Ralf Stumm

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide is up-regulated in cortical pyramidal cells after focal ischemia and protects neurons from mild hypoxic/ischemic damage
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Neurochem 103:1666-81. 2007
  2. ncbi request reprint Patterns of SDF-1alpha and SDF-1gamma mRNAs, migration pathways, and phenotypes of CXCR4-expressing neurons in the developing rat telencephalon
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 502:382-99. 2007
  3. ncbi request reprint Neuronal types expressing mu- and delta-opioid receptor mRNA in the rat hippocampal formation
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Comp Neurol 469:107-18. 2004
  4. ncbi request reprint CXC chemokine receptor 4 regulates neuronal migration and axonal pathfinding in the developing nervous system: implications for neuronal regeneration in the adult brain
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Mol Endocrinol 38:377-82. 2007
  5. ncbi request reprint Somatostatin receptor 2 is activated in cortical neurons and contributes to neurodegeneration after focal ischemia
    Ralf K Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 24:11404-15. 2004
  6. doi request reprint Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain
    Bastian Schönemeier
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 510:207-20. 2008
  7. ncbi request reprint Expression of the mu-opioid receptor is induced in dentate gyrus granule cells after focal cerebrocortical ischaemia and stimulation of entorhinal afferents
    Ralf Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    Eur J Neurosci 22:1032-44. 2005
  8. ncbi request reprint Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling
    Dai Fei Wu
    Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Biol Chem 282:22239-47. 2007
  9. ncbi request reprint Comparative analysis of mu-opioid receptor expression in immune and neuronal cells
    Christine Börner
    Department of Pharmacology and Toxicology, University of Magdeburg, Madgeburg, Germany
    J Neuroimmunol 188:56-63. 2007
  10. ncbi request reprint CXCR4 prevents dispersion of granule neuron precursors in the adult dentate gyrus
    Clara Schultheiß
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Hippocampus 23:1345-58. 2013

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide is up-regulated in cortical pyramidal cells after focal ischemia and protects neurons from mild hypoxic/ischemic damage
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Neurochem 103:1666-81. 2007
    ..PACAP confers protection to ischemic neurons by maintaining Erk1/2 signaling via neuronal PAC1 and by increasing neuroprotective factor production via astroglial PAC1...
  2. ncbi request reprint Patterns of SDF-1alpha and SDF-1gamma mRNAs, migration pathways, and phenotypes of CXCR4-expressing neurons in the developing rat telencephalon
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 502:382-99. 2007
    ..We propose that regulated expression of SDF-1 in the intermediate/subventricular zone influences lateromedial tangential migration of CXCR4-expressing GABAergic neurons...
  3. ncbi request reprint Neuronal types expressing mu- and delta-opioid receptor mRNA in the rat hippocampal formation
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Comp Neurol 469:107-18. 2004
    ....
  4. ncbi request reprint CXC chemokine receptor 4 regulates neuronal migration and axonal pathfinding in the developing nervous system: implications for neuronal regeneration in the adult brain
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Mol Endocrinol 38:377-82. 2007
    ..The present review summarizes patterns and functions of the SDF-1/CXCR4 system in the rodent brain with a focus on the developing and adult cerebral cortex...
  5. ncbi request reprint Somatostatin receptor 2 is activated in cortical neurons and contributes to neurodegeneration after focal ischemia
    Ralf K Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 24:11404-15. 2004
    ..In summary, we provide direct evidence for activation of SSTR2 by an endogenous ligand after focal ischemia. Activation of functional SSTR2 receptors contributes to increased SSTR2 gene expression and postischemic neurodegeneration...
  6. doi request reprint Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain
    Bastian Schönemeier
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 510:207-20. 2008
    ..Thus, CXCR4 and CXCR7 may cooperate or act independently in SDF-1-dependent neuronal development. In mature neurons and blood vessels CXCR7 appears to be the preponderant SDF-1-receptor...
  7. ncbi request reprint Expression of the mu-opioid receptor is induced in dentate gyrus granule cells after focal cerebrocortical ischaemia and stimulation of entorhinal afferents
    Ralf Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    Eur J Neurosci 22:1032-44. 2005
    ..In activated, MOR-expressing granule cells, inhibitory opioids may counter-regulate glutamatergic excitation by the perforant path...
  8. ncbi request reprint Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling
    Dai Fei Wu
    Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Biol Chem 282:22239-47. 2007
    ..Taken together, these data provide evidence that M6a may act as a scaffolding molecule in the regulation of GPCR endocytosis and intracellular trafficking...
  9. ncbi request reprint Comparative analysis of mu-opioid receptor expression in immune and neuronal cells
    Christine Börner
    Department of Pharmacology and Toxicology, University of Magdeburg, Madgeburg, Germany
    J Neuroimmunol 188:56-63. 2007
    ....
  10. ncbi request reprint CXCR4 prevents dispersion of granule neuron precursors in the adult dentate gyrus
    Clara Schultheiß
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Hippocampus 23:1345-58. 2013
    ..Only few misplaced cells survived permanently as ectopic neurons. Thus, CXCR4 signaling maintains the NSC pool in the DG and specifies the inner one-third of the GCL as differentiation area for immature granule neurons...
  11. doi request reprint Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway
    Ying Jian Liang
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Cell Res 18:768-79. 2008
    ..In conclusion, our results strongly indicate that M6a modulates MOPr endocytosis and post-endocytotic sorting and has an important role in receptor regulation...
  12. doi request reprint Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus
    Angela Kolodziej
    Institut fur Pharmakologie und Toxikologie, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 28:4488-500. 2008
    ..Therefore, our findings suggest that tonic activation of CXCR4 in newly formed granule cells by endogenous SDF-1 is essential for neurogenesis-dependent long-term memory in the adult hippocampus...
  13. pmc Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus
    Wiebke Mueller
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    PLoS ONE 8:e64975. 2013
    ..Hierarchical organization of CXCR4 phosphorylation explains why small deletions at the extreme CXCR4 C terminus typically associated with WHIM syndrome severely alter CXCR4 function...
  14. pmc CXC chemokine receptor 7 (CXCR7) affects the migration of GnRH neurons by regulating CXCL12 availability
    Fani Memi
    Department of Cell and Developmental Biology, University College London, WC1E 6BT, United Kingdom, Department of Pharmacology and Toxicology, University Hospital Jena, Friedrich Schiller University, 07747 Jena, Germany, and Department of Immunology, Monash University, Alfred Medical Research and Education Precinct AMREP, Melbourne, Victoria 3000, Australia
    J Neurosci 33:17527-37. 2013
    ..These findings imply that CXCR7 regulates CXCL12 availability by acting as a scavenger along the migratory path of GnRH neurons and, thus, influences the migration of these cells in a noncell-autonomous manner. ..
  15. doi request reprint Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain
    Bastian Schönemeier
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neuroimmunol 198:39-45. 2008
    ..These patterns suggest that SDF-1 may influence vascular, astroglial, and neuronal functions via CXCR7 and mediate cell recruitment to ischemic brain areas via CXCR4...
  16. doi request reprint Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation
    Florian Pöll
    Department of Pharmacology and Toxicology, Friedrich Schiller University, Drackendorfer Strasse 1, D 07747 Jena, Germany
    Mol Endocrinol 24:436-46. 2010
    ..Yet, we find that they promote strikingly different patterns of sst(2A) receptor phosphorylation and, hence, stimulate functionally distinct pools of beta-arrestin...
  17. doi request reprint Analgesic tolerance to high-efficacy agonists but not to morphine is diminished in phosphorylation-deficient S375A μ-opioid receptor knock-in mice
    Gisela Grecksch
    Institute of Pharmacology and Toxicology, Faculty of Medicine, Otto von Guericke University, D 39120 Magdeburg, Germany
    J Neurosci 31:13890-6. 2011
    ..Whereas tolerance induced by DAMGO or etonitazene requires agonist-driven phosphorylation of S375, the development and maintenance of antinociceptive tolerance to morphine occurs independent of S375 phosphorylation...
  18. doi request reprint Endogenous opioids inhibit ischemia-induced generation of immature hippocampal neurons via the mu-opioid receptor
    Angela Kolodziej
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur J Neurosci 27:1311-9. 2008
    ..Our findings suggest that activated signalling via endogenous opioids and the MOP limits the enhanced generation of neuronal cells after ischemic corticostriatal lesions...
  19. doi request reprint Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1
    Thomas Fischer
    Department of Pharmacology and Toxicology, Friedrich Schiller University, Nonnenplan 4, 07743 Jena, Germany
    J Clin Endocrinol Metab 93:4519-24. 2008
    ..However, due to the lack of monoclonal and limited availability of specific polyclonal anti-sst2A antibodies, only very few patients can currently benefit from in vitro sst2 evaluation...
  20. ncbi request reprint CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons
    Philipp Abe
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Jena 07747, Germany
    Development 141:1857-63. 2014
    ..Our findings imply that interfering with the CXCL12-scavenging activity of CXCR7 causes loss of CXCR4 function as a consequence of excessive CXCL12-mediated CXCR4 activation and degradation. ..
  21. ncbi request reprint Differential beta-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes
    Giovanni Tulipano
    Institut fur Pharmakologie und Toxikologie, Otto von Guericke Universitat, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Biol Chem 279:21374-82. 2004
    ..Together, these findings may provide important clues about the regulation of receptor responsiveness during long-term administration of somatostatin analogs...
  22. ncbi request reprint Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors
    Dai Fei Wu
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurochem 104:1132-43. 2008
    ....
  23. ncbi request reprint Immunofluorescent identification of neuropeptide B-containing nerve fibers and terminals in the rat hypothalamus
    Stefan Schulz
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Neurosci Lett 411:67-71. 2007
    ..Together, NPB and its receptor GPR7 exist in close proximity in the rat hypothalamus and are, hence, ideally positioned to modulate neuroendocrine functions...
  24. pmc Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues
    Frauke Hoffmann
    Institute of Pharmacology and Toxicology, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
    J Biol Chem 287:28362-77. 2012
    ..Regulatory pathways targeting CXCR7 C-terminal serine/threonine sites may control the CXCL12 scavenger activity of CXCR7...
  25. pmc Rapid, transient, and dose-dependent expression of hsp70 messenger RNA in the rat brain after morphine treatment
    Susanne Ammon-Treiber
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, Leipziger Street 44, D 39120 Magdeburg, Germany
    Cell Stress Chaperones 9:182-97. 2004
    ..It may be speculated that increased expression of Hsp70 after morphine application protects brain structures against potentially hazardous effects of opiates...
  26. pmc Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375
    Stefan Schulz
    Institut fur Pharmakologie und Toxikologie, Otto von Guericke Universitat, Magdeburg, Germany
    EMBO J 23:3282-9. 2004
    ..Thus, morphine promotes terminal MOR desensitization by inducing a persistent modification of Ser(375)...
  27. ncbi request reprint CXCR4 regulates interneuron migration in the developing neocortex
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:5123-30. 2003
    ..Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development...
  28. ncbi request reprint Carboxyl-terminal multi-site phosphorylation regulates internalization and desensitization of the human sst2 somatostatin receptor
    Andreas Lehmann
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University, 07747 Jena, Germany
    Mol Cell Endocrinol 387:44-51. 2014
    ..Together, our findings demonstrate for the first time that agonist-selective sst2 receptor internalization is regulated by multi-site phosphorylation of its carboxyl-terminal tail. ..
  29. pmc CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney
    Sammy Haege
    Institute of Pharmacology and Toxicology, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany
    PLoS ONE 7:e42814. 2012
    ..Although it is established that CXCR7 regulates heart and brain development in conjunction with CXCL12 and CXCR4, little is known about the influence of CXCR7 on CXCL12 dependent kidney development...
  30. ncbi request reprint A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia
    Ralf K Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 22:5865-78. 2002
    ..Thus, the isoform-specific regulation of SDF-1 expression modulates neurotransmission and cerebral infiltration via distinct CXCR4-dependent pathways...
  31. ncbi request reprint Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization
    Manuela Pfeiffer
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Biol Chem 278:51630-7. 2003
    ..Together, our findings indicate that MOR1 by virtue of its physical interaction with NK1 is sequestered via an endocytotic pathway with delayed recycling and resensitization kinetics...
  32. ncbi request reprint Immunolocalization of full-length NK1 tachykinin receptors in human tumors
    Stefan Schulz
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Histochem Cytochem 54:1015-20. 2006
    ..NK1 receptor visualization with this simple and rapid immunohistochemical method will facilitate identification of tumors with a sufficient receptor overexpression for diagnostic or therapeutic intervention using SP analogs...