Research Topics
Genomes and Genes | Luca SimeoniSummaryAffiliation: Otto-von-Guericke University Country: Germany Publications
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Publications
The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functionsLuca Simeoni
Otto von Guericke University, Institute of Immunology, Magdeburg, Germany
Mol Cell Biol 25:7557-68. 2005..These results demonstrate that SIT is a critical negative regulator of TCR-mediated signaling and finely tunes the signals required for thymic selection and peripheral T-cell activation...- A methodology for the structural and functional analysis of signaling and regulatory networksSteffen Klamt
Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, D 39106 Magdeburg, Germany
BMC Bioinformatics 7:56. 2006..While the structural analysis of metabolic networks is a well-established field, similar methodologies have been scarcely developed and applied to signaling and regulatory networks... - Normal T-cell development and immune functions in TRIM-deficient miceUwe Kölsch
Institute of Immunology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
Mol Cell Biol 26:3639-48. 2006..The lack of an evident phenotype could indicate that TRIM shares redundant functions with other transmembrane adaptors involved in regulating the immune response... 
SIT and TRIM determine T cell fate in the thymusUwe Koelsch
Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
J Immunol 181:5930-9. 2008..In summary, we demonstrated that SIT and TRIM regulate cell fate of developing thymocytes, thus identifying them as essential regulators of central tolerance...- Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cellsXiaoqian Wang
Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
J Immunol 180:6703-12. 2008..Collectively, our data provide signaling signatures that are associated with proliferation or apoptosis of T cells... - The transmembrane adaptor protein SIT inhibits TCR-mediated signalingBörge Arndt
Institute of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, Magdeburg, Germany
PLoS ONE 6:e23761. 2011..In summary, the data identify SIT as an important modulator of TCR-mediated signaling that regulates T-cell activation, homeostasis and tolerance... 
Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cellsJessica Horn
Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
J Immunol 183:5756-67. 2009..Collectively, our data indicate a differential requirement for SLP76 in TCR- vs CXCR4-mediated inside-out signaling pathways regulating T cell adhesion and migration...- Control of lymphocyte development and activation by negative regulatory transmembrane adapter proteinsLuca Simeoni
Institute of Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany
Immunol Rev 224:215-28. 2008..Collectively, these data demonstrate that TRAPs are important modulators of immune cell activation and function. Finally, it appears that TRAPs possess redundant yet not completely overlapping functions... - Regulation of T cell homeostasis by the transmembrane adaptor protein SITVilmos Posevitz
Institute of Molecular and Clinical Immunology, Otto von Guericke University, Leipziger Strasse 44, Magdeburg, Germany
J Immunol 180:1634-42. 2008..Finally, we show that SIT-deficient T cells develop a mechanism analogous to sensory adaptation as they up-regulate CD5, down-regulate the coreceptor, and display impaired TCR-mediated ZAP-70 activation... - TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cellsNicole Warnecke
Institute of Molecular and Clinical Immunology, Otto von Guericke University, Leipziger Strasse 44, Magdeburg 39120, Germany
EMBO Rep 13:386-91. 2012..Thus, RasGRP1 and Grb2/Sos are insulators of signals that lead to Ras activation induced by different stimuli, rather than cooperating downstream of the TCR... - Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulationBoerge Arndt
Otto von Guericke University, Institute of Molecular and Clinical Immunology, Leipziger Str 44, 39120 Magdeburg, Germany
J Immunol Methods 387:276-83. 2013..In summary, our analysis documents TCR signaling kinetics and suggests that iAbs are better suited for studying TCR-mediated signaling as they mimic antigen specific systems... - Adaptors and linkers in T and B cellsLuca Simeoni
Institute of Immunology, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
Curr Opin Immunol 16:304-13. 2004..Finally, an involvement of the cytosolic adaptors ADAP, SKAP-55 and Cbl-b in the regulation of lymphocyte adhesion and migration has been demonstrated... - Right time, right place: the organization of membrane proximal signalingLuca Simeoni
Institute of Immunology, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
Semin Immunol 17:35-49. 2005..Our study of these novel molecules is shedding new insights into the positive and negative regulatory mechanisms which fine tune antigen receptor signaling... - Transmembrane adapters: attractants for cytoplasmic effectorsJonathan A Lindquist
Institute of Immunology, Otto-von-Guericke University, Magdeburg, Germany
Immunol Rev 191:165-82. 2003..The membrane association of TRAPs places them near to the immunoreceptors, a position from which they coordinate and modulate the signals they receive to produce an appropriate cellular response... - A logical model provides insights into T cell receptor signalingJulio Saez Rodriguez
Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
PLoS Comput Biol 3:e163. 2007..We think that it holds valuable potential in foreseeing the effects of drugs and network modifications...