Research Topics
Genomes and Genes | G KeilhoffSummaryAffiliation: Otto-von-Guericke University Country: Germany Publications
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Publications
Vav deficiency impedes peripheral nerve regeneration in miceGerburg Keilhoff
Institute of Biochemistry and Cell Biology, University of Magdeburg, Magdeburg, Germany
Restor Neurol Neurosci 30:463-79. 2012..The actin cytoskeleton is critical to all of these processes; therefore, activators of the cytoskeleton such as Rho GTPases and RhoGEFS such as Vav2 and Vav3 represent attractive targets for therapeutic intervention...- Spontaneous hypothermia is not able to completely counteract cardiac arrest-induced mitochondrial impairment in the rat heartGerburg Keilhoff
Institute of Biochemistry and Cell Biology, University of Magdeburg, Magdeburg, Germany
Neonatology 103:131-3. 2013..Patients could benefit from the control of mitochondrial function during hypothermic intervention. When indicated, substances could be supplemented that support mitochondrial function, e.g. antioxidative-acting vitamins and ubiquinone... 
Effects of antipsychotics on dentate gyrus stem cell proliferation and survival in animal models: a critical updateGerburg Keilhoff
Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany
Neural Plast 2012:832757. 2012..We will specifically discuss the vitamin D deficiency model, the poly I:C model, the ketamine model, and the postnatal ventral hippocampal lesion model, all of which reflect core neurodevelopmental issues underlying schizophrenia onset...- Magnetic nanoparticles in primary neural cell cultures are mainly taken up by microgliaJosephine Pinkernelle
Institute of Biochemistry and Cell Biology, Otto von Guericke University Magdeburg, Leipziger Str, 44, 39120 Magdeburg, Germany
BMC Neurosci 13:32. 2012..Previously studies mostly reported cellular uptake in cell lines. Here we present a systematic study on the uptake of magnetic nanoparticles (MNPs) by primary cells of the nervous system... - nNOS deficiency-induced cell proliferation depletes the neurogenic reserveGerburg Keilhoff
Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Strasse 44, 39114 Magdeburg, Germany
Neurosci Lett 505:248-53. 2011..The effect of nNOS-KO, inducing cell proliferation only temporarily, consists with the concept that neuronal stem cells have a finite proliferation capacity... - Selection of reference genes for quantitative real-time PCR in a rat asphyxial cardiac arrest modelKristina Langnaese
Institute of Medical Neurobiology, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
BMC Mol Biol 9:53. 2008..Moreover, experimental groups treated with the anti-inflammatory and anti-apoptotic drug minocycline have been included in the study as well... 
Expression pattern of peptidylarginine deiminase in rat and human Schwann cellsGerburg Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
Dev Neurobiol 68:101-14. 2008..These data suggest that, similar to the CNS, citrullination of proteins may also exert a specific role in thecourse of PNS development and repair...- Haloperidol normalized prenatal vitamin D depletion-induced reduction of hippocampal cell proliferation in adult ratsGerburg Keilhoff
Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Strasse, Magdeburg, Germany
Neurosci Lett 476:94-8. 2010.... - Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degenerationGerburg Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Exp Neurol 212:189-200. 2008..In common nerve grafts, however, where Wallerian degeneration is a prerequisite, the anti-angiogenic and macrophage-depressing effect is an obstacle for regeneration... - Triggered by asphyxia neurogenesis seems not to be an endogenous repair mechanism, gliogenesis more like itG Keilhoff
Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
Neuroscience 171:869-84. 2010..Furthermore, from the finding of microglia proliferation up to 90 days after insult we conclude that delayed cell death processes take place which should be considered for further therapy strategies... - Minocycline neuroprotection in a rat model of asphyxial cardiac arrest is limitedGerburg Keilhoff
Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
Resuscitation 82:341-9. 2011..The study investigated a possible neuroprotective potency of minocycline in an experimental asphyxial cardiac arrest (ACA) rat model. Clinically important survival times were evaluated thus broadening common experimental approaches... - Risperidone and haloperidol promote survival of stem cells in the rat hippocampusGerburg Keilhoff
Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
Eur Arch Psychiatry Clin Neurosci 260:151-62. 2010.... - 2,7-Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formationH Possel
Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Germany
FEBS Lett 416:175-8. 1997..In conclusion, DCF-H was demonstrated to be an excellent peroxynitrite marker with the potential to detect peroxynitrite formation in living cells... - Lack of neuronal NOS has consequences for the expression of POMC and POMC-derived peptides in the mouse pituitaryG Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Germany
Acta Histochem 103:397-412. 2001..Our data demonstrate that the lack of nNOS substantially affects cellular levels of pituitary opioid peptides, which may have consequences for the response of these animals to stress and pain... - Peroxynitrite mediated damage and lowered superoxide tolerance in primary cortical glial cultures after induction of the inducible isoform of NOSH Noack
Institut für Medizinische Neurobiologie, Otto von Guericke Universitat, Magdeburg, Germany
Glia 28:13-24. 1999..At physiological levels of superoxide and within a wide range of higher superoxide levels this nitrosative stress is well balanced in cultured glial cells by protective mechanisms... - Haloperidol and clozapine decrease S100B release from glial cellsJ Steiner
Department of Psychiatry, University of Magdeburg, Germany
Neuroscience 167:1025-31. 2010..These data suggest that elevated levels of S100B in bodily fluids of schizophrenic patients are normalized rather than increased by the effects of antipsychotic drugs on glial cells... - Revascularization of tissue-engineered nerve grafts and invasion of macrophagesH Fansa
Department of Plastic, Reconstructive and Hand Surgery, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
Tissue Eng 7:519-24. 2001..As these grafts are lacking Wallerian degeneration delayed macrophage invasion may not impair degeneration-dependent regeneration, but presence of macrophage derived or induced growth factors may be decreased... - Nitric oxide synthase, an essential factor in peripheral nerve regenerationG Keilhoff
Institute of Medical Neurobiology, University of Magdeburg Leipziger Strasse 44, D 39120 Magdeburg, Germany
Cell Mol Biol (Noisy-le-grand) 49:885-97. 2003..A lack of eNOS was well tolerated, although a delay in nerve revascularization was observed. Thus, after peripheral nerve lesion, regular NOS activity is essential for cell survival and recovery with reference to the nNOS isoform... - Cryopreservation of peripheral nerve graftsH Fansa
Department of Plastic, Reconstructive and Hand Surgery, Otto von Guericke University, Magdeburg, Germany
Muscle Nerve 23:1227-33. 2000..Grafts subjected to controlled freezing support axonal regeneration to a certain extent, but further studies are required to assess various cooling patterns, cryoprotectants, and graft revascularization... - Nitrosative stress in primary glial cultures after induction of the inducible isoform of nitric oxide synthase (i-NOS)H Noack
Institute for Medical Neurobiology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
Toxicology 148:133-42. 2000..The higher GSH-levels in the microglial cells of unstimulated cultures represents a buffer which, under the conditions of i-NOS catalyzed NO-formation, prevents a decline of the microglial GSH-levels below that of the astrocytes... - Glutathione levels in primary glial cultures: monochlorobimane provides evidence of cell type-specific distributionS Chatterjee
Institute for Medical Neurobiology, Otto von Guericke Universitat, Magdeburg, Germany
Glia 27:152-61. 1999.... - Low and infrequent expression of nitric oxide synthase/NADPH-diaphorase in neurons of the human supraoptic nucleus: a histochemical studyH G Bernstein
Department of Psychiatry, Otto v Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
J Chem Neuroanat 20:177-83. 2000..No correlation was found between the expression of the enzyme in supraoptic neurons and the psychiatric status of the patients... - Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extractL Schild
Department of Pathological Biochemistry, Otto von Guericke University, Magdeburg, Germany
Phytomedicine 17:589-97. 2010..It may have a high potency in cancer therapy and cancer prophylaxis... - Citrulline immunohistochemistry for demonstration of NOS activity in vivo and in vitroG Keilhoff
Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, Magdeburg, D 39120, Germany
Nitric Oxide 4:343-53. 2000.... - Hypothalamic nitric oxide synthase in affective disorder: focus on the suprachiasmatic nucleusH G Bernstein
Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Cell Mol Biol (Noisy-le-grand) 51:279-84. 2005..The number of neurophysin-expressing SCN neurons was also fewer in cases with mood disorder. It is concluded that SCN-derived NO may be a relevant pathophysiological factor in neuropsychiatric disorders... - In vivo predegeneration of peripheral nerves: an effective technique to obtain activated Schwann cells for nerve conduitsG Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Germany
J Neurosci Methods 89:17-24. 1999..The Schwann cells from predegenerated nerves revealed an increased proliferation rate compared to the control, whereas fibroblast contamination was decreased. Best results were obtained 1 week after predegeneration... - Tissue engineering of peripheral nerves: A comparison of venous and acellular muscle grafts with cultured Schwann cellsH Fansa
Department of Plastic, Reconstructive, and Hand Surgery, Institute of Medical Neurobiology, University of Magdeburg, Germany
Plast Reconstr Surg 107:485-94; discussion 495-6. 2001.... - Regeneration of peripheral nerves after clenbuterol treatment in a rat modelO Frerichs
Department of Plastic, Reconstructive, and Hand Surgery, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
Muscle Nerve 24:1687-91. 2001..Thus, therapy with 100 microg/kg clenbuterol daily after coaptation of a sciatic nerve showed a positive influence on clinical, histological, and morphometrical parameters in the rat model. The underlying mechanism remains unclear... - Tissue engineering of peripheral nerves: Epineurial grafts with application of cultured Schwann cellsH Fansa
Department of Plastic, Reconstructive and Hand Surgery, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
Microsurgery 23:72-7. 2003.... - Differences in peripheral nerve degeneration/regeneration between wild-type and neuronal nitric oxide synthase knockout miceGerburg Keilhoff
Institute of Medical Neurobiology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
J Neurosci Res 68:432-41. 2002.... - Inhibiting effect of minocycline on the regeneration of peripheral nervesGerburg Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, D 39120 Magdeburg, Germany
Dev Neurobiol 67:1382-95. 2007..Therefore, we suggest that additional research into optimizing minocycline intervention for treatment of neurodegenerative diseases is needed before further clinical trials are performed... - S100B is expressed in, and released from, OLN-93 oligodendrocytes: Influence of serum and glucose deprivationJ Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
Neuroscience 154:496-503. 2008..Studies on S100B in bodily fluids should be carefully interpreted in order to avoid misleading hypotheses concerning the specific involvement of astrocytes, due to the various cellular sources of S100B... - The effect of the immunosuppressant FK 506 on peripheral nerve regeneration following nerve graftingH Fansa
Department of Plastic, Reconstructive and Hand Surgery, and the Institute of Medical Neurobiology, University of Magdeburg, Germany
J Hand Surg Br 24:38-42. 1999..Whether this is related to a pruning mechanism or to a down-regulation of regenerative processes in the nerve due to possible neurotoxic effects of FK 506 remains unknown... - Repeated application of ketamine to rats induces changes in the hippocampal expression of parvalbumin, neuronal nitric oxide synthase and cFOS similar to those found in human schizophreniaG Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Neuroscience 126:591-8. 2004.... - Interaction of nitric oxide donors and ascorbic acid on D-[3H] aspartate efflux from rat striatal slicesM Reiser
Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Germany
Neurochem Res 24:61-7. 1999..Ascorbate was shown to exert its effect primarily by influencing the decomposition of these nitric oxide donors rather than by a direct interaction of ascorbate with nitric monoxide on glutamate release... - Strain specific differences in a cardio-pulmonary resuscitation rat modelU Ebmeyer
Institute of Medical Neurobiology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
Resuscitation 53:189-200. 2002..Neuronal damages in the CA1 region in Wistar rats appeared to be more as shrunken cell bodies and pyknotic nuclei before resorption took place, whereas in Sprague-Dawley rats appeared in the same region... - Cell proliferation is influenced by bulbectomy and normalized by imipramine treatment in a region-specific mannerGerburg Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
Neuropsychopharmacology 31:1165-76. 2006..Further to this, we discuss a possible link between the pathogenesis of depression and changed neuronal plasticity in the SVZ... - Expression of hypothalamic peptides in mice lacking neuronal nitric oxide synthase: reduced beta-END immunoreactivity in the arcuate nucleusH G Bernstein
Department of Psychiatry, University of Magdeburg, Germany
Neuroendocrinology 68:403-11. 1998..Hence, the reduction of hypothalamic beta-END is probably a posttranslational event that might reflect a disturbed endorphinergic innervation of those hypothalamic neurons which normally express nNOS... - Protection of primary glial cells by grape seed proanthocyanidin extract against nitrosative/oxidative stressS Roychowdhury
Otto-von-Guericke University, Institute for Medical Neurobiology, Leipziger Strasse 44, Magdeburg, D-39120, Germany
Nitric Oxide 5:137-49. 2001..Furthermore, GSPE pretreatment protects the microglial GSH pool during high output NO production and results in an elevation of the H(2)O(2) tolerance in astroglial cells... - Further immunohistochemical evidence for impaired NO signaling in the hypothalamus of depressed patientsH G Bernstein
Department of Psychiatry, University of Magdeburg, D 39120 Magdeburg, Germany
Ann N Y Acad Sci 973:91-3. 2002..The number of NOS-immunoreactive SCN neurons was significantly reduced in depression. We conclude that affective disorders are accompanied by impaired hypothalamic NO signaling... - Altered laminar distribution of hippocampal zinc in mutant mice lacking neuronal nitric oxide synthase. A histochemical studyG Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120, Magdeburg, Germany
Neurosci Lett 305:173-6. 2001..Our data show that life-long withdrawal of neuronal-derived NO has effects on the accumulation of zinc in the hippocampal formation of mice... - Peripheral nerve tissue engineering: autologous Schwann cells vs. transdifferentiated mesenchymal stem cellsGerburg Keilhoff
Institute of Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany
Tissue Eng 12:1451-65. 2006..The results indicate that transdifferentiated MSCs implanted into devitalized muscle grafts are able to support peripheral nerve regeneration to some extent, and offer a potential for new therapeutic strategies... - Fatty acid synthase as a novel target for meningioma therapyDaniela Haase
Department of Neuropathology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
Neuro Oncol 12:844-54. 2010..Collectively, our data suggest that the increased FAS expression in human meningiomas represents a novel therapeutic target for the treatment of unresectable or malignant meningioma... - Bridging extra large defects of peripheral nerves: possibilities and limitations of alternative biological grafts from acellular muscle and Schwann cellsGerburg Keilhoff
Institute of Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany
Tissue Eng 11:1004-14. 2005.... - Bio-compatibility of type I/III collagen matrix for peripheral nerve reconstructionGerburg Keilhoff
Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Biomaterials 24:2779-87. 2003..From this results, we conclude that collagen-type I/III can serve as template to design "living" nerve conduits, which may be able to ensure nerve regeneration through extended nerve gaps... - Increased neurogenesis in a rat ketamine model of schizophreniaGerburg Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
Biol Psychiatry 56:317-22. 2004..While neuron birth is largely completed by the end of gestation, granule neurons of the dentate gyrus are generated throughout life, thus offering an opportunity to investigate neurogenesis postnatally... - Distinct Ca2+ thresholds determine cytochrome c release or permeability transition pore opening in brain mitochondriaL Schild
Institute of Clinical Chemistry, Department of Pathological Biochemistry, Institute of Medical Neurobiology, Institute of Neurobiochemistry, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
FASEB J 15:565-7. 2001..Our findings might reflect a fundamental mechanism to protect postmitotic neuronal tissue against necrotic devastation and inflammation... - Impairment of endothelial nitric oxide synthase causes abnormal fat and glycogen deposition in liverLorenz Schild
Institute of Clinical Chemistry, Department of Pathobiochemistry, Otto von Guericke University Magdeburg, Leipziger Street 44, 39120 Magdeburg, Germany
Biochim Biophys Acta 1782:180-7. 2008..In support of this view, more visceral fat and 70% higher body weight was determined in one year old eNOS-KO mice in comparison to WT animals... - Influence of insulin-like growth factor-I (IGF-I) on nerve autografts and tissue-engineered nerve graftsHisham Fansa
Department of Plastic, Reconstructive and Hand Surgery, Medical Faculty, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
Muscle Nerve 26:87-93. 2002..Seemingly, in these grafts the interactive feedback mechanisms of neuron, glial cell, and extracellular matrix are not established, and IGF-I cannot exert its action as a pleiotrophic signal... - Distinct H2O2 concentration promotes proliferation of tumour cells after transient oxygen/glucose deprivationLorenz Schild
Institute of Clinical Chemistry and Pathological Biochemistry, Otto von Guericke University, Magdeburg, Germany
Free Radic Res 42:237-43. 2008..An essential factor is a distinct H(2)O(2) concentration. Massive elevation as well as significant reduction of H(2)O(2) concentration impairs the proliferation process... - Neuronal NOS deficiency promotes apoptotic cell death of spinal cord neurons after peripheral nerve transectionGerburg Keilhoff
Institute of Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
Nitric Oxide 10:101-11. 2004..Thus, NO supply turned out to be essential for cell survival and recovery with reference to the neuronal NOS isoform... - Neuronal nitric oxide synthase is the dominant nitric oxide supplier for the survival of dorsal root ganglia after peripheral nerve axotomyGerburg Keilhoff
Institute of Medical Neurobiology, Medical Faculty, Otto von Guericke University, Leipziger Strasse 44, D 39120, Magdeburg, Germany
J Chem Neuroanat 24:181-7. 2002..Whereas a lack of eNOS was tolerated, deficiency of nNOS led to an enhanced cell loss. The results suggest a crucial role of NO supply after transection of peripheral nerves with a particular significance of the nNOS isoform... - S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric researchJohann Steiner
Department of Psychiatry, University of Magdeburg, Germany
Psychoneuroendocrinology 35:321-4. 2010..In conclusion, physiological S100B levels in humans appear to closely reflect adipose tissue mass, which should therefore be considered as an important confounding factor in clinical studies examining the role of S100B... - NOS-mediated differences in peripheral nerve graft revascularization and regenerationGerburg Keilhoff
Institute of Medical Neurobiology, Medical Faculty, Otto-von-Guericke-University, Leipziger Strasse 44, 39120 Magdeburg, Germany
Neuroreport 13:1463-8. 2002.... - Life imaging of peroxynitrite in rat microglial and astroglial cells: Role of superoxide and antioxidantsHeiko Possel
Institute of Medical Neurobiology, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany
Glia 38:339-50. 2002..Among the substances under investigation in this study, glutathione and the synthetic compound ebselen had a major effect on preventing peroxynitrite formation, whereas ascorbate failed to decrease peroxynitrite levels... - Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARCChristian Mawrin
Department of Neuropathology, Friedrich Schiller University, Jena, Germany
Brain Pathol 20:200-10. 2010..Collectively, these results suggest that APN expression and enzymatic function is reduced in aggressive meningiomas, and that alterations in the balance between APN and SPARC might favor meningioma invasion... - Protection of hippocampal slices against hypoxia/hypoglycemia injury by a Gynostemma pentaphyllum extractL Schild
Department of Pathological Biochemistry, Otto von Guericke University, Magdeburg, Germany
Phytomedicine 16:734-43. 2009..It should be beneficial as prophylactic nutrition supplement and during revascularization of arterial blood vessels from stroke and other ischemic events such as coronary occlusion... - Cathepsin K generates enkephalin from beta-endorphin: a new mechanism with possible relevance for schizophreniaUwe Lendeckel
Institute of Experimental Internal Medicine, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Neurochem Int 54:410-7. 2009.... - The many faces of nitric oxide in schizophrenia. A reviewHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Schizophr Res 78:69-86. 2005..Thus, NO and its metabolites are not suitable diagnostic tools to distinguish schizophrenia from psychically healthy control cases or from other brain disorders... - Citrulline immunohistochemistry may not necessarily identify nitric oxide synthase activity: the pitfall of peptidylarginine deiminaseGerburg Keilhoff
Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Nitric Oxide 8:31-8. 2003..Our immunocytochemical observations were corroborated by Western blot analysis showing several bands of citrulline-positive proteins, whose number and staining intensity depended on kainate treatment and calcium ions... - Transdifferentiation of mesenchymal stem cells into Schwann cell-like myelinating cellsGerburg Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Eur J Cell Biol 85:11-24. 2006..In contrast to SC, in some cases, single tMSC were able to myelinate more than one axon. Our findings demonstrate that it may be possible to differentiate MSC into therapeutically useful cells for clinical applications... - Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophreniaNadine Farkas
Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
World J Biol Psychiatry 11:556-66. 2010..3, a gene locus which has been linked to schizophrenia, and some of its putative substrates are altered in schizophrenia... - Transdifferentiated mesenchymal stem cells as alternative therapy in supporting nerve regeneration and myelinationGerburg Keilhoff
Institute of Medical Neurobiology, Otto von Guericke University, Magdeburg, Germany
Cell Mol Neurobiol 26:1235-52. 2006..1... - Expression and function of somatostatin receptors in peripheral nerve sheath tumorsChristian Mawrin
Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
J Neuropathol Exp Neurol 64:1080-8. 2005..Furthermore, our findings suggest a potential clinical role for somatostatin receptor agonists in tumor imaging and/or treatment of schwannomas and MPNSTs... - Collagen nerve conduits--assessment of biocompatibility and axonal regenerationFelix Stang
Institute of Medical Neurobiology and Department of Plastic, Reconstructive and Hand Surgery, University of Magdeburg, Germany
Biomed Mater Eng 15:3-12. 2005..From these results, we conclude that a sufficient biocompatibility of bioartificial nerve conduits is a necessary prerequisite, however, it remains only one of several parameters important for peripheral nerve regeneration... - Structural parameters of collagen nerve grafts influence peripheral nerve regenerationFelix Stang
Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D-39120 Magdeburg, Germany
Biomaterials 26:3083-91. 2005..This indicates that not only viable Schwann cells are an imperative prerequisite but also structural parameters determine peripheral nerve regeneration... - Host responses after acellular muscle basal lamina allografting used as a matrix for tissue engineered nerve grafts1Hisham Fansa
Department of Plastic, Reconstructive and Hand Surgery, Otto von Guericke University, Magdeburg, Germany
Transplantation 74:381-7. 2002..We established grafts from Schwann cells and basal lamina from acellular muscles. These grafts offer a regeneration that is comparable to autologous nerve grafts... - Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extractC Muller
Department of Pathological Biochemistry, Otto von Guericke University, Magdeburg, Germany
Phytomedicine 19:395-401. 2012..Therefore, GP could be beneficial for patients with diabetes mellitus and NAFLD... - Differentially expressed genes in hippocampal cell cultures in response to an excitotoxic insult by quinolinic acidB Seidel
Institute of Medical Neurobiology, University of Magdeburg Otto von Guericke, Leipziger Strasse 44, D 39120, Magdeburg, Germany
Brain Res Mol Brain Res 60:296-300. 1998..The results provide emphasis to the participation of proteolysis and protease inhibition in neurodegenerative processes... - Reconstruction of peripheral nerves using acellular nerve grafts with implanted cultured Schwann cellsOnno Frerichs
Department of Plastic, Reconstructive and Hand Surgery, University of Magdeburg, Magdeburg, Germany
Microsurgery 22:311-5. 2002..Acellular grafts are able to bridge nerve gaps of up to 2 cm in the rat model, but even the addition of cultivated Schwann cells did not lead to results as good as in the group with autologous nerve grafts... - Evidence for a wide extra-astrocytic distribution of S100B in human brainJohann Steiner
Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
BMC Neurosci 8:2. 2007..However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity... - Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brainHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Germany
Brain Res Bull 69:546-59. 2006..Our data show that NRG-1alpha expression is lower in the adult human brain than in the developing brain, and, therefore, support a role for NRG-1alpha in brain development... - Nitric oxide promotes intracellular calcium release from mitochondria in striatal neuronsThomas F W Horn
Institute for Medical Neurobiology, University of Magdeburg, Germany
FASEB J 16:1611-22. 2002..An NO-activated mitochondrial permeability transition pore may lead to cell death after overstimulation of NMDA receptors... - Oxidative stress in glial cultures: detection by DAF-2 fluorescence used as a tool to measure peroxynitrite rather than nitric oxideSanjoy Roychowdhury
Otto-von-Guericke University, Institute for Medical Neurobiology, Magdeburg, Germany
Glia 38:103-14. 2002..Nevertheless, our results also indicate that measurement of DCF fluorescence is a better tool for monitoring intracellular changes in the levels of NO and/or peroxynitrite than DAF-2... - ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytesHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
J Neurosci Res 75:353-60. 2004..Thus, ADAM12 may be regarded a new suitable marker for this cell type... - Successful intramuscular neurotization is dependent on the denervation period. A histomorphological study of the gracilis muscle in ratsGerburg Keilhoff
Institute for Medical Neurobiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Muscle Nerve 31:221-8. 2005..Quantity and quality of motor endplate formation depended on the denervation period. Thus, in special clinical situations intramuscular neurotization within a distinct time window provides a good reconstructive option... - Cytosolic and mitochondrial glutathione in microglial cells are differentially affected by oxidative/nitrosative stressSanjoy Roychowdhury
Institute for Medical Neurobiology, Otto-von-Guericke University, Leipziger Strasse 44, D-39120 Magdeburg, Germany
Nitric Oxide 8:39-47. 2003..We conclude that endogenous NO production in microglial cells does not compromise the mt-GSH pool which, in turn, might explain the ability of these cells to combat high-output NO production... - Neuronal nitric oxide synthase controls enzyme activity pattern of mitochondria and lipid metabolismLorenz Schild
Institut für Klinische Chemie und Pathologische Biochemie, Bereich Pathologische Biochemie, Medizinische Fakultät der Otto von Guericke Universität Magdeburg, Magdeburg, Germany
FASEB J 20:145-7. 2006..Furthermore, liver mitochondria from nNOS-KO mice consumed pyruvate at a higher rate and released more citric acid. Our data document a previously unrecognized role of endogenous NO in the regulation of lipid metabolism... - Immunohistochemical evidence for impaired neuregulin-1 signaling in the prefrontal cortex in schizophrenia and in unipolar depressionIris Bertram
Exp Psychiatry Lab, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Ann N Y Acad Sci 1096:147-56. 2007..Reduced NRG-1alpha protein concentrations were found in brains of schizophrenics after Western blot analysis. The diminished expression of NRG-1alpha strongly supports an early neurodevelopmental component to schizophrenia... - Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegrationLorenz Schild
Institut für Klinische Chemie und Pathologische Biochemie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
J Biol Chem 278:25454-60. 2003.... - Brain region-specific changes in the expression of calcium sensor proteins after repeated applications of ketamine to ratsHans Gert Bernstein
Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120, Magdeburg, Germany
Neurosci Lett 339:95-8. 2003..G., Braunewell, K.-H., Spilker, C., Danos, P., Baumann, B., Funke, S., Diekmann, S., Gundelfinger, E.D. and Bogerts, B., NeuroReport, 13 (2002) 393-396]... - The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger alpha-phenyl-N-tert-butyl nitroneChristine Rauca
Department of Pharmacology and Toxicology, Faculty of Medicine, Otto-von-Guericke University Magdeburg, Leipziger Street 44, 39120 Magdeburg, Germany
Brain Res 1009:203-12. 2004..Adaptive mechanisms, as the induction of Mn-SOD, may be taken into consideration to counteract oxidative stress-mediated free radical formation... - UVB irradiation-induced impairment of keratinocytes and adaptive responses to oxidative stressIngrid Wiswedel
Department of Pathological Biochemistry, Institute of Clinical Chemistry and Pathological Biochemistry, Germany
Free Radic Res 41:1017-27. 2007..From the data it can be concluded that keratinocytes are sufficiently protected at low UVB doses, whereas higher doses lead to irreversible cell damage...