P Vorwerk

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi request reprint Alternative splicing of exon 17 and a missense mutation in exon 20 of the insulin receptor gene in two brothers with a novel syndrome of insulin resistance (congenital fiber-type disproportion myopathy)
    P Vorwerk
    Department of Pediatric Hematology and Oncology, Otto von Guericke University, Magdeburg, Germany
    Horm Res 52:211-20. 1999
  2. pmc Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia
    P Vorwerk
    Department of Paediatric Oncology, Otto von Guericke University Magdeburg, Emanuel Larisch Weg 17 19, D 39112 Magdeburg, Germany
    Mol Pathol 55:40-5. 2002
  3. ncbi request reprint Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor
    Peter Vorwerk
    Department of Pediatric Oncology, Otto von Guericke University, Emanuel Larisch Weg 17 19, D 39112 Magdeburg, Germany
    Endocrinology 143:1677-85. 2002
  4. ncbi request reprint Loss of imprinting of IGF-II gene in children with acute lymphoblastic leukemia
    Peter Vorwerk
    Department of Pediatric Oncology, Otto von Guericke University, Emanuel Larisch Weg 17 19, D 39112 Magdeburg, Germany
    Leuk Res 27:807-12. 2003
  5. ncbi request reprint Insulin-like growth factor binding protein-2 at diagnosis of childhood acute lymphoblastic leukemia and the prediction of relapse risk
    Peter Vorwerk
    Department of Pediatric Hematology Oncology, University Otto von Guericke Magdeburg, E Larisch Weg 17 19, D 39112 Magdeburg, Germany
    J Clin Endocrinol Metab 90:3022-7. 2005
  6. pmc CTGF (IGFBP-rP2) is specifically expressed in malignant lymphoblasts of patients with acute lymphoblastic leukaemia (ALL)
    P Vorwerk
    Department of Pediatric Hematology and Oncology, Otto von Guericke University Magdeburg, E Larisch Weg 17 19, Magdeburg, D 39112, Germany
    Br J Cancer 83:756-60. 2000
  7. pmc Elevated serum levels of IGFBP-2 found in children suffering from acute leukaemia is accompanied by the occurrence of IGFBP-2 mRNA in the tumour clone
    H Wex
    Department of Paediatric Haematology and Oncology, Otto von Guericke University Magdeburg, Germany
    Br J Cancer 78:515-20. 1998
  8. ncbi request reprint Plasma leptin and leptin receptor expression in childhood acute lymphoblastic leukemia
    Heike Wex
    Department of Paediatric Haematology and Oncology, Otto von Guericke University, Magdeburg, Germany
    Int J Hematol 76:446-52. 2002
  9. ncbi request reprint Insulin-like growth factor-binding protein 4 in children with acute lymphoblastic leukemia
    Heike Wex
    University Otto von Guericke, Department of Pediatric Hematology and Oncology, Magdeburg, Germany
    Int J Hematol 82:137-42. 2005

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Alternative splicing of exon 17 and a missense mutation in exon 20 of the insulin receptor gene in two brothers with a novel syndrome of insulin resistance (congenital fiber-type disproportion myopathy)
    P Vorwerk
    Department of Pediatric Hematology and Oncology, Otto von Guericke University, Magdeburg, Germany
    Horm Res 52:211-20. 1999
    ..A third brother who inherited both normal alleles has an normal muscle phenotype and insulin sensitivity, suggesting a direct linkage of these IR mutations with the CFTDM phenotype...
  2. pmc Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia
    P Vorwerk
    Department of Paediatric Oncology, Otto von Guericke University Magdeburg, Emanuel Larisch Weg 17 19, D 39112 Magdeburg, Germany
    Mol Pathol 55:40-5. 2002
    ..To understand the endocrine, paracrine, and autocrine potential of the malignant transformed progenitor cells, the ability of these cells to express components of the IGF system needs to be investigated...
  3. ncbi request reprint Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor
    Peter Vorwerk
    Department of Pediatric Oncology, Otto von Guericke University, Emanuel Larisch Weg 17 19, D 39112 Magdeburg, Germany
    Endocrinology 143:1677-85. 2002
    ....
  4. ncbi request reprint Loss of imprinting of IGF-II gene in children with acute lymphoblastic leukemia
    Peter Vorwerk
    Department of Pediatric Oncology, Otto von Guericke University, Emanuel Larisch Weg 17 19, D 39112 Magdeburg, Germany
    Leuk Res 27:807-12. 2003
    ..The importance of LOI in ALL-patients needs to be further evaluated to determine its impact in leukemogenesis...
  5. ncbi request reprint Insulin-like growth factor binding protein-2 at diagnosis of childhood acute lymphoblastic leukemia and the prediction of relapse risk
    Peter Vorwerk
    Department of Pediatric Hematology Oncology, University Otto von Guericke Magdeburg, E Larisch Weg 17 19, D 39112 Magdeburg, Germany
    J Clin Endocrinol Metab 90:3022-7. 2005
    ....
  6. pmc CTGF (IGFBP-rP2) is specifically expressed in malignant lymphoblasts of patients with acute lymphoblastic leukaemia (ALL)
    P Vorwerk
    Department of Pediatric Hematology and Oncology, Otto von Guericke University Magdeburg, E Larisch Weg 17 19, Magdeburg, D 39112, Germany
    Br J Cancer 83:756-60. 2000
    ..5% (2 of 57) were positive for this gene. The role of CTGF (IGFBP-rP2) in lymphoblastic leukaemogenesis requires further evaluation, as does its potential utility as a tumour marker...
  7. pmc Elevated serum levels of IGFBP-2 found in children suffering from acute leukaemia is accompanied by the occurrence of IGFBP-2 mRNA in the tumour clone
    H Wex
    Department of Paediatric Haematology and Oncology, Otto von Guericke University Magdeburg, Germany
    Br J Cancer 78:515-20. 1998
    ..Furthermore, possible functional consequences of elevated IGFBP-2 were outlined...
  8. ncbi request reprint Plasma leptin and leptin receptor expression in childhood acute lymphoblastic leukemia
    Heike Wex
    Department of Paediatric Haematology and Oncology, Otto von Guericke University, Magdeburg, Germany
    Int J Hematol 76:446-52. 2002
    ..Finally, some hypotheses that might explain the decrease of leptin levels in the presence of the tumor clone are discussed...
  9. ncbi request reprint Insulin-like growth factor-binding protein 4 in children with acute lymphoblastic leukemia
    Heike Wex
    University Otto von Guericke, Department of Pediatric Hematology and Oncology, Magdeburg, Germany
    Int J Hematol 82:137-42. 2005
    ..IGFBP-4 was exclusively expressed in cell lines derived either from B-cells or from myelomonocytic cells, whereas IGFBP-4 was not expressed in T-cell lines...