Christoph Rocken

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi Generalized AA-amyloidosis in a 58-year-old Caucasian woman with an 18-month history of gastrointestinal tuberculosis
    C Rocken
    Institute of Pathology, Otto von Guericke University, Magdeburg, Germany
    Virchows Arch 434:95-100. 1999
  2. ncbi ALys amyloidosis caused by compound heterozygosity in exon 2 (Thr70Asn) and exon 4 (Trp112Arg) of the lysozyme gene
    Christoph Rocken
    Institute of Pathology, Otto von Guericke University, Magdeburg, Germany
    Hum Mutat 27:119-20. 2006
  3. pmc Advanced glycation end products and receptor for advanced glycation end products in AA amyloidosis
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Am J Pathol 162:1213-20. 2003
  4. ncbi Influence of tissue fixation on the microextraction and identification of amyloid proteins
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    J Lab Clin Med 146:244-50. 2005
  5. ncbi Amyloid in surgical pathology
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Virchows Arch 443:3-16. 2003
  6. pmc Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma
    C Rocken
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    J Clin Pathol 58:1069-75. 2005
  7. ncbi Ectopeptidases are differentially expressed in hepatocellular carcinomas
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Int J Oncol 24:487-95. 2004
  8. pmc Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation
    C Rocken
    Institute of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Ann Rheum Dis 64:808-15. 2005
  9. ncbi The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism
    Christoph Rocken
    Department of Pathology, Institutes of Experimental Internal Medicine, Clinical Chemistry, and Biometrics, Otto von Guericke University, Magdeburg, Germany
    Clin Cancer Res 11:2526-30. 2005
  10. ncbi Proteomics in pathology, research and practice
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Pathol Res Pract 200:69-82. 2004

Collaborators

Detail Information

Publications95

  1. ncbi Generalized AA-amyloidosis in a 58-year-old Caucasian woman with an 18-month history of gastrointestinal tuberculosis
    C Rocken
    Institute of Pathology, Otto von Guericke University, Magdeburg, Germany
    Virchows Arch 434:95-100. 1999
    ..AA-amyloid can thus be present in serious inflammatory disease even during the first 9 months after the initial clinical presentation...
  2. ncbi ALys amyloidosis caused by compound heterozygosity in exon 2 (Thr70Asn) and exon 4 (Trp112Arg) of the lysozyme gene
    Christoph Rocken
    Institute of Pathology, Otto von Guericke University, Magdeburg, Germany
    Hum Mutat 27:119-20. 2006
    ..Interestingly, this form of ALys amyloidosis is also characterized by the occurrence of proteolytic fragments of lysozyme in the amyloid deposits...
  3. pmc Advanced glycation end products and receptor for advanced glycation end products in AA amyloidosis
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Am J Pathol 162:1213-20. 2003
    ..Other as yet unidentified variables, especially of the heterogeneous group of AGEs, probably modulate transcription of RAGE and influence amyloidogenesis. CML serum levels, in turn, may prove useful in predicting patients at risk...
  4. ncbi Influence of tissue fixation on the microextraction and identification of amyloid proteins
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    J Lab Clin Med 146:244-50. 2005
    ....
  5. ncbi Amyloid in surgical pathology
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Virchows Arch 443:3-16. 2003
    ..This review focuses on the epidemiology, clinical features, pathology and diagnosis of amyloid in surgical pathology...
  6. pmc Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma
    C Rocken
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    J Clin Pathol 58:1069-75. 2005
    ....
  7. ncbi Ectopeptidases are differentially expressed in hepatocellular carcinomas
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Int J Oncol 24:487-95. 2004
    ..CD13 shows a characteristic canalicular distribution pattern and may be important for cell polarization and bile compartmentalization in HCCs, while CD143 may influence angiogenesis...
  8. pmc Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation
    C Rocken
    Institute of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Ann Rheum Dis 64:808-15. 2005
    ..Previous studies have provided evidence that endosomes or lysosomes might be involved in the processing of SAA, and contribute to the pathology of AA amyloidosis...
  9. ncbi The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism
    Christoph Rocken
    Department of Pathology, Institutes of Experimental Internal Medicine, Clinical Chemistry, and Biometrics, Otto von Guericke University, Magdeburg, Germany
    Clin Cancer Res 11:2526-30. 2005
    ..In the present study, we aimed to substantiate the putative significance of angiotensin I-converting enzyme (ACE) on gastric cancer biology by investigating the influence of its gene polymorphism on gastric cancer progression...
  10. ncbi Proteomics in pathology, research and practice
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Pathol Res Pract 200:69-82. 2004
    ..Special emphasis is put on the former Human Protein Index project...
  11. ncbi 16th Amyloidforum organized by the German Society of Amyloid Diseases, April 2002, Vienna, Austria
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Amyloid 9:207-11. 2002
  12. ncbi Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Circulation 106:2091-7. 2002
    ..Structural changes, like atrial fibrosis, may increase the likelihood of atrial fibrillation (AF) occurring in response to triggering events. The influence of isolated atrial amyloidosis (IAA) is largely unknown...
  13. ncbi Hepatic angiomyolipoma in a 26-year-old Caucasian woman with a history of tibial osteosarcoma
    C Rocken
    Institute of Pathology, Otto von Guericke University, Magdeburg, Germany
    Pathol Res Pract 195:765-72. 1999
    ..Whilst the tibial osteosarcoma showed LOH at p16, no genetic alterations or increased telomerase activity were found in the angiomyolipoma. The occurrence of both these tumours in this patient is therefore probably a coincidence...
  14. ncbi Plasmacytoma of the tonsil with AL amyloidosis: evidence of post-fibrillogenic proteolysis of the fibril protein
    C Rocken
    Institute of Pathology, Otto von Guericke University, Magdeburg, Germany
    Virchows Arch 436:336-44. 2000
    ....
  15. ncbi Pathology and pathogenesis of hepatocellular carcinoma
    C Rocken
    Department of Pathology, Otto von Guericke University of Magdeburg, Germany
    Dig Dis 19:269-78. 2001
    ..However, there is still great need for the definition of objective morphological, phenotypic and genetic markers for the progression of HCC...
  16. ncbi Pathology, diagnosis and pathogenesis of AA amyloidosis
    Christoph Rocken
    Department of Pathology, Otto von Guericke University of Magdeburg, Germany
    Virchows Arch 440:111-22. 2002
    ....
  17. ncbi Amyloidosis of the breast
    Christoph Rocken
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Virchows Arch 440:527-35. 2002
    ....
  18. ncbi CD26/DP IV in T cell activation and autoimmunity
    Vera Preller
    Institute of Immunology Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Adv Exp Med Biol 575:187-93. 2006
  19. ncbi Proteome analysis of gastric cancer metastasis by two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-mass spectrometry for identification of metastasis-related proteins
    Jie Chen
    Department of Gastroenterology, Hepatology and Infectious Diseases, Research Center Immunology Institute of Experimental Internal Medicine, and Pathology, Otto von Guericke University, Magdeburg, Germany
    J Proteome Res 3:1009-16. 2004
    ..Combining well-defined animal models with proteome analysis will improve our understanding of the fundamental changes that contribute to the process of carcinogenesis and the formation of metastases in gastric cancer...
  20. ncbi The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer
    Stacy Carl-McGrath
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Int J Oncol 25:1223-32. 2004
    ....
  21. doi Atrial expression of endothelial nitric oxide synthase in patients with and without atrial fibrillation
    Alicja Bukowska
    Institute of Experimental Internal Medicine, University Hospital Magdeburg, Magdeburg, Germany
    Cardiovasc Pathol 19:e51-60. 2010
    ..This study was designed to determine the endocardial expression of eNOS in atrial tissue samples from patients with and without AF...
  22. ncbi The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer
    Stacy Carl-McGrath
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Int J Oncol 26:17-24. 2005
    ..The resultant modulation of the tumor-host interface may contribute to the pathogenesis, development or progression of gastric cancer...
  23. pmc The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients
    Christoph Rocken
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Neoplasia 9:716-22. 2007
    ..Our study shows that ACE is differentially expressed in CRCs and that gene polymorphism is associated with gender-specific differences in primary tumor size and patient survival...
  24. ncbi Cleavage of AL amyloid proteins and AL amyloid deposits by cathepsins B, K, and L
    Silvia Bohne
    Institute of Pathology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Pathol 203:528-37. 2004
    ..However, the efficiency with which proteolysis occurs depends on the concentration of active protease recruited at the sites of amyloid deposition, and possibly on the structure of the AL amyloid proteins...
  25. ncbi Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis
    Jie Chen
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Carcinogenesis 26:37-43. 2005
    ..Therefore, metastatic cancer cells seem to harbour a heterogenous genetic and epigenetic background, in which cancer cells may exhibit APC promoter methylation that is independent of APC expression...
  26. ncbi The angiotensin I-converting enzyme gene insertion/deletion polymorphism is linked to early gastric cancer
    Matthias P A Ebert
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Cancer Epidemiol Biomarkers Prev 14:2987-9. 2005
    ..Our study provides further evidence that the ACE insertion/deletion gene polymorphism may be linked to the development of early gastric cancer...
  27. doi Angiotensin II-generating enzymes, angiotensin-converting enzyme (ACE) and mast cell chymase (CMA1), in gastric inflammation may be regulated by H. pylori and associated cytokines
    Stacy Carl-McGrath
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Pathology 41:419-27. 2009
    ..ACE inhibitors have been shown to have a protective or healing effect on gastric ulcers and colitis in animal models, which could be related to the local expression of ACE...
  28. pmc Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma
    Antal Csepregi
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, 39120 Magdeburg, Germany
    BMC Cancer 10:317. 2010
    ..Herein, we evaluated CDKN2A promoter methylation and p16 protein expression for the differentiation of hepatocellular carcinoma (HCC) from other liver tumors...
  29. doi ATTR amyloid in the carpal tunnel ligament is frequently of wildtype transthyretin origin
    Zarina Gioeva
    Institute of Pathology, Christian Albrechts University Kiel, Kiel, Germany
    Amyloid 20:1-6. 2013
    ..No significant difference was found between the two study groups. ATTR amyloid in the carpal tunnel ligament is commonly of wildtype origin and genetic counseling is not mandatory in these patients...
  30. ncbi Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2'-deoxycytidine
    Jie Chen
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg 39120, Germany
    Clin Exp Metastasis 21:389-97. 2004
    ..In conclusion, using global gene expression analysis together with inhibition of DNA methylation, we demonstrate that hypermethylation of the promoters of certain cancer-related genes may play a role in cancer metastasis...
  31. ncbi The tyrosine kinase inhibitor imatinib fails to inhibit pancreatic cancer progression
    Jie Chen
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Leipzigerstr 44, D 39120 Magdeburg, Germany
    Cancer Lett 233:328-37. 2006
    ..Quality of life was similar in both groups. In this small series of pancreatic cancer patients, treatment with imatinib was not associated with a significant control of cancer progression...
  32. ncbi Determinants and consequences of atrial fibrosis in patients undergoing open heart surgery
    Andreas Goette
    Division of Cardiology, University Hospital Magdeburg, Leipziger Str 44, 39120, Magdeburg Germany
    Cardiovasc Res 54:390-6. 2002
    ..Increased atrial fibrosis may indicate the presence of an intrinsic arrhythmogenic substrate. The aim of this prospective study was to determine whether atrial fibrosis is associated with increased prevalence of AF after OHS...
  33. doi Comparison of different tissue sampling methods for protein extraction from formalin-fixed and paraffin-embedded tissue specimens
    Ilona Gräntzdörffer
    Department of Pathology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    Exp Mol Pathol 88:190-6. 2010
    ..In this study, we explored the possibility to standardize tissue sampling from paraffin blocks and compared the protein extracts with those obtained from fresh frozen material...
  34. doi Angiotensin II receptor blockade reduces tachycardia-induced atrial adhesion molecule expression
    Andreas Goette
    Division of Cardiology, Otto von Guericke University Hospital Magdeburg, Magdeburg, Germany
    Circulation 117:732-42. 2008
    ....
  35. pmc APC promoter methylation and protein expression in hepatocellular carcinoma
    Antal Csepregi
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Cancer Res Clin Oncol 134:579-89. 2008
    ..We investigated the impact of promoter methylation on APC protein expression in patients with hepatocellular carcinoma (HCC)...
  36. ncbi Protective role of heat shock protein 27 in gastric mucosal injury
    Matthias P A Ebert
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    J Pathol 207:177-84. 2005
    ..This indicates that HSP27 expression is critical for mucosal protection in the stomach...
  37. doi Amyloid in endomyocardial biopsies
    Barbara Kieninger
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Virchows Arch 456:523-32. 2010
    ..Glu54Asp) and were classified as suffering from hereditary ATTR amyloidosis. Amyloid in endomyocardial biopsies is most commonly of immunoglobulin light chain origin, followed by non-hereditary and hereditary-type ATTR amyloid...
  38. ncbi Clinical proteomics in lung diseases
    Nadine Waldburg
    Division of Pneumology and Critical Care, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Pathol Res Pract 200:147-54. 2004
    ..Our results and the studies reviewed in this paper represent just the beginning of detailed studies that should unravel the relevance and the functional consequences of differential protein expressions in the diseased lung...
  39. ncbi Angiotensin I-converting enzyme (CD143) is down-regulated in focal nodular hyperplasia of the liver
    Ilona Gräntzdörffer
    Department of Pathology and dagger Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany
    Am J Surg Pathol 28:84-8. 2004
    ..The observed variations in expression patterns for CD143 might be of diagnostic use in surgical pathology...
  40. ncbi Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues
    Stacy Carl-McGrath
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Pathology 40:13-24. 2008
    ..The GSDMDC family has been linked to cancer development and progression, and this is the first study analysing the expression and intracellular localisation of GSDML...
  41. doi Modulation of cytokine production and silica-induced lung fibrosis by inhibitors of aminopeptidase N and of dipeptidyl peptidase-IV-related proteases
    Ulrike C Kuhlmann
    Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Life Sci 84:1-11. 2009
    ..Here we investigated for the first time the effects of DP-IV-related protease inhibitors and APN inhibitors on chronic inflammatory lung diseases...
  42. pmc Cigarette smoking induces atrial fibrosis in humans via nicotine
    Andreas Goette
    Institute of Experimental Internal Medicine, Division of Cardiology, Department of Cardiovascular Surgery, University Hospital Magdeburg, Magdeburg, Germany
    Heart 93:1056-63. 2007
    ..Cigarette smoking (CS) promotes endothelial dysfunction and atherosclerosis in the vascular bed. The impact of smoking on atrial myocardium is not defined in humans...
  43. doi Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression
    Oleg Tchernitsa
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    J Pathol 222:310-9. 2010
    ..Gastric cancer shows a complex derangement of the miRNA-ome, including Dicer and Drosha. These changes correlate independently with patient prognosis and probably influence local tumour growth and nodal spread...
  44. ncbi Clinical implications of alpha-fetoprotein expression in gastric adenocarcinoma
    Jie Chen
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Dig Dis 21:357-62. 2003
    ..Few cases have been reported in Germany until now. Here we report on a patient with an AFP-producing gastric cancer and a subsequent analysis of AFP expression in a more extended series of gastric cancer patients...
  45. doi LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma
    Jan Simon Steffen
    Institute of Pathology, Christian Albrechts University, Kiel, Germany
    Virchows Arch 461:355-65. 2012
    ..025). Our systematic analysis indicates that LGR4 and LGR6 may play a role in GC biology. Future studies will have to demonstrate whether these are also putative diagnostic, prognostic, and/or therapeutic targets for GC...
  46. pmc KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications
    Katharina Balschun
    Department of Pathology, Christian Albrechts University, Kiel, Germany
    J Mol Diagn 13:436-45. 2011
    ..When metastases occur in these patients, the genotype has diagnostic and therapeutic implications and should be determined from the simultaneous or metachronous distant metastases...
  47. pmc Hereditary apolipoprotein AI-associated amyloidosis in surgical pathology specimens: identification of three novel mutations in the APOA1 gene
    Magdalena Eriksson
    Department of Pathology, Charite University Hospital, Berlin, Germany
    J Mol Diagn 11:257-62. 2009
    ..Patients with alterations in codons 1 to 75 mostly develop hepatic and renal amyloidosis, while carriers of mutations in residues 173 to 178 mainly suffer from cardiac, laryngeal, and cutaneous amyloidosis...
  48. ncbi Increased expression of ADAM family members in human breast cancer and breast cancer cell lines
    Uwe Lendeckel
    Institute of Experimental Internal Medicine, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany
    J Cancer Res Clin Oncol 131:41-8. 2005
    ..We wished to investigate the expression of ADAM 9, 10, 12, 15, and in human breast cancer...
  49. ncbi The angiotensin II/angiotensin II receptor system correlates with nodal spread in intestinal type gastric cancer
    Christoph Rocken
    Department of Pathology, Charite University Hospital, Chariteplatz 1, D 10117 Berlin, Germany
    Cancer Epidemiol Biomarkers Prev 16:1206-12. 2007
    ..45-248.24). Our study shows that AT1R and AT2R are expressed locally in gastric cancer and that the combination of AT1R expression and ACE I/D gene polymorphism correlates with nodal spread in intestinal type gastric cancer...
  50. doi Prevalence of germline mutations in the TTR gene in a consecutive series of surgical pathology specimens with ATTR amyloid
    Magdalena Eriksson
    Department of Pathology, Medical Clinic of Gastroenterology, Hepatology, and Endocrinology, Charite University Hospital, Berlin, Germany
    Am J Surg Pathol 33:58-65. 2009
    ..To conclude, the hereditary form of ATTR amyloid seems to be more common in elderly patients than previously thought. It is, therefore, important to genetically test every patient when diagnosing ATTR amyloidosis...
  51. ncbi Feasibility of histological grading and staging of chronic viral hepatitis using specimens obtained by thin-needle biopsy
    Daniela Petz
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Virchows Arch 442:238-44. 2003
    ..This study showed that grading and staging of chronic viral hepatitis is feasible in TNB specimens and that intra- and interobserver variability poses a greater problem than needle size...
  52. ncbi Immunocytochemical identification of low-affinity NTS2 neurotensin receptors in parietal cells of human gastric mucosa
    Stefan Schulz
    Department of Pharmacology and Toxicology, Otto von Guericke University, Magdeburg, Germany
    J Endocrinol 191:121-8. 2006
    ..v. administration of neurotensin...
  53. pmc The spatial distribution of LGR5+ cells correlates with gastric cancer progression
    Eva Simon
    Institute of Pathology, Christian Albrechts University, Kiel, Germany
    PLoS ONE 7:e35486. 2012
    ..3 months). Our results show that LGR5 is differentially expressed in gastrointestinal cancers and that the spatial histoanatomical distribution of LGR5(+) cells has to be considered when their tumour biological significance is sought...
  54. ncbi Hereditary lattice corneal dystrophy is associated with corneal amyloid deposits enclosing C-terminal fragments of keratoepithelin
    Barbara Stix
    Institute of Pathology, Otto von Guericke University, Magdeburg, Germany
    Invest Ophthalmol Vis Sci 46:1133-9. 2005
    ..To investigate the molecular basis of hereditary lattice corneal dystrophy (LCD) type IIIA associated with corneal amyloid deposits afflicting several members of a four-generation family...
  55. ncbi Gene polymorphisms of the NOD-2/CARD-15 gene and the risk of gastric cancer in Germany
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, D 39120 Magdeburg, Germany
    Anticancer Res 28:757-62. 2008
    ..NOD-2 is involved in the intracellular recognition of bacterial muramyl dipeptides, and three independent polymorphisms of this gene have been identified as risk factors for the development of Crohn's disease...
  56. ncbi Immunocytochemical localisation of plasma membrane GHRH receptors in human tumours using a novel anti-peptide antibody
    Solveig Schulz
    Department of Obstetrics and Gynecology, Otto von Guericke University, 39120 Magdeburg, Germany
    Eur J Cancer 42:2390-6. 2006
    ..The GHRH receptor visualisation could be of value for a rapid immunohistochemical identification of those tumours which could be a target for diagnostic or therapeutic intervention using GHRH analogues...
  57. doi Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis
    Wilko Weichert
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Lancet Oncol 9:139-48. 2008
    ..We aimed to clarify these expression patterns and identify potential diagnostic and prognostic uses of selected class I HDAC isoforms in gastric cancer...
  58. ncbi The expression of low density lipoprotein receptor-related protein in colorectal carcinoma
    Katrin Obermeyer
    Department of Pathology, Otto von Guericke University, Magdeburg, and Charité University Hospital, Berlin, Germany
    Oncol Rep 17:361-7. 2007
    ..038 and 0.018, respectively). We provide evidence that LRP is expressed in colorectal cancer. As LRP forms complexes with u-PA and its inhibitor, we suspect that LRP can influence the known effects of u-PA on tumor biology...
  59. doi PTAA and B10: new approaches to amyloid detection in tissue-evaluation of amyloid detection in tissue with a conjugated polyelectrolyte and a fibril-specific antibody fragment
    Barbara Kieninger
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Amyloid 18:47-52. 2011
    ..We analysed the suitability of two little known substances for the detection of amyloid in surgical pathology specimens, that is the conjugated polyelectrolyte polythiophene acetic acid (PTAA) and the camelid antibody domain B10...
  60. ncbi Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    J Pathol 207:32-42. 2005
    ..Although no correlation of cathepsin X expression and TNM stage was found, our study demonstrates that cathepsin X plays a role not only in the chronic inflammation of gastric mucosa but also in the tumourigenesis of gastric cancer...
  61. ncbi Calpains and cytokines in fibrillating human atria
    Andreas Goette
    Division of Cardiology, Department of Internal Medicine, University Hospital Magdeburg, 39120 Magdeburg, Germany
    Am J Physiol Heart Circ Physiol 283:H264-72. 2002
    ..In conclusion, atria of patients with permanent AF show evidence of calpain I activation that might contribute to structural remodeling and contractile dysfunction, whereas there is no evidence of activation of tissue cytokines...
  62. ncbi Identification of the thrombin light chain a as the single best mass for differentiation of gastric cancer patients from individuals with dyspepsia by proteome analysis
    Matthias P A Ebert
    Department of Gastroenterology, General Surgery and Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    J Proteome Res 4:586-90. 2005
    ....
  63. doi Three German fibrinogen Aalpha-chain amyloidosis patients with the p.Glu526Val mutation
    Magdalena Eriksson
    Department of Pathology, Charite University Hospital, Chariteplatz 1, Berlin, Germany
    Virchows Arch 453:25-31. 2008
    ..In the cases described here, the use of antibodies directed against fibrinogen, followed by direct gene sequencing, revealed the underlying cause...
  64. pmc Altered expression of membrane-bound and soluble CD95/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosis
    Frank Buhling
    Institute of Immunology, Otto von Guericke University, Magdeburg, Germany
    Respir Res 6:37. 2005
    ..We also analysed the effects of tumor necrosis factor-beta on FasL-induced cell death...
  65. ncbi Overexpression of cathepsin B in gastric cancer identified by proteome analysis
    Matthias P A Ebert
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Proteomics 5:1693-704. 2005
    ....
  66. pmc Genotypic and phenotypic characterization of side population of gastric cancer cell lines
    Rosa Schmuck
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Am J Pathol 178:1792-804. 2011
    ..Phenotypic characteristics of this distinct cell population are also present in gastric cancer tissue, and correlate with patient survival...
  67. ncbi A giant pancreatic serous microcystic adenoma with 20 years follow-up
    Hans Ulrich Schulz
    Chirurgie Department of Surgery, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Langenbecks Arch Surg 392:209-13. 2007
    ..There is only little information about the spontaneous course of large pancreatic serous tumours. We followed up a white woman with a giant serous microcystic adenoma over more than 20 years...
  68. ncbi Immunolocalization of full-length NK1 tachykinin receptors in human tumors
    Stefan Schulz
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Histochem Cytochem 54:1015-20. 2006
    ..NK1 receptor visualization with this simple and rapid immunohistochemical method will facilitate identification of tumors with a sufficient receptor overexpression for diagnostic or therapeutic intervention using SP analogs...
  69. ncbi Advanced glycation end products in intervertebral discs and hip joint capsules: correlation with senile amyloid?
    Tina Foitschik
    Institute of Pathology, Marienkrankenhaus, Hamburg, Germany
    Amyloid 12:167-73. 2005
    ..However, the amyloid proteins appear not to be modified and AGE modification is not a general characteristic of senile amyloidoses...
  70. ncbi Recent developments in chemotherapy of advanced gastric cancer
    Tobias Götze
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Dig Dis 22:360-5. 2004
    ..While the efficacy of most treatment regimens is only limited, new developments may indicate that treatment with chemotherapy may confer some benefit in the future...
  71. ncbi Expression of opioid receptor subtypes and their ligands in fibrillating human atria
    Uwe Lendeckel
    Institute of Experimental Internal Medicine, Otto von Magdeburg, Magdeburg, Germany
    Pacing Clin Electrophysiol 28:S275-9. 2005
    ..Persistent AF is associated with the down-regulation of the opioid receptor/ligand expression. This suggests a loss of protective capacity in the fibrillating atrial tissue, resulting in an ultrastructural remodeling of atrial myocytes...
  72. doi Proteomics of pancreatic cancer
    Ilona Gräntzdörffer
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Pancreas 36:329-36. 2008
    ..This will hopefully lead to the discovery of prognostic and predictive biomarkers that help to improve prognosis of pancreatic cancer patients...
  73. ncbi Effect of atrial fibrillation on hematopoietic progenitor cells: a novel pathophysiological role of the atrial natriuretic peptide?
    Andreas Goette
    University Hospital Magdeburg, Division of Cardiology, Leipziger Str 44, 39120 Magdeburg, Germany
    Circulation 108:2446-9. 2003
    ..Studies suggest that myocardial progenitor cells invade atrial tissue. So far it is unclear, however, whether an atrial disease per se affects circulating HPCs...
  74. ncbi Budesonide induces complete remission in autoimmune hepatitis
    Antal Csepregi
    Department of Gastroenterology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    World J Gastroenterol 12:1362-6. 2006
    ..However, only 65% of the patients enter complete histological remission. Recently, budesonide (BUD) was reported to be a promising alternative. In this study we assessed the efficacy and safety of BUD in AIH...
  75. doi Cohort study based on the seventh edition of the TNM classification for gastric cancer: proposal of a new staging system
    Viktoria S Warneke
    Department of Pathology, Christian Albrechts University, Arnold Heller Strasse 3, Kiel, Germany
    J Clin Oncol 29:2364-71. 2011
    ..We investigated the effect of the new TNM classification on gastric cancer staging...
  76. ncbi Identification of gastric cancer patients by serum protein profiling
    Matthias P A Ebert
    Department of Gastroenterology, Otto von Guericke University, D 39120 Magdeburg, Germany
    J Proteome Res 3:1261-6. 2004
    ..ProteinChip technology in conjunction with bioinformatics allows the highly sensitive and specific recognition of gastric cancer patients...
  77. ncbi Loss of beta-catenin expression in metastatic gastric cancer
    Matthias P A Ebert
    Otto von Guericke University, Department of Gastroenterology, Hepatology, and Infectious Diseases, Leipzigerstr 44, D 39120 Magdeburg, Germany
    J Clin Oncol 21:1708-14. 2003
    ..Beta-catenin (beta-catenin) participates in intercellular adhesion and is an integral part of the Wnt signaling pathway. The role of beta-catenin in the pathogenesis of gastric cancer and its metastasis is largely unknown...
  78. doi Prevalence and origin of amyloid in kidney biopsies
    Hanna von Hutten
    Department of Pathology, Charite University Hospital, D 10117 Berlin, Germany
    Am J Surg Pathol 33:1198-205. 2009
    ..AFib amyloidosis was found to be the most prevalent type of hereditary renal amyloidosis, illustrating the necessity of a thorough classification of the amyloid proteins...
  79. doi Phenotypic and genotypic characterization of carcinomas of the papilla of Vater has prognostic and putative therapeutic implications
    Ilona Kohler
    Department of Pathology, Charite University Hospital, Berlin, Germany
    Am J Clin Pathol 135:202-11. 2011
    ..Besides the poorly differentiated CPV, the most common KRAS wild type makes them a putative target for an anti-epidermal growth factor receptor therapy...
  80. pmc Differential Expression of SPARC in Intestinal-type Gastric Cancer Correlates with Tumor Progression and Nodal Spread
    Konrad Franke
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Transl Oncol 2:310-20. 2009
    ..In this study, genes that were upregulated in the lymph node metastases of gastric cancer were identified and may serve as putative novel therapeutic target...
  81. ncbi Immunohistochemical localization of CCK1 cholecystokinin receptors in normal and neoplastic human tissues
    Stefan Schulz
    Department of Pharmacology and Toxicology, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Clin Endocrinol Metab 90:6149-55. 2005
    ..Although it is well established that CCK receptors are widely distributed throughout the normal gastrointestinal tract, little is known about their cellular and subcellular localization in human normal and neoplastic tissues...
  82. ncbi Application of proteome analysis to the assessment of prognosis and response prediction in clinical oncology
    Christoph Rocken
    Institute of Pathology, Charite University Hospital, Chariteplatz 1, D 10117 Berlin, Germany
    Curr Cancer Drug Targets 8:141-5. 2008
    ..This review summarizes recent efforts, challenges and limitations of proteome analysis in the assessment of prognosis and response-prediction in human cancers...
  83. ncbi Immunocytochemical identification of VPAC1, VPAC2, and PAC1 receptors in normal and neoplastic human tissues with subtype-specific antibodies
    Solveig Schulz
    Department of Obstetrics and Gynecology, Otto von Guericke University, Magdeburg, Germany
    Clin Cancer Res 10:8235-42. 2004
    ..VIP/PACAP receptor visualization with this simple and rapid immunohistochemical method will facilitate identification of tumors with a sufficient receptor overexpression for diagnostic or therapeutic intervention...
  84. ncbi Ambulatory treatment with intravenous norepinephrine in a patient with end stage renal disease and generalized AA amyloidosis
    Eike Wrenger
    Division of Nephrology, Department of Internal Medicine, Otto von Guericke University, Magdeburg, Germany
    Amyloid 9:47-51. 2002
    ..A continuous ambulatory treatment with catecholamines could be a possible treatment - at least temporarily - in amyloid cases in which all other attempts have failed to prevent chronic life-threatening hypotension...
  85. pmc Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers
    Matthias P A Ebert
    Epigenomics Inc, Seattle, WA, USA
    Neoplasia 7:771-8. 2005
    ..The high frequency of TPEF methylation in this series of colorectal cancers underscores the importance of epigenetic changes as targets for the development of molecular tests for cancer diagnosis...
  86. ncbi Effects of imatinib mesylate on adenoid cystic carcinomas
    Hans Joachim Ochel
    Clinic for Radiation Therapy, Medical Faculty, Otto von Guericke University, 39120 Magdeburg, Germany
    Anticancer Res 25:3659-64. 2005
    ..A substantial fraction of the tumors expresses c-Kit or the platelet-derived growth factor receptor beta (PDGFRbeta), both targets for imatinib mesylate. No standard systemic therapy is known for these neoplasms...
  87. ncbi Solid-pseudopapillary tumor of the pancreatic tail
    Frank Eder
    Department of General Surgery, Otto von Guericke University, Medical Faculty, Leipziger Strasse 44, Magdeburg D 39120, Germany
    World J Gastroenterol 11:4117-9. 2005
    ..The rare solid-pseudopapillary tumor of the pancreas has a good prognosis after successful oncological resection...
  88. pmc Pivotal role of cathepsin K in lung fibrosis
    Frank Buhling
    Department of Pathology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Am J Pathol 164:2203-16. 2004
    ..We believe that this is the first study to show that catK plays a pivotal role in lung matrix homeostasis under physiological and pathological conditions...
  89. ncbi Peripheral neuropathy in systemic lupus erythematosus: pathomorphological features and distribution pattern of matrix metalloproteinases
    Christian Mawrin
    Institut für Neuropathologie, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule Aachen, Aachen, Germany
    Acta Neuropathol 105:365-72. 2003
    ....
  90. ncbi Synchronous granulomatous cholecystitis and fibroelastosis of the gallbladder
    Matthias Evert
    Institute of Pathology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Virchows Arch 445:655-8. 2004
    ..The influence of bile that leaked into the interstitium or a specific local tissue response to cytokines secreted by histiocytes are among the possible explanations for its development in our case...
  91. ncbi Acute exacerbation of autoimmune hepatitis induced by Twinrix
    Antal Csepregi
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Leipziger Strasse 44, Magdeburg D 39120, Germany
    World J Gastroenterol 11:4114-6. 2005
    ....
  92. ncbi Immunohistochemical classification of amyloid in surgical pathology revisited
    Anja Kebbel
    Department of Pathology, Otto von Guericke University, Magdeburg, and Department of Pathology, Charite University Hospital, Berlin, Germany
    Am J Surg Pathol 30:673-83. 2006
    ....
  93. ncbi Immunohistochemical detection of bombesin receptor subtypes GRP-R and BRS-3 in human tumors using novel antipeptide antibodies
    Solveig Schulz
    Department of Obstetrics and Gynecology, Otto von Guericke University, 39120, Magdeburg, Germany
    Virchows Arch 449:421-7. 2006
    ..The development of these novel antipeptide antibodies will facilitate the identification of those tumors, which may be targets for diagnostic or radiotherapeutic application of subtype-selective BN analogs...
  94. doi Seminal vesicle amyloidosis does not provide any protection from invasion by prostate cancer
    Andreas Erbersdobler
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    BJU Int 103:324-6. 2009
    ..To determine whether seminal vesicle amyloidosis (SVA, an unusual finding in prostatectomy specimens, with deposits usually localized and asymptomatic) affects the extension of prostate cancer into the SVs...
  95. doi Localized insulin-derived amyloidosis in patients with diabetes mellitus: a case report
    Saniye Yumlu
    Department of Pathology, Charite University Hospital, D 10117 Berlin, Germany
    Hum Pathol 40:1655-60. 2009
    ....