Hendrik Bielau

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. ncbi request reprint Dysregulation of GABAergic neurotransmission in mood disorders: a postmortem study
    Hendrik Bielau
    Department of Psychiatry, Psychotherapy, and Psychosomatic Medicine, Otto von Guericke University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:157-69. 2007
  2. ncbi request reprint Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Psychiatr Res 42:151-7. 2008
  3. ncbi request reprint S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric study
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 42:868-76. 2008
  4. doi request reprint A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 261:47-58. 2011
  5. doi request reprint A postmortem assessment of mammillary body volume, neuronal number and densities, and fornix volume in subjects with mood disorders
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:637-46. 2012
  6. doi request reprint Reduced density of hypothalamic VGF-immunoreactive neurons in schizophrenia: a potential link to impaired growth factor signaling and energy homeostasis
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:365-74. 2012
  7. pmc Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neuroinflammation 8:94. 2011
  8. doi request reprint Dopamine-glutamate abnormalities in the frontal cortex associated with the catechol-O-methyltransferase (COMT) in schizophrenia
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Brain Res 1269:166-75. 2009
  9. doi request reprint Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 26:1273-9. 2012
  10. doi request reprint The volumes of the fornix in schizophrenia and affective disorders: a post-mortem study
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Psychiatry Res 164:265-73. 2008

Detail Information

Publications22

  1. ncbi request reprint Dysregulation of GABAergic neurotransmission in mood disorders: a postmortem study
    Hendrik Bielau
    Department of Psychiatry, Psychotherapy, and Psychosomatic Medicine, Otto von Guericke University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:157-69. 2007
    ..Possibly, existing deficits of GABAergic neurotransmission will be compensated or overcompensated by antidepressants. Additionally, albeit speculative, an imbalance between GABA production and transport might be of relevance...
  2. ncbi request reprint Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Psychiatr Res 42:151-7. 2008
    ..Therefore, the hypothesis of microglial activation during acute psychosis was proposed. Alternatively, "suicide" could be a diagnosis-independent factor leading to microgliosis...
  3. ncbi request reprint S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric study
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 42:868-76. 2008
    ..However, no histological study has been published on the cellular distribution of S100B in the brain of individuals with schizophrenia to clarify this hypothesis...
  4. doi request reprint A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 261:47-58. 2011
    ..037, r = -0.9). The histopathological abnormality of the decreased neuronal density in the lateral septal nucleus, which is an important limbic region involved in emotions, might be a neuropathological correlate of bipolar disorder...
  5. doi request reprint A postmortem assessment of mammillary body volume, neuronal number and densities, and fornix volume in subjects with mood disorders
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:637-46. 2012
    ..Furthermore, the fornix volumes were significantly reduced only in the control subjects with heart failure. Taken together, these results show that the mammillary bodies are compromised in depression...
  6. doi request reprint Reduced density of hypothalamic VGF-immunoreactive neurons in schizophrenia: a potential link to impaired growth factor signaling and energy homeostasis
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:365-74. 2012
    ..7 kg/m(2)). In conclusion, apart from beneficial effects on synaptic plasticity and neurogenesis, VGF may be linked to schizophrenia-related alterations in energy homeostasis...
  7. pmc Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neuroinflammation 8:94. 2011
    ..These peripheral immune processes may be accompanied by microglial activation in subregions of the anterior cingulate cortex where depression-associated alterations of glutamatergic neurotransmission have been described...
  8. doi request reprint Dopamine-glutamate abnormalities in the frontal cortex associated with the catechol-O-methyltransferase (COMT) in schizophrenia
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Brain Res 1269:166-75. 2009
    ..Our study demonstrates that schizophrenia might involve increased COMT expression in glial cells in the frontal cortex, which might be associated with a neuronal-glial abnormality and a disturbed dopamine-glutamate interaction...
  9. doi request reprint Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 26:1273-9. 2012
    ..The identification of diverse immune endophenotypes may facilitate the development of distinct anti-inflammatory schizophrenia therapies to normalize BBB function, (auto)antibody production or microglial activity...
  10. doi request reprint The volumes of the fornix in schizophrenia and affective disorders: a post-mortem study
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Psychiatry Res 164:265-73. 2008
    ....
  11. ncbi request reprint Volumetric analysis of the hypothalamus, amygdala and hippocampus in non-suicidal and suicidal mood disorder patients--a post-mortem study
    Hendrik Bielau
    Department of Psychiatry and Psychotherapy, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    CNS Neurol Disord Drug Targets 12:914-20. 2013
    ..The detected differences between suicidal and non-suicidal patients suggest that suicidal performances might be related to the degree of structural deficits. ..
  12. doi request reprint S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric research
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Psychoneuroendocrinology 35:321-4. 2010
    ..In conclusion, physiological S100B levels in humans appear to closely reflect adipose tissue mass, which should therefore be considered as an important confounding factor in clinical studies examining the role of S100B...
  13. ncbi request reprint Volume deficits of subcortical nuclei in mood disorders A postmortem study
    Hendrik Bielau
    Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 255:401-12. 2005
    ..In conclusion our data suggest that pathways presumably involved in mood regulation have structural pathology in affective disorders with more pronounced abnormalities in bipolar disorder...
  14. ncbi request reprint Immunohistochemical evidence for impaired neuregulin-1 signaling in the prefrontal cortex in schizophrenia and in unipolar depression
    Iris Bertram
    Exp Psychiatry Lab, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:147-56. 2007
    ..Reduced NRG-1alpha protein concentrations were found in brains of schizophrenics after Western blot analysis. The diminished expression of NRG-1alpha strongly supports an early neurodevelopmental component to schizophrenia...
  15. pmc Evidence for a wide extra-astrocytic distribution of S100B in human brain
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
    BMC Neurosci 8:2. 2007
    ..However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity...
  16. doi request reprint Increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims: possible implications for heroin neurotoxicity
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany Electronic address
    Acta Histochem 116:182-90. 2014
    ....
  17. ncbi request reprint Differences in activation of the dorsal raphe nucleus depending on performance of suicide
    Hendrik Bielau
    Department of Psychiatry, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Brain Res 1039:43-52. 2005
    ..Antidepressants appear to contribute to cellular activation in the rostral part of the dorsal raphe...
  18. ncbi request reprint Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Acta Neuropathol 112:305-16. 2006
    ..In conclusion, the present data suggest the absence of microgliosis but decreased cerebral lateralization of ameboid microglia in schizophrenia...
  19. ncbi request reprint Possible impact of microglial cells and the monocyte-macrophage system on suicidal behavior
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    CNS Neurol Disord Drug Targets 12:971-9. 2013
    ..Therefore, different patterns of immune activation may be observed when comparing newly diseased patients with those who are chronically ill. ..
  20. ncbi request reprint Volumetric analysis of septal region in schizophrenia and affective disorder
    Ralf Brisch
    Dept of Psychiatry, Psychotherapy and Psychosomatic Medicine, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:140-8. 2007
    ..01) was found, but not in patients with affective disorder (P = 0.53). The finding of enlarged CSP in schizophrenia strongly supports the hypothesis of an early developmental abnormality in this key structure of the limbic system...
  21. ncbi request reprint The changes in AgNOR parameters of dorsal raphe nucleus neurons are related to suicide
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Debowa 23, 80 204 Gdansk, Poland
    Leg Med (Tokyo) 9:251-7. 2007
    ..The results suggest DRN neurons hypoactivity specific for suicide. Whether observed phenomenon is a "common trait" existing also in other diagnostic groups of mental disorders remains an open question...
  22. ncbi request reprint The changes of AgNOR parameters of anterior cingulate pyramidal neurons are region-specific in suicidal and non-suicidal depressive patients
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdask, Gdask, Poland
    World J Biol Psychiatry 8:245-55. 2007
    ..028). The results suggest that regionally differentiated depression- and suicide-specific disturbed function of the most important AC output cells exists in depressive patients...