Johann Steiner

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. doi A new pathophysiological aspect of S100B in schizophrenia: potential regulation of S100B by its scavenger soluble RAGE
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Biol Psychiatry 65:1107-10. 2009
  2. pmc S100B Serum Levels in Schizophrenia Are Presumably Related to Visceral Obesity and Insulin Resistance
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Cardiovasc Psychiatry Neurol 2010:480707. 2010
  3. doi Immune system and glucose metabolism interaction in schizophrenia: a chicken-egg dilemma
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany Center for Behavioral Brain Sciences, Magdeburg, Germany Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 48:287-94. 2014
  4. doi Decrease of serum S100B during an oral glucose tolerance test correlates inversely with the insulin response
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany Center for Behavioral Brain Sciences, Magdeburg, Germany Electronic address
    Psychoneuroendocrinology 39:33-8. 2014
  5. ncbi Possible impact of microglial cells and the monocyte-macrophage system on suicidal behavior
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    CNS Neurol Disord Drug Targets 12:971-9. 2013
  6. doi Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    JAMA Psychiatry 70:271-8. 2013
  7. doi Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    World J Biol Psychiatry 13:482-92. 2012
  8. doi Increased S100B+ NK cell counts in acutely ill schizophrenia patients are correlated with the free cortisol index, but not with S100B serum levels
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 26:564-7. 2012
  9. doi Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:509-18. 2010
  10. doi Haloperidol and clozapine decrease S100B release from glial cells
    J Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Neuroscience 167:1025-31. 2010

Collaborators

Detail Information

Publications60

  1. doi A new pathophysiological aspect of S100B in schizophrenia: potential regulation of S100B by its scavenger soluble RAGE
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Biol Psychiatry 65:1107-10. 2009
    ..Our study focused on its scavenger, soluble receptor for advanced glycation end products (sRAGE). Given the benefits of sRAGE in metabolic and inflammatory diseases, we hypothesized a similar effect in schizophrenia...
  2. pmc S100B Serum Levels in Schizophrenia Are Presumably Related to Visceral Obesity and Insulin Resistance
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Cardiovasc Psychiatry Neurol 2010:480707. 2010
    ....
  3. doi Immune system and glucose metabolism interaction in schizophrenia: a chicken-egg dilemma
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany Center for Behavioral Brain Sciences, Magdeburg, Germany Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 48:287-94. 2014
    ..Alternatively, shared underlying factors may be responsible for the co-occurrence of immune system and glucose metabolism disturbances in schizophrenia. ..
  4. doi Decrease of serum S100B during an oral glucose tolerance test correlates inversely with the insulin response
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany Center for Behavioral Brain Sciences, Magdeburg, Germany Electronic address
    Psychoneuroendocrinology 39:33-8. 2014
    ..To improve comparability between clinical studies assessing conditions with rather mild changes of serum S100B, blood should be taken in a more standardized way (e.g., after fasting overnight)...
  5. ncbi Possible impact of microglial cells and the monocyte-macrophage system on suicidal behavior
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    CNS Neurol Disord Drug Targets 12:971-9. 2013
    ..Therefore, different patterns of immune activation may be observed when comparing newly diseased patients with those who are chronically ill. ..
  6. doi Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    JAMA Psychiatry 70:271-8. 2013
    ....
  7. doi Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    World J Biol Psychiatry 13:482-92. 2012
    ..It is not clear, however, whether such changes are associated with corresponding neuroinflammatory responses and disturbances of neurotransmission...
  8. doi Increased S100B+ NK cell counts in acutely ill schizophrenia patients are correlated with the free cortisol index, but not with S100B serum levels
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 26:564-7. 2012
    ..Notably, elevated S100B+ NK cell counts may be linked with stress axis activation...
  9. doi Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:509-18. 2010
    ..In addition to disease stage or subtype and medication, cigarette smoking and stress are important co-factors...
  10. doi Haloperidol and clozapine decrease S100B release from glial cells
    J Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Neuroscience 167:1025-31. 2010
    ..These data suggest that elevated levels of S100B in bodily fluids of schizophrenic patients are normalized rather than increased by the effects of antipsychotic drugs on glial cells...
  11. ncbi S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric study
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 42:868-76. 2008
    ..However, no histological study has been published on the cellular distribution of S100B in the brain of individuals with schizophrenia to clarify this hypothesis...
  12. doi S100B protein in neurodegenerative disorders
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Clin Chem Lab Med 49:409-24. 2011
    ..Moreover, there is no consistent evidence for a correlation between disease severity and concentrations of S100B in CSF or serum. Therefore, S100B has limited usefulness for monitoring disease progression...
  13. doi Protective effects of haloperidol and clozapine on energy-deprived OLN-93 oligodendrocytes
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 261:477-82. 2011
    ..A new mechanism of antipsychotic action is suggested, which may help to establish new oligodendrocyte-directed therapies of schizophrenia...
  14. doi Human CD8(+) T cells and NK cells express and secrete S100B upon stimulation
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 25:1233-41. 2011
    ..In various physiological and pathological conditions S100B might function as an interface to immunological processes, distinct from known cytokine- and chemokine-mediated pathways...
  15. doi S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric research
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Psychoneuroendocrinology 35:321-4. 2010
    ..In conclusion, physiological S100B levels in humans appear to closely reflect adipose tissue mass, which should therefore be considered as an important confounding factor in clinical studies examining the role of S100B...
  16. pmc Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neuroinflammation 8:94. 2011
    ..These peripheral immune processes may be accompanied by microglial activation in subregions of the anterior cingulate cortex where depression-associated alterations of glutamatergic neurotransmission have been described...
  17. ncbi S100B is expressed in, and released from, OLN-93 oligodendrocytes: Influence of serum and glucose deprivation
    J Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Neuroscience 154:496-503. 2008
    ..Studies on S100B in bodily fluids should be carefully interpreted in order to avoid misleading hypotheses concerning the specific involvement of astrocytes, due to the various cellular sources of S100B...
  18. doi Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 43:1095-105. 2009
    ..Furthermore, it might contribute to the altered metabolism of certain neuropeptides (IGF-I and IGF-II, beta-endorphin), in schizophrenia...
  19. ncbi S100B-immunopositive astrocytes and oligodendrocytes in the hippocampus are differentially afflicted in unipolar and bipolar depression: a postmortem study
    Tomasz Gos
    Department of Psychiatry, University of Magdeburg, Germany Institute of Forensic Medicine, Medical University of Gdansk, Gdansk, Poland
    J Psychiatr Res 47:1694-9. 2013
    ..However, brain studies on the cellular distribution pattern of S100B in depressed patients are lacking so far. Such analyses are crucial, since S100B has been detected in various other cell types, even outside the central nervous system...
  20. doi Increased nuclear Olig1-expression in the pregenual anterior cingulate white matter of patients with major depression: a regenerative attempt to compensate oligodendrocyte loss?
    Jennifer Mosebach
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 47:1069-79. 2013
    ..Olig1, an oligodendroglial transcription factor, might be important in this context, but has not been systematically studied so far...
  21. doi Increased density of prohibitin-immunoreactive oligodendrocytes in the dorsolateral prefrontal white matter of subjects with schizophrenia suggests extraneuronal roles for the protein in the disease
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Neuromolecular Med 14:270-80. 2012
    ....
  22. doi [Shortage of doctors in psychiatric hospitals--providing for the future by reorganizing medical services]
    Wolfgang Jordan
    Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
    Psychiatr Prax 38:S16-24. 2011
    ..The essential steps and instruments of process optimisation in medical services for a psychiatric clinic are elucidated and discussed in the context of demographic changes, generation change, and a new concept of values...
  23. doi Beacon-like/ubiquitin-5-like immunoreactivity is highly expressed in human hypothalamus and increased in haloperidol-treated schizophrenics and a rat model of schizophrenia
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Psychoneuroendocrinology 33:340-51. 2008
    ..The latter assumption finds some support by data obtained in rats with ventral hippocampus lesion...
  24. ncbi Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Psychiatr Res 42:151-7. 2008
    ..Therefore, the hypothesis of microglial activation during acute psychosis was proposed. Alternatively, "suicide" could be a diagnosis-independent factor leading to microgliosis...
  25. doi [Definition of the core area of medical services in the psychiatric-psychotherapeutic field--the prerequisite for any delegation]
    Wolfgang Jordan
    Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
    Psychiatr Prax 38:S8-15. 2011
    ....
  26. doi Reduced density of hypothalamic VGF-immunoreactive neurons in schizophrenia: a potential link to impaired growth factor signaling and energy homeostasis
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:365-74. 2012
    ..7 kg/m(2)). In conclusion, apart from beneficial effects on synaptic plasticity and neurogenesis, VGF may be linked to schizophrenia-related alterations in energy homeostasis...
  27. doi Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophrenia
    Nadine Farkas
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    World J Biol Psychiatry 11:556-66. 2010
    ..3, a gene locus which has been linked to schizophrenia, and some of its putative substrates are altered in schizophrenia...
  28. doi Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 26:1273-9. 2012
    ..The identification of diverse immune endophenotypes may facilitate the development of distinct anti-inflammatory schizophrenia therapies to normalize BBB function, (auto)antibody production or microglial activity...
  29. pmc Evidence for a wide extra-astrocytic distribution of S100B in human brain
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
    BMC Neurosci 8:2. 2007
    ..However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity...
  30. doi A postmortem assessment of mammillary body volume, neuronal number and densities, and fornix volume in subjects with mood disorders
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:637-46. 2012
    ..Furthermore, the fornix volumes were significantly reduced only in the control subjects with heart failure. Taken together, these results show that the mammillary bodies are compromised in depression...
  31. doi A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 261:47-58. 2011
    ..037, r = -0.9). The histopathological abnormality of the decreased neuronal density in the lateral septal nucleus, which is an important limbic region involved in emotions, might be a neuropathological correlate of bipolar disorder...
  32. ncbi Ribosomal DNA transcription in the anterior cingulate cortex is decreased in unipolar but not bipolar I depression
    Tomasz Gos
    Department of Forensic Medicine, Medical University of Gdansk, ul Debowa 23, 80 204 Gdansk, Poland Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany Department of Zoology Developmental Neurobiology, Institute of Biology, Otto von Guericke University, Magdeburg, Germany Electronic address
    Psychiatry Res 210:338-45. 2013
    ..Furthermore, in our cohort, unipolar and bipolar I depression could be differentiated relative to the presumed AC hypoactivity and psychotropic medication did not counteract the observed effect. ..
  33. doi Immunohistochemical evidence for impaired nitric oxide signaling of the locus coeruleus in bipolar disorder
    Hendrik Bielau
    Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany
    Brain Res 1459:91-9. 2012
    ..The current data on nNOS suggest a dysregulation of the nitrergic system in bipolar disorder. Future studies may clarify the potential role of glial cells in the context of the described nNOS deficit...
  34. doi Dopamine-glutamate abnormalities in the frontal cortex associated with the catechol-O-methyltransferase (COMT) in schizophrenia
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Brain Res 1269:166-75. 2009
    ..Our study demonstrates that schizophrenia might involve increased COMT expression in glial cells in the frontal cortex, which might be associated with a neuronal-glial abnormality and a disturbed dopamine-glutamate interaction...
  35. doi The volumes of the fornix in schizophrenia and affective disorders: a post-mortem study
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Psychiatry Res 164:265-73. 2008
    ....
  36. doi Demonstration of decreased activity of dorsal raphe nucleus neurons in depressed suicidal patients by the AgNOR staining method
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    J Affect Disord 111:251-60. 2008
    ..The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of limbic structures crucial for the regulation of emotionally influenced behaviour...
  37. ncbi Dysregulation of GABAergic neurotransmission in mood disorders: a postmortem study
    Hendrik Bielau
    Department of Psychiatry, Psychotherapy, and Psychosomatic Medicine, Otto von Guericke University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:157-69. 2007
    ..Possibly, existing deficits of GABAergic neurotransmission will be compensated or overcompensated by antidepressants. Additionally, albeit speculative, an imbalance between GABA production and transport might be of relevance...
  38. doi Increased density of GAD65/67 immunoreactive neurons in the posterior subiculum and parahippocampal gyrus in treated patients with chronic schizophrenia
    Stefanie Schreiber
    Department of Neurology, University of Magdeburg, Magdeburg, Germany
    World J Biol Psychiatry 12:57-65. 2011
    ..While GAD has been studied in several brain regions, its expression in the posterior hippocampus formation has not been investigated in schizophrenia...
  39. ncbi Decreased expression of nardilysin in SH-SY5Y cells under ethanol stress and reduced density of nardilysin-expressing neurons in brains of alcoholics
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany Electronic address
    J Psychiatr Res 47:343-9. 2013
    ..basalis of Meynert, paraventricular, and supraoptic nuclei. The alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism...
  40. doi Increased density of AKAP5-expressing neurons in the anterior cingulate cortex of subjects with bipolar disorder
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 47:699-705. 2013
    ....
  41. ncbi Volumetric analysis of the hypothalamus, amygdala and hippocampus in non-suicidal and suicidal mood disorder patients--a post-mortem study
    Hendrik Bielau
    Department of Psychiatry and Psychotherapy, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    CNS Neurol Disord Drug Targets 12:914-20. 2013
    ..The detected differences between suicidal and non-suicidal patients suggest that suicidal performances might be related to the degree of structural deficits. ..
  42. doi Distinct structural alterations independently contributing to working memory deficits and symptomatology in paranoid schizophrenia
    Kathrin C Zierhut
    Department of Psychiatry, Otto von Guericke University Magdeburg, Germany
    Cortex 49:1063-72. 2013
    ..2) GMV reductions in the temporal and mediofrontal cortex are involved in the development of positive symptoms and impair WM performance, too...
  43. ncbi Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Acta Neuropathol 112:305-16. 2006
    ..In conclusion, the present data suggest the absence of microgliosis but decreased cerebral lateralization of ameboid microglia in schizophrenia...
  44. doi Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disorders
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Neuropharmacology 62:237-46. 2012
    ..The reported increased expression of agmatinase suggests a functional relevance of the enzyme in the pathophysiology of human affective disorders. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  45. doi Disease severity is correlated to tract specific changes of fractional anisotropy in MD and CM thalamus--a DTI study in major depressive disorder
    Annemarie Osoba
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    J Affect Disord 149:116-28. 2013
    ..Especially thalamic disconnections have been functionally revealed, however, their structural correlates have not been distinctly investigated for its highly diverse subnuclei...
  46. ncbi Nitric oxide and schizophrenia: present knowledge and emerging concepts of therapy
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    CNS Neurol Disord Drug Targets 10:792-807. 2011
    ..Although certain alterations of brain NO metabolism are not unique to, or indicative of, schizophrenia, their modulation might be a promising therapeutic option for the future...
  47. doi Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary
    Hans Gert Bernstein
    HansDepartment of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    J Chem Neuroanat 35:216-24. 2008
    ..Some immunolabeling was also present in the neurohypophysis. The putative importance of the distribution of the enzyme in brain and pituitary is discussed in relation to its main known substrates, insulin, Abeta, and beta-endorphin...
  48. doi The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia
    Kathrin Zierhut
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
    Psychiatry Res 183:187-94. 2010
    ..Declarative memory disturbances, known to substantially contribute to cognitive impairment in schizophrenia, have previously been attributed to prefrontal as well as hippocampal dysfunction...
  49. ncbi S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 264:311-6. 2014
    ..This data reinforce the importance of oligodendrocytes in schizophrenia, shedding more light to its pathobiology...
  50. doi Increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims: possible implications for heroin neurotoxicity
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany Electronic address
    Acta Histochem 116:182-90. 2014
    ....
  51. doi Wide distribution of CREM immunoreactivity in adult and fetal human brain, with an increased expression in dentate gyrus neurons of Alzheimer's as compared to normal aging brains
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Amino Acids 45:1373-83. 2013
    ..In Alzheimer's brain, we found an increased cellular expression of CREM in dentate gyrus neurons as compared to controls. We discuss our results with regard to the putative roles of CREM in brain development and in cognition...
  52. ncbi Hippocampal CA1 deformity is related to symptom severity and antipsychotic dosage in schizophrenia
    Kathrin C Zierhut
    Department of Psychiatry, Leipziger Straße 44, 39120 Magdeburg, Germany
    Brain 136:804-14. 2013
    ..Owing to its physiological function, deficits in CA1 may be directly involved in the pathogenesis of hallucinations and delusions, core symptoms in schizophrenia...
  53. ncbi Age-related increase of VGF-expression in T lymphocytes
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Aging (Albany NY) 6:440-53. 2014
    ..We conclude that VGF contributes to survival and function of peripheral T cells. The age-dependent increase in VGF-expression could serve as mechanism that counterregulates the decrease in functionality of T lymphocytes. ..
  54. ncbi Disruption of glutamate-glutamine-GABA cycle significantly impacts on suicidal behaviour: survey of the literature and own findings on glutamine synthetase
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120Magdeburg, Germany
    CNS Neurol Disord Drug Targets 12:900-13. 2013
    ....
  55. doi Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Expert Rev Neurother 9:1059-71. 2009
    ....
  56. doi Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus--a DTI tractography study
    Ulf Eckert
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Hum Brain Mapp 33:2627-37. 2012
    ....
  57. pmc Increased cerebrospinal fluid and serum levels of S100B in first-onset schizophrenia are not related to a degenerative release of glial fibrillar acidic protein, myelin basic protein and neurone-specific enolase from glia or neurones
    J Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Neurol Neurosurg Psychiatry 77:1284-7. 2006
    ..To assess levels of glial fibrillar acidic protein (GFAP), myelin basic protein (MBP), neurone-specific enolase (NSE) and S100B in patients with first-onset schizophrenia...
  58. doi Deep brain stimulation of the nucleus accumbens for the treatment of addiction
    Ulf J Muller
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Ann N Y Acad Sci 1282:119-28. 2013
    ..Finally, we call attention to key ethical issues related to using DBS to treat addiction that are important for future research and the design of clinical trials...
  59. doi [Legal aspects of delegation and reorganisation of medical services in the psychiatric field]
    Wolfgang Jordan
    Klinik fur Psychiatrie und Psychotherapie, Klinikum Magdeburg gemeinnützige GmbH, Magdeburg, Germany
    Psychiatr Prax 38:S1-7. 2011
    ..The present paper outlines the legal, organisational and health policy aspects of delegation and the reorganisation of medical activities in the field of psychiatry...
  60. pmc Mood disorders are glial disorders: evidence from in vivo studies
    Matthias L Schroeter
    Department of Psychiatry, Queen Elizabeth Hospital, 10362 Berlin, Germany
    Cardiovasc Psychiatry Neurol 2010:780645. 2010
    ..S100B can be regarded as a potential diagnostic biomarker for mood disorders and as a biomarker for successful antidepressive treatment...