G Keilhoff

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi request reprint Structural parameters of collagen nerve grafts influence peripheral nerve regeneration
    Felix Stang
    Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Biomaterials 26:3083-91. 2005
  2. pmc Evidence for a wide extra-astrocytic distribution of S100B in human brain
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
    BMC Neurosci 8:2. 2007
  3. ncbi request reprint Citrulline immunohistochemistry for demonstration of NOS activity in vivo and in vitro
    G Keilhoff
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, Magdeburg, D 39120, Germany
    Nitric Oxide 4:343-53. 2000
  4. ncbi request reprint Differences in peripheral nerve degeneration/regeneration between wild-type and neuronal nitric oxide synthase knockout mice
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    J Neurosci Res 68:432-41. 2002
  5. ncbi request reprint Transdifferentiation of mesenchymal stem cells into Schwann cell-like myelinating cells
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Eur J Cell Biol 85:11-24. 2006
  6. ncbi request reprint Successful intramuscular neurotization is dependent on the denervation period. A histomorphological study of the gracilis muscle in rats
    Gerburg Keilhoff
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Muscle Nerve 31:221-8. 2005
  7. ncbi request reprint Neuronal nitric oxide synthase is the dominant nitric oxide supplier for the survival of dorsal root ganglia after peripheral nerve axotomy
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Medical Faculty, Otto von Guericke University, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    J Chem Neuroanat 24:181-7. 2002
  8. ncbi request reprint Increased neurogenesis in a rat ketamine model of schizophrenia
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
    Biol Psychiatry 56:317-22. 2004
  9. ncbi request reprint Cell proliferation is influenced by bulbectomy and normalized by imipramine treatment in a region-specific manner
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
    Neuropsychopharmacology 31:1165-76. 2006
  10. ncbi request reprint Citrulline immunohistochemistry may not necessarily identify nitric oxide synthase activity: the pitfall of peptidylarginine deiminase
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Nitric Oxide 8:31-8. 2003

Detail Information

Publications83

  1. ncbi request reprint Structural parameters of collagen nerve grafts influence peripheral nerve regeneration
    Felix Stang
    Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Biomaterials 26:3083-91. 2005
    ..This indicates that not only viable Schwann cells are an imperative prerequisite but also structural parameters determine peripheral nerve regeneration...
  2. pmc Evidence for a wide extra-astrocytic distribution of S100B in human brain
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
    BMC Neurosci 8:2. 2007
    ..However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity...
  3. ncbi request reprint Citrulline immunohistochemistry for demonstration of NOS activity in vivo and in vitro
    G Keilhoff
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, Magdeburg, D 39120, Germany
    Nitric Oxide 4:343-53. 2000
    ....
  4. ncbi request reprint Differences in peripheral nerve degeneration/regeneration between wild-type and neuronal nitric oxide synthase knockout mice
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    J Neurosci Res 68:432-41. 2002
    ....
  5. ncbi request reprint Transdifferentiation of mesenchymal stem cells into Schwann cell-like myelinating cells
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Eur J Cell Biol 85:11-24. 2006
    ..In contrast to SC, in some cases, single tMSC were able to myelinate more than one axon. Our findings demonstrate that it may be possible to differentiate MSC into therapeutically useful cells for clinical applications...
  6. ncbi request reprint Successful intramuscular neurotization is dependent on the denervation period. A histomorphological study of the gracilis muscle in rats
    Gerburg Keilhoff
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Muscle Nerve 31:221-8. 2005
    ..Quantity and quality of motor endplate formation depended on the denervation period. Thus, in special clinical situations intramuscular neurotization within a distinct time window provides a good reconstructive option...
  7. ncbi request reprint Neuronal nitric oxide synthase is the dominant nitric oxide supplier for the survival of dorsal root ganglia after peripheral nerve axotomy
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Medical Faculty, Otto von Guericke University, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    J Chem Neuroanat 24:181-7. 2002
    ..Whereas a lack of eNOS was tolerated, deficiency of nNOS led to an enhanced cell loss. The results suggest a crucial role of NO supply after transection of peripheral nerves with a particular significance of the nNOS isoform...
  8. ncbi request reprint Increased neurogenesis in a rat ketamine model of schizophrenia
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
    Biol Psychiatry 56:317-22. 2004
    ..While neuron birth is largely completed by the end of gestation, granule neurons of the dentate gyrus are generated throughout life, thus offering an opportunity to investigate neurogenesis postnatally...
  9. ncbi request reprint Cell proliferation is influenced by bulbectomy and normalized by imipramine treatment in a region-specific manner
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
    Neuropsychopharmacology 31:1165-76. 2006
    ..Further to this, we discuss a possible link between the pathogenesis of depression and changed neuronal plasticity in the SVZ...
  10. ncbi request reprint Citrulline immunohistochemistry may not necessarily identify nitric oxide synthase activity: the pitfall of peptidylarginine deiminase
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Nitric Oxide 8:31-8. 2003
    ..Our immunocytochemical observations were corroborated by Western blot analysis showing several bands of citrulline-positive proteins, whose number and staining intensity depended on kainate treatment and calcium ions...
  11. ncbi request reprint Repeated application of ketamine to rats induces changes in the hippocampal expression of parvalbumin, neuronal nitric oxide synthase and cFOS similar to those found in human schizophrenia
    G Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Neuroscience 126:591-8. 2004
    ....
  12. ncbi request reprint Neuronal NOS deficiency promotes apoptotic cell death of spinal cord neurons after peripheral nerve transection
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Nitric Oxide 10:101-11. 2004
    ..Thus, NO supply turned out to be essential for cell survival and recovery with reference to the neuronal NOS isoform...
  13. ncbi request reprint Bio-compatibility of type I/III collagen matrix for peripheral nerve reconstruction
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Biomaterials 24:2779-87. 2003
    ..From this results, we conclude that collagen-type I/III can serve as template to design "living" nerve conduits, which may be able to ensure nerve regeneration through extended nerve gaps...
  14. ncbi request reprint Lack of neuronal NOS has consequences for the expression of POMC and POMC-derived peptides in the mouse pituitary
    G Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Germany
    Acta Histochem 103:397-412. 2001
    ..Our data demonstrate that the lack of nNOS substantially affects cellular levels of pituitary opioid peptides, which may have consequences for the response of these animals to stress and pain...
  15. ncbi request reprint Nitric oxide synthase, an essential factor in peripheral nerve regeneration
    G Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Cell Mol Biol (Noisy-le-grand) 49:885-97. 2003
    ..A lack of eNOS was well tolerated, although a delay in nerve revascularization was observed. Thus, after peripheral nerve lesion, regular NOS activity is essential for cell survival and recovery with reference to the nNOS isoform...
  16. ncbi request reprint In vivo predegeneration of peripheral nerves: an effective technique to obtain activated Schwann cells for nerve conduits
    G Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Germany
    J Neurosci Methods 89:17-24. 1999
    ..The Schwann cells from predegenerated nerves revealed an increased proliferation rate compared to the control, whereas fibroblast contamination was decreased. Best results were obtained 1 week after predegeneration...
  17. ncbi request reprint 2,7-Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation
    H Possel
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Germany
    FEBS Lett 416:175-8. 1997
    ..In conclusion, DCF-H was demonstrated to be an excellent peroxynitrite marker with the potential to detect peroxynitrite formation in living cells...
  18. ncbi request reprint Expression of hypothalamic peptides in mice lacking neuronal nitric oxide synthase: reduced beta-END immunoreactivity in the arcuate nucleus
    H G Bernstein
    Department of Psychiatry, University of Magdeburg, Germany
    Neuroendocrinology 68:403-11. 1998
    ..Hence, the reduction of hypothalamic beta-END is probably a posttranslational event that might reflect a disturbed endorphinergic innervation of those hypothalamic neurons which normally express nNOS...
  19. ncbi request reprint Peroxynitrite mediated damage and lowered superoxide tolerance in primary cortical glial cultures after induction of the inducible isoform of NOS
    H Noack
    Institut für Medizinische Neurobiologie, Otto von Guericke Universitat, Magdeburg, Germany
    Glia 28:13-24. 1999
    ..At physiological levels of superoxide and within a wide range of higher superoxide levels this nitrosative stress is well balanced in cultured glial cells by protective mechanisms...
  20. ncbi request reprint Revascularization of tissue-engineered nerve grafts and invasion of macrophages
    H Fansa
    Department of Plastic, Reconstructive and Hand Surgery, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    Tissue Eng 7:519-24. 2001
    ..As these grafts are lacking Wallerian degeneration delayed macrophage invasion may not impair degeneration-dependent regeneration, but presence of macrophage derived or induced growth factors may be decreased...
  21. ncbi request reprint Low and infrequent expression of nitric oxide synthase/NADPH-diaphorase in neurons of the human supraoptic nucleus: a histochemical study
    H G Bernstein
    Department of Psychiatry, Otto v Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    J Chem Neuroanat 20:177-83. 2000
    ..No correlation was found between the expression of the enzyme in supraoptic neurons and the psychiatric status of the patients...
  22. doi request reprint Preconditioning of brain slices against hypoxia induced injury by a Gynostemma pentaphyllum extract--stimulation of anti-oxidative enzyme expression
    L Schild
    Department of Pathological Biochemistry, Otto von Guericke University, Magdeburg D 39120, Germany
    Phytomedicine 19:812-8. 2012
    ..Our results demonstrate that the prophylactic administration of the ethanolic extract from Gynostemma pentaphyllum has a high potential to protect from ischemia/reperfusion injury...
  23. ncbi request reprint Nitrosative stress in primary glial cultures after induction of the inducible isoform of nitric oxide synthase (i-NOS)
    H Noack
    Institute for Medical Neurobiology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Toxicology 148:133-42. 2000
    ..The higher GSH-levels in the microglial cells of unstimulated cultures represents a buffer which, under the conditions of i-NOS catalyzed NO-formation, prevents a decline of the microglial GSH-levels below that of the astrocytes...
  24. ncbi request reprint Hypothalamic nitric oxide synthase in affective disorder: focus on the suprachiasmatic nucleus
    H G Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Cell Mol Biol (Noisy-le-grand) 51:279-84. 2005
    ..The number of neurophysin-expressing SCN neurons was also fewer in cases with mood disorder. It is concluded that SCN-derived NO may be a relevant pathophysiological factor in neuropsychiatric disorders...
  25. doi request reprint Haloperidol and clozapine decrease S100B release from glial cells
    J Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Neuroscience 167:1025-31. 2010
    ..These data suggest that elevated levels of S100B in bodily fluids of schizophrenic patients are normalized rather than increased by the effects of antipsychotic drugs on glial cells...
  26. ncbi request reprint Cryopreservation of peripheral nerve grafts
    H Fansa
    Department of Plastic, Reconstructive and Hand Surgery, Otto von Guericke University, Magdeburg, Germany
    Muscle Nerve 23:1227-33. 2000
    ..Grafts subjected to controlled freezing support axonal regeneration to a certain extent, but further studies are required to assess various cooling patterns, cryoprotectants, and graft revascularization...
  27. doi request reprint Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extract
    L Schild
    Department of Pathological Biochemistry, Otto von Guericke University, Magdeburg, Germany
    Phytomedicine 17:589-97. 2010
    ..It may have a high potency in cancer therapy and cancer prophylaxis...
  28. ncbi request reprint Tissue engineering of peripheral nerves: A comparison of venous and acellular muscle grafts with cultured Schwann cells
    H Fansa
    Department of Plastic, Reconstructive, and Hand Surgery, Institute of Medical Neurobiology, University of Magdeburg, Germany
    Plast Reconstr Surg 107:485-94; discussion 495-6. 2001
    ....
  29. ncbi request reprint Tissue engineering of peripheral nerves: Epineurial grafts with application of cultured Schwann cells
    H Fansa
    Department of Plastic, Reconstructive and Hand Surgery, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    Microsurgery 23:72-7. 2003
    ....
  30. ncbi request reprint Glutathione levels in primary glial cultures: monochlorobimane provides evidence of cell type-specific distribution
    S Chatterjee
    Institute for Medical Neurobiology, Otto von Guericke Universitat, Magdeburg, Germany
    Glia 27:152-61. 1999
    ....
  31. doi request reprint Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Exp Neurol 212:189-200. 2008
    ..In common nerve grafts, however, where Wallerian degeneration is a prerequisite, the anti-angiogenic and macrophage-depressing effect is an obstacle for regeneration...
  32. ncbi request reprint Regeneration of peripheral nerves after clenbuterol treatment in a rat model
    O Frerichs
    Department of Plastic, Reconstructive, and Hand Surgery, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Muscle Nerve 24:1687-91. 2001
    ..Thus, therapy with 100 microg/kg clenbuterol daily after coaptation of a sciatic nerve showed a positive influence on clinical, histological, and morphometrical parameters in the rat model. The underlying mechanism remains unclear...
  33. ncbi request reprint Peripheral nerve tissue engineering: autologous Schwann cells vs. transdifferentiated mesenchymal stem cells
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany
    Tissue Eng 12:1451-65. 2006
    ..The results indicate that transdifferentiated MSCs implanted into devitalized muscle grafts are able to support peripheral nerve regeneration to some extent, and offer a potential for new therapeutic strategies...
  34. ncbi request reprint Transdifferentiated mesenchymal stem cells as alternative therapy in supporting nerve regeneration and myelination
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany
    Cell Mol Neurobiol 26:1235-52. 2006
    ..1...
  35. ncbi request reprint Protection of primary glial cells by grape seed proanthocyanidin extract against nitrosative/oxidative stress
    S Roychowdhury
    Otto-von-Guericke University, Institute for Medical Neurobiology, Leipziger Strasse 44, Magdeburg, D-39120, Germany
    Nitric Oxide 5:137-49. 2001
    ..Furthermore, GSPE pretreatment protects the microglial GSH pool during high output NO production and results in an elevation of the H(2)O(2) tolerance in astroglial cells...
  36. doi request reprint Risperidone and haloperidol promote survival of stem cells in the rat hippocampus
    Gerburg Keilhoff
    Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:151-62. 2010
    ....
  37. ncbi request reprint Collagen nerve conduits--assessment of biocompatibility and axonal regeneration
    Felix Stang
    Institute of Medical Neurobiology and Department of Plastic, Reconstructive and Hand Surgery, University of Magdeburg, Germany
    Biomed Mater Eng 15:3-12. 2005
    ..From these results, we conclude that a sufficient biocompatibility of bioartificial nerve conduits is a necessary prerequisite, however, it remains only one of several parameters important for peripheral nerve regeneration...
  38. ncbi request reprint Expression pattern of peptidylarginine deiminase in rat and human Schwann cells
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
    Dev Neurobiol 68:101-14. 2008
    ..These data suggest that, similar to the CNS, citrullination of proteins may also exert a specific role in thecourse of PNS development and repair...
  39. ncbi request reprint Further immunohistochemical evidence for impaired NO signaling in the hypothalamus of depressed patients
    H G Bernstein
    Department of Psychiatry, University of Magdeburg, D 39120 Magdeburg, Germany
    Ann N Y Acad Sci 973:91-3. 2002
    ..The number of NOS-immunoreactive SCN neurons was significantly reduced in depression. We conclude that affective disorders are accompanied by impaired hypothalamic NO signaling...
  40. doi request reprint Dysregulation of iron protein expression in the G93A model of amyotrophic lateral sclerosis
    M Hadzhieva
    Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
    Neuroscience 230:94-101. 2013
    ..Since RA treatment increased cytoplasmic reactive oxygen species (ROS) levels in these cells, an IRE/IRP independent, ROS-mediated mechanism may account for dysregulation of iron-related genes...
  41. ncbi request reprint Altered laminar distribution of hippocampal zinc in mutant mice lacking neuronal nitric oxide synthase. A histochemical study
    G Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Neurosci Lett 305:173-6. 2001
    ..Our data show that life-long withdrawal of neuronal-derived NO has effects on the accumulation of zinc in the hippocampal formation of mice...
  42. ncbi request reprint Interaction of nitric oxide donors and ascorbic acid on D-[3H] aspartate efflux from rat striatal slices
    M Reiser
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Germany
    Neurochem Res 24:61-7. 1999
    ..Ascorbate was shown to exert its effect primarily by influencing the decomposition of these nitric oxide donors rather than by a direct interaction of ascorbate with nitric monoxide on glutamate release...
  43. ncbi request reprint The effect of the immunosuppressant FK 506 on peripheral nerve regeneration following nerve grafting
    H Fansa
    Department of Plastic, Reconstructive and Hand Surgery, and the Institute of Medical Neurobiology, University of Magdeburg, Germany
    J Hand Surg Br 24:38-42. 1999
    ..Whether this is related to a pruning mechanism or to a down-regulation of regenerative processes in the nerve due to possible neurotoxic effects of FK 506 remains unknown...
  44. ncbi request reprint NOS-mediated differences in peripheral nerve graft revascularization and regeneration
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Medical Faculty, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Neuroreport 13:1463-8. 2002
    ....
  45. doi request reprint S100B is expressed in, and released from, OLN-93 oligodendrocytes: Influence of serum and glucose deprivation
    J Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Neuroscience 154:496-503. 2008
    ..Studies on S100B in bodily fluids should be carefully interpreted in order to avoid misleading hypotheses concerning the specific involvement of astrocytes, due to the various cellular sources of S100B...
  46. ncbi request reprint Differentially expressed genes in hippocampal cell cultures in response to an excitotoxic insult by quinolinic acid
    B Seidel
    Institute of Medical Neurobiology, University of Magdeburg Otto von Guericke, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Brain Res Mol Brain Res 60:296-300. 1998
    ..The results provide emphasis to the participation of proteolysis and protease inhibition in neurodegenerative processes...
  47. doi request reprint Triggered by asphyxia neurogenesis seems not to be an endogenous repair mechanism, gliogenesis more like it
    G Keilhoff
    Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Neuroscience 171:869-84. 2010
    ..Furthermore, from the finding of microglia proliferation up to 90 days after insult we conclude that delayed cell death processes take place which should be considered for further therapy strategies...
  48. doi request reprint Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophrenia
    Nadine Farkas
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    World J Biol Psychiatry 11:556-66. 2010
    ..3, a gene locus which has been linked to schizophrenia, and some of its putative substrates are altered in schizophrenia...
  49. ncbi request reprint Bridging extra large defects of peripheral nerves: possibilities and limitations of alternative biological grafts from acellular muscle and Schwann cells
    Gerburg Keilhoff
    Institute of Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany
    Tissue Eng 11:1004-14. 2005
    ....
  50. ncbi request reprint Cytosolic and mitochondrial glutathione in microglial cells are differentially affected by oxidative/nitrosative stress
    Sanjoy Roychowdhury
    Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Nitric Oxide 8:39-47. 2003
    ..We conclude that endogenous NO production in microglial cells does not compromise the mt-GSH pool which, in turn, might explain the ability of these cells to combat high-output NO production...
  51. ncbi request reprint Distinct Ca2+ thresholds determine cytochrome c release or permeability transition pore opening in brain mitochondria
    L Schild
    Institute of Clinical Chemistry, Department of Pathological Biochemistry, Institute of Medical Neurobiology, Institute of Neurobiochemistry, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    FASEB J 15:565-7. 2001
    ..Our findings might reflect a fundamental mechanism to protect postmitotic neuronal tissue against necrotic devastation and inflammation...
  52. ncbi request reprint [Cultivating human Schwann cells for tissue engineering of peripheral nerves]
    H Fansa
    Klinik für Plastische, Wiederherstellungs und Handchirurgie, Medizinische Fakultat, Otto von Guericke Universitat, Magdeburg
    Handchir Mikrochir Plast Chir 32:181-6. 2000
    ..The age-dependent proliferation underlines the need for alternative sources for Schwann cells...
  53. ncbi request reprint [The influence on nerve regeneration by the beta2-receptor agonist clenbuterol]
    O Frerichs
    Klinik für Plastische, Wiederherstellungs und Handchirurgie, Otto von Guericke Universitat Magdeburg, Germany
    Handchir Mikrochir Plast Chir 34:84-8. 2002
    ..The assessment was done histologically, morphometrically and clinically. The weight ratio of the soleus and extensor digitorum muscles of the operated to the contralateral side was measured...
  54. ncbi request reprint [The asphyxia-cardiac arrest rat model for developing mechanism of effect oriented therapeutic concepts after cardiopulmonary resuscitation]
    U Ebmeyer
    Universitätsklinik für Anaesthesiologie und Intensivtherapie, Medizinischen Fakultat, Otto von Guericke Universitat Magdeburg
    Anaesthesiol Reanim 26:159-65. 2001
    ....
  55. pmc Selection of reference genes for quantitative real-time PCR in a rat asphyxial cardiac arrest model
    Kristina Langnaese
    Institute of Medical Neurobiology, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
    BMC Mol Biol 9:53. 2008
    ..Moreover, experimental groups treated with the anti-inflammatory and anti-apoptotic drug minocycline have been included in the study as well...
  56. ncbi request reprint The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger alpha-phenyl-N-tert-butyl nitrone
    Christine Rauca
    Department of Pharmacology and Toxicology, Faculty of Medicine, Otto von Guericke University Magdeburg, Leipziger Street 44, 39120 Magdeburg, Germany
    Brain Res 1009:203-12. 2004
    ..Adaptive mechanisms, as the induction of Mn-SOD, may be taken into consideration to counteract oxidative stress-mediated free radical formation...
  57. ncbi request reprint UVB irradiation-induced impairment of keratinocytes and adaptive responses to oxidative stress
    Ingrid Wiswedel
    Department of Pathological Biochemistry, Institute of Clinical Chemistry and Pathological Biochemistry, Germany
    Free Radic Res 41:1017-27. 2007
    ..From the data it can be concluded that keratinocytes are sufficiently protected at low UVB doses, whereas higher doses lead to irreversible cell damage...
  58. ncbi request reprint Inhibiting effect of minocycline on the regeneration of peripheral nerves
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, D 39120 Magdeburg, Germany
    Dev Neurobiol 67:1382-95. 2007
    ..Therefore, we suggest that additional research into optimizing minocycline intervention for treatment of neurodegenerative diseases is needed before further clinical trials are performed...
  59. ncbi request reprint Oxidative stress in glial cultures: detection by DAF-2 fluorescence used as a tool to measure peroxynitrite rather than nitric oxide
    Sanjoy Roychowdhury
    Otto von Guericke University, Institute for Medical Neurobiology, Magdeburg, Germany
    Glia 38:103-14. 2002
    ..Nevertheless, our results also indicate that measurement of DCF fluorescence is a better tool for monitoring intracellular changes in the levels of NO and/or peroxynitrite than DAF-2...
  60. ncbi request reprint Life imaging of peroxynitrite in rat microglial and astroglial cells: Role of superoxide and antioxidants
    Heiko Possel
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Glia 38:339-50. 2002
    ..Among the substances under investigation in this study, glutathione and the synthetic compound ebselen had a major effect on preventing peroxynitrite formation, whereas ascorbate failed to decrease peroxynitrite levels...
  61. ncbi request reprint The many faces of nitric oxide in schizophrenia. A review
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Schizophr Res 78:69-86. 2005
    ..Thus, NO and its metabolites are not suitable diagnostic tools to distinguish schizophrenia from psychically healthy control cases or from other brain disorders...
  62. ncbi request reprint Influence of insulin-like growth factor-I (IGF-I) on nerve autografts and tissue-engineered nerve grafts
    Hisham Fansa
    Department of Plastic, Reconstructive and Hand Surgery, Medical Faculty, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Muscle Nerve 26:87-93. 2002
    ..Seemingly, in these grafts the interactive feedback mechanisms of neuron, glial cell, and extracellular matrix are not established, and IGF-I cannot exert its action as a pleiotrophic signal...
  63. ncbi request reprint Neuronal nitric oxide synthase controls enzyme activity pattern of mitochondria and lipid metabolism
    Lorenz Schild
    Institut für Klinische Chemie und Pathologische Biochemie, Bereich Pathologische Biochemie, Medizinische Fakultät der Otto von Guericke Universität Magdeburg, Magdeburg, Germany
    FASEB J 20:145-7. 2006
    ..Furthermore, liver mitochondria from nNOS-KO mice consumed pyruvate at a higher rate and released more citric acid. Our data document a previously unrecognized role of endogenous NO in the regulation of lipid metabolism...
  64. ncbi request reprint Expression and function of somatostatin receptors in peripheral nerve sheath tumors
    Christian Mawrin
    Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
    J Neuropathol Exp Neurol 64:1080-8. 2005
    ..Furthermore, our findings suggest a potential clinical role for somatostatin receptor agonists in tumor imaging and/or treatment of schwannomas and MPNSTs...
  65. ncbi request reprint Host responses after acellular muscle basal lamina allografting used as a matrix for tissue engineered nerve grafts1
    Hisham Fansa
    Department of Plastic, Reconstructive and Hand Surgery, Otto von Guericke University, Magdeburg, Germany
    Transplantation 74:381-7. 2002
    ..We established grafts from Schwann cells and basal lamina from acellular muscles. These grafts offer a regeneration that is comparable to autologous nerve grafts...
  66. ncbi request reprint Nitric oxide promotes intracellular calcium release from mitochondria in striatal neurons
    Thomas F W Horn
    Institute for Medical Neurobiology, University of Magdeburg, Germany
    FASEB J 16:1611-22. 2002
    ..An NO-activated mitochondrial permeability transition pore may lead to cell death after overstimulation of NMDA receptors...
  67. ncbi request reprint Brain region-specific changes in the expression of calcium sensor proteins after repeated applications of ketamine to rats
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Neurosci Lett 339:95-8. 2003
    ..G., Braunewell, K.-H., Spilker, C., Danos, P., Baumann, B., Funke, S., Diekmann, S., Gundelfinger, E.D. and Bogerts, B., NeuroReport, 13 (2002) 393-396]...
  68. ncbi request reprint Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Germany
    Brain Res Bull 69:546-59. 2006
    ..Our data show that NRG-1alpha expression is lower in the adult human brain than in the developing brain, and, therefore, support a role for NRG-1alpha in brain development...
  69. ncbi request reprint Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration
    Lorenz Schild
    Institut für Klinische Chemie und Pathologische Biochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Biol Chem 278:25454-60. 2003
    ....
  70. ncbi request reprint ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neurosci Res 75:353-60. 2004
    ..Thus, ADAM12 may be regarded a new suitable marker for this cell type...
  71. ncbi request reprint Strain specific differences in a cardio-pulmonary resuscitation rat model
    U Ebmeyer
    Institute of Medical Neurobiology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Resuscitation 53:189-200. 2002
    ..Neuronal damages in the CA1 region in Wistar rats appeared to be more as shrunken cell bodies and pyknotic nuclei before resorption took place, whereas in Sprague-Dawley rats appeared in the same region...
  72. doi request reprint Protection of hippocampal slices against hypoxia/hypoglycemia injury by a Gynostemma pentaphyllum extract
    L Schild
    Department of Pathological Biochemistry, Otto von Guericke University, Magdeburg, Germany
    Phytomedicine 16:734-43. 2009
    ..It should be beneficial as prophylactic nutrition supplement and during revascularization of arterial blood vessels from stroke and other ischemic events such as coronary occlusion...
  73. pmc Fatty acid synthase as a novel target for meningioma therapy
    Daniela Haase
    Department of Neuropathology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Neuro Oncol 12:844-54. 2010
    ..Collectively, our data suggest that the increased FAS expression in human meningiomas represents a novel therapeutic target for the treatment of unresectable or malignant meningioma...
  74. doi request reprint Haloperidol normalized prenatal vitamin D depletion-induced reduction of hippocampal cell proliferation in adult rats
    Gerburg Keilhoff
    Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Strasse, Magdeburg, Germany
    Neurosci Lett 476:94-8. 2010
    ....
  75. ncbi request reprint Reconstruction of peripheral nerves using acellular nerve grafts with implanted cultured Schwann cells
    Onno Frerichs
    Department of Plastic, Reconstructive and Hand Surgery, University of Magdeburg, Magdeburg, Germany
    Microsurgery 22:311-5. 2002
    ..Acellular grafts are able to bridge nerve gaps of up to 2 cm in the rat model, but even the addition of cultivated Schwann cells did not lead to results as good as in the group with autologous nerve grafts...
  76. doi request reprint Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract
    C Muller
    Department of Pathological Biochemistry, Otto von Guericke University, Magdeburg, Germany
    Phytomedicine 19:395-401. 2012
    ..Therefore, GP could be beneficial for patients with diabetes mellitus and NAFLD...
  77. doi request reprint S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric research
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Psychoneuroendocrinology 35:321-4. 2010
    ..In conclusion, physiological S100B levels in humans appear to closely reflect adipose tissue mass, which should therefore be considered as an important confounding factor in clinical studies examining the role of S100B...
  78. ncbi request reprint Immunohistochemical evidence for impaired neuregulin-1 signaling in the prefrontal cortex in schizophrenia and in unipolar depression
    Iris Bertram
    Exp Psychiatry Lab, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:147-56. 2007
    ..Reduced NRG-1alpha protein concentrations were found in brains of schizophrenics after Western blot analysis. The diminished expression of NRG-1alpha strongly supports an early neurodevelopmental component to schizophrenia...
  79. doi request reprint Impairment of endothelial nitric oxide synthase causes abnormal fat and glycogen deposition in liver
    Lorenz Schild
    Institute of Clinical Chemistry, Department of Pathobiochemistry, Otto von Guericke University Magdeburg, Leipziger Street 44, 39120 Magdeburg, Germany
    Biochim Biophys Acta 1782:180-7. 2008
    ..In support of this view, more visceral fat and 70% higher body weight was determined in one year old eNOS-KO mice in comparison to WT animals...
  80. doi request reprint Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia
    Alicja Bukowska
    University Hospital Magdeburg, Institute of Experimental Internal Medicine, Leipzigerstrasse 44, 39120 Magdeburg, Germany
    Exp Biol Med (Maywood) 233:558-74. 2008
    ..This study demonstrates that calcium inward current via L-type calcium channels contributes to oxidative stress and increased expression of oxidative stress markers and adhesion molecules during cardiac tachyarrhythmia...
  81. doi request reprint Cathepsin K generates enkephalin from beta-endorphin: a new mechanism with possible relevance for schizophrenia
    Uwe Lendeckel
    Institute of Experimental Internal Medicine, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Neurochem Int 54:410-7. 2009
    ....
  82. doi request reprint Distinct H2O2 concentration promotes proliferation of tumour cells after transient oxygen/glucose deprivation
    Lorenz Schild
    Institute of Clinical Chemistry and Pathological Biochemistry, Otto von Guericke University, Magdeburg, Germany
    Free Radic Res 42:237-43. 2008
    ..An essential factor is a distinct H(2)O(2) concentration. Massive elevation as well as significant reduction of H(2)O(2) concentration impairs the proliferation process...
  83. pmc Rapid pacing of embryoid bodies impairs mitochondrial ATP synthesis by a calcium-dependent mechanism--a model of in vitro differentiated cardiomyocytes to study molecular effects of tachycardia
    Lorenz Schild
    Institute of Clinical Chemistry, Department of Pathobiochemistry, Otto von Guericke University Magdeburg, and Division of Cardiology, University Hospital Magdeburg, Germany
    Biochim Biophys Acta 1762:608-15. 2006
    ..The in vitro pacing model presented here reflects changes occurring during tachycardia and, thus, allows functional analyses of the signaling pathways involved...