Hans Gert Bernstein

Summary

Affiliation: Otto-von-Guericke University
Country: Germany

Publications

  1. doi request reprint Increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims: Possible implications for heroin neurotoxicity
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany Electronic address
    Acta Histochem 116:182-90. 2014
  2. doi request reprint Wide distribution of CREM immunoreactivity in adult and fetal human brain, with an increased expression in dentate gyrus neurons of Alzheimer's as compared to normal aging brains
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Amino Acids 45:1373-83. 2013
  3. ncbi request reprint Disruption of glutamate-glutamine-GABA cycle significantly impacts on suicidal behaviour: survey of the literature and own findings on glutamine synthetase
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120Magdeburg, Germany
    CNS Neurol Disord Drug Targets 12:900-13. 2013
  4. doi request reprint Nardilysin in human brain diseases: both friend and foe
    H G Bernstein
    Department of Psychiatry, Otto v Guericke University Magdeburg, Germany
    Amino Acids 45:269-78. 2013
  5. doi request reprint Increased density of AKAP5-expressing neurons in the anterior cingulate cortex of subjects with bipolar disorder
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 47:699-705. 2013
  6. doi request reprint Decreased expression of nardilysin in SH-SY5Y cells under ethanol stress and reduced density of nardilysin-expressing neurons in brains of alcoholics
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany Electronic address
    J Psychiatr Res 47:343-9. 2013
  7. doi request reprint Increased density of prohibitin-immunoreactive oligodendrocytes in the dorsolateral prefrontal white matter of subjects with schizophrenia suggests extraneuronal roles for the protein in the disease
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Neuromolecular Med 14:270-80. 2012
  8. doi request reprint A postmortem assessment of mammillary body volume, neuronal number and densities, and fornix volume in subjects with mood disorders
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:637-46. 2012
  9. ncbi request reprint Nitric oxide and schizophrenia: present knowledge and emerging concepts of therapy
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    CNS Neurol Disord Drug Targets 10:792-807. 2011
  10. doi request reprint Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary
    Hans Gert Bernstein
    HansDepartment of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    J Chem Neuroanat 35:216-24. 2008

Detail Information

Publications68

  1. doi request reprint Increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims: Possible implications for heroin neurotoxicity
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany Electronic address
    Acta Histochem 116:182-90. 2014
    ....
  2. doi request reprint Wide distribution of CREM immunoreactivity in adult and fetal human brain, with an increased expression in dentate gyrus neurons of Alzheimer's as compared to normal aging brains
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Amino Acids 45:1373-83. 2013
    ..In Alzheimer's brain, we found an increased cellular expression of CREM in dentate gyrus neurons as compared to controls. We discuss our results with regard to the putative roles of CREM in brain development and in cognition...
  3. ncbi request reprint Disruption of glutamate-glutamine-GABA cycle significantly impacts on suicidal behaviour: survey of the literature and own findings on glutamine synthetase
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120Magdeburg, Germany
    CNS Neurol Disord Drug Targets 12:900-13. 2013
    ....
  4. doi request reprint Nardilysin in human brain diseases: both friend and foe
    H G Bernstein
    Department of Psychiatry, Otto v Guericke University Magdeburg, Germany
    Amino Acids 45:269-78. 2013
    ..We herein show that nardilysin is a Janus-faced enzyme with regard to brain pathology, being probably neuropathogenic in some diseases, but neuroprotective in others. ..
  5. doi request reprint Increased density of AKAP5-expressing neurons in the anterior cingulate cortex of subjects with bipolar disorder
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 47:699-705. 2013
    ....
  6. doi request reprint Decreased expression of nardilysin in SH-SY5Y cells under ethanol stress and reduced density of nardilysin-expressing neurons in brains of alcoholics
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany Electronic address
    J Psychiatr Res 47:343-9. 2013
    ..basalis of Meynert, paraventricular, and supraoptic nuclei. The alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism...
  7. doi request reprint Increased density of prohibitin-immunoreactive oligodendrocytes in the dorsolateral prefrontal white matter of subjects with schizophrenia suggests extraneuronal roles for the protein in the disease
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Neuromolecular Med 14:270-80. 2012
    ....
  8. doi request reprint A postmortem assessment of mammillary body volume, neuronal number and densities, and fornix volume in subjects with mood disorders
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:637-46. 2012
    ..Furthermore, the fornix volumes were significantly reduced only in the control subjects with heart failure. Taken together, these results show that the mammillary bodies are compromised in depression...
  9. ncbi request reprint Nitric oxide and schizophrenia: present knowledge and emerging concepts of therapy
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    CNS Neurol Disord Drug Targets 10:792-807. 2011
    ..Although certain alterations of brain NO metabolism are not unique to, or indicative of, schizophrenia, their modulation might be a promising therapeutic option for the future...
  10. doi request reprint Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary
    Hans Gert Bernstein
    HansDepartment of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    J Chem Neuroanat 35:216-24. 2008
    ..Some immunolabeling was also present in the neurohypophysis. The putative importance of the distribution of the enzyme in brain and pituitary is discussed in relation to its main known substrates, insulin, Abeta, and beta-endorphin...
  11. doi request reprint Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 43:1095-105. 2009
    ..Furthermore, it might contribute to the altered metabolism of certain neuropeptides (IGF-I and IGF-II, beta-endorphin), in schizophrenia...
  12. doi request reprint Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Expert Rev Neurother 9:1059-71. 2009
    ....
  13. doi request reprint Partial loss of parvalbumin-containing hippocampal interneurons in dementia with Lewy bodies
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Neuropathology 31:1-10. 2011
    ..It remains to be elucidated if the numerical decrease of this particular subset of hippocampal interneurons has consequences for the gamma (20-80 Hz) frequency activity in DLB patients...
  14. doi request reprint Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disorders
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Neuropharmacology 62:237-46. 2012
    ..The reported increased expression of agmatinase suggests a functional relevance of the enzyme in the pathophysiology of human affective disorders. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  15. ncbi request reprint Differences in activation of the dorsal raphe nucleus depending on performance of suicide
    Hendrik Bielau
    Department of Psychiatry, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Brain Res 1039:43-52. 2005
    ..Antidepressants appear to contribute to cellular activation in the rostral part of the dorsal raphe...
  16. doi request reprint Increased nuclear Olig1-expression in the pregenual anterior cingulate white matter of patients with major depression: a regenerative attempt to compensate oligodendrocyte loss?
    Jennifer Mosebach
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 47:1069-79. 2013
    ..Olig1, an oligodendroglial transcription factor, might be important in this context, but has not been systematically studied so far...
  17. ncbi request reprint S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric study
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Psychiatr Res 42:868-76. 2008
    ..However, no histological study has been published on the cellular distribution of S100B in the brain of individuals with schizophrenia to clarify this hypothesis...
  18. doi request reprint Reduced density of ADAM 12-immunoreactive oligodendrocytes in the anterior cingulate white matter of patients with schizophrenia
    Nadine Farkas
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    World J Biol Psychiatry 11:556-66. 2010
    ..3, a gene locus which has been linked to schizophrenia, and some of its putative substrates are altered in schizophrenia...
  19. ncbi request reprint Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    J Psychiatr Res 42:151-7. 2008
    ..Therefore, the hypothesis of microglial activation during acute psychosis was proposed. Alternatively, "suicide" could be a diagnosis-independent factor leading to microgliosis...
  20. doi request reprint Beacon-like/ubiquitin-5-like immunoreactivity is highly expressed in human hypothalamus and increased in haloperidol-treated schizophrenics and a rat model of schizophrenia
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Psychoneuroendocrinology 33:340-51. 2008
    ..The latter assumption finds some support by data obtained in rats with ventral hippocampus lesion...
  21. ncbi request reprint Hippocampal expression of the calcium sensor protein visinin-like protein-1 in schizophrenia
    Hans Gert Bernstein
    Department of Psychiatry of the University Magdeburg, Leipziger Str 44, D 39120, Germany
    Neuroreport 13:393-6. 2002
    ..In schizophrenics fewer pyramidal cells but more interneurons were immunostained. Our data point to an involvement of the protein in the altered hippocampal circuitry in schizophrenia...
  22. doi request reprint Reduced density of hypothalamic VGF-immunoreactive neurons in schizophrenia: a potential link to impaired growth factor signaling and energy homeostasis
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 262:365-74. 2012
    ..7 kg/m(2)). In conclusion, apart from beneficial effects on synaptic plasticity and neurogenesis, VGF may be linked to schizophrenia-related alterations in energy homeostasis...
  23. ncbi request reprint Dysregulation of GABAergic neurotransmission in mood disorders: a postmortem study
    Hendrik Bielau
    Department of Psychiatry, Psychotherapy, and Psychosomatic Medicine, Otto von Guericke University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:157-69. 2007
    ..Possibly, existing deficits of GABAergic neurotransmission will be compensated or overcompensated by antidepressants. Additionally, albeit speculative, an imbalance between GABA production and transport might be of relevance...
  24. ncbi request reprint Localization of neuregulin-1alpha (heregulin-alpha) and one of its receptors, ErbB-4 tyrosine kinase, in developing and adult human brain
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Germany
    Brain Res Bull 69:546-59. 2006
    ..Our data show that NRG-1alpha expression is lower in the adult human brain than in the developing brain, and, therefore, support a role for NRG-1alpha in brain development...
  25. ncbi request reprint Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Acta Neuropathol 112:305-16. 2006
    ..In conclusion, the present data suggest the absence of microgliosis but decreased cerebral lateralization of ameboid microglia in schizophrenia...
  26. ncbi request reprint ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neurosci Res 75:353-60. 2004
    ..Thus, ADAM12 may be regarded a new suitable marker for this cell type...
  27. pmc ADAM 12: a putative marker of oligodendrogliomas?
    Dimitrios Kanakis
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany aristoteles
    Dis Markers 34:81-91. 2013
    ..From our data showing that ADAM 12 is highly expressed in, but not restricted to, oligodendrogliomas, we conclude that ADAM 12 immunohistochemistry may be a helpful tool in the diagnosis of brain tumours...
  28. ncbi request reprint Strongly reduced number of parvalbumin-immunoreactive projection neurons in the mammillary bodies in schizophrenia: further evidence for limbic neuropathology
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:120-7. 2007
    ..However, in the MB parvalbumin labels a subpopulation of glutamate/aspartate-containing neurons projecting mainly to the anterior thalamus. Thus, our data provide new evidence for impaired limbic circuits in schizophrenia...
  29. doi request reprint Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?
    Stefan Busse
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 26:1273-9. 2012
    ..The identification of diverse immune endophenotypes may facilitate the development of distinct anti-inflammatory schizophrenia therapies to normalize BBB function, (auto)antibody production or microglial activity...
  30. doi request reprint Increased S100B+ NK cell counts in acutely ill schizophrenia patients are correlated with the free cortisol index, but not with S100B serum levels
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Brain Behav Immun 26:564-7. 2012
    ..Notably, elevated S100B+ NK cell counts may be linked with stress axis activation...
  31. doi request reprint Protective effects of haloperidol and clozapine on energy-deprived OLN-93 oligodendrocytes
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 261:477-82. 2011
    ..A new mechanism of antipsychotic action is suggested, which may help to establish new oligodendrocyte-directed therapies of schizophrenia...
  32. doi request reprint A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 261:47-58. 2011
    ..037, r = -0.9). The histopathological abnormality of the decreased neuronal density in the lateral septal nucleus, which is an important limbic region involved in emotions, might be a neuropathological correlate of bipolar disorder...
  33. ncbi request reprint Immunohistochemical evidence for impaired neuregulin-1 signaling in the prefrontal cortex in schizophrenia and in unipolar depression
    Iris Bertram
    Exp Psychiatry Lab, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:147-56. 2007
    ..Reduced NRG-1alpha protein concentrations were found in brains of schizophrenics after Western blot analysis. The diminished expression of NRG-1alpha strongly supports an early neurodevelopmental component to schizophrenia...
  34. ncbi request reprint Increased neurogenesis in a rat ketamine model of schizophrenia
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
    Biol Psychiatry 56:317-22. 2004
    ..While neuron birth is largely completed by the end of gestation, granule neurons of the dentate gyrus are generated throughout life, thus offering an opportunity to investigate neurogenesis postnatally...
  35. ncbi request reprint Volumetric analysis of septal region in schizophrenia and affective disorder
    Ralf Brisch
    Dept of Psychiatry, Psychotherapy and Psychosomatic Medicine, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:140-8. 2007
    ..01) was found, but not in patients with affective disorder (P = 0.53). The finding of enlarged CSP in schizophrenia strongly supports the hypothesis of an early developmental abnormality in this key structure of the limbic system...
  36. pmc Evidence for a wide extra-astrocytic distribution of S100B in human brain
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str, 44, D 39120 Magdeburg, Germany
    BMC Neurosci 8:2. 2007
    ..However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity...
  37. doi request reprint Dopamine-glutamate abnormalities in the frontal cortex associated with the catechol-O-methyltransferase (COMT) in schizophrenia
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Brain Res 1269:166-75. 2009
    ..Our study demonstrates that schizophrenia might involve increased COMT expression in glial cells in the frontal cortex, which might be associated with a neuronal-glial abnormality and a disturbed dopamine-glutamate interaction...
  38. pmc Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    J Neuroinflammation 8:94. 2011
    ..These peripheral immune processes may be accompanied by microglial activation in subregions of the anterior cingulate cortex where depression-associated alterations of glutamatergic neurotransmission have been described...
  39. doi request reprint S100B serum levels are closely correlated with body mass index: an important caveat in neuropsychiatric research
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Psychoneuroendocrinology 35:321-4. 2010
    ..In conclusion, physiological S100B levels in humans appear to closely reflect adipose tissue mass, which should therefore be considered as an important confounding factor in clinical studies examining the role of S100B...
  40. doi request reprint Risperidone and haloperidol promote survival of stem cells in the rat hippocampus
    Gerburg Keilhoff
    Institute of Biochemistry and Cell Biology, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:151-62. 2010
    ....
  41. ncbi request reprint Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia: a replication study
    Peter Danos
    Department of Psychiatry, University Hospital Giessen and Marburg, Location Giessen, Germany
    Psychiatry Res 140:281-9. 2005
    ..Taken together, the present results suggest that schizophrenia is associated with a moderate volume reduction in the left mediodorsal thalamic nucleus, while the neuron density and the total neuron number are unchanged...
  42. doi request reprint Stereologic investigation of the posterior part of the hippocampus in schizophrenia
    Andrea Schmitt
    Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075, Gottingen, Germany
    Acta Neuropathol 117:395-407. 2009
    ....
  43. doi request reprint Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    World J Biol Psychiatry 13:482-92. 2012
    ..It is not clear, however, whether such changes are associated with corresponding neuroinflammatory responses and disturbances of neurotransmission...
  44. doi request reprint Immunohistochemical evidence for impaired nitric oxide signaling of the locus coeruleus in bipolar disorder
    Hendrik Bielau
    Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany
    Brain Res 1459:91-9. 2012
    ..The current data on nNOS suggest a dysregulation of the nitrergic system in bipolar disorder. Future studies may clarify the potential role of glial cells in the context of the described nNOS deficit...
  45. doi request reprint Association between myelin basic protein expression and left entorhinal cortex pre-alpha cell layer disorganization in schizophrenia
    Eleni Parlapani
    Department of Psychiatry, University of Goettingen, Germany
    Brain Res 1301:126-34. 2009
    ..Correlation between reduced MBP as a sign of down-regulated MBP gene expression and disorganization of pre-alpha-cell clusters supports a neurodevelopmental origin of pathological processes in schizophrenia...
  46. doi request reprint Demonstration of decreased activity of dorsal raphe nucleus neurons in depressed suicidal patients by the AgNOR staining method
    Tomasz Gos
    Institute of Forensic Medicine, Medical University of Gdansk, Poland Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    J Affect Disord 111:251-60. 2008
    ..The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of limbic structures crucial for the regulation of emotionally influenced behaviour...
  47. ncbi request reprint Volume deficits of subcortical nuclei in mood disorders A postmortem study
    Hendrik Bielau
    Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 255:401-12. 2005
    ..In conclusion our data suggest that pathways presumably involved in mood regulation have structural pathology in affective disorders with more pronounced abnormalities in bipolar disorder...
  48. ncbi request reprint A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia
    Hans Gert Bernstein
    Department of Psychiatry, Faculty of Medicine, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Schizophr Res 96:246-56. 2007
    ..These observations add to existing evidence for a de-regulation of neuronal Ca(2+)-signaling in schizophrenia...
  49. ncbi request reprint The many faces of nitric oxide in schizophrenia. A review
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Schizophr Res 78:69-86. 2005
    ..Thus, NO and its metabolites are not suitable diagnostic tools to distinguish schizophrenia from psychically healthy control cases or from other brain disorders...
  50. ncbi request reprint Detection of nitric oxide synthase (NOS) immunoreactive neurons in the human septal area: a matter of method?
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Street 44, D 39120 Magdeburg, Germany
    J Chem Neuroanat 27:247-50. 2004
    ..5% glutaraldehyde, followed by sucrose protection of the specimens. We show herein that there are indeed nitric oxide synthase-containing neurons in the human septum, thus supporting results from previous biochemical studies...
  51. doi request reprint Cathepsin K generates enkephalin from beta-endorphin: a new mechanism with possible relevance for schizophrenia
    Uwe Lendeckel
    Institute of Experimental Internal Medicine, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Neurochem Int 54:410-7. 2009
    ....
  52. doi request reprint Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:509-18. 2010
    ..In addition to disease stage or subtype and medication, cigarette smoking and stress are important co-factors...
  53. doi request reprint The volumes of the fornix in schizophrenia and affective disorders: a post-mortem study
    Ralf Brisch
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Psychiatry Res 164:265-73. 2008
    ....
  54. doi request reprint Increased density of GAD65/67 immunoreactive neurons in the posterior subiculum and parahippocampal gyrus in treated patients with chronic schizophrenia
    Stefanie Schreiber
    Department of Neurology, University of Magdeburg, Magdeburg, Germany
    World J Biol Psychiatry 12:57-65. 2011
    ..While GAD has been studied in several brain regions, its expression in the posterior hippocampus formation has not been investigated in schizophrenia...
  55. ncbi request reprint Volumetric analysis of the hypothalamus, amygdala and hippocampus in non-suicidal and suicidal mood disorder patients--a post-mortem study
    Hendrik Bielau
    Department of Psychiatry and Psychotherapy, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    CNS Neurol Disord Drug Targets 12:914-20. 2013
    ..The detected differences between suicidal and non-suicidal patients suggest that suicidal performances might be related to the degree of structural deficits. ..
  56. ncbi request reprint Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain
    Hans Gert Bernstein
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    J Histochem Cytochem 51:1109-12. 2003
    ..Therefore, one prerequisite for functional studies in rodent models aimed at elucidation of mechanisms with relevance for humans can be based on the present findings...
  57. ncbi request reprint Volumes of association thalamic nuclei in schizophrenia: a postmortem study
    Peter Danos
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Schizophr Res 60:141-55. 2003
    ..However, the findings of a substantial volume reduction of the THAL suggest that the volumes of additional thalamic nuclei may be also reduced in schizophrenia...
  58. ncbi request reprint Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha
    Georg Reiser
    Klinik fur Psychiatrie, Psychotherapie und Psychosomatische Medizin, Medizinische Fakultat, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Neuroreport 13:2417-9. 2002
    ..Therefore proteins such as p42(IP4), central players in signaling, may be appropriate targets for preventing neurodegenerative processes...
  59. ncbi request reprint Cell proliferation is influenced by bulbectomy and normalized by imipramine treatment in a region-specific manner
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany
    Neuropsychopharmacology 31:1165-76. 2006
    ..Further to this, we discuss a possible link between the pathogenesis of depression and changed neuronal plasticity in the SVZ...
  60. ncbi request reprint Brain region-specific changes in the expression of calcium sensor proteins after repeated applications of ketamine to rats
    Hans Gert Bernstein
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, D 39120, Magdeburg, Germany
    Neurosci Lett 339:95-8. 2003
    ..G., Braunewell, K.-H., Spilker, C., Danos, P., Baumann, B., Funke, S., Diekmann, S., Gundelfinger, E.D. and Bogerts, B., NeuroReport, 13 (2002) 393-396]...
  61. pmc S100B Serum Levels in Schizophrenia Are Presumably Related to Visceral Obesity and Insulin Resistance
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Cardiovasc Psychiatry Neurol 2010:480707. 2010
    ....
  62. doi request reprint Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    JAMA Psychiatry 70:271-8. 2013
    ....
  63. doi request reprint S100B protein in neurodegenerative disorders
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Clin Chem Lab Med 49:409-24. 2011
    ..Moreover, there is no consistent evidence for a correlation between disease severity and concentrations of S100B in CSF or serum. Therefore, S100B has limited usefulness for monitoring disease progression...
  64. doi request reprint Decrease of serum S100B during an oral glucose tolerance test correlates inversely with the insulin response
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany Center for Behavioral Brain Sciences, Magdeburg, Germany Electronic address
    Psychoneuroendocrinology 39:33-8. 2014
    ..To improve comparability between clinical studies assessing conditions with rather mild changes of serum S100B, blood should be taken in a more standardized way (e.g., after fasting overnight)...
  65. ncbi request reprint The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain
    Hans Gert Bernstein
    Department of Psychiatry, Faculty of Medicine, Otto von Guericke University, Magdeburg, Germany
    Brain Res 1134:107-12. 2007
    ..In addition we found no segregation of np65 immunolabel in hippocampal subregions like it was reported previously for the rat. These results might indicate different cellular functions of the molecule in different species...
  66. ncbi request reprint The ventral lateral posterior nucleus of the thalamus in schizophrenia: a post-mortem study
    Peter Danos
    Department of Psychiatry, University of Magdeburg, Leipziger Str 44, 39120, Magdeburg, Germany
    Psychiatry Res 114:1-9. 2002
    ..The present results suggest that the total neuron number of the left VLp is reduced in the schizophrenia group, which may reflect disturbed cerebello-thalamocortical and basal ganglia-thalamocortical circuits in this disease...
  67. ncbi request reprint Differential distribution of spermidine/spermine-like immunoreactivity in neurons of the adult rat brain
    Gregor Laube
    Institute for Medical Neurobiology, Medical Faculty, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 444:369-86. 2002
    ..The prominent localization of spermidine/spermine in neurosecretory neurons might point to a functional role different from channel/receptor modification. In these neurons, polyamines might be involved in secretory processes...
  68. doi request reprint A new pathophysiological aspect of S100B in schizophrenia: potential regulation of S100B by its scavenger soluble RAGE
    Johann Steiner
    Department of Psychiatry, University of Magdeburg, Germany
    Biol Psychiatry 65:1107-10. 2009
    ..Our study focused on its scavenger, soluble receptor for advanced glycation end products (sRAGE). Given the benefits of sRAGE in metabolic and inflammatory diseases, we hypothesized a similar effect in schizophrenia...