Martin Leverkus

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi request reprint CD95-mediated signals in the skin: going out with an (inflammatory) bang?
    Martin Leverkus
    Laboratory for Experimental Dermatology, Department of Dermatology and Venerology, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    J Invest Dermatol 126:2364-6. 2006
  2. ncbi request reprint Bullous allergic hypersensitivity to bed bug bites mediated by IgE against salivary nitrophorin
    Martin Leverkus
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    J Invest Dermatol 126:91-6. 2006
  3. ncbi request reprint "Bak (and Bax) to the future"--of primary melanoma prognosis?
    Martin Leverkus
    Laboratory for Experimental Dermatology, Department of Dermatology and Venereology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Invest Dermatol 126:1212-4. 2006
  4. doi request reprint FLIP ing the coin? Death receptor-mediated signals during skin tumorigenesis
    Martin Leverkus
    Department of Dermatology and Venerology, Laboratory for Experimental Dermatology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Exp Dermatol 17:614-22. 2008
  5. pmc Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex
    Shyam M Kavuri
    Department of Dermatology and Venereology, Laboratory for Experimental Dermatology, Otto von Guericke University Magdeburg, Magdeburg 39120, Germany
    J Biol Chem 286:16631-46. 2011
  6. ncbi request reprint cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes
    Tina Wachter
    University of Wurzburg Medical School, Department of Dermatology, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Biol Chem 279:52824-34. 2004
  7. ncbi request reprint TRAIL-induced apoptosis and gene induction in HaCaT keratinocytes: differential contribution of TRAIL receptors 1 and 2
    Martin Leverkus
    University of Wurzburg Medical School, Department of Dermatology, Wurzburg, Germany
    J Invest Dermatol 121:149-55. 2003
  8. ncbi request reprint NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2
    Philip Diessenbacher
    Laboratory for Experimental Dermatology, Department of Dermatology and Venerology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Invest Dermatol 128:1134-47. 2008
  9. doi request reprint Cell death in the skin: how to study its quality and quantity?
    Roman Makarov
    Section of Molecular Dermatology, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University Heidelberg, Heidelberg, Germany
    Methods Mol Biol 961:201-18. 2013
  10. doi request reprint The contact allergen nickel sensitizes primary human endothelial cells and keratinocytes to TRAIL-mediated apoptosis
    Marc Schmidt
    Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Cell Mol Med 14:1760-76. 2010

Collaborators

Detail Information

Publications44

  1. ncbi request reprint CD95-mediated signals in the skin: going out with an (inflammatory) bang?
    Martin Leverkus
    Laboratory for Experimental Dermatology, Department of Dermatology and Venerology, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    J Invest Dermatol 126:2364-6. 2006
    ..This more pleiotropic function of CD95L as enhancer of inflammation may be equally important to apoptosis induction of keratinocytes, at least in eczema...
  2. ncbi request reprint Bullous allergic hypersensitivity to bed bug bites mediated by IgE against salivary nitrophorin
    Martin Leverkus
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    J Invest Dermatol 126:91-6. 2006
    ..lectularius nitrophorin, but not to 37 kDa C. lectularius apyrase. Our data demonstrate that bullous cimicosis may be the late-phase response of an allergic IgE-mediated hypersensitivity to C. lectularius nitrophorin...
  3. ncbi request reprint "Bak (and Bax) to the future"--of primary melanoma prognosis?
    Martin Leverkus
    Laboratory for Experimental Dermatology, Department of Dermatology and Venereology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Invest Dermatol 126:1212-4. 2006
    ..Consequently, inactivation of mitochondrial signaling pathways of apoptosis may not only be a prerequisite for melanoma progression but may also hamper therapeutic efforts with chemotherapeutic drugs...
  4. doi request reprint FLIP ing the coin? Death receptor-mediated signals during skin tumorigenesis
    Martin Leverkus
    Department of Dermatology and Venerology, Laboratory for Experimental Dermatology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Exp Dermatol 17:614-22. 2008
    ..In this respect, cFLIP may act to 'FLIP the coin' during the development of keratinocyte skin cancer...
  5. pmc Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex
    Shyam M Kavuri
    Department of Dermatology and Venereology, Laboratory for Experimental Dermatology, Otto von Guericke University Magdeburg, Magdeburg 39120, Germany
    J Biol Chem 286:16631-46. 2011
    ..cFLIP-mediated inhibition of CD95 and TRAIL DR could be of crucial importance during keratinocyte skin carcinogenesis and for the activation of innate and/or adaptive immune responses triggered by DR activation in the skin...
  6. ncbi request reprint cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes
    Tina Wachter
    University of Wurzburg Medical School, Department of Dermatology, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Biol Chem 279:52824-34. 2004
    ..Hence, cFLIP(L) modulation in keratinocytes may not only influence apoptosis sensitivity but may also lead to altered death receptor-dependent skin inflammation...
  7. ncbi request reprint TRAIL-induced apoptosis and gene induction in HaCaT keratinocytes: differential contribution of TRAIL receptors 1 and 2
    Martin Leverkus
    University of Wurzburg Medical School, Department of Dermatology, Wurzburg, Germany
    J Invest Dermatol 121:149-55. 2003
    ..Taken together, our data suggest that beside its potent pro-apoptotic role, LZ-TRAIL leads to pro-inflammatory responses that are mainly mediated by TRAIL receptor 1 in HaCaT keratinocytes...
  8. ncbi request reprint NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2
    Philip Diessenbacher
    Laboratory for Experimental Dermatology, Department of Dermatology and Venerology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    J Invest Dermatol 128:1134-47. 2008
    ....
  9. doi request reprint Cell death in the skin: how to study its quality and quantity?
    Roman Makarov
    Section of Molecular Dermatology, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University Heidelberg, Heidelberg, Germany
    Methods Mol Biol 961:201-18. 2013
    ..These methods include crystal violet assay, hypodiploidy analysis, caspase-8 cleavage, release of HMGB1, annexin V/propidium iodide co-staining, and Hoechst/SYTOX green co-staining...
  10. doi request reprint The contact allergen nickel sensitizes primary human endothelial cells and keratinocytes to TRAIL-mediated apoptosis
    Marc Schmidt
    Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Cell Mol Med 14:1760-76. 2010
    ....
  11. doi request reprint Suprabasal spongiosis in acute eczematous dermatitis: cFLIP maintains resistance of basal keratinocytes to T-cell-mediated apoptosis
    Nicole Armbruster
    Department of Dermatology, Venereology and Allergology, University of Wurzburg, Wurzburg, Germany
    J Invest Dermatol 129:1696-702. 2009
    ....
  12. pmc Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
    Peter Geserick
    Department of Dermatology and Venereology, Otto von Guericke University Magdeburg, Germany
    J Cell Biol 187:1037-54. 2009
    ..These results demonstrate a fundamental role for RIP1 in CD95 signaling and provide support for a physiological role of caspase-independent death receptor-mediated cell death...
  13. pmc cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
    Maria Feoktistova
    Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University Heidelberg, Heidelberg, Germany
    Mol Cell 43:449-63. 2011
    ..The differential quality of cell death mediated by the Ripoptosome may cause important pathophysiological consequences during inflammatory responses...
  14. ncbi request reprint Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner
    Andreas Wicovsky
    Department of Molecular Internal Medicine, Medical Clinic and Polyclinic II, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Biol Chem 282:2174-83. 2007
    ..Thus, sustained JNK activation by TNF has no obligate role in TNF-induced cell death and is mediated by caspases and reactive oxygen species in a cell type-specific manner...
  15. doi request reprint Sentinel lymph node biopsy status is a key parameter to stratify the prognostic heterogeneity of malignant melanoma in high-risk tumors >4.0 mm
    Daniela Göppner
    Department of Dermatology and Venereology, Otto von Guericke University, Magdeburg, Germany
    Dermatology 222:59-66. 2011
    ..The value of sentinel lymph node biopsy (SLNB) as a useful strategy to assess the risk of future metastasis in high-risk melanomas (>4.0 mm) is controversially discussed...
  16. doi request reprint Effector pathways during eczematous dermatitis: where inflammation meets cell death
    Andreas Kerstan
    Department of Dermatology, Venerology and Allergology, University of Wurzburg, Germany
    Exp Dermatol 18:893-9. 2009
    ..Further advances will come from identification of the immunoregulatory mechanisms involved in the pathogenesis of eczematous dermatitis. Potential therapeutic interventions are discussed...
  17. doi request reprint Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis
    Maria Feoktistova
    Section of Molecular Dermatology, Department of Dermatology, Venereology, and Allergology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany
    Cell Cycle 11:460-7. 2012
    ..Our study thus supports and extends the intriguing role of the Ripoptosome for the regulation of apoptosis and necroptosis...
  18. ncbi request reprint Candida albicans triggers activation of distinct signaling pathways to establish a proinflammatory gene expression program in primary human endothelial cells
    Verena Müller
    Department of Dermatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    J Immunol 179:8435-45. 2007
    ..Our study provides the first comprehensive analysis of endothelial gene responses to C. albicans and presents novel insights into the complex signaling patterns triggered by this important pathogen...
  19. doi request reprint Premonitory epidermolysis bullosa acquisita mimicking eyelid dermatitis: successful treatment with rituximab and protein A immunoapheresis
    Ilja Kubisch
    Department of Dermatology and Venereology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Am J Clin Dermatol 11:289-93. 2010
    ..Consequently, dermatologists should be aware of this rare differential diagnosis of eyelid dermatitis where a contact allergy or atopic dermatitis is absent...
  20. pmc Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing
    Daniela Siegmund
    Department of Molecular Internal Medicine, Medical Polyclinic, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Mol Cell Biol 25:6363-79. 2005
    ..Overexpression of FLIP(L) and FLIP(S) inhibited Fas- as well as TRAIL-mediated NF-kappaB activation and apoptosis induction in IFN-gamma-primed cells suggesting that both responses are coregulated at the level of the DISC...
  21. doi request reprint On the TRAIL to overcome BRAF-inhibitor resistance
    Peter Geserick
    Section of Molecular Dermatology, Medical Faculty Mannheim, Department of Dermatology, Venereology, and Allergology, University Heidelberg, Mannheim, Germany
    J Invest Dermatol 134:315-8. 2014
    ..We give an overview about the importance of the crosstalk of extrinsic and mitochondrial apoptotic signaling and propose other combination therapies that may prevent or overcome secondary resistance in melanoma. ..
  22. ncbi request reprint Cyclosporin A abolishes CD28-mediated resistance to CD95-induced apoptosis via superinduction of caspase-3
    Andreas Kerstan
    Institute for Virology and Immunobiology, University of Wurzburg, Versbacher Strasse 7, D 97078 Wurzburg, Germany
    J Immunol 177:7689-97. 2006
    ..Taken together, these findings suggest that CsA promotes sensitivity to CD95-mediated apoptosis in CD28-stimulated T cells by superinduction of the caspase-3 gene via a mechanism involving suppression of the calcineurin pathway...
  23. ncbi request reprint MHC class II-mediated apoptosis in dendritic cells: a role for membrane-associated and mitochondrial signaling pathways
    Martin Leverkus
    University of Wurzburg Medical School, Department of Dermatology, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Int Immunol 15:993-1006. 2003
    ....
  24. doi request reprint BerEP4-negative basal cell carcinoma on the palm: case report and review of the literature
    Anna Mleczko
    Department of Dermatology and Venereology, University of Magdeburg, Germany
    J Dtsch Dermatol Ges 9:140-3. 2011
    ..We review the literature on these rare BCC in atypical anatomical regions, and discuss the cellular origin of BCC in such locations...
  25. ncbi request reprint Recurrent hemolysis-associated pseudoerysipelas of the lower legs in a patient with congenital spherocytosis
    Martin Leverkus
    Department of Dermatology, University of Wurzburg, Germany
    J Am Acad Dermatol 51:1019-23. 2004
    ..These eruptions might be caused by intermittent hemolysis-induced inflammation as a result of the increased osmotic fragility of the erythrocytes and may evolve to chronic leg ulcers later in life...
  26. doi request reprint Control of large institutional scabies outbreaks
    Johanna Stoevesandt
    Department of Dermatology, Venereology and Allergology, University Hospital Wurzburg, Josef Schneider Straße 2, Wurzburg, Germany
    J Dtsch Dermatol Ges 10:637-47. 2012
    ..Scabies outbreaks in community facilities may reach large dimensions and take a protracted course. Highly contagious crusted scabies is a major cause of nosocomial outbreaks...
  27. doi request reprint Malignant epithelial tumors: Part II. Therapy and prevention
    Ioannis Manousaridis
    Department of Dermatology, Venereology and Allergology of the Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 11:9-25; quiz 26-7. 2013
    ..The decision about the best therapeutic option depends on location, age, and general health of the patient as well as the risk of tumor recurrence...
  28. doi request reprint Dual role of the mitochondrial protein frataxin in astrocytic tumors
    Elmar Kirches
    Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
    Lab Invest 91:1766-76. 2011
    ..These data contrast to a general tumor suppressor function of FXN but suggest a dual, pro-proliferative but chemosensitizing role in astrocytic tumors...
  29. pmc Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation
    Martin Leverkus
    Department of Dermatology, University of Wurzburg Medical School, 97080 Wurzburg, Germany
    Mol Cell Biol 23:777-90. 2003
    ....
  30. ncbi request reprint [Multilocular furunculosis and chronic-persisting eczema in a 17-year-old patient]
    Daniela Göppner
    Klinik für Dermatologie und Venerologie, Otto von Guericke Universitat Magdeburg, Magdeburg, Germany
    J Dtsch Dermatol Ges 4:766-9. 2006
  31. doi request reprint First diagnosis of Martin-Albright syndrome in a 58-year-old patient
    Sven R Quist
    Department of Dermatology and Venereology, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    J Dtsch Dermatol Ges 7:43-5. 2009
    ..The clinical diagnosis was confirmed by detection of reduced activity of Gsalpha. In patients with cutaneous calcification and disturbed calcium metabolism, AHO is an important differential diagnostic consideration...
  32. ncbi request reprint Soft nodules at the tip of the tongue of a 26-year-old man
    Martin Leverkus
    University of Wurzburg, Wurzburg, Germany
    Arch Dermatol 139:1647-52. 2003
  33. doi request reprint Malignant epithelial tumors: Part I. Pathophysiology and clinical features
    Martin Leverkus
    Department of Dermatology, Venereology and Allergology of the Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Dtsch Dermatol Ges 10:457-71; quiz 472. 2012
    ..Furthermore, the article gives an overview of inherited syndromes that predispose to malignant epithelial tumors...
  34. pmc Basal cell carcinoma: from the molecular understanding of the pathogenesis to targeted therapy of progressive disease
    Daniela Göppner
    Department of Dermatology and Venerology, Otto von Guericke University Magdeburg, Leipziger St 44, 39120 Magdeburg, Germany
    J Skin Cancer 2011:650258. 2011
    ..This paper summarizes the current understanding of BCC carcinogenesis and describes the current "mechanism-based" therapeutic strategies...
  35. pmc Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled
    Thorsten Gnad
    Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany
    Mol Cancer 9:31. 2010
    ..pylori...
  36. pmc Prognostic parameters for the primary care of melanoma patients: what is really risky in melanoma?
    Daniela Göppner
    Department of Dermatology and Venereology, Otto von Guericke University Hospital, Leipziger Str 44, 39120 Magdeburg, Germany
    J Skin Cancer 2011:521947. 2011
    ..This review summarizes the current understanding of carcinogenesis and gives a detailed overview of known morphologic and potentially future genetic prognostic parameters in malignant melanoma...
  37. pmc NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
    Sebastian Kreuz
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    J Cell Biol 166:369-80. 2004
    ..Thus, protection against Fas-induced apoptosis in a FLIP-independent manner converted a proapoptotic Fas signal into an inflammatory NFkappaB-related response...
  38. ncbi request reprint FLICE/caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes
    Alessandra Marconi
    Institute of Dermatology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    J Cell Sci 117:5815-23. 2004
    ..However, the release of cytochrome c and the later activation of caspase-9 seem to suggest that the intrinsic mitochondrial pathway may intervene as a positive feedback loop of caspase activation...
  39. ncbi request reprint Imiquimod: unexpected killer
    Martin Leverkus
    J Invest Dermatol 122:XV-XVI. 2004
  40. ncbi request reprint Increased expression and a potential anti-inflammatory role of TRAIL in atopic dermatitis
    Ekatherina Vassina
    Department of Pharmacology, University of Bern, Bern, Switzerland
    J Invest Dermatol 125:746-52. 2005
    ..Moreover, increased expression of IL-1Ra was observed in keratinocytes of AD lesional skin. These data suggest that TRAIL-expressing inflammatory skin cells may contribute to the epidermal activation of the IL-1Ra gene in AD...
  41. ncbi request reprint Acute generalised exanthematous pustulosis with subepidermal blisters of the distal extremities induced by diltiazem
    Anja Gesierich
    Dermatology 213:48-9. 2006
  42. ncbi request reprint Yersinia YopP-induced apoptotic cell death in murine dendritic cells is partially independent from action of caspases and exhibits necrosis-like features
    Sabine Gröbner
    Institute of Medical Microbiology and Hygiene, Eberhard Karls University of Tubingen, Elfriede Aulhorn Str 6, D 72076, Tubingen, Germany
    Apoptosis 11:1959-68. 2006
    ..However, it has to be resolved if necrosis-like DC death occurs independently from apoptotic events or as an apoptotic epiphenomenon...
  43. ncbi request reprint Reduced joining of DNA ends correlates with chromosomal instability in three melanoma cell lines
    Thomas M Rünger
    Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA
    Tumour Biol 24:100-8. 2003
    ..Although a small sample was studied, this raises the possibility that defects in DNA end joining may also contribute to genetic instability and chromosome aberrations in melanoma...
  44. ncbi request reprint IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia
    Cell 131:682-93. 2007
    ..Cells treated with an IAC, or those in which cIAP1 was deleted, became sensitive to apoptosis induced by exogenous TNFalpha, suggesting novel uses of these compounds in treating cancer...