S Krueger

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi request reprint ADAMTS1 is regulated by interleukin-1beta, not by hypoxia, in chondrosarcoma
    Thomas Kalinski
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Hum Pathol 38:86-94. 2007
  2. ncbi request reprint Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    J Pathol 207:32-42. 2005
  3. ncbi request reprint Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture--regulation of cathepsin B expression and invasiveness
    Sabine Krueger
    Department of Pathology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Cancer Lett 223:313-22. 2005
  4. ncbi request reprint Helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via JNK and ERK
    Sabine Krueger
    Institute of Pathology, Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg, Germany
    J Biol Chem 281:2868-75. 2006
  5. ncbi request reprint Helicobacter pylori alters the distribution of ZO-1 and p120ctn in primary human gastric epithelial cells
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Pathol Res Pract 203:433-44. 2007
  6. ncbi request reprint Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype
    S Krueger
    Department of Pathology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Cancer Gene Ther 8:522-8. 2001
  7. ncbi request reprint Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line
    S Krueger
    Department of Pathology, Otto von Guericke University Magdeburg, Germany
    Cancer Res 59:6010-4. 1999
  8. doi request reprint Regulation of cathepsin X overexpression in H. pylori-infected gastric epithelial cells and macrophages
    Sabine Krueger
    Institute of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Pathol 217:581-8. 2009
  9. ncbi request reprint Antisense inhibition of urokinase: effect on malignancy in a human osteosarcoma cell line
    C Haeckel
    Institute of Pathology, Otto von Guericke University Magdeburg, Germany
    Int J Cancer 77:153-60. 1998
  10. ncbi request reprint Expression of cathepsin K in the human embryo and fetus
    C Haeckel
    Department of Pathology, Otto von Guericke University Magdeburg, Germany
    Dev Dyn 216:89-95. 1999

Collaborators

Detail Information

Publications25

  1. ncbi request reprint ADAMTS1 is regulated by interleukin-1beta, not by hypoxia, in chondrosarcoma
    Thomas Kalinski
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Hum Pathol 38:86-94. 2007
    ..We believe that IL-1beta has a stronger impact on vascularization in chondrosarcomas than hypoxia, as both factors, ADAMTS1 and VEGF-A, are regulated in a way that favors angiogenesis...
  2. ncbi request reprint Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    J Pathol 207:32-42. 2005
    ..Although no correlation of cathepsin X expression and TNM stage was found, our study demonstrates that cathepsin X plays a role not only in the chronic inflammation of gastric mucosa but also in the tumourigenesis of gastric cancer...
  3. ncbi request reprint Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture--regulation of cathepsin B expression and invasiveness
    Sabine Krueger
    Department of Pathology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Cancer Lett 223:313-22. 2005
    ..This is dependent on the functional activity of cathepsin B as shown by specific siRNA's and seems to be regulated by activation of ERK1/2 and p38 signal transduction pathways...
  4. ncbi request reprint Helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via JNK and ERK
    Sabine Krueger
    Institute of Pathology, Department of Gastroenterology, Hepatology and Infectious Diseases, Magdeburg, Germany
    J Biol Chem 281:2868-75. 2006
    ..Induction of MMP-1 is further implicated in complex processes induced by H. pylori, resulting in tissue degradation and remodeling of the gastric mucosa...
  5. ncbi request reprint Helicobacter pylori alters the distribution of ZO-1 and p120ctn in primary human gastric epithelial cells
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Pathol Res Pract 203:433-44. 2007
    ..These alterations, triggered by H. pylori infection, are associated with an elongation phenotype and increased migration...
  6. ncbi request reprint Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype
    S Krueger
    Department of Pathology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Cancer Gene Ther 8:522-8. 2001
    ..The random control did not show any inhibitory effect. These data demonstrate that in MNNG/HOS cells cathepsin L influences cellular malignancy by promoting migration and basement membrane degradation...
  7. ncbi request reprint Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line
    S Krueger
    Department of Pathology, Otto von Guericke University Magdeburg, Germany
    Cancer Res 59:6010-4. 1999
    ..Adhesion to collagen I and matrigel matrices was not affected. These results demonstrate that cathepsin B is involved in the complex proteolytic processes in invasive osteosarcomas...
  8. doi request reprint Regulation of cathepsin X overexpression in H. pylori-infected gastric epithelial cells and macrophages
    Sabine Krueger
    Institute of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Pathol 217:581-8. 2009
    ..Our results suggest that H. pylori induced overexpression of CTSX in macrophages and epithelium through specific cytokines that are initiated by CagA-dependent pathways in a cell type-dependent manner...
  9. ncbi request reprint Antisense inhibition of urokinase: effect on malignancy in a human osteosarcoma cell line
    C Haeckel
    Institute of Pathology, Otto von Guericke University Magdeburg, Germany
    Int J Cancer 77:153-60. 1998
    ..Our data show that in MNNG/HOS urokinase influences cellular malignancy by promoting migration and selective adhesion. These specific functions were notable in addition to the effects on invasion and basement membrane degradation...
  10. ncbi request reprint Expression of cathepsin K in the human embryo and fetus
    C Haeckel
    Department of Pathology, Otto von Guericke University Magdeburg, Germany
    Dev Dyn 216:89-95. 1999
    ..The functional aspects of cathepsin K expression in nonosteoclastic cells and potential conclusions on physiological and pathological conditions in the embryo-fetal or adult organism remain to be investigated. Dev Dyn 1999;216:89-95...
  11. ncbi request reprint Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines
    A Kido
    Department of Pathology, Otto von Guericke University Magdeburg, Germany
    Clin Exp Metastasis 17:857-63. 1999
    ..Cellular migration correlated highly with APN activity (r = 0.79, P < 0.002). These findings suggest that APN contributes to the invasive potential of human osteosarcomas enhanced by IL-6 and SIL-6R...
  12. pmc Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after Helicobacter pylori infection
    Anja Bernhardt
    Institute of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    J Biol Chem 285:33691-700. 2010
    ..Primary epithelial cells from stomach of Ctsx(-/-) mice represent an excellent model of H. pylori gastritis to elaborate the special functions of Ctsx in regulating the immune response to H. pylori...
  13. pmc Cessation of embolic signals after antithrombotic prevention is related to reduced risk of recurrent arterioembolic transient ischaemic attack and stroke
    M Goertler
    Department of Neurology, University of Magdeburg, Magdeburg, Germany
    J Neurol Neurosurg Psychiatry 72:338-42. 2002
    ....
  14. ncbi request reprint Acetylsalicylic acid and microembolic events detected by transcranial Doppler in symptomatic arterial stenoses
    M Goertler
    Department of Neurology, University of Magdeburg, Germany
    Cerebrovasc Dis 11:324-9. 2001
    ..The occurrence of these microembolic events within the Doppler spectrum should be influenced by antithrombotic agents of proven efficacy in these patients mainly by reducing cerebral embolism...
  15. ncbi request reprint Establishment and characterization of the permanent human cell line C3842 derived from a secondary chondrosarcoma in Ollier's disease
    Thomas Kalinski
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Virchows Arch 446:287-99. 2005
    ..In conclusion, the cell line C3842 provides the first model of a secondary chondrosarcoma in Ollier's disease in vitro, which is characterized by distinct features of such malignant cartilage tumors...
  16. ncbi request reprint Helicobacter pylori-induced downregulation of the secretory leukocyte protease inhibitor (SLPI) in gastric epithelial cell lines and its functional relevance for H. pylori-mediated diseases
    Thomas Wex
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Biol Chem 387:893-901. 2006
    ..pylori-infected subjects has a functional relevance for gastric mucosa and the H. pylori-induced decrease in SLPI is primarily regulated at the posttranslational level...
  17. ncbi request reprint Differential expression of VEGF-A and angiopoietins in cartilage tumors and regulation by interleukin-1beta
    Thomas Kalinski
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Cancer 106:2028-38. 2006
    ..As interleukin (IL)-1beta has been found to be an indispensable factor in angiogenic signaling, we further analyzed the effect of IL-1beta on the expression of VEGF-A, Ang-1, and Ang-2 using a previously established cell culture model...
  18. ncbi request reprint The expression of low density lipoprotein receptor-related protein in colorectal carcinoma
    Katrin Obermeyer
    Department of Pathology, Otto von Guericke University, Magdeburg, and Charité University Hospital, Berlin, Germany
    Oncol Rep 17:361-7. 2007
    ..038 and 0.018, respectively). We provide evidence that LRP is expressed in colorectal cancer. As LRP forms complexes with u-PA and its inhibitor, we suspect that LRP can influence the known effects of u-PA on tumor biology...
  19. ncbi request reprint Inhibitory effect of antisense aminopeptidase N (APN/CD13) cDNA transfection on the invasive potential of osteosarcoma cells
    Akira Kido
    Department of Pathology, Otto von Guericke University, Magdeburg, Germany
    Clin Exp Metastasis 20:585-92. 2003
    ..These findings demonstrate that APN plays an active role in the cellular attachment and proteolytic degradation of the extracellular matrix in the metastatic process of osteosarcomas...
  20. ncbi request reprint Close localization of DAP-kinase positive tumour-associated macrophages and apoptotic colorectal cancer cells
    R Schneider-Stock
    Department of Pathology, Otto von Guericke University Magdeburg, Germany
    J Pathol 209:95-105. 2006
    ....
  21. doi request reprint Helicobacter pylori regulates p21(WAF1) by histone H4 acetylation
    Guoqing Xia
    Institute of Experimental Internal Medicine, University Hospital Magdeburg, Otto von Guericke University Magdeburg, Leipziger Street 44, D 39120 Magdeburg, Germany
    Biochem Biophys Res Commun 369:526-31. 2008
    ..The elucidation of the epigenetic regulation of p21(WAF1) by H. pylori may help to dissect the pathogenetic mechanisms underlying the development and progression of H. pylori associated diseases...
  22. ncbi request reprint Expression of hepatocyte growth factor and c-MET in skull base chordoma
    Takahiko Naka
    Department of Pathology, Faculty of Medicine, Magdeburg University, Magdeburg, Germany
    Cancer 112:104-10. 2008
    ..Conversely, to the authors' knowledge, little is known regarding the significance of HGF/c-MET expression in skull base chordoma...
  23. doi request reprint The cathepsin family and their role in colorectal cancer
    Doerthe Kuester
    Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Pathol Res Pract 204:491-500. 2008
    ..Furthermore, we give an overview of the recent developments of cathepsins in animal models and in in vitro experiments of colorectal disease, and provide information on inhibitors of cathepsins as possible therapeutics...
  24. pdf Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
    Hala Gali-Muhtasib
    Department of Biology, American University of Beirut, Beirut, Lebanon
    J Cell Mol Med 12:330-42. 2008
    ..These data should encourage further in vivo testing and support the potential use of TQ as a therapeutic agent in human colorectal cancer...
  25. ncbi request reprint A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum
    Marwan Alfalah
    Department of Physiological Chemistry, School of Veterinary Medicine, D 30559 Hannover, Germany
    J Biol Chem 281:11894-900. 2006
    ..Because the patient bearing this mutation suffered from leukemia, possible links to the pathogenesis of leukemia are discussed...