Peter Malfertheiner

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi request reprint Cardia-type metaplasia arising in the remnant esophagus after cardia resection
    Ulrich Peitz
    Department of Gastroenterology, Hepatology and Infectiology, Otto von Guericke University, Magdeburg, Germany
    Gastrointest Endosc 59:810-7. 2004
  2. ncbi request reprint The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism
    Christoph Rocken
    Department of Pathology, Institutes of Experimental Internal Medicine, Clinical Chemistry, and Biometrics, Otto von Guericke University, Magdeburg, Germany
    Clin Cancer Res 11:2526-30. 2005
  3. pmc Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver
    Kerstin Schütte
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Leipziger Str, 44, Magdeburg 39120, Germany
    BMC Gastroenterol 14:117. 2014
  4. pmc Functional and topological properties in hepatocellular carcinoma transcriptome
    Ignat Drozdov
    British Heart Foundation Centre of Excellence, King s College London, London, United Kingdom
    PLoS ONE 7:e35510. 2012
  5. pmc STW 5 (Iberogast®)--a safe and effective standard in the treatment of functional gastrointestinal disorders
    Bertram Ottillinger
    Life Sciences Consultancy, Brunnthal Hofolding, Germany
    Wien Med Wochenschr 163:65-72. 2013
  6. pmc L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN)--a randomized multicentre trial
    Matthias Kraft
    Department of Medicine A, University Medicine Greifswald, Friedrich Löffler Straße 23a, Greifswald 17475, Germany
    Nutr J 11:52. 2012
  7. pmc Quorum sensing in the probiotic bacterium Escherichia coli Nissle 1917 (Mutaflor) - evidence that furanosyl borate diester (AI-2) is influencing the cytokine expression in the DSS colitis mouse model
    Christoph A Jacobi
    Department of Internal Medicine I, University Clinic Tübingen, Otfried Müllerstr, 10, 72076, Tubingen, Germany
    Gut Pathog 4:8. 2012
  8. pmc A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy
    Sara Fill Malfertheiner
    Department of Obstetrics and Gynecology, Medical Faculty of Otto von Guericke University, Gerhart Hauptmann Str, 35, 39108, Magdeburg, Germany
    BMC Gastroenterol 12:131. 2012
  9. pmc Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn's disease
    Dimitrios P Bogdanos
    Division of Transplantation Immunology and Mucosal Biology, King s College London School of Medicine at King s College Hospital, Denmark Hill Campus, Bessemer Road, London SE5 9RJ, UK
    BMC Gastroenterol 12:102. 2012
  10. doi request reprint Helicobacter pylori: clinical management
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Curr Opin Gastroenterol 28:608-14. 2012

Collaborators

Detail Information

Publications143 found, 100 shown here

  1. ncbi request reprint Cardia-type metaplasia arising in the remnant esophagus after cardia resection
    Ulrich Peitz
    Department of Gastroenterology, Hepatology and Infectiology, Otto von Guericke University, Magdeburg, Germany
    Gastrointest Endosc 59:810-7. 2004
    ..The aim of this study was to investigate the mucosal effects of esophagogastrostomy, an artificial interface between esophageal squamous and gastric oxyntic epithelium...
  2. ncbi request reprint The number of lymph node metastases in gastric cancer correlates with the angiotensin I-converting enzyme gene insertion/deletion polymorphism
    Christoph Rocken
    Department of Pathology, Institutes of Experimental Internal Medicine, Clinical Chemistry, and Biometrics, Otto von Guericke University, Magdeburg, Germany
    Clin Cancer Res 11:2526-30. 2005
    ..In the present study, we aimed to substantiate the putative significance of angiotensin I-converting enzyme (ACE) on gastric cancer biology by investigating the influence of its gene polymorphism on gastric cancer progression...
  3. pmc Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver
    Kerstin Schütte
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Leipziger Str, 44, Magdeburg 39120, Germany
    BMC Gastroenterol 14:117. 2014
    ..A small proportion of patients with HCC is diagnosed in the non-cirrhotic liver (NCL). Data on patients with HCC in NCL in advanced stages are scarce...
  4. pmc Functional and topological properties in hepatocellular carcinoma transcriptome
    Ignat Drozdov
    British Heart Foundation Centre of Excellence, King s College London, London, United Kingdom
    PLoS ONE 7:e35510. 2012
    ..Our work provides a systems-wide resource for deeper understanding of molecular mechanisms in HCC progression and may be used further to define novel targets for efficient treatment or diagnosis of this disease...
  5. pmc STW 5 (Iberogast®)--a safe and effective standard in the treatment of functional gastrointestinal disorders
    Bertram Ottillinger
    Life Sciences Consultancy, Brunnthal Hofolding, Germany
    Wien Med Wochenschr 163:65-72. 2013
    ..04%. The worldwide spontaneous reporting system confirmed this profile. STW 5 has a favorable tolerability which is relevant for long-term treatment...
  6. pmc L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN)--a randomized multicentre trial
    Matthias Kraft
    Department of Medicine A, University Medicine Greifswald, Friedrich Löffler Straße 23a, Greifswald 17475, Germany
    Nutr J 11:52. 2012
    ..Cachexia, a >10% loss of body-weight, is one factor determining the poor prognosis of pancreatic cancer. Deficiency of L-Carnitine has been proposed to cause cancer cachexia...
  7. pmc Quorum sensing in the probiotic bacterium Escherichia coli Nissle 1917 (Mutaflor) - evidence that furanosyl borate diester (AI-2) is influencing the cytokine expression in the DSS colitis mouse model
    Christoph A Jacobi
    Department of Internal Medicine I, University Clinic Tübingen, Otfried Müllerstr, 10, 72076, Tubingen, Germany
    Gut Pathog 4:8. 2012
    ..abstract:..
  8. pmc A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy
    Sara Fill Malfertheiner
    Department of Obstetrics and Gynecology, Medical Faculty of Otto von Guericke University, Gerhart Hauptmann Str, 35, 39108, Magdeburg, Germany
    BMC Gastroenterol 12:131. 2012
    ..The aim of this study was to assess the prevalence and severity of GERD symptoms during the course of pregnancy. Furthermore current practice in medical care for GERD during pregnancy was assessed...
  9. pmc Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn's disease
    Dimitrios P Bogdanos
    Division of Transplantation Immunology and Mucosal Biology, King s College London School of Medicine at King s College Hospital, Denmark Hill Campus, Bessemer Road, London SE5 9RJ, UK
    BMC Gastroenterol 12:102. 2012
    ..We investigated anti-GP2 IgA and IgG antibodies as novel serological parameters in CD and assessed their association with distinct disease phenotypes...
  10. doi request reprint Helicobacter pylori: clinical management
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Curr Opin Gastroenterol 28:608-14. 2012
    ..This review gives an overview on selected areas of the H. pylori infection and their clinical implications...
  11. doi request reprint Molecular aspects in the diagnosis of gastric cancer
    Jan Bornschein
    Otto von Guericke University of Magdeburg, Department of Gastroenterology, Hepatology and Infectious Diseases, Leipziger Str 44, D 39120 Magdeburg, Germany 0049 391 6713100 0049 391 6713105
    Expert Opin Med Diagn 3:585-96. 2009
    ..For the development of effective prevention and treatment modalities, it is essential to unravel the basic mechanisms of gastric carcinogenesis...
  12. pmc GERD assessment including pH metry predicts a high response rate to PPI standard therapy
    Arne Kandulski
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Leipziger Str, 44, 39120, Magdeburg, Germany
    BMC Gastroenterol 13:12. 2013
    ..Aim of the study was to assess the need for doubling esomeprazole standard dose (40 mg) for 4 weeks in PPI naive patients with typical reflux symptoms and diagnosis of GERD based on endoscopy and 48 hours, wireless pH metry...
  13. ncbi request reprint Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus Report
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Gut 61:646-64. 2012
    ..Recommendations are provided on the basis of the best current evidence and plausibility to guide doctors involved in the management of this infection associated with various clinical conditions...
  14. doi request reprint The intriguing relationship of Helicobacter pylori infection and acid secretion in peptic ulcer disease and gastric cancer
    P Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Dig Dis 29:459-64. 2011
    ....
  15. doi request reprint Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial
    Peter Malfertheiner
    Gastroenterologie, Hepatologie und Infektiologie, Otto von Guericke Universtität, Magdeburg, Germany
    Lancet 377:905-13. 2011
    ..Our aim was to assess the efficacy and safety of a new, single-capsule treatment versus the gold standard for H pylori eradication...
  16. ncbi request reprint Peptic ulcer disease
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Lancet 374:1449-61. 2009
    ..We discuss the role of these agents in the causes of ulcer disease and therapeutic and preventive strategies for drug-induced ulcers. The rare but increasingly problematic H pylori-negative NSAID-negative ulcer is also examined...
  17. doi request reprint Role of Helicobacter pylori infection in gastric cancer pathogenesis: a chance for prevention
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Leipziger, Magdeburg, Germany
    J Dig Dis 11:2-11. 2010
    ..The recognition of H. pylori infection as a critical risk factor in the development of gastric cancer opens the chance for new venues in prevention strategies...
  18. doi request reprint Helicobacter pylori infection and current clinical areas of contention
    Peter Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Curr Opin Gastroenterol 26:618-23. 2010
    ..A final aspect is dedicated to novel treatment regimens for overcoming the increasing treatment failures with proton pump inhibitor-based triple standards...
  19. pmc Treating critically ill patients with probiotics: Beneficial or dangerous?
    Christoph A Jacobi
    Universitatsklinikum Magdeburg, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Leipzigerstr, 44, 39120 Magdeburg, Germany
    Gut Pathog 3:2. 2011
    ..This article reviews the current evidence of the use of bacteria in critically ill patients in intensive care settings...
  20. doi request reprint Evolution of gastro-oesophageal reflux disease over 5 years under routine medical care--the ProGERD study
    P Malfertheiner
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Aliment Pharmacol Ther 35:154-64. 2012
    ..The evolution of gastro-oesophageal reflux disease (GERD) under current management options remains uncertain...
  21. ncbi request reprint Helicobacter pylori--a timeless source of lessons and research initiatives
    Peter Malfertheiner
    Otto von Guericke University, Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg, Germany
    Helicobacter 12:85-9. 2007
    ..pylori has allowed the collection of many lessons which have allowed the medical and scientific profession to progress, and these lessons are also valuable for life beyond scientific boundaries...
  22. ncbi request reprint Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    J Pathol 207:32-42. 2005
    ..Although no correlation of cathepsin X expression and TNM stage was found, our study demonstrates that cathepsin X plays a role not only in the chronic inflammation of gastric mucosa but also in the tumourigenesis of gastric cancer...
  23. ncbi request reprint Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease
    Eike Hollenbach
    Institute of Experimental Internal Medicine, Department of Gastroenterology, Hepatology and Infectiology, Otto von Guericke University, Magdeburg D 39120, Germany
    J Biol Chem 280:14981-8. 2005
    ..Because bacterial products are suggested to be the key pathogenic agents triggering IBD, inhibition of the NOD/RICK pathway may serve as a novel target of future therapies in human IBD...
  24. doi request reprint Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, 39120 Magdeburg, Germany
    Hum Pathol 43:1745-54. 2012
    ....
  25. doi request reprint Enteroscopy
    Klaus Monkemuller
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Best Pract Res Clin Gastroenterol 22:789-811. 2008
    ....
  26. ncbi request reprint Helicobacter pylori-induced downregulation of the secretory leukocyte protease inhibitor (SLPI) in gastric epithelial cell lines and its functional relevance for H. pylori-mediated diseases
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Biol Chem 387:893-901. 2006
    ..pylori-infected subjects has a functional relevance for gastric mucosa and the H. pylori-induced decrease in SLPI is primarily regulated at the posttranslational level...
  27. doi request reprint Progression of specialized intestinal metaplasia at the cardia to macroscopically evident Barrett's esophagus: an entity of concern in the ProGERD study
    Andreas Leodolter
    Department of Gastroenterology, Hepatology and Infectious Diseases, Sana Klinikum Remscheid, Germany
    Scand J Gastroenterol 47:1429-35. 2012
    ..The authors aim was to evaluate prospectively the progression of SIM+ to macroscopically evident Barrett's esophagus (BE/SIM+), and to identify risk factors for this progression...
  28. ncbi request reprint Secretory leukocyte protease inhibitor expression in various types of gastritis: a specific role of Helicobacter pylori infection
    Istvan Hritz
    Department of Gastroenterology, Hepatology and Infectious Diseases, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Eur J Gastroenterol Hepatol 18:277-82. 2006
    ..The aim of the study was to investigate whether SLPI downregulation of gastric mucosa represents a specific phenomenon of H. pylori infection or is generally linked to gastric inflammation...
  29. ncbi request reprint TFF3 expression at the esophagogastric junction is increased in gastro-esophageal reflux disease (GERD)
    Ulrich Peitz
    Department of Gastroenterology, Hepatology, and Infectiology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Peptides 25:771-7. 2004
    ..pylori status or to tumor necrosis factor-alpha (TNF-alpha) expression. The expression of TFF3 at the cardia may represent an adaptation to GERD and precede the development of Barrett's esophagus...
  30. ncbi request reprint Cathepsins K, L, B, X and W are differentially expressed in normal and chronically inflamed gastric mucosa
    Frank Buhling
    Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Biol Chem 385:439-45. 2004
    ..Immunohistochemistry revealed specific expression of cathepsin X (macrophages), cathepsin K (parietal cells) and cathepsin W (lymphocytes), whereas cathepsins B and L were predominantly expressed in epithelial cells...
  31. ncbi request reprint Interleukin 1 beta (IL1B) gene polymorphisms are not associated with gastric carcinogenesis in Germany
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Anticancer Res 30:505-11. 2010
    ..Polymorphisms of interleukin-1 beta gene (IL1B-511C>T) are considered as risk factor for gastric carcinogenesis, but conflicting data have been reported recently...
  32. pmc Prevalence of H pylori associated "high risk gastritis" for development of gastric cancer in patients with normal endoscopic findings
    Andreas Leodolter
    Department of Gastroenterology and Hepatology, Otto von Guericke University, Leipziger Street 44, Magdeburg D 39120, Germany
    World J Gastroenterol 12:5509-12. 2006
    ..To investigate the prevalence of H pylori associated corpus-predominant gastritis (CPG) or pangastritis, severe atrophy, and intestinal metaplasia (IM) in patients without any significant abnormal findings during upper-GI endoscopy...
  33. ncbi request reprint Gastro-oesophageal reflux disease is associated with up-regulation of desmosomal components in oesophageal mucosa
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Histopathology 60:405-15. 2012
    ..Gastro-oesophageal reflux disease (GERD) is associated with impaired epithelial barrier function. This study was aimed at investigating the role of desmosomal proteins in relation to GERD...
  34. doi request reprint Helicobacter pylori infection and short-term intake of low-dose aspirin have different effects on alpha-1 antitrypsin/alpha-1 peptidase inhibitor (alpha1-PI) levels in antral mucosa and peripheral blood
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Scand J Gastroenterol 43:1194-201. 2008
    ....
  35. doi request reprint Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study
    Ulrich Peitz
    Department of Gastroenterology, Hepatology, and Infectious Diseases, University of Magdeburg, Magdeburg, Germany
    J Gastroenterol Hepatol 26:82-9. 2011
    ..pylori) antibodies. The aim of the present study was to evaluate whether serum markers correlate with and predict gastric atrophy in gastroesophageal reflux disease (GERD) patients...
  36. ncbi request reprint Naturally occurring regulatory T cells (CD4+, CD25high, FOXP3+) in the antrum and cardia are associated with higher H. pylori colonization and increased gene expression of TGF-beta1
    Arne Kandulski
    Department of Gastroenterology, Hepatology and Infectious Diseases, Leipziger Str 44, D 39120, Germany
    Helicobacter 13:295-303. 2008
    ..FOXP3 was shown to be expressed in a subset of Treg cells known as 'naturally occurring Treg cells'. These cells have not been sufficiently studied in context to H. pylori-induced inflammation in human gastric mucosa...
  37. pmc Serological assessment of gastric mucosal atrophy in gastric cancer
    Jan Bornschein
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    BMC Gastroenterol 12:10. 2012
    ..Aim of this study was to assess the performance of these serological tests in the presence of gastric neoplasia...
  38. ncbi request reprint Down-regulation of secretory leukocyte protease inhibitor expression in gastric mucosa is a general phenomenon in Helicobacter pylori-related gastroduodenal diseases
    Thomas Wex
    Clinic for Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Dig Dis 22:390-5. 2004
    ..Recently, a local down-regulation of antral SLPI expression in Helicobacter pylori (Hp)-infected healthy volunteers was demonstrated...
  39. doi request reprint Detection of neuroendocrine tumors of the small bowel by double balloon enteroscopy
    Michael Bellutti
    Department of Gastroenterology, Hepatology and Infectious Diseases, Universitatsklinikum, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Dig Dis Sci 54:1050-8. 2009
    ..The objective of this study was to evaluate the use of double balloon enteroscopy (DBE) for the detection of the primary tumor in patients with NET...
  40. ncbi request reprint Proteinase-activated receptor-2 in the pathogenesis of gastroesophageal reflux disease
    Arne Kandulski
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Am J Gastroenterol 105:1934-43. 2010
    ..This study aimed to evaluate the expression of PAR-2 in human esophageal mucosa of patients with gastroesophageal reflux disease (GERD) in relation to mucosal alterations...
  41. doi request reprint The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis
    Marino Venerito
    Department of Gastroenterology, Hepatology, Infectious Diseases, Otto von Guericke University Hospital, Leipziger Str 44, D 39120 Magdeburg, Germany
    Cancer Lett 270:218-28. 2008
    ..These results suggest an involvement of the COX-LOX pathway in gastric carcinogenesis...
  42. ncbi request reprint Localization of TFF3 peptide in human esophageal submucosal glands and gastric cardia: differentiation of two types of gastric pit cells along the rostro-caudal axis
    Irina Kouznetsova
    Institut für Molekularbiologie und Medizinische Chemie, Universitatsklinikum, Otto von Guericke Universitat Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Cell Tissue Res 328:365-74. 2007
    ..This indicates the special requirement, particularly of the esophagogastric junction, for TFF3-triggered protection and repair...
  43. ncbi request reprint The angiotensin I-converting enzyme gene insertion/deletion polymorphism is linked to early gastric cancer
    Matthias P A Ebert
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Cancer Epidemiol Biomarkers Prev 14:2987-9. 2005
    ..Our study provides further evidence that the ACE insertion/deletion gene polymorphism may be linked to the development of early gastric cancer...
  44. doi request reprint Gastroesophageal reflux disease does not lead to changes in the secretory leukocyte protease inhibitor expression in esophageal mucosa
    Thomas Wex
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Eur J Gastroenterol Hepatol 21:150-8. 2009
    ..Here, it was investigated whether the presence of GERD was associated with changes of mucosal SLPI expression...
  45. ncbi request reprint Protective role of heat shock protein 27 in gastric mucosal injury
    Matthias P A Ebert
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    J Pathol 207:177-84. 2005
    ..This indicates that HSP27 expression is critical for mucosal protection in the stomach...
  46. ncbi request reprint Helicobacter pylori but not gastrin is associated with the development of colonic neoplasms
    Michael Selgrad
    Department of Gastroenterology Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Int J Cancer 135:1127-31. 2014
    ..pylori positive and negative patients. In conclusion, H. pylori infection, including CagA expression is associated with an increased risk for the development of colonic neoplasm. ..
  47. ncbi request reprint Loss of beta-catenin expression in metastatic gastric cancer
    Matthias P A Ebert
    Otto von Guericke University, Department of Gastroenterology, Hepatology, and Infectious Diseases, Leipzigerstr 44, D 39120 Magdeburg, Germany
    J Clin Oncol 21:1708-14. 2003
    ..Beta-catenin (beta-catenin) participates in intercellular adhesion and is an integral part of the Wnt signaling pathway. The role of beta-catenin in the pathogenesis of gastric cancer and its metastasis is largely unknown...
  48. pmc Early involvement of death-associated protein kinase promoter hypermethylation in the carcinogenesis of Barrett's esophageal adenocarcinoma and its association with clinical progression
    Doerthe Kuester
    Department of Pathology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Neoplasia 9:236-45. 2007
    ..003). Thus, we consider DAPK inactivation by promoter hypermethylation as an early event in Barrett's carcinogenesis and suggest that a decreased protein expression of DAPK likely plays a role in the development and progression of BA...
  49. pmc Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma
    Antal Csepregi
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, 39120 Magdeburg, Germany
    BMC Cancer 10:317. 2010
    ..Herein, we evaluated CDKN2A promoter methylation and p16 protein expression for the differentiation of hepatocellular carcinoma (HCC) from other liver tumors...
  50. ncbi request reprint [Fulminant duodenal bleeding as first manifestation of a neuroendocrine carcinoma of the pancreatic head]
    Kerstin Schütte
    Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Otto von Guericke Universitat Magdeburg, Magdeburg, Germany
    Med Klin (Munich) 105:291-5. 2010
    ..Afterwards, the systemic therapy was changed to a palliative chemotherapy with streptozotocin and 5-fluorouracil due to local progression of the disease and a Ki-67 index of 4% in the primary tumor...
  51. pmc APC promoter methylation and protein expression in hepatocellular carcinoma
    Antal Csepregi
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Cancer Res Clin Oncol 134:579-89. 2008
    ..We investigated the impact of promoter methylation on APC protein expression in patients with hepatocellular carcinoma (HCC)...
  52. ncbi request reprint Reflux esophagitis or Helicobacter infection? - diagnostic value of the inflammatory pattern in metaplastic mucosa at the squamocolumnar junction
    Thomas Guenther
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Pathol Res Pract 203:831-7. 2007
    ..reflux-caused metaplasia...
  53. doi request reprint Lectin UEA-I-binding proteins are specifically increased in the squamous epithelium of patients with Barrett's esophagus
    Helmut Neumann
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Digestion 78:201-7. 2008
    ..Lectins represent a group of specific carbohydrate binding proteins that can be used as sensitive tools for the analysis of glycosylation patterns...
  54. ncbi request reprint Upregulation of cathepsin W-expressing T cells is specific for autoimmune atrophic gastritis compared to other types of chronic gastritis
    Doerthe Kuester
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Leipziger Str 44, Magdeburg 39120, Germany
    World J Gastroenterol 11:5951-7. 2005
    ..To investigate a pathophysiological role of cathepsin W (CatW), a putative thiol-dependent cysteine protease, which is specifically expressed in cytotoxic lymphocytes, in different types of chronic inflammation of the gastric mucosa...
  55. ncbi request reprint Gastroesophageal reflux disease leads to major alterations in lectin-binding in the columnar epithelium of the gastroesophageal junction
    Helmut Neumann
    Otto von Guericke University Magdeburg, Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg, Germany
    Scand J Gastroenterol 42:791-8. 2007
    ..The aim was to investigate the binding patterns of lectins UEA-I, DBA, HPA and PNA at the squamocolumnar junction in relation to the existence of gastroesophageal reflux disease (GERD) and Helicobacter pylori (H. pylori) infection...
  56. pmc Role of tight junction proteins in gastroesophageal reflux disease
    Klaus Monkemuller
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Magdeburg, Germany
    BMC Gastroenterol 12:128. 2012
    ..The aim of the study was to investigate the expression pattern of selected components involved in the formation of tight junctions in relation to GERD...
  57. ncbi request reprint The tyrosine kinase inhibitor imatinib fails to inhibit pancreatic cancer progression
    Jie Chen
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Leipzigerstr 44, D 39120 Magdeburg, Germany
    Cancer Lett 233:328-37. 2006
    ..Quality of life was similar in both groups. In this small series of pancreatic cancer patients, treatment with imatinib was not associated with a significant control of cancer progression...
  58. ncbi request reprint Chronic mucosal inflammation of the gastric cardia in gastroesophageal reflux disease is not regulated by FOXP3-expressing T cells
    Arne Kandulski
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Magdeburg 39120, Germany
    Dig Dis Sci 54:1940-6. 2009
    ..Regulatory T cells have been demonstrated for H. pylori-induced gastritis, whereas their role has not been studied in GERD...
  59. doi request reprint Short-term/low-dose aspirin-induced duodenal erosions are not dependent on Helicobacter pylori infection, cyclooxygenase expression and prostaglandin E2 levels
    Marino Venerito
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Scand J Gastroenterol 43:801-9. 2008
    ..The aim of this study was to investigate the effects of low-dose aspirin on the induction of duodenal erosions, the expression of cyclooxygenases and prostaglandin (PG)-E(2) levels in healthy subjects according to their H. pylori status...
  60. doi request reprint H. pylori infection is a key risk factor for proximal gastric cancer
    Jan Bornschein
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Dig Dis Sci 55:3124-31. 2010
    ..Despite evidence for the association of distal gastric cancer (GC) with the H. pylori infection, relevance of the infection for proximal GC is uncertain...
  61. ncbi request reprint Helicobacter pylori infection, but not low-dose aspirin, results in a local reduction of the secretory leukocyte protease inhibitor in gastroduodenal mucosa
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Tongji Medical College of Basic Medical Sciences, Huazhong University of Wuhan, China
    Helicobacter 11:31-8. 2006
    ..Therefore, the effect of low-dose aspirin on gastrointestinal SLPI expression was analyzed in the context of H. pylori infection...
  62. ncbi request reprint Small-bowel metaplasia arising in the remnant esophagus after esophagojejunostomy--a [corrected] prospective study in patients with a history of total gastrectomy
    Ulrich Peitz
    Clinic of Gastroenterology, Hepatology, and Infectiology, Otto von Guericke University, Magdeburg, Germany
    Am J Gastroenterol 100:2062-70. 2005
    ..The aim of this study was to detect esophageal columnar metaplasia after total gastrectomy with esophagojejunostomy, a condition of enteric, but nonacidic reflux...
  63. ncbi request reprint Hepatic toxicity after radioembolization of the liver using (90)Y-microspheres: sequential lobar versus whole liver approach
    Ricarda Seidensticker
    Universitatsklinikum Magdeburg, Klinik für Radiologie and Nuklearmedizin, Magdeburg, Germany
    Cardiovasc Intervent Radiol 35:1109-18. 2012
    ..To gain further perspective, we evaluated the toxicity rates of sequential lobar versus "whole liver" (90)Y-radioembolization...
  64. ncbi request reprint Aberrant methylation of DAPK in long-standing ulcerative colitis and ulcerative colitis-associated carcinoma
    Doerthe Kuester
    Department of Pathology, Hepatology and Infectious Diseases, Otto von Guericke University, 39120 Magdeburg, Germany
    Pathol Res Pract 206:616-24. 2010
    ....
  65. ncbi request reprint Gastrointestinal endoscopy in the elderly: current issues
    Klaus Monkemuller
    Department of Internal Medicine, Gastroenterology, Hepatology and Infectious Diseases, Marienhospital GmbH, Josef Albers Strasse 70, Bottrop, Germany
    Best Pract Res Clin Gastroenterol 23:821-7. 2009
    ..The aim of this article is to review the role of endoscopy in elderly patients, paying special emphasis on indications, special precautions and specific interventions...
  66. doi request reprint Protease-activated receptor-2 (PAR2) in human gastric mucosa as mediator of proinflammatory effects in Helicobacter pylori infection
    Arne Kandulski
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Helicobacter 16:452-8. 2011
    ..In vitro experiments using gastric tumor cell lines, murine models and one clinical study provided evidence for a potential role of PAR2 in Helicobacter pylori-induced gastritis...
  67. doi request reprint Interleukin-1beta and interleukin-8 expression correlate with the histomorphological changes in esophageal mucosa of patients with erosive and non-erosive reflux disease
    Klaus Monkemuller
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Digestion 79:186-95. 2009
    ..Gastroesophageal reflux disease (GERD) leads to endoscopic and histomorphological changes in the gastroesophageal (GE) mucosa...
  68. ncbi request reprint Dyspepsia and IBS symptoms in patients with NERD, ERD and Barrett's esophagus
    Helmut Neumann
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Dig Dis 26:243-7. 2008
    ..Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are highly prevalent in the general population as does gastroesophageal reflux disease (GERD). Therefore, it is expected that these conditions may frequently overlap...
  69. ncbi request reprint Proteome analysis of gastric cancer metastasis by two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-mass spectrometry for identification of metastasis-related proteins
    Jie Chen
    Department of Gastroenterology, Hepatology and Infectious Diseases, Research Center Immunology Institute of Experimental Internal Medicine, and Pathology, Otto von Guericke University, Magdeburg, Germany
    J Proteome Res 3:1009-16. 2004
    ..Combining well-defined animal models with proteome analysis will improve our understanding of the fundamental changes that contribute to the process of carcinogenesis and the formation of metastases in gastric cancer...
  70. ncbi request reprint Promoter hypermethylation of p16INK4a, E-cadherin, O6-MGMT, DAPK and FHIT in adenocarcinomas of the esophagus, esophagogastric junction and proximal stomach
    Hans Ulrich Schildhaus
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Int J Oncol 26:1493-500. 2005
    ..DAPK (0.54 on average) and FHIT methylation (0.77 on average) were also observed in NT samples. This might constitute an early epigenetic precursor lesion in the normally-appearing tissue surrounding the tumor...
  71. ncbi request reprint Microarray analysis of gene expression in metastatic gastric cancer cells after incubation with the methylation inhibitor 5-aza-2'-deoxycytidine
    Jie Chen
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg 39120, Germany
    Clin Exp Metastasis 21:389-97. 2004
    ..In conclusion, using global gene expression analysis together with inhibition of DNA methylation, we demonstrate that hypermethylation of the promoters of certain cancer-related genes may play a role in cancer metastasis...
  72. doi request reprint Chemoprevention of adenocarcinoma associated with Barrett's esophagus: potential options
    Helmut Neumann
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Dig Dis 27:18-23. 2009
    ..Thus, attention should also be given to potential targets for prevention strategies that might arrest or delay the progression of BE to EAC. This article focuses on known and postulated targets for prevention of distal esophageal cancer...
  73. ncbi request reprint Helicobacter pylori and molecular mechanisms of gastric carcinogenesis: targets for prevention and therapy
    Mark Juhasz
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke Uiversity, Leipzigerstr 44, D 39120 Magdeburg, Germany
    Expert Rev Anticancer Ther 4:97-103. 2004
    ....
  74. ncbi request reprint Inflammatory bowel diseases: multiple benefits from therapy with dipeptidyl- and alanyl-aminopeptidase inhibitors
    Ute Bank
    IMTM GmbH, Department ImmunoPharm, Magdeburg, Germany
    Front Biosci 13:3699-713. 2008
    ....
  75. ncbi request reprint Computed tomography-guided high-dose-rate brachytherapy in hepatocellular carcinoma: safety, efficacy, and effect on survival
    Konrad Mohnike
    Klinik fur Radiologie und Nuklearmedizin, Otto von Guericke University, Magdeburg, Germany
    Int J Radiat Oncol Biol Phys 78:172-9. 2010
    ..To determine the safety and efficacy of computed tomography (CT)-guided brachytherapy in hepatocellular carcinoma (HCC)...
  76. ncbi request reprint Helicobacter pylori: diagnosis and treatment
    Michael Selgrad
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Curr Opin Gastroenterol 25:549-56. 2009
    ..This review focuses on the current diagnostic methods and their clinical implications, as well as on established and novel treatment strategies...
  77. ncbi request reprint Helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via JNK and ERK
    Sabine Krueger
    Institute of Pathology, Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg, Germany
    J Biol Chem 281:2868-75. 2006
    ..Induction of MMP-1 is further implicated in complex processes induced by H. pylori, resulting in tissue degradation and remodeling of the gastric mucosa...
  78. ncbi request reprint Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis
    Jie Chen
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Carcinogenesis 26:37-43. 2005
    ..Therefore, metastatic cancer cells seem to harbour a heterogenous genetic and epigenetic background, in which cancer cells may exhibit APC promoter methylation that is independent of APC expression...
  79. ncbi request reprint From gastric inflammation to gastric cancer
    Jan Bornschein
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Dig Dis 28:609-14. 2010
    ..The detection of individuals at high risk for gastric cancer would help to design appropriate strategies for prevention and surveillance...
  80. ncbi request reprint Impact of the operator's experience on value of high-resolution transabdominal ultrasound in the diagnosis of choledocholithiasis: a prospective comparison using endoscopic retrograde cholangiography as the gold standard
    Steffen Rickes
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Leipziger Strasse 44, DE 39120 Magdeburg, Germany
    Scand J Gastroenterol 41:838-43. 2006
    ....
  81. doi request reprint Sorafenib therapy in patients with advanced hepatocellular carcinoma in advanced liver cirrhosis
    Kerstin Schütte
    Departments of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Digestion 83:275-82. 2011
    ..We aimed to evaluate the tolerability and efficiency of sorafenib in patients with advanced HCC and different stages of liver cirrhosis, and in combination with locoregional therapy...
  82. doi request reprint Helicobacter pylori infection and fundic gastric atrophy are not associated with esophageal squamous cell carcinoma: a case-control study
    Marino Venerito
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Eur J Gastroenterol Hepatol 23:859-64. 2011
    ..The aim of this case-control study was to investigate whether H. pylori infection and FGA carry an increased risk for OSCC...
  83. doi request reprint Molecular markers of pancreatic cancer: development and clinical relevance
    Lucia C Fry
    Division of Gastroenterology, Otto von Guericke University, Magdeburg, Germany
    Langenbecks Arch Surg 393:883-90. 2008
    ..Therefore, one of the major goals in clinical pancreatology is to find molecular markers, specific and sensitive enough to make an early and correct diagnosis of pancreatic cancer, before it has disseminated and become untreatable...
  84. ncbi request reprint Dyspepsia and Helicobacter pylori
    Michael Selgrad
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Dig Dis 26:210-4. 2008
    ..pylori induced gastritis. In patients presenting with alarm features a prompt upper endoscopy should be performed to exclude peptic ulcer disease, esophageal and gastric malignancies or other more rare upper gastrointestinal diseases...
  85. pmc Mucosal Progranulin expression is induced by H. pylori, but independent of Secretory Leukocyte Protease Inhibitor (SLPI) expression
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Leipziger Str, 44, Magdeburg, D 39120, Germany
    BMC Gastroenterol 11:63. 2011
    ..pylori-induced reduction of SLPI and the resulting increase of elastase-derived activity would reduce the Progranulin protein levels both ex vivo and in vitro...
  86. ncbi request reprint Endoscopic retrograde cholangiopancreatography using the single balloon enteroscope technique in patients with Roux-en-Y anastomosis
    Helmut Neumann
    Department of Gastroenterology, Hepatology and Infectious Diseases, Universitatsklinikum Magdeburg, Magdeburg, Germany
    Digestion 80:52-7. 2009
    ..The aim of this cohort study was to assess the technical success of ERCP with the single balloon enteroscope (SBE) in patients with Roux-en-Y anastomosis...
  87. ncbi request reprint Hepatocellular carcinoma and liver cirrhosis: assessment of the liver function after Yttrium-90 radioembolization with resin microspheres or after CT-guided high-dose-rate brachytherapy
    Ricarda Ruhl
    Klinik fur Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg AöR, Magdeburg, Germany
    Dig Dis 27:189-99. 2009
    ..To identify changes of liver function after single-fraction irradiation or yttrium-90 radioembolization ((90)Y-RE) of hepatocellular carcinoma associated with liver cirrhosis on the basis of laboratory data...
  88. ncbi request reprint ERCP with the double balloon enteroscope in patients with Roux-en-Y anastomosis
    Klaus Monkemuller
    Interdisciplinary Endoscopy, Universitatsklinikum Magdeburg, Otto von Guericke University, Magdeburg, Germany
    Surg Endosc 23:1961-7. 2009
    ..We assessed the technical success of performing ERCP with the double balloon enteroscope (DBE) in patients with Roux-en-Y anastomosis...
  89. doi request reprint Zonulin is not increased in the cardiac and esophageal mucosa of patients with gastroesophageal reflux disease
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Peptides 30:1082-7. 2009
    ..In conclusion, despite its established role for intestinal permeability, Zonulin seems not to be involved in the regulation of epithelial barrier function in relation to GERD...
  90. pmc Impact of endoscopy-based research on quality of life in healthy volunteers
    Alexander Link
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Leipziger St 44, 39120 Magdeburg, Germany
    World J Gastroenterol 16:467-73. 2010
    ..To study the impact of an endoscopy-based long-term study on the quality of life in healthy volunteers (HV)...
  91. ncbi request reprint Omeprazole-induced cough in a patient with gastroesophageal reflux disease
    Ines Reiche
    Institute of Clinical Pharmacology, Otto von Guericke University, Magdeburg, Germany
    Eur J Gastroenterol Hepatol 22:880-2. 2010
    ..Therefore, physicians should be aware of the onset or an exacerbation of cough during omeprazole therapy...
  92. pmc Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians
    Juozas Kupcinskas
    Department of Gastroenterology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania
    BMC Med Genet 12:112. 2011
    ....
  93. ncbi request reprint Enantioselective quantification of omeprazole and its main metabolites in human serum by chiral HPLC-atmospheric pressure photoionization tandem mass spectrometry
    Jens Martens-Lobenhoffer
    Institute of Clinical Pharmacology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 857:301-7. 2007
    ..5-375 ng/ml for the 5-hydroxyomeprazole enantiomers, respectively. Intra- and inter-day relative standard deviations are <7% for omeprazole and 5-hydroxyomeprazole enantiomers, and <9% for omeprazole-sulfon, respectively...
  94. ncbi request reprint Whipple's disease: an endoscopic and histologic study
    Klaus Monkemuller
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Digestion 77:161-5. 2008
    ..Nevertheless, there are scant data on the endoscopic appearance of WD. The aim of this study was to provide a detailed endoscopic-pathologic assessment of patients with WD...
  95. ncbi request reprint A two-step method for the extraction of high-quality RNA from endoscopic biopsies
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Magdeburg, Germany
    Clin Chem Lab Med 41:1033-7. 2003
    ..The two-step method described here is a suitable option for extracting high-quality RNA from endoscopic biopsies when other standard protocols fail...
  96. ncbi request reprint Prevention of gastric cancer: a challenging but feasible task
    Lucia C Fry
    Department of Gastroenterology, Hepatology and Infectious Diseases, Universitiitsklinikum Magdeburg, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Acta Gastroenterol Latinoam 37:110-7. 2007
    ..At present time, the main challenge remains to find out at what point mucosal abnormalities are no longer reversible and gastric cancer development cannot be prevented despite H. pylori eradication...
  97. doi request reprint Gastroesophageal reflux disease and management in advanced pregnancy: a prospective survey
    Sara Fill Malfertheiner
    Department of Obstetrics and Gynecology, Otto von Guericke University, Magdeburg, Gerhart Hauptmann Strasse 35, DE 39108 Magdeburg, Germany
    Digestion 79:115-20. 2009
    ..The aim of this survey was to study the prevalence of GERD, the frequency and severity of typical GERD symptoms, and their impact on quality of life and therapeutic management in advanced pregnancy...
  98. ncbi request reprint Reduced PTEN expression in gastric cancer and in the gastric mucosa of gastric cancer relatives
    Guo Fei
    Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto von Guericke University, Madgeburg, Germany
    Eur J Gastroenterol Hepatol 14:297-303. 2002
    ..In order to assess the role of PTEN in gastric carcinogenesis, we analysed the expression of PTEN in human gastric cancer and in the gastric mucosa of cancer relatives...
  99. ncbi request reprint Markers for predicting severity and progression of acute pancreatitis
    Kerstin Schütte
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Best Pract Res Clin Gastroenterol 22:75-90. 2008
    ..Indication, timing and consequences of the methods applied need to be carefully considered and incorporated into clinical assessments to avoid costs and harm to the patient...
  100. ncbi request reprint Evaluation of a near-patient fecal antigen test for the assessment of Helicobacter pylori status
    Andreas Leodolter
    Department of Gastroenterology, Hepatology and Infectious Diseases University of Magdeburg, Magdeburg, Germany
    Diagn Microbiol Infect Dis 48:145-7. 2004
    ..In this first evaluation in 100 patients before and after H. pylori eradication therapy we observed a sensitivity (76%) and specificity (98%) of this near-patient test...