Luca Simeoni

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi request reprint SIT and TRIM determine T cell fate in the thymus
    Uwe Koelsch
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
    J Immunol 181:5930-9. 2008
  2. pmc The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions
    Luca Simeoni
    Otto von Guericke University, Institute of Immunology, Magdeburg, Germany
    Mol Cell Biol 25:7557-68. 2005
  3. pmc A methodology for the structural and functional analysis of signaling and regulatory networks
    Steffen Klamt
    Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, D 39106 Magdeburg, Germany
    BMC Bioinformatics 7:56. 2006
  4. pmc Normal T-cell development and immune functions in TRIM-deficient mice
    Uwe Kölsch
    Institute of Immunology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Mol Cell Biol 26:3639-48. 2006
  5. pmc TCR activation kinetics and feedback regulation in primary human T cells
    Mateusz Poltorak
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Leipziger Str, 44, 39120, Magdeburg, Germany
    Cell Commun Signal 11:4. 2013
  6. ncbi request reprint Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells
    Xiaoqian Wang
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
    J Immunol 180:6703-12. 2008
  7. ncbi request reprint Sos1 regulates sustained TCR-mediated Erk activation
    Mateusz Poltorak
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
    Eur J Immunol 44:1535-40. 2014
  8. doi request reprint Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX
    Börge Arndt
    Institutes of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Leukoc Biol 93:353-62. 2013
  9. pmc The transmembrane adaptor protein SIT inhibits TCR-mediated signaling
    Börge Arndt
    Institute of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    PLoS ONE 6:e23761. 2011
  10. doi request reprint Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins
    Luca Simeoni
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
    Immunol Rev 224:215-28. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint SIT and TRIM determine T cell fate in the thymus
    Uwe Koelsch
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
    J Immunol 181:5930-9. 2008
    ..In summary, we demonstrated that SIT and TRIM regulate cell fate of developing thymocytes, thus identifying them as essential regulators of central tolerance...
  2. pmc The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions
    Luca Simeoni
    Otto von Guericke University, Institute of Immunology, Magdeburg, Germany
    Mol Cell Biol 25:7557-68. 2005
    ..These results demonstrate that SIT is a critical negative regulator of TCR-mediated signaling and finely tunes the signals required for thymic selection and peripheral T-cell activation...
  3. pmc A methodology for the structural and functional analysis of signaling and regulatory networks
    Steffen Klamt
    Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, D 39106 Magdeburg, Germany
    BMC Bioinformatics 7:56. 2006
    ..While the structural analysis of metabolic networks is a well-established field, similar methodologies have been scarcely developed and applied to signaling and regulatory networks...
  4. pmc Normal T-cell development and immune functions in TRIM-deficient mice
    Uwe Kölsch
    Institute of Immunology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Mol Cell Biol 26:3639-48. 2006
    ..The lack of an evident phenotype could indicate that TRIM shares redundant functions with other transmembrane adaptors involved in regulating the immune response...
  5. pmc TCR activation kinetics and feedback regulation in primary human T cells
    Mateusz Poltorak
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Leipziger Str, 44, 39120, Magdeburg, Germany
    Cell Commun Signal 11:4. 2013
    ..A growing body of evidence indicates that differences in the magnitude and the duration of the signal are critical determinants in eliciting cellular responses...
  6. ncbi request reprint Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells
    Xiaoqian Wang
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
    J Immunol 180:6703-12. 2008
    ..Collectively, our data provide signaling signatures that are associated with proliferation or apoptosis of T cells...
  7. ncbi request reprint Sos1 regulates sustained TCR-mediated Erk activation
    Mateusz Poltorak
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
    Eur J Immunol 44:1535-40. 2014
    ..In summary, our data show for the first time that the two guanine nucleotide exchange factors expressed in T cells are differentially involved in the regulation of the duration of Erk phosphorylation and T-cell activation. ..
  8. doi request reprint Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX
    Börge Arndt
    Institutes of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Leukoc Biol 93:353-62. 2013
    ..Collectively, our data indicate that SIT and LAX are important negative regulators of immune responses that functionally cooperate...
  9. pmc The transmembrane adaptor protein SIT inhibits TCR-mediated signaling
    Börge Arndt
    Institute of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    PLoS ONE 6:e23761. 2011
    ..In summary, the data identify SIT as an important modulator of TCR-mediated signaling that regulates T-cell activation, homeostasis and tolerance...
  10. doi request reprint Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteins
    Luca Simeoni
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
    Immunol Rev 224:215-28. 2008
    ..Collectively, these data demonstrate that TRAPs are important modulators of immune cell activation and function. Finally, it appears that TRAPs possess redundant yet not completely overlapping functions...
  11. ncbi request reprint Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells
    Jessica Horn
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
    J Immunol 183:5756-67. 2009
    ..Collectively, our data indicate a differential requirement for SLP76 in TCR- vs CXCR4-mediated inside-out signaling pathways regulating T cell adhesion and migration...
  12. ncbi request reprint Regulation of T cell homeostasis by the transmembrane adaptor protein SIT
    Vilmos Posevitz
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Leipziger Strasse 44, Magdeburg, Germany
    J Immunol 180:1634-42. 2008
    ..Finally, we show that SIT-deficient T cells develop a mechanism analogous to sensory adaptation as they up-regulate CD5, down-regulate the coreceptor, and display impaired TCR-mediated ZAP-70 activation...
  13. ncbi request reprint T cell activation results in conformational changes in the Src family kinase Lck to induce its activation
    Anja Stirnweiss
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Sci Signal 6:ra13. 2013
    ..These data show the dynamic, local activation through conformational change of Lck at sites of TCR engagement...
  14. doi request reprint Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation
    Boerge Arndt
    Otto von Guericke University, Institute of Molecular and Clinical Immunology, Leipziger Str 44, 39120 Magdeburg, Germany
    J Immunol Methods 387:276-83. 2013
    ..In summary, our analysis documents TCR signaling kinetics and suggests that iAbs are better suited for studying TCR-mediated signaling as they mimic antigen specific systems...
  15. pmc TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells
    Nicole Warnecke
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Leipziger Strasse 44, Magdeburg 39120, Germany
    EMBO Rep 13:386-91. 2012
    ..Thus, RasGRP1 and Grb2/Sos are insulators of signals that lead to Ras activation induced by different stimuli, rather than cooperating downstream of the TCR...
  16. ncbi request reprint Adaptors and linkers in T and B cells
    Luca Simeoni
    Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Curr Opin Immunol 16:304-13. 2004
    ..Finally, an involvement of the cytosolic adaptors ADAP, SKAP-55 and Cbl-b in the regulation of lymphocyte adhesion and migration has been demonstrated...
  17. ncbi request reprint Right time, right place: the organization of membrane proximal signaling
    Luca Simeoni
    Institute of Immunology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Semin Immunol 17:35-49. 2005
    ..Our study of these novel molecules is shedding new insights into the positive and negative regulatory mechanisms which fine tune antigen receptor signaling...
  18. ncbi request reprint Transmembrane adapters: attractants for cytoplasmic effectors
    Jonathan A Lindquist
    Institute of Immunology, Otto von Guericke University, Magdeburg, Germany
    Immunol Rev 191:165-82. 2003
    ..The membrane association of TRAPs places them near to the immunoreceptors, a position from which they coordinate and modulate the signals they receive to produce an appropriate cellular response...
  19. pmc PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells
    Michal Smida
    Institute of Molecular and Clinical Immunology, Otto von Guericke University, Leipziger Strasse 44, Magdeburg, 39120, Germany
    Cell Commun Signal 11:28. 2013
    ..Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test whether the loss of PAG resulted in lymphocyte transformation...
  20. pmc A logical model provides insights into T cell receptor signaling
    Julio Saez-Rodriguez
    Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
    PLoS Comput Biol 3:e163. 2007
    ..We think that it holds valuable potential in foreseeing the effects of drugs and network modifications...