Research Topics
Genomes and Genes | Johann SteinerSummaryAffiliation: Otto-von-Guericke University Country: Germany Publications
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Publications
A new pathophysiological aspect of S100B in schizophrenia: potential regulation of S100B by its scavenger soluble RAGEJohann Steiner
Department of Psychiatry, University of Magdeburg, Germany
Biol Psychiatry 65:1107-10. 2009..Our study focused on its scavenger, soluble receptor for advanced glycation end products (sRAGE). Given the benefits of sRAGE in metabolic and inflammatory diseases, we hypothesized a similar effect in schizophrenia...- Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitisJohann Steiner
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
JAMA Psychiatry 70:271-8. 2013.... - Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrityJohann Steiner
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
World J Biol Psychiatry 13:482-92. 2012..It is not clear, however, whether such changes are associated with corresponding neuroinflammatory responses and disturbances of neurotransmission... - Increased S100B+ NK cell counts in acutely ill schizophrenia patients are correlated with the free cortisol index, but not with S100B serum levelsJohann Steiner
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
Brain Behav Immun 26:564-7. 2012..Notably, elevated S100B+ NK cell counts may be linked with stress axis activation... - Human CD8(+) T cells and NK cells express and secrete S100B upon stimulationJohann Steiner
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
Brain Behav Immun 25:1233-41. 2011..In various physiological and pathological conditions S100B might function as an interface to immunological processes, distinct from known cytokine- and chemokine-mediated pathways... - S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric researchJohann Steiner
Department of Psychiatry, University of Magdeburg, Germany
Psychoneuroendocrinology 35:321-4. 2010..In conclusion, physiological S100B levels in humans appear to closely reflect adipose tissue mass, which should therefore be considered as an important confounding factor in clinical studies examining the role of S100B... - Acute schizophrenia is accompanied by reduced T cell and increased B cell immunityJohann Steiner
Department of Psychiatry, University of Magdeburg, Germany
Eur Arch Psychiatry Clin Neurosci 260:509-18. 2010..In addition to disease stage or subtype and medication, cigarette smoking and stress are important co-factors... - Haloperidol and clozapine decrease S100B release from glial cellsJ Steiner
Department of Psychiatry, University of Magdeburg, Germany
Neuroscience 167:1025-31. 2010..These data suggest that elevated levels of S100B in bodily fluids of schizophrenic patients are normalized rather than increased by the effects of antipsychotic drugs on glial cells... 
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?Johann Steiner
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
J Neuroinflammation 8:94. 2011..These peripheral immune processes may be accompanied by microglial activation in subregions of the anterior cingulate cortex where depression-associated alterations of glutamatergic neurotransmission have been described...- S100B protein in neurodegenerative disordersJohann Steiner
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
Clin Chem Lab Med 49:409-24. 2011..Moreover, there is no consistent evidence for a correlation between disease severity and concentrations of S100B in CSF or serum. Therefore, S100B has limited usefulness for monitoring disease progression... - Protective effects of haloperidol and clozapine on energy-deprived OLN-93 oligodendrocytesJohann Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
Eur Arch Psychiatry Clin Neurosci 261:477-82. 2011..A new mechanism of antipsychotic action is suggested, which may help to establish new oligodendrocyte-directed therapies of schizophrenia... 
S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric studyJohann Steiner
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
J Psychiatr Res 42:868-76. 2008..However, no histological study has been published on the cellular distribution of S100B in the brain of individuals with schizophrenia to clarify this hypothesis...- S100B is expressed in, and released from, OLN-93 oligodendrocytes: Influence of serum and glucose deprivationJ Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
Neuroscience 154:496-503. 2008..Studies on S100B in bodily fluids should be carefully interpreted in order to avoid misleading hypotheses concerning the specific involvement of astrocytes, due to the various cellular sources of S100B... - Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophreniaHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
J Psychiatr Res 43:1095-105. 2009..Furthermore, it might contribute to the altered metabolism of certain neuropeptides (IGF-I and IGF-II, beta-endorphin), in schizophrenia... - Increased density of prohibitin-immunoreactive oligodendrocytes in the dorsolateral prefrontal white matter of subjects with schizophrenia suggests extraneuronal roles for the protein in the diseaseHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
Neuromolecular Med 14:270-80. 2012.... - [Shortage of doctors in psychiatric hospitals--providing for the future by reorganizing medical services]Wolfgang Jordan
Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
Psychiatr Prax 38:S16-24. 2011..The essential steps and instruments of process optimisation in medical services for a psychiatric clinic are elucidated and discussed in the context of demographic changes, generation change, and a new concept of values... - Beacon-like/ubiquitin-5-like immunoreactivity is highly expressed in human hypothalamus and increased in haloperidol-treated schizophrenics and a rat model of schizophreniaHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Psychoneuroendocrinology 33:340-51. 2008..The latter assumption finds some support by data obtained in rats with ventral hippocampus lesion... - Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicideJohann Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
J Psychiatr Res 42:151-7. 2008..Therefore, the hypothesis of microglial activation during acute psychosis was proposed. Alternatively, "suicide" could be a diagnosis-independent factor leading to microgliosis... - [Definition of the core area of medical services in the psychiatric-psychotherapeutic field--the prerequisite for any delegation]Wolfgang Jordan
Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
Psychiatr Prax 38:S8-15. 2011.... - Reduced density of hypothalamic VGF-immunoreactive neurons in schizophrenia: a potential link to impaired growth factor signaling and energy homeostasisStefan Busse
Department of Psychiatry, University of Magdeburg, Germany
Eur Arch Psychiatry Clin Neurosci 262:365-74. 2012..7 kg/m(2)). In conclusion, apart from beneficial effects on synaptic plasticity and neurogenesis, VGF may be linked to schizophrenia-related alterations in energy homeostasis... - Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophreniaNadine Farkas
Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
World J Biol Psychiatry 11:556-66. 2010..3, a gene locus which has been linked to schizophrenia, and some of its putative substrates are altered in schizophrenia... - Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?Stefan Busse
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
Brain Behav Immun 26:1273-9. 2012..The identification of diverse immune endophenotypes may facilitate the development of distinct anti-inflammatory schizophrenia therapies to normalize BBB function, (auto)antibody production or microglial activity... - Evidence for a wide extra-astrocytic distribution of S100B in human brainJohann Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
BMC Neurosci 8:2. 2007..However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity... - A postmortem assessment of mammillary body volume, neuronal number and densities, and fornix volume in subjects with mood disordersHans Gert Bernstein
Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
Eur Arch Psychiatry Clin Neurosci 262:637-46. 2012..Furthermore, the fornix volumes were significantly reduced only in the control subjects with heart failure. Taken together, these results show that the mammillary bodies are compromised in depression... - A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorderRalf Brisch
Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
Eur Arch Psychiatry Clin Neurosci 261:47-58. 2011..037, r = -0.9). The histopathological abnormality of the decreased neuronal density in the lateral septal nucleus, which is an important limbic region involved in emotions, might be a neuropathological correlate of bipolar disorder... - Immunohistochemical evidence for impaired nitric oxide signaling of the locus coeruleus in bipolar disorderHendrik Bielau
Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany
Brain Res 1459:91-9. 2012..The current data on nNOS suggest a dysregulation of the nitrergic system in bipolar disorder. Future studies may clarify the potential role of glial cells in the context of the described nNOS deficit... - Dopamine-glutamate abnormalities in the frontal cortex associated with the catechol-O-methyltransferase (COMT) in schizophreniaRalf Brisch
Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Brain Res 1269:166-75. 2009..Our study demonstrates that schizophrenia might involve increased COMT expression in glial cells in the frontal cortex, which might be associated with a neuronal-glial abnormality and a disturbed dopamine-glutamate interaction... - The volumes of the fornix in schizophrenia and affective disorders: a post-mortem studyRalf Brisch
Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Psychiatry Res 164:265-73. 2008.... - Demonstration of decreased activity of dorsal raphe nucleus neurons in depressed suicidal patients by the AgNOR staining methodTomasz Gos
Institute of Forensic Medicine, Medical University of Gdansk, Poland Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
J Affect Disord 111:251-60. 2008..The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of limbic structures crucial for the regulation of emotionally influenced behaviour... - Increased density of GAD65/67 immunoreactive neurons in the posterior subiculum and parahippocampal gyrus in treated patients with chronic schizophreniaStefanie Schreiber
Department of Neurology, University of Magdeburg, Magdeburg, Germany
World J Biol Psychiatry 12:57-65. 2011..While GAD has been studied in several brain regions, its expression in the posterior hippocampus formation has not been investigated in schizophrenia... - Dysregulation of GABAergic neurotransmission in mood disorders: a postmortem studyHendrik Bielau
Department of Psychiatry, Psychotherapy, and Psychosomatic Medicine, Otto von Guericke University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
Ann N Y Acad Sci 1096:157-69. 2007..Possibly, existing deficits of GABAergic neurotransmission will be compensated or overcompensated by antidepressants. Additionally, albeit speculative, an imbalance between GABA production and transport might be of relevance... - Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralizationJohann Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
Acta Neuropathol 112:305-16. 2006..In conclusion, the present data suggest the absence of microgliosis but decreased cerebral lateralization of ameboid microglia in schizophrenia... - S100B Serum Levels in Schizophrenia Are Presumably Related to Visceral Obesity and Insulin ResistanceJohann Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
Cardiovasc Psychiatry Neurol 2010:480707. 2010.... - Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disordersHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Neuropharmacology 62:237-46. 2012..The reported increased expression of agmatinase suggests a functional relevance of the enzyme in the pathophysiology of human affective disorders. This article is part of a Special Issue entitled 'Anxiety and Depression'... - Nitric oxide and schizophrenia: present knowledge and emerging concepts of therapyHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
CNS Neurol Disord Drug Targets 10:792-807. 2011..Although certain alterations of brain NO metabolism are not unique to, or indicative of, schizophrenia, their modulation might be a promising therapeutic option for the future... - The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophreniaKathrin Zierhut
Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
Psychiatry Res 183:187-94. 2010..Declarative memory disturbances, known to substantially contribute to cognitive impairment in schizophrenia, have previously been attributed to prefrontal as well as hippocampal dysfunction... - Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitaryHans Gert Bernstein
HansDepartment of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
J Chem Neuroanat 35:216-24. 2008..Some immunolabeling was also present in the neurohypophysis. The putative importance of the distribution of the enzyme in brain and pituitary is discussed in relation to its main known substrates, insulin, Abeta, and beta-endorphin... - Hippocampal CA1 deformity is related to symptom severity and antipsychotic dosage in schizophreniaKathrin C Zierhut
Department of Psychiatry, Leipziger Straße 44, 39120 Magdeburg, Germany
Brain 136:804-14. 2013..Owing to its physiological function, deficits in CA1 may be directly involved in the pathogenesis of hallucinations and delusions, core symptoms in schizophrenia... - Distinct structural alterations independently contributing to working memory deficits and symptomatology in paranoid schizophreniaKathrin C Zierhut
Department of Psychiatry, Otto von Guericke University Magdeburg, Germany Center for Behavioral Brain Sciences Magdeburg CBBS, Germany
Cortex 49:1063-72. 2013..2) GMV reductions in the temporal and mediofrontal cortex are involved in the development of positive symptoms and impair WM performance, too... - Decreased expression of nardilysin in SH-SY5Y cells under ethanol stress and reduced density of nardilysin-expressing neurons in brains of alcoholicsHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany Electronic address
J Psychiatr Res 47:343-9. 2013..basalis of Meynert, paraventricular, and supraoptic nuclei. The alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism... - Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapyHans Gert Bernstein
Department of Psychiatry, Otto von Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Expert Rev Neurother 9:1059-71. 2009.... - Increased density of AKAP5-expressing neurons in the anterior cingulate cortex of subjects with bipolar disorderHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Germany Electronic address
J Psychiatr Res 47:699-705. 2013.... - Increased cerebrospinal fluid and serum levels of S100B in first-onset schizophrenia are not related to a degenerative release of glial fibrillar acidic protein, myelin basic protein and neurone-specific enolase from glia or neuronesJ Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
J Neurol Neurosurg Psychiatry 77:1284-7. 2006..To assess levels of glial fibrillar acidic protein (GFAP), myelin basic protein (MBP), neurone-specific enolase (NSE) and S100B in patients with first-onset schizophrenia... - Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography studyUlf Eckert
Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
Hum Brain Mapp 33:2627-37. 2012..Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc... - [Legal aspects of delegation and reorganisation of medical services in the psychiatric field]Wolfgang Jordan
Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
Psychiatr Prax 38:S1-7. 2011..The present paper outlines the legal, organisational and health policy aspects of delegation and the reorganisation of medical activities in the field of psychiatry... - Mood disorders are glial disorders: evidence from in vivo studiesMatthias L Schroeter
Department of Psychiatry, Queen Elizabeth Hospital, 10362 Berlin, Germany
Cardiovasc Psychiatry Neurol 2010:780645. 2010..S100B can be regarded as a potential diagnostic biomarker for mood disorders and as a biomarker for successful antidepressive treatment...