics 123:1162-70. 2009..Our goal was to investigate the risk factors for sudden infant death syndrome in the infants' sleep environment for a population in which few infants sleep prone as a result of education campaigns...
Neuropathology of Hashimoto's encephalopathyW Paulus
J Neurol Neurosurg Psychiatry 74:1009; author reply 1009. 2003
[Cholesterol granuloma at the sella region: a new method of the differential diagnosis of craniopharyngioma]I Vajtai
, , ,
Orv Hetil 142:451-7. 2001..They most probably represent a clinically relevant entity in the ontogenesis of adamantinomatous craniopharyngiomas with predisposing factors yet to be elucidated...
Voluntary motor drive: possible reduction in Tourette syndromeC A Heise
Child and Adolescent Psychiatry, University of Gottingen, Gottingen, Germany
J Neural Transm 115:857-61. 2008..The findings support the notion, that TS shows possible reduction of VMD and is associated with central motor threshold alterations confined to the very motor networks related to the tics observed...
Differential expression of versican isoforms in brain tumorsW Paulus
Institute of Neuropathology, University Hospital, Zurich, Switzerland
J Neuropathol Exp Neurol 55:528-33. 1996..Furthermore, increased expression in tumor vessels and decreased expression in glioma ECM of the anti-adhesive versican may be related to marked local invasivity and rarity of extracranial metastasis of gliomas...
Piracetam affects facilitatory I-wave interaction in the human motor cortexS Wischer
Department of Clinical Neurophysiology, University of Goettingen, Robert-Koch-Strasse 40, D-37075, Goettingen, Germany
Clin Neurophysiol 112:275-9. 2001..Shortening of the I-wave peak latencies is a new phenomenon. The results are discussed on the basis of the known therapeutic effects of piracetam in cortical myoclonus and as nootropic agent...
[Primary CNS lymphoma in azathioprine therapy for autoimmune diseases: review of the literature and case report]F Kastner
Klinik und Poliklinik fur Neurologie, Universitatsklinikum, Albert Schweitzer Strasse 33, 48129 Munster
Nervenarzt 78:451-6. 2007..The risk of primary CNS lymphoma under azathioprine treatment for an autoimmune disease with a possible congenital immunodeficiency is presented and the literature is reviewed...
[Modulation of cortical excitability by transcranial direct current stimulation]M A Nitsche
Abteilung Klinische Neurophysiolgie, Georg August Universitat Gottingen
Nervenarzt 73:332-5. 2002....
Fibre-related nitric oxide synthase (NOS) in Duchenne muscular dystrophyK Punkt
Institute of Anatomy, University of Leipzig, Liebigstrasse 13, 04103 Leipzig, Germany
Acta Histochem 109:228-36. 2007..High NOS expression in regenerating DMD muscle fibres can be well reconciled with reports about the protective role of endogenous NO in inflammatory diseases and in muscle repair...
Shaping the effects of transcranial direct current stimulation of the human motor cortexM A Nitsche
Department for Clinical Neurophysiology, Georg August University, Goettingen, Germany
J Neurophysiol 97:3109-17. 2007..For future applications of tDCS, such paradigms may help to achieve more selective tDCS effects...
Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humansM A Nitsche
Department of Clinical Neurophysiology, University of Goettingen, Germany
Neurology 57:1899-901. 2001..The feasibility of inducing long-lasting excitability modulations in a noninvasive, painless, and reversible way makes this technique a potentially valuable tool in neuroplasticity modulation...
[Therapy and prophylaxis of facial neuralgias and other forms of facial pain syndromes -- revised recommendations of the German Society of Migraine and Headache]W Paulus
Abteilung Klinische Neurophysiologie der Universität Göttingen
Schmerz 17:74-91. 2003..Therapeutic recommendations are based on evidence based medicine criteria (EBM)...
Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humansM A Nitsche
Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
J Physiol 553:293-301. 2003..The selective elimination of tDCS-driven excitability enhancements by carbamazepine proposes a role for this drug in focussing the effects of cathodal tDCS, which may have important future clinical applications...
Transcranial direct current stimulation (tDCS)W Paulus
Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
Suppl Clin Neurophysiol 56:249-54. 2003..Safe stimulation protocols have to be developed which allow an extension of the duration of after-effects towards a somewhat permanent state, supposing a beneficial effect can be found in neurological diseases or in neurorehabilitation...
Pharmacology of transcranial direct current stimulation: missing effect of riluzoleD Liebetanz
Department of Clinical Neurophysiology, Georg-August University, Robert-Koch Strasse 40, , Germany
Suppl Clin Neurophysiol 56:282-7. 2003
Effects of transcranial direct current stimulation over the human motor cortex on corticospinal and transcallosal excitabilityN Lang
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Exp Brain Res 156:439-43. 2004....
Encephalitis due to a hantavirus infectionF Bergmann
Department of Clinical Neurophysiology, , Robert-Koch Str. 40, 37075, , Germany
J Infect 45:58-9. 2002
[Plasma exchange therapy for steroid-unresponsive multiple sclerosis relapses: clinical experience with 16 patients]S Schilling
,
Nervenarzt 77:430-8. 2006..In pediatric MS, two of three patients showed clear improvement. These data argue for a very good therapeutic effect of plasma exchange if performed early and with adequate indication...
External modulation of visual perception in humansA Antal
Department of Clinical Neurophysiology, , Robert Koch Str. 40, , Germany
Neuroreport 12:3553-5. 2001..The present study also support the view that this method using weak current can be a non-invasive promising tool to induce reversible focal changes in the nervous system...
Functional MRI of cortical activations induced by transcranial magnetic stimulation (TMS)J Baudewig
, , Germany
Neuroreport 12:3543-8. 2001..The observation of BOLD MRI activations probably reflects the afferent intracortical processing of real movements...
A close look at autoimmune muscle disorders: association of Lambert-Eaton myasthenic syndrome with dermatomyositisR Mossner
Dermatology
Scand J Rheumatol 33:271-5. 2004..As specific treatment for LEMS is available, it is important to identify those DM/PM patients who suffer from concomitant LEMS...
