S M Bode-Boger

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. pmc Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia
    Jan Sören Padberg
    Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Munster, Albert Schweitzer Campus A1, Munster 48149, Germany
    Exp Transl Stroke Med 4:24. 2012
  2. ncbi request reprint The L-arginine paradox: Importance of the L-arginine/asymmetrical dimethylarginine ratio
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Pharmacol Ther 114:295-306. 2007
  3. ncbi request reprint Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Am Soc Nephrol 17:1128-34. 2006
  4. ncbi request reprint Asymmetric dimethylarginine (ADMA) accelerates cell senescence
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital Otto von Guericke University, Magdeburg, Germany
    Vasc Med 10:S65-71. 2005
  5. ncbi request reprint Aspirin reduces endothelial cell senescence
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Germany
    Biochem Biophys Res Commun 334:1226-32. 2005
  6. ncbi request reprint [Influence of L-arginine on development of atherosclerosis: what is the therapeutically assured?]
    S M Bode-Boger
    Institut fur Klinische Pharmakologie, Universitatsklinikum, Otto von Guericke Universitat Magdeburg
    Dtsch Med Wochenschr 130:593-8. 2005
  7. ncbi request reprint Oral L-arginine improves endothelial function in healthy individuals older than 70 years
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Magdeburg, Germany
    Vasc Med 8:77-81. 2003
  8. ncbi request reprint Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease
    R H Boger
    Institute of Clinical Pharmacology, Hannover Medical School, Germany
    J Am Coll Cardiol 32:1336-44. 1998
  9. ncbi request reprint Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia
    R H Boger
    Institute of Clinical Pharmacology, Medical School, Hannover, Germany
    Arterioscler Thromb Vasc Biol 20:1557-64. 2000
  10. ncbi request reprint LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases
    R H Boger
    Institute of Clinical Pharmacology, Hannover Medical School, Germany
    Circ Res 87:99-105. 2000

Collaborators

Detail Information

Publications17

  1. pmc Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia
    Jan Sören Padberg
    Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Munster, Albert Schweitzer Campus A1, Munster 48149, Germany
    Exp Transl Stroke Med 4:24. 2012
    ..abstract:..
  2. ncbi request reprint The L-arginine paradox: Importance of the L-arginine/asymmetrical dimethylarginine ratio
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Pharmacol Ther 114:295-306. 2007
    ..Testing patients for ADMA and L-arginine plasma levels for calculating the L-arginine/ADMA ratio might be an adequate strategy...
  3. ncbi request reprint Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Am Soc Nephrol 17:1128-34. 2006
    ..It is concluded that SDMA might be a useful parameter for detecting patients in very early stages of chronic kidney disease and for determining their risk for developing cardiovascular disease...
  4. ncbi request reprint Asymmetric dimethylarginine (ADMA) accelerates cell senescence
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital Otto von Guericke University, Magdeburg, Germany
    Vasc Med 10:S65-71. 2005
    ..This study provides evidence that modest changes of intracellular ADMA levels are associated with significant effects on slowing down endothelial senescence...
  5. ncbi request reprint Aspirin reduces endothelial cell senescence
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Germany
    Biochem Biophys Res Commun 334:1226-32. 2005
    ..These findings demonstrate that aspirin delays the onset of endothelial senescence by preventing a decrease in NO formation/generation. This might provide a therapeutic strategy aimed at blocking aging-induced NO inhibition...
  6. ncbi request reprint [Influence of L-arginine on development of atherosclerosis: what is the therapeutically assured?]
    S M Bode-Boger
    Institut fur Klinische Pharmakologie, Universitatsklinikum, Otto von Guericke Universitat Magdeburg
    Dtsch Med Wochenschr 130:593-8. 2005
    ..Several possible mechanisms of action of L-arginine are discussed. An assessment of L-arginine as a therapeutic agent from the point of view of a clinical pharmacologist is given...
  7. ncbi request reprint Oral L-arginine improves endothelial function in healthy individuals older than 70 years
    Stefanie M Bode-Boger
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Magdeburg, Germany
    Vasc Med 8:77-81. 2003
    ..05). We conclude that in healthy very old age endothelial function is impaired and may be improved by oral L-arginine supplementation, probably due to normalization of the L-arginine/ADMA ratio...
  8. ncbi request reprint Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease
    R H Boger
    Institute of Clinical Pharmacology, Hannover Medical School, Germany
    J Am Coll Cardiol 32:1336-44. 1998
    ..Administration of L-arginine improves nitric oxide (NO) formation and endothelium-dependent vasodilation in atherosclerotic patients...
  9. ncbi request reprint Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia
    R H Boger
    Institute of Clinical Pharmacology, Medical School, Hannover, Germany
    Arterioscler Thromb Vasc Biol 20:1557-64. 2000
    ..Because ADMA acts as a competitive inhibitor of endothelial nitric oxide synthase, these findings suggest a novel mechanism for impaired endothelial function in hyperhomocyst(e)inemia...
  10. ncbi request reprint LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases
    R H Boger
    Institute of Clinical Pharmacology, Hannover Medical School, Germany
    Circ Res 87:99-105. 2000
    ..These findings suggest a novel mechanism by which ADMA concentration is elevated in hypercholesterolemia, leading to endothelial dysfunction and atherosclerosis...
  11. ncbi request reprint Organic nitrates in cardiovascular disease
    S M Bode-Boger
    Institut fur Klinische Pharmakologie, Otto von Guericke Universitat, Magdeburg, Germany
    Cell Mol Biol (Noisy-le-grand) 51:307-20. 2005
    ..In general, nitrates are remarkably safe drugs and are well tolerated. Appropriate clinical trials are needed to answer the question whether nitrates can do more than symptomatic relief in cardiovascular disease...
  12. ncbi request reprint Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans
    R H Boger
    Institute of Clinical Pharmacology, Hannover Medical School, 30623 Hannover, Germany
    Clin Sci (Lond) 100:161-7. 2001
    ..This finding may have importance for understanding the mechanism(s) leading to homocyst(e)ine-associated vascular disease, and its potential treatment...
  13. ncbi request reprint Role of endogenous nitric oxide in circadian blood pressure regulation in healthy humans and in patients with hypertension or atherosclerosis
    S M Bode-Boger
    Institute of Clinical Pharmacology, Medical School, Hannover, Germany
    J Investig Med 48:125-32. 2000
    ....
  14. ncbi request reprint Asymmetric dimethylarginine, derangements of the endothelial nitric oxide synthase pathway, and cardiovascular diseases
    R H Boger
    Institute of Clinical Pharmacology, Medical School, Hannover, Germany
    Semin Thromb Hemost 26:539-45. 2000
    ..Moreover, it may be a marker or even a risk factor for cardiovascular disease. Therefore, pharmacological modulation of ADMA concentration may be a novel therapeutic target in cardiovascular diseases...
  15. ncbi request reprint Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox
    D Tsikas
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30623, Hannover, Germany
    FEBS Lett 478:1-3. 2000
    ..In the present work, evidence for the hypothesis that the endogenous NOS inhibitors methylarginines, asymmetric dimethylarginine being the most powerful (IC(50) 1.5 microM), are responsible for the L-arginine paradox is presented...
  16. ncbi request reprint Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure
    J T Kielstein
    University, Magdeburg, Magdeburg, Medical School Hannover, Germany
    Eur J Clin Invest 33:370-5. 2003
    ..Patients with heart failure are characterized by impaired nitric oxide-dependent endothelial vasodilation and, in addition, by reduced renal perfusion...
  17. ncbi request reprint The clinical pharmacology of L-arginine
    R H Boger
    Institute of Clinical Pharmacology, Hannover Medical School, D 30623 Hannover, Germany
    Annu Rev Pharmacol Toxicol 41:79-99. 2001
    ..Several long-term studies have been performed that show that chronic oral administration of L-arginine or intermittent infusion therapy with L-arginine can improve clinical symptoms of cardiovascular disease in man...