G Northoff

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi Pedophilia is linked to reduced activation in hypothalamus and lateral prefrontal cortex during visual erotic stimulation
    Martin Walter
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Biol Psychiatry 62:698-701. 2007
  2. ncbi GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: a combined fMRI/MEG study with placebo and lorazepam
    Georg Northoff
    Department of Neurology, Section of Behavioral Neurology, Beth Israel Deaconess Medical Center, Harvard University, Kirstein Building KS 454, 330 Brookline Avenue, Boston, 02215 MA, USA
    J Cogn Neurosci 14:348-70. 2002
  3. ncbi Affective judgment and beneficial decision making: ventromedial prefrontal activity correlates with performance in the Iowa Gambling Task
    Georg Northoff
    Department of Psychiatry, University of Zurich, Zurich, Switzerland
    Hum Brain Mapp 27:572-87. 2006
  4. ncbi Psychopathology and pathophysiology of the self in depression - neuropsychiatric hypothesis
    Georg Northoff
    Laboratory of Neuroimaging and Neurophilosophy, Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Affect Disord 104:1-14. 2007
  5. ncbi Reciprocal modulation and attenuation in the prefrontal cortex: an fMRI study on emotional-cognitive interaction
    Georg Northoff
    Laboratory for Magnetic Brain Stimulation, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 21:202-12. 2004
  6. ncbi Orbitofrontal cortical dysfunction in akinetic catatonia: a functional magnetic resonance imaging study during negative emotional stimulation
    Georg Northoff
    University of Magdeburg, Department of Psychiatry, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Schizophr Bull 30:405-27. 2004
  7. pmc Neuroscience of decision making and informed consent: an investigation in neuroethics
    Georg Northoff
    Department of Psychiatry, Section for Neurophilosophy, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Med Ethics 32:70-3. 2006
  8. ncbi Self-referential processing in our brain--a meta-analysis of imaging studies on the self
    Georg Northoff
    Department of Neurology, Harvard University, Cambridge, MA 02138, USA
    Neuroimage 31:440-57. 2006
  9. doi Neuropsychiatry. An old discipline in a new gestalt bridging biological psychiatry, neuropsychology, and cognitive neurology
    Georg Northoff
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 258:226-38. 2008
  10. ncbi Differential parametric modulation of self-relatedness and emotions in different brain regions
    Georg Northoff
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Hum Brain Mapp 30:369-82. 2009

Detail Information

Publications48

  1. ncbi Pedophilia is linked to reduced activation in hypothalamus and lateral prefrontal cortex during visual erotic stimulation
    Martin Walter
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Biol Psychiatry 62:698-701. 2007
    ..Although pedophilic patients are sexually attracted to prepubescent children, they show no sexual interest toward adults. This study aimed to investigate the neural correlates of deficits of sexual and emotional arousal in pedophiles...
  2. ncbi GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: a combined fMRI/MEG study with placebo and lorazepam
    Georg Northoff
    Department of Neurology, Section of Behavioral Neurology, Beth Israel Deaconess Medical Center, Harvard University, Kirstein Building KS 454, 330 Brookline Avenue, Boston, 02215 MA, USA
    J Cogn Neurosci 14:348-70. 2002
    ..Such a modulation of orbito-frontal cortical emotional function by lorazepam has to be distinguished from its effects on cortical motor function as being independent from the kind of processing either emotional or nonemotional...
  3. ncbi Affective judgment and beneficial decision making: ventromedial prefrontal activity correlates with performance in the Iowa Gambling Task
    Georg Northoff
    Department of Psychiatry, University of Zurich, Zurich, Switzerland
    Hum Brain Mapp 27:572-87. 2006
    ..These findings suggest that the degree to which subjects recruit the VMPFC during affective judgment is related to beneficial performance in decision making in gambling...
  4. ncbi Psychopathology and pathophysiology of the self in depression - neuropsychiatric hypothesis
    Georg Northoff
    Laboratory of Neuroimaging and Neurophilosophy, Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Affect Disord 104:1-14. 2007
    ..The question of the self has intrigued philosophers and psychologists for a long time. More recently distinct concepts of self have also been suggested in neuroscience more specifically in neuroimaging...
  5. ncbi Reciprocal modulation and attenuation in the prefrontal cortex: an fMRI study on emotional-cognitive interaction
    Georg Northoff
    Laboratory for Magnetic Brain Stimulation, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 21:202-12. 2004
    ..Reciprocal modulation and attenuation in medial and lateral prefrontal cortex might constitute the neurophysiologic basis for emotional-cognitive interaction as observed in both healthy and psychiatric subjects...
  6. ncbi Orbitofrontal cortical dysfunction in akinetic catatonia: a functional magnetic resonance imaging study during negative emotional stimulation
    Georg Northoff
    University of Magdeburg, Department of Psychiatry, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Schizophr Bull 30:405-27. 2004
    ..Because we investigated postacute patients, orbitofrontal cortical alterations may be interpreted as a trait marker predisposing for development of catatonic syndrome in schizophrenic or affective psychosis...
  7. pmc Neuroscience of decision making and informed consent: an investigation in neuroethics
    Georg Northoff
    Department of Psychiatry, Section for Neurophilosophy, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Med Ethics 32:70-3. 2006
    ..It is concluded that current progress in the neurosciences could complement and change the way in which we approach ethical problems in neuropsychiatry...
  8. ncbi Self-referential processing in our brain--a meta-analysis of imaging studies on the self
    Georg Northoff
    Department of Neurology, Harvard University, Cambridge, MA 02138, USA
    Neuroimage 31:440-57. 2006
    ..We conclude that self-referential processing in CMS constitutes the core of our self and is critical for elaborating experiential feelings of self, uniting several distinct concepts evident in current neuroscience...
  9. doi Neuropsychiatry. An old discipline in a new gestalt bridging biological psychiatry, neuropsychology, and cognitive neurology
    Georg Northoff
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 258:226-38. 2008
    ....
  10. ncbi Differential parametric modulation of self-relatedness and emotions in different brain regions
    Georg Northoff
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Hum Brain Mapp 30:369-82. 2009
    ..hum..
  11. ncbi Delayed onset of late movement-related cortical potentials and abnormal response to lorazepam in catatonia
    G Northoff
    Department of Psychiatry of Otto von Guericke, University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Schizophr Res 44:193-211. 2000
    ..Differential and stronger response to lorazepam in catatonia suggests dysfunction in inhibitory control of cortical motor function with increased gaba-ergic sensitivity...
  12. ncbi Functional dissociation between medial and lateral prefrontal cortical spatiotemporal activation in negative and positive emotions: a combined fMRI/MEG study
    G Northoff
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Dusseldorf, Germany
    Cereb Cortex 10:93-107. 2000
    ..Such a functional dissociation between medial and lateral orbito-frontal/prefrontal cortex during negative and positive emotional processing lends further support to the assumption of a functional subdivision in the orbitofrontal cortex...
  13. pmc Decreased density of GABA-A receptors in the left sensorimotor cortex in akinetic catatonia: investigation of in vivo benzodiazepine receptor binding
    G Northoff
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
    J Neurol Neurosurg Psychiatry 67:445-50. 1999
    ..The benzodiazepine receptor distribution was therefore investigated in akinetic catatonia with single photon emission tomography (SPECT) using iodine-123-iomazenil ((123) I Iomazenil)...
  14. ncbi Impairment in visual-spatial function in catatonia: a neuropsychological investigation
    G Northoff
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
    Schizophr Res 37:133-47. 1999
    ..The data suggest attentional-motor and fronto-parietal dysfunction in catatonia, a conclusion which should be considered as preliminary, however, due to the small sample size...
  15. ncbi [Subjective experience and neuronal integration in the brain: do we need a first-person neuroscience?]
    G Northoff
    Klinik fur Psychiatrie, Psychotherapie und Psychosomatische Medizin der Otto von Guericke Universität Magdeburg, Leipziger Strasse 44, 39120 Magdeburg
    Fortschr Neurol Psychiatr 74:627-34. 2006
    ..It is concluded that First-Person-Neuroscience can contribute to reveal abnormal brain function in psychiatric disorders and ultimately to development of diagnostic and therapeutic markers...
  16. ncbi Effects of single-pulse transcranial magnetic stimulation (TMS) on functional brain activity: a combined event-related TMS and evoked potential study
    G Thut
    Laboratory for Magnetic Brain Stimulation, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Kirstein Building KS 454, Boston, MA 02215, USA
    Clin Neurophysiol 114:2071-80. 2003
    ....
  17. doi The resting brain and our self: self-relatedness modulates resting state neural activity in cortical midline structures
    F Schneider
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Neuroscience 157:120-31. 2008
    ..This lends further support to the presumed involvement of these regions in processing internally-oriented self-relatedness as distinguished from externally-oriented self-relatedness...
  18. doi Glutamate modulates resting state activity in the perigenual anterior cingulate cortex - a combined fMRI-MRS study
    B Enzi
    Department of Psychiatry, LWL University Hospital Bochum, Ruhr University Bochum, Bochum, Germany
    Neuroscience 227:102-9. 2012
    ....
  19. ncbi Schizophrenia and anteroventral thalamic nucleus: selective decrease of parvalbumin-immunoreactive thalamocortical projection neurons
    P Danos
    Department of Psychiatry, University of Magdeburg, FRG
    Psychiatry Res 82:1-10. 1998
    ..The reductions of parvalbumin-positive thalamocortical projection neurons were not correlated with the length of disease, this finding supporting the neurodevelopmental etiology of structural abnormalities in schizophrenia...
  20. ncbi Is our self based on reward? Self-relatedness recruits neural activity in the reward system
    M de Greck
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Neuroimage 39:2066-75. 2008
    ..In sum, our findings indicate sustained recruitment of the reward system during self-relatedness. These findings may contribute to a better understanding of the reward-based nature of our self...
  21. ncbi Differential effects of low-frequency rTMS at the occipital pole on visual-induced alpha desynchronization and visual-evoked potentials
    G Thut
    Laboratory for Magnetic Brain Stimulation, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Kirstein Building KS 454, Boston, MA 02215, USA
    Neuroimage 18:334-47. 2003
    ..This is consistent with the idea that alpha desynchronization serves an integrative role through a corticocortical "gating function."..
  22. ncbi [Neurobiological basis of depressive disorders]
    C Stoppel
    Klinik fur Psychiatrie, Psychotherapie und Psychosomatische Medizin der Otto von Guericke Universität Magdeburg, Germany
    Fortschr Neurol Psychiatr 74:696-705. 2006
    ..Finally therapeutic implications that could be derived from these results will be presented, showing up putative possibilities for diagnosis and treatment of depressive syndromes...
  23. ncbi Cortical sulcal enlargement in catatonic schizophrenia: a planimetric CT study
    G Northoff
    Department of Psychiatry, University of Magdeburg, Germany
    Psychiatry Res 91:45-54. 1999
    ..e. orbitofrontal) enlargement. Catatonic schizophrenia, the most severe sub-type with regard to clinical symptomatology and brain pathology, showed fronto-parietal cortical alterations...
  24. ncbi Serum levels of amitriptyline and therapeutic effect in non-delusional moderately to severely depressed in-patients: a therapeutic window relationship
    S Ulrich
    Institute of Clinical Pharmacology, University Hospital, Otto-von-Guericke University, Magdeburg, Germany
    Pharmacopsychiatry 34:33-40. 2001
    ..Also taking into account other reports, this therapeutic window can be defined as being between about 70 and 220 ng/ml. The assay of serum levels of At can be used to lower the risk of unsatisfactory therapeutic outcome...
  25. ncbi Catatonia and neuroleptic malignant syndrome: psychopathology and pathophysiology
    G Northoff
    Department of Behavioral Neurology, Beth Israel Deaconess Medical Center, Harvard University, Kirstein Building KS 454, 330 Brookline Avenue, Boston, MA 02215, U S A
    J Neural Transm 109:1453-67. 2002
    ..Consequently, one may characterize catatonia as a cortical "psychomotor syndrome" while NMS may rather be regarded as subcortical "motor syndrome"...
  26. ncbi How does our brain constitute defense mechanisms? First-person neuroscience and psychoanalysis
    Georg Northoff
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Magdeburg, Magdeburg, Germany
    Psychother Psychosom 76:141-53. 2007
    ....
  27. ncbi Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder
    Simone Grimm
    Department of Psychiatry, University of Zurich, Switzerland
    Biol Psychiatry 63:369-76. 2008
    ....
  28. ncbi GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI
    Georg Northoff
    Department of Psychiatry, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Nat Neurosci 10:1515-7. 2007
    ..Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA...
  29. doi High resolution fMRI of subcortical regions during visual erotic stimulation at 7 T
    Martin Walter
    Department of Psychiatry, University Hospital Otto v Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    MAGMA 21:103-11. 2008
    ....
  30. ncbi Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy
    Felix Bermpohl
    Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 27:662-77. 2006
    ..This enhancement effect is not present in neutral pictures and might parallel accentuated subjective feeling states...
  31. doi Distinguishing specific sexual and general emotional effects in fMRI-subcortical and cortical arousal during erotic picture viewing
    Martin Walter
    Department of Psychiatry, University Hospital, Magdeburg, Germany
    Neuroimage 40:1482-94. 2008
    ..No differences were found in these effects when comparing females and males. Our findings demonstrate for the first time neural differentiation between emotional and sexual components in the neural network underlying sexual arousal...
  32. doi The trans-species concept of self and the subcortical-cortical midline system
    Georg Northoff
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Trends Cogn Sci 12:259-64. 2008
    ..Recent data suggest that SRP is operating via a central integrative neural system made up of subcortical-cortical midline structures (SCMSs), that are homologous across mammalian species...
  33. doi Culture-sensitive neural substrates of human cognition: a transcultural neuroimaging approach
    Shihui Han
    Culture and Social Cognitive Neuroscience Laboratory, Department of Psychology, Peking University, 5 Yiheyuan Road, Beijing, China
    Nat Rev Neurosci 9:646-54. 2008
    ..The findings provide a novel approach by which to distinguish culture-sensitive from culture-invariant neural mechanisms of human cognition...
  34. ncbi Left prefrontal repetitive transcranial magnetic stimulation impairs performance in affective go/no-go task
    Felix Bermpohl
    Psychiatry and Psychology Institute, University of Sao Paulo, Brazil
    Neuroreport 16:615-9. 2005
    ..Our findings demonstrate a functionally relevant lateralization of the prefrontal contribution to affective go/no-go tasks...
  35. ncbi Dissociable networks for the expectancy and perception of emotional stimuli in the human brain
    Felix Bermpohl
    Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02132, USA
    Neuroimage 30:588-600. 2006
    ..This dissociation may reflect a distinction between anticipatory and perceptive components of emotional stimulus processing...
  36. ncbi How do we modulate our emotions? Parametric fMRI reveals cortical midline structures as regions specifically involved in the processing of emotional valences
    Alexander Heinzel
    Behavioral Neurology Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02215, USA
    Brain Res Cogn Brain Res 25:348-58. 2005
    ..We conclude that the psychological concept of emotional valence may be related to neural processing in cortical midline regions...
  37. ncbi Executive dysfunction, self, and ego pathology in schizophrenia: an exploratory study of neuropsychology and personality
    Heinz Boeker
    Department of Psychiatry, University of Zurich, CH 8032 Zurich, Switzerland
    Compr Psychiatry 47:7-19. 2006
    ..It can therefore be concluded that ego pathology must be distinguished from positive and negative symptoms in both underlying neuropsychological dysfunction and predisposing changes in personality...
  38. ncbi Effect of low-frequency transcranial magnetic stimulation on an affective go/no-go task in patients with major depression: role of stimulation site and depression severity
    Felix Bermpohl
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Psychiatry Res 141:1-13. 2006
    ..Further studies are needed to determine whether the present paradigm could be used to predict antidepressant treatment success or to individualize stimulation parameters according to specific pathology...
  39. ncbi Cortical midline structures and the self
    Georg Northoff
    Laboratory for Magnetic Brain Stimulation, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Trends Cogn Sci 8:102-7. 2004
    ..All of these subfunctions are related to distinct regions within the CMS. This relationship between self-referential processing and CMS might provide novel insight into the neural correlates underlying the constitution of the self...
  40. ncbi NMDA hypofunction in the posterior cingulate as a model for schizophrenia: an exploratory ketamine administration study in fMRI
    Georg Northoff
    Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Schizophr Res 72:235-48. 2005
    ..We therefore conducted an fMRI study using the NMDA antagonist ketamine in healthy human subjects during episodic memory retrieval, which is supposed to activate the posterior cingulate...
  41. ncbi Deficit in decision making in catatonic schizophrenia: an exploratory study
    Raiko Bark
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Psychiatry Res 134:131-41. 2005
    ..In conclusion, our preliminary results suggest a specific deficit in catatonic schizophrenia in those neuropsychological measures that are associated with ventral prefrontal cortical function...
  42. ncbi Segregated neural representation of distinct emotion dimensions in the prefrontal cortex-an fMRI study
    Simone Grimm
    Department of Psychiatry, University of Zurich, Switzerland
    Neuroimage 30:325-40. 2006
    ..In conclusion, our results indicate segregated neural representation of the different emotion dimensions in different prefrontal cortical regions...
  43. ncbi Is emotion regulation self-regulation?
    Georg Northoff
    Trends Cogn Sci 9:408-9; author reply 409-10. 2005
  44. doi Neurophilosophical perspectives of neuroimaging in forensic psychiatry-giving way to a paradigm shift?
    Joachim Witzel
    Central State Forensic Psychiatric Hospital of Saxony Anhalt, Uchtspringe, Germany
    Behav Sci Law 26:113-30. 2008
    ..We conclude that such a process could contribute to a paradigm shift in forensic psychiatry, which will have profound implications for offenders, forensic psychologists and psychiatrists, the law and society in general...
  45. ncbi Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia: a replication study
    Peter Danos
    Department of Psychiatry, University Hospital Giessen and Marburg, Location Giessen, Germany
    Psychiatry Res 140:281-9. 2005
    ..Taken together, the present results suggest that schizophrenia is associated with a moderate volume reduction in the left mediodorsal thalamic nucleus, while the neuron density and the total neuron number are unchanged...
  46. ncbi Why do we need a philosophy of the brain?
    Georg Northoff
    Trends Cogn Sci 8:484-5. 2004
  47. ncbi What catatonia can tell us about "top-down modulation": a neuropsychiatric hypothesis
    Georg Northoff
    Laboratory for Magnetic Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Behav Brain Sci 25:555-77; discussion 578-604. 2002
    ....
  48. ncbi Brain pathology in pedophilic offenders: evidence of volume reduction in the right amygdala and related diencephalic structures
    Kolja Schiltz
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Saxony Anhalt 39120, Germany
    Arch Gen Psychiatry 64:737-46. 2007
    ..However, the role of alterations in brain structures that are crucial in the development of sexual behavior has not yet been systematically studied in pedophilic subjects...