Christoph Otto

Summary

Country: Germany

Publications

  1. doi request reprint Immunisation with an allogeneic peptide promotes the induction of antigen-specific MHC II(pos) CD4+ rat T cells demonstrating immunostimulatory properties
    Christoph Otto
    Experimental Surgery, Experimental Transplantation Immunology, Clinic of General, Visceral, Vascular, and Paediatric Surgery, Surgical Clinic I, University of Wurzburg Hospital, Oberdürrbacher Str 6, D 97080 Wurzburg, Germany
    Transpl Immunol 26:220-9. 2012
  2. pmc Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides
    Christoph Otto
    Experimental Transplantation Immunology, Department of Surgery, University of Wurzburg Hospital, Oberdürrbacher Str, 6, D 97080 Wurzburg, Germany
    BMC Cancer 8:122. 2008
  3. ncbi request reprint MHC class II-mediated antigen presentation by alloreactive rat CD4+ T cells does not induce regulatory properties
    C Otto
    Experimental Transplantation Immunology, Department of Surgery, University of Wurzburg, Wurzburg, Germany
    Transplant Proc 38:755-6. 2006
  4. pmc Inhibitory effects of rat bone marrow-derived dendritic cells on naïve and alloantigen-specific CD4+ T cells: a comparison between dendritic cells generated with GM-CSF plus IL-4 and dendritic cells generated with GM-CSF plus IL-10
    George Tiurbe
    Experimental Transplantation Immunology Unit, Department of Surgery, , , , Germany
    BMC Res Notes 2:12. 2009
  5. doi request reprint Analysis of parathyroid graft rejection suggests alloantigen-specific production of nitric oxide by iNOS-positive intragraft macrophages
    Anja Matuschek
    Experimental Surgery, Experimental Transplantation Immunology, Clinic of General, Visceral, Vascular, and Paediatric Surgery Surgical Clinic I, University of Wurzburg Hospital, Wurzburg, Germany
    Transpl Immunol 21:183-91. 2009
  6. pmc LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus?
    Burkhard H A von Rahden
    Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Oberduerrbacher Strasse 6, Wuerzburg, Germany
    J Exp Clin Cancer Res 30:23. 2011
  7. pmc The intraportal injection model: a practical animal model for hepatic metastases and tumor cell dissemination in human colon cancer
    Andreas Thalheimer
    Department of Surgery, University of Wuerzburg Hospital, Wuerzburg, Germany
    BMC Cancer 9:29. 2009
  8. ncbi request reprint Short-term immunosuppression after rat parathyroid allotransplantation
    Stephan Timm
    Department of Surgery, University of Wurzburg, Wurzburg, Germany
    Microsurgery 23:503-7. 2003
  9. ncbi request reprint Allogeneic core amino acids of an immunodominant allopeptide are important for MHC binding and TCR recognition
    Ana Gabriela Sitaru
    Department of Surgery, University of Wurzburg, Wurzburg, Germany
    Hum Immunol 65:817-25. 2004
  10. ncbi request reprint Human antibody SC-1 reduces disseminated tumor cells in nude mice with human gastric cancer
    Bertram Illert
    Department of Surgery, Chirurgische Klinik I, Center of Operative Medicine, University of Wurzburg, Oberdürrbacher Str 6, D 97080 Wurzburg, Germany
    Oncol Rep 13:765-70. 2005

Collaborators

Detail Information

Publications41

  1. doi request reprint Immunisation with an allogeneic peptide promotes the induction of antigen-specific MHC II(pos) CD4+ rat T cells demonstrating immunostimulatory properties
    Christoph Otto
    Experimental Surgery, Experimental Transplantation Immunology, Clinic of General, Visceral, Vascular, and Paediatric Surgery, Surgical Clinic I, University of Wurzburg Hospital, Oberdürrbacher Str 6, D 97080 Wurzburg, Germany
    Transpl Immunol 26:220-9. 2012
    ..Therefore, we used freshly isolated primed rat CD4+ T cells induced by immunisation with an allogeneic peptide P1, which is involved in allograft rejection...
  2. pmc Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides
    Christoph Otto
    Experimental Transplantation Immunology, Department of Surgery, University of Wurzburg Hospital, Oberdürrbacher Str, 6, D 97080 Wurzburg, Germany
    BMC Cancer 8:122. 2008
    ....
  3. ncbi request reprint MHC class II-mediated antigen presentation by alloreactive rat CD4+ T cells does not induce regulatory properties
    C Otto
    Experimental Transplantation Immunology, Department of Surgery, University of Wurzburg, Wurzburg, Germany
    Transplant Proc 38:755-6. 2006
    ..In conclusion, the R73(pos), Ox6(pos) T cells act as professional APCs with the possible biological capability of amplifying the local immune response to the allograft...
  4. pmc Inhibitory effects of rat bone marrow-derived dendritic cells on naïve and alloantigen-specific CD4+ T cells: a comparison between dendritic cells generated with GM-CSF plus IL-4 and dendritic cells generated with GM-CSF plus IL-10
    George Tiurbe
    Experimental Transplantation Immunology Unit, Department of Surgery, , , , Germany
    BMC Res Notes 2:12. 2009
    ..This indicates that IL-4 DC and IL-10 DC may differ in the quality of their costimulation although no differences in the surface expression of costimulatory molecules were found...
  5. doi request reprint Analysis of parathyroid graft rejection suggests alloantigen-specific production of nitric oxide by iNOS-positive intragraft macrophages
    Anja Matuschek
    Experimental Surgery, Experimental Transplantation Immunology, Clinic of General, Visceral, Vascular, and Paediatric Surgery Surgical Clinic I, University of Wurzburg Hospital, Wurzburg, Germany
    Transpl Immunol 21:183-91. 2009
    ..In the present study we analysed whether the destruction of primarily nonvascularised parathyroid allografts is also mediated by iNOS-positive macrophages...
  6. pmc LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus?
    Burkhard H A von Rahden
    Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Oberduerrbacher Strasse 6, Wuerzburg, Germany
    J Exp Clin Cancer Res 30:23. 2011
    ..Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis...
  7. pmc The intraportal injection model: a practical animal model for hepatic metastases and tumor cell dissemination in human colon cancer
    Andreas Thalheimer
    Department of Surgery, University of Wuerzburg Hospital, Wuerzburg, Germany
    BMC Cancer 9:29. 2009
    ....
  8. ncbi request reprint Short-term immunosuppression after rat parathyroid allotransplantation
    Stephan Timm
    Department of Surgery, University of Wurzburg, Wurzburg, Germany
    Microsurgery 23:503-7. 2003
    ..Whether the combination of an additional graft pretreatment and immunosuppression has an impact on graft function will be further examined...
  9. ncbi request reprint Allogeneic core amino acids of an immunodominant allopeptide are important for MHC binding and TCR recognition
    Ana Gabriela Sitaru
    Department of Surgery, University of Wurzburg, Wurzburg, Germany
    Hum Immunol 65:817-25. 2004
    ..Identification of MHC and TCR contact residues should facilitate the development of antigen-specific therapies to inhibit or regulate the indirect alloimmune response...
  10. ncbi request reprint Human antibody SC-1 reduces disseminated tumor cells in nude mice with human gastric cancer
    Bertram Illert
    Department of Surgery, Chirurgische Klinik I, Center of Operative Medicine, University of Wurzburg, Oberdürrbacher Str 6, D 97080 Wurzburg, Germany
    Oncol Rep 13:765-70. 2005
    ..The reduction of DTCs in SC-1 animals was due to reduction in bone marrow (p=0.032 compared to controls), but not in blood (p=0.1158). Treatment with SC-1 significantly reduced the number of DTCs in bone marrow in this animal model...
  11. ncbi request reprint Detection of disseminated tumor cells in nude mice with human gastric cancer
    Bertram Illert
    Department of Surgery, University Hospital, University of Wurzburg, Germany
    Clin Exp Metastasis 20:549-54. 2003
    ..In group II no DTC were detected in bone marrow. We conclude that orthotopic transplantation is a prerequisite for the development of DTC and metastasizing tumor growth in this modified gastric cancer model...
  12. ncbi request reprint Optimization of a metastasizing human gastric cancer model in nude mice
    Bertram Illert
    Department of Surgery, University of Wurzburg, Wurzburg, Germany
    Microsurgery 23:508-12. 2003
    ..Unlike animals in series 1, animals in series 2 developed metastases and MRD. In conclusion, the optimized SOI technique presented here represents a reproducible and reliably metastasizing gastric cancer model...
  13. ncbi request reprint Rat parathyroid allotransplantation: Influence of MHC antigen expression on graft survival
    S Timm
    Department of Surgery, , , Germany
    Microsurgery 21:221-2. 2001
    ..These results indicate that immunogenicity of rat parathyroid tissue might be determined by the amount of MHC class I expressed in donor parenchymal cells. Further experiments are necessary to validate this observation...
  14. ncbi request reprint Orthotopic liver/small bowel transplantation in rats: a microsurgical model inducing tolerance
    D Meyer
    Department of Surgery, , Josef-Schneider Strasse 2, , Germany
    Microsurgery 21:156-62. 2001
    ..The initiation of T-cell apoptosis is one possible explanation for the specific immunosuppressive effect of the liver allograft, which also supports the simultaneously transplanted small bowel allograft in our model...
  15. ncbi request reprint "Tolerogenic effect" of the liver for a small bowel allograft
    D Meyer
    Department of Surgery, University of Wuerzburg, Germany
    Transpl Int 13:S123-6. 2000
    ..In contrast to other LSBTx rat models, these results reflect observations after human LSBTx, in which the rate of acute and chronic rejection is also significantly lower than after human SBTx...
  16. ncbi request reprint Donor-derived alloantigen-presenting cells persist in the liver allograft during tolerance induction
    D Meyer
    Department of Surgery, University of Wuerzburg, Josef Schneider Strasse 2, Germany
    Transpl Int 13:12-20. 2000
    ..However, the kinetics of the detected donor APC population in the liver suggests their important role in modifying the recipient's immune response towards tolerance...
  17. ncbi request reprint Prolongation of small bowel allograft survival with a sequential therapy consisting of a synthetic MHC class II peptide and temporarily low-dose cyclosporine A
    Christoph Otto
    Experimental Transplantation Immunology, Department of Surgery, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Hum Immunol 63:880-7. 2002
    ..B2-specific T cells in the late phase. Therefore, the combination of RT1.B2 with low-dose CsA shifts the immunological response and protects small bowel allograft rejection...
  18. ncbi request reprint Concomitant liver transplantation reduces the rate of chronic small bowel allograft rejection
    D Meyer
    Department of Surgery, University of Wuerzburg, Wuerzburg, Germany
    Transplant Proc 34:1040-1. 2002
  19. ncbi request reprint Disseminated tumor cells in the blood of patients with gastric cancer are an independent predictive marker of poor prognosis
    Bertram Illert
    Department of Surgery, University of Wurzburg, Germany
    Scand J Gastroenterol 40:843-9. 2005
    ..In this study the prognostic relevance of DTC in the blood of gastric cancer patients was investigated...
  20. ncbi request reprint Modulation of the immune response with major histocompatability class II peptides via the indirect pathway of allorecognition after kidney and small bowel transplantation
    M Gasser
    Department of Surgery, University of Wurzburg, Germany
    Transplant Proc 34:2244-5. 2002
  21. ncbi request reprint Apoptosis of T lymphocytes in liver and/or small bowel allografts during tolerance induction
    D Meyer
    Department of Surgery, University of Wuerzburg, Germany
    Transplantation 66:1530-6. 1998
    ..The aim of this study was to investigate whether apoptosis may play a role in T-cell regulation during rejection and subsequent tolerance induction after liver transplantation (LTx) and combined liver/small bowel transplantation (LSBTx)...
  22. doi request reprint Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging
    Andreas Thalheimer
    Department of General, Visceral, Vascular, and Paediatric Surgery, University Hospital of Wurzburg, Wurzburg, Germany Electronic address
    J Surg Res 185:143-51. 2013
    ..The aim of this study was to establish a reliable, reproducible colorectal hepatic metastases cancer animal model...
  23. ncbi request reprint Hierarchical immunogenicity of donor MHC class I peptides in allotransplantation
    Ana Gabriela Sitaru
    Experimental Transplantation Immunology, Department of Surgery, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Hum Immunol 63:871-9. 2002
    ....
  24. ncbi request reprint Tolerance induction following orthotopic rat liver transplantation: cytokine production by CD4+ T cells determines the immunological response
    H J Gassel
    Department of Surgery, Exp Transplantation Immunology Unit of the Department of Surgery, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Transplant Proc 34:1429-30. 2002
  25. ncbi request reprint Different kinetics of donor cell populations after isolated liver and combined liver/small bowel transplantation
    S Löffeler
    Department of Surgery, University of Wurzburg, Germany
    Transpl Int 13:S537-40. 2000
    ..Microchimerism apparently plays no significant role in either transplantation model. The number of sinusoidal donor leukocytes, however, mirrors closely host immune responses...
  26. ncbi request reprint Mechanisms of tolerance induction after rat liver transplantation: intrahepatic CD4(+) T cells produce different cytokines during rejection and tolerance in response to stimulation
    Christoph Otto
    Experimental Transplantation Immunology Unit, Department of Surgery, University of Wurzburg, Wurzburg, Germany
    J Gastrointest Surg 6:455-63. 2002
    ..This result indicates the presence of an intragraft Th2-like CD4(+) T cell population, which may have a regulatory function in the induction of liver tolerance...
  27. doi request reprint Inhibition of nuclear translocation of calcineurin suppresses T-cell activation and prevents acute rejection of donor hearts
    Franziska Panther
    Department of Medicine I, University of Wuerzburg, Wurzburg, Germany
    Transplantation 91:597-604. 2011
    ..This synthetic peptide prevented CnA nuclear translocation in vitro. The purpose of this study was to demonstrate that this novel approach could potentially inhibit T-cell function in vitro and in vivo...
  28. pmc CIP2A influences survival in colon cancer and is critical for maintaining Myc expression
    Armin Wiegering
    Department of General, Visceral, Vascular and Paediatric Surgery Department of Surgery I, University Hospital Wuerzburg, Wuerzburg, Germany Department of Biochemistry and Molecular Biology, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 8:e75292. 2013
    ..Expression of CIP2A was found to be dependent on MAPK activity, linking elevated c-Myc expression to deregulated signal transduction in colon cancer. ..
  29. pmc MMP-1 is a (pre-)invasive factor in Barrett-associated esophageal adenocarcinomas and is associated with positive lymph node status
    Martin Grimm
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Wuerzburg Hospital, Oberduerrbacher Strasse 6, 97080 Wuerzburg, Germany
    J Transl Med 8:99. 2010
    ..Esophageal adenocarcinomas (EACs) arise due to gastroesophageal reflux, with Barrett's esophagus (BE) regarded as precancerous lesion. Matrix metalloproteinases (MMPs) might play a role during the multistep carcinogenetic process...
  30. doi request reprint Ischemia-reperfusion injury-induced pulmonary mitochondrial damage
    Sebastian Patrick Sommer
    Department of Cardiothoracic and Thoracic Vascular Surgery, University Hospital Wurzburg, Wurzburg, Germany
    J Heart Lung Transplant 30:811-8. 2011
    ..Impaired mitochondrial integrity predisposes to cellular energy depletion, free radical generation, and cell death. This study analyzed mitochondrial damage induced by warm pulmonary IR...
  31. ncbi request reprint Long-term small bowel allograft function induced by short-term FK 506 application is associated with split tolerance
    W Timmermann
    Department of Surgery, University of Wuerzburg, Germany
    Transpl Int 13:S532-6. 2000
    ..The split tolerance revealed by our in vivo and in vitro results enabled acceptance of both the small bowel allograft without signs of chronic rejection and of donor-specific heart allografts...
  32. ncbi request reprint Immunogenicity of parathyroid allografts in the rat: immunosuppressive dosages effective in passenger leukocyte-rich small bowel transplants are not effective in parathyroid gland transplants with few passenger leukocytes
    S Timm
    Department of Surgery, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Langenbecks Arch Surg 389:46-52. 2004
    ..We compared the response to short-term immunosuppression of parathyroid gland transplants possessing few passenger leukocytes with that of passenger leukocyte-rich small bowel transplants...
  33. ncbi request reprint Analysis of cellular events in hepatic allografts: donor progenitors induce intragraft chimerism
    H J Gassel
    Department of Surgery, University of Wuerzburg, Germany
    Transpl Int 13:S465-70. 2000
    ..The persistent coexistence of donor and recipient cells within the liver allograft (intrahepatic chimerism) appears to be characteristic and may be important for long-term acceptance...
  34. ncbi request reprint Influence of donor MHC class I antigen expression on graft survival after rat parathyroid allotransplantation
    S Timm
    Department of Surgery, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Langenbecks Arch Surg 386:430-3. 2001
    ..We investigated the influence of donor MHC antigen expression on graft survival after parathyroid transplantation in three different strain combinations...
  35. ncbi request reprint Investigation of the immunosuppressive potential of anti-CD28 antibodies for selective inhibition of the T-cell mediated alloresponse
    C Otto
    Experimental Transplantation Immunology Unit of the Department of Surgery, University of Wuerzburg, Wuerzburg, Germany
    Transplant Proc 34:2376. 2002
  36. doi request reprint Tumor cell dissemination in a human colon cancer animal model: orthotopic implantation or intraportal injection?
    A Thalheimer
    Department of Surgery, University of Wurzburg Hospital, Wurzburg, Germany
    Eur Surg Res 42:195-200. 2009
    ..The development of therapeutic strategies for treatment of metastasized colorectal carcinoma requires biologically relevant and adequate animal models generating both metastases and the dissemination of tumor cells...
  37. doi request reprint Duodenal-jejunal bypass improves glycemia and decreases SGLT1-mediated glucose absorption in rats with streptozotocin-induced type 2 diabetes
    Christian Ferdinand Jurowich
    Department of General, Visceral, Vascular and Paediatric Surgery, University Hospital of Wurzburg, Oberdürrbacher Str 6, Wurzburg, Germany
    Ann Surg 258:89-97. 2013
    ..To elucidate whether duodenal-jejunal-bypass (DJB), which improves blood glucose control, changes activity of Na-D-glucose cotransporter SGLT1 in small intestine...
  38. pmc Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress
    Christoph Klingelhoeffer
    Experimental Surgery, Department of Surgery, University of Wurzburg Hospital, Germany
    BMC Complement Altern Med 12:61. 2012
    ..The purpose of this study was to analyse the impact of catalase, an important hydrogen peroxide-detoxifying enzyme, on the resistance of cancer cells to ascorbic acid mediated oxidative stress...
  39. pmc Glutathione preconditioning ameliorates mitochondria dysfunction during warm pulmonary ischemia-reperfusion injury
    Sebastian Patrick Sommer
    Department of Cardiothoracic and Thoracic Vascular Surgery, University Hospital Wurzburg, and Insitute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    Eur J Cardiothorac Surg 41:140-8; discussion 148. 2012
    ..We have shown previously that IR induces pulmonary mitochondrial damage. This study elucidates the impact of GSH preconditioning on the integrity and function of pulmonary mitochondria in the setting of warm pulmonary IR...
  40. ncbi request reprint Persistence of stable intragraft cell chimerism in rat liver allografts after drug-induced tolerance
    H J Gassel
    Experimental Transplantation Immunology of the Department of Surgery, Institute of Pathology, University of Wuerzburg, D-97060 Wuerzburg, Germany
    Transplantation 71:1848-52. 2001
    ..It seems that the coexistence of donor cells with infiltrating recipient cells within liver grafts, termed intrahepatic cell chimerism, is characteristic for tolerated liver allografts...
  41. pmc Early immunological changes associated with laryngeal transplantation in a major histocompatibility complex-matched pig model
    E Barker
    Laryngeal Research Group, Faculty of Medicine and Dentistry, University of Bristol, Bristol, UK
    Clin Exp Immunol 146:503-8. 2006
    ..Therefore, the significance of IRI in exacerbating loss of function or rejection of a laryngeal allograft is open to question. Longer-term studies are required...