M Oppermann

Summary

Country: Germany

Publications

  1. pmc Systemic complement activation in age-related macular degeneration
    Hendrik P N Scholl
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    PLoS ONE 3:e2593. 2008
  2. doi request reprint Modern determination of complement activation
    Martin Oppermann
    Abteilung Zelluläre und Molekulare Immunologie, Zentrum für Hygiene und Humangenetik, Humboldtallee 34, Gottingen, Germany
    Semin Thromb Hemost 36:611-9. 2010
  3. ncbi request reprint Chemokine receptor CCR5: insights into structure, function, and regulation
    Martin Oppermann
    Department of Immunology, Georg August University Gottingen, Kreuzbergring 57, 37075, Germany
    Cell Signal 16:1201-10. 2004
  4. ncbi request reprint Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus
    M Oppermann
    Department of Immunology, University of Gottingen, 37075 Gottingen, Germany
    J Biol Chem 274:8875-85. 1999
  5. ncbi request reprint Quantitation of components of the alternative pathway of complement (APC) by enzyme-linked immunosorbent assays
    M Oppermann
    Department of Immunology, University of Gottingen, F R G
    J Immunol Methods 133:181-90. 1990
  6. ncbi request reprint Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization
    K Kraft
    Department of Immunology, University of Gottingen, 37075 Gottingen, Germany
    J Biol Chem 276:34408-18. 2001
  7. ncbi request reprint Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis
    M Mohr
    Department of Anaesthesiology, Critical Care and Emergency Medicine, University of Goettingen, Germany
    Eur J Clin Invest 28:227-34. 1998
  8. ncbi request reprint Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis
    Evgeni Ponimaskin
    Abteilung Neuro und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, Germany
    Mol Pharmacol 67:1434-43. 2005
  9. ncbi request reprint G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers
    Friederike Huttenrauch
    Department of Cellular and Molecular Immunology, Georg August University, Gottingen, Germany
    J Biol Chem 280:37503-15. 2005
  10. pmc The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein
    M Oppermann
    Department of Immunology, University of Gottingen, Gottingen, Germany
    Clin Exp Immunol 144:342-52. 2006

Collaborators

Detail Information

Publications24

  1. pmc Systemic complement activation in age-related macular degeneration
    Hendrik P N Scholl
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    PLoS ONE 3:e2593. 2008
    ..Furthermore, the data provide evidence for an association of systemic activation of the alternative complement pathway with genetic variants of CFH that were previously linked to AMD susceptibility...
  2. doi request reprint Modern determination of complement activation
    Martin Oppermann
    Abteilung Zelluläre und Molekulare Immunologie, Zentrum für Hygiene und Humangenetik, Humboldtallee 34, Gottingen, Germany
    Semin Thromb Hemost 36:611-9. 2010
    ..Several confounding factors also have to be taken into account to allow a correct interpretation of the results...
  3. ncbi request reprint Chemokine receptor CCR5: insights into structure, function, and regulation
    Martin Oppermann
    Department of Immunology, Georg August University Gottingen, Kreuzbergring 57, 37075, Germany
    Cell Signal 16:1201-10. 2004
    ..This review discusses recent advances in the elucidation of the structure and function of CCR5, as well as the complex mechanisms that regulate CCR5 signalling and cell surface expression...
  4. ncbi request reprint Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus
    M Oppermann
    Department of Immunology, University of Gottingen, 37075 Gottingen, Germany
    J Biol Chem 274:8875-85. 1999
    ..This study demonstrates that chemokines differ in their ability to induce CCR5 phosphorylation and desensitization and provides a molecular mechanism for the agonist-induced attenuation of CCR5 signaling...
  5. ncbi request reprint Quantitation of components of the alternative pathway of complement (APC) by enzyme-linked immunosorbent assays
    M Oppermann
    Department of Immunology, University of Gottingen, F R G
    J Immunol Methods 133:181-90. 1990
    ..The latter should permit the quantitation of other complement split products...
  6. ncbi request reprint Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization
    K Kraft
    Department of Immunology, University of Gottingen, 37075 Gottingen, Germany
    J Biol Chem 276:34408-18. 2001
    ..Together these results indicate that post-translational modifications of carboxyl-terminal serine and cysteine residues have a significant impact on receptor deactivation and internalization...
  7. ncbi request reprint Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis
    M Mohr
    Department of Anaesthesiology, Critical Care and Emergency Medicine, University of Goettingen, Germany
    Eur J Clin Invest 28:227-34. 1998
    ..We analysed the effects of complement depletion and of C5a inhibition on haemodynamic parameters, oxygen delivery (DO2), oxygen consumption (VO2), oxygen extraction ratio (OER) and blood lactate levels after live bacteria infusion in pigs...
  8. ncbi request reprint Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis
    Evgeni Ponimaskin
    Abteilung Neuro und Sinnesphysiologie, Physiologisches Institut, Universitat Gottingen, Germany
    Mol Pharmacol 67:1434-43. 2005
    ....
  9. ncbi request reprint G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers
    Friederike Huttenrauch
    Department of Cellular and Molecular Immunology, Georg August University, Gottingen, Germany
    J Biol Chem 280:37503-15. 2005
    ..These results show that GRKs and beta-arrestin are involved in heterologous receptor regulation by cross-phosphorylating and co-internalizing unligated receptors within homo- or hetero-oligomeric protein complexes...
  10. pmc The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein
    M Oppermann
    Department of Immunology, University of Gottingen, Gottingen, Germany
    Clin Exp Immunol 144:342-52. 2006
    ....
  11. ncbi request reprint Detection of the CCR5-Delta32 HIV resistance gene in Bronze Age skeletons
    S Hummel
    Historic Anthropology and Human Ecology, Institute of Zoology and Anthropology, Georg August University, Gottingen, Germany
    Genes Immun 6:371-4. 2005
    ..The results also argue against the possibility of plague representing a major selective force that caused rapid increase in CCR5-Delta32 gene frequencies within these populations...
  12. ncbi request reprint Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif
    Friederike Huttenrauch
    Department of Immunology, University of Gottingen, Kreuzbergring 57, 37075 Gottingen, Germany
    J Biol Chem 277:30769-77. 2002
    ..These results suggest that a conserved sequence motif within the second intracellular loop of CCR5 that is known to be involved in G protein activation plays a significant role in beta-arrestin binding to CCR5...
  13. ncbi request reprint Elevated plasma levels of the immunosuppressive complement fragment Ba in renal failure
    M Oppermann
    Department of Immunology, University of Gottingen, Germany
    Kidney Int 40:939-47. 1991
    ..These results suggest that the accumulation of Ba contributes to the defective immune response in patients with renal failure...
  14. ncbi request reprint Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. Identification of a potential ligand binding site on the NH2-terminal domain
    M Oppermann
    Department of Immunology, University of Gottingen, FRG
    J Immunol 151:3785-94. 1993
    ..These results imply that an amino acid sequence rich in aspartate within the receptor aminoterminus represents both an immunodominant epitope and a ligand binding site on the C5aR...
  15. ncbi request reprint Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies
    Beatrix Pollok-Kopp
    Department of Immunology, Georg August University, 37075 Gottingen, Germany
    J Biol Chem 278:2190-8. 2003
    ....
  16. pmc Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors
    M Oppermann
    Department of Immunology, University of Gottingen, Germany
    Immunology 82:516-21. 1994
    ..The binding of the C5a anaphylatoxin to cellular receptors represents an effective control mechanism that protects the organism from systemic effects of this potent phlogistic mediator...
  17. ncbi request reprint pH-independent endocytic cycling of the chemokine receptor CCR5
    Nathalie Signoret
    Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
    Traffic 5:529-43. 2004
    ..Our data show that exposure to low pH is not required for RANTES or MIP-1beta dissociation from CCR5, or for recycling of internalised CCR5 to the cell surface...
  18. pmc Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor
    Elena S Suvorova
    Department of Microbiology, Montana State University, Bozeman, MT 59717, USA
    Biochim Biophys Acta 1783:1261-70. 2008
    ..Our studies support a model in which the L318/L319 stabilizes an amphipathic helix (Q305-R320) in the membrane-proximal region of C5aR...
  19. ncbi request reprint Dynamics of protein kinase C-mediated phosphorylation of the complement C5a receptor on serine 334
    Beatrix Pollok-Kopp
    Department of Cellular and Molecular Immunology, Georg August University, 37073 Gottingen, Germany
    J Biol Chem 282:4345-53. 2007
    ....
  20. pmc Agonist-induced endocytosis of CC chemokine receptor 5 is clathrin dependent
    Nathalie Signoret
    Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
    Mol Biol Cell 16:902-17. 2005
    ..However, sequestration of cholesterol with filipin interferes with agonist binding to CCR5, suggesting that cholesterol and/or lipid raft domains play some role in the events required for CCR5 activation before internalization...
  21. ncbi request reprint Surface expression and endocytosis of the human cytomegalovirus-encoded chemokine receptor US28 is regulated by agonist-independent phosphorylation
    Thilo Mokros
    Max Delbruck Center for Molecular Medicine, Department of Tumorgenetics and Immunogenetics, Berlin, Germany
    J Biol Chem 277:45122-8. 2002
    ..Thus, constitutive US28 phosphorylation regulates receptor endocytosis and receptor surface display and may thereby provide a pathogenic mechanism for a potential decoy function of the virally encoded receptor...
  22. ncbi request reprint Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis
    Bernard Lagane
    Institut Pasteur, Unite d Immunologie Virale, 28 rue du Dr Roux, 75015 Paris, France
    Mol Pharmacol 67:1966-76. 2005
    ..These results have implications for how distinct biological responses of CCR5 might rely on a different set of receptor conformations...
  23. ncbi request reprint Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome
    Mihaly Jozsi
    Junior Research Group Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany
    Blood 110:1516-8. 2007
    ..These results suggest that aHUS-associated FH autoantibodies mimic the effect of C-terminal FH mutations, as they inhibit the regulatory function of FH at cell surfaces by blocking its C-terminal recognition region...
  24. ncbi request reprint Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
    Gastroenterology 131:1518-29. 2006
    ..Furthermore, although clinical trials to evaluate the efficacy of targeting the CCL25/CCR9 axis for the treatment of Crohn's disease are being conducted, preclinical data in animal models of IBD are lacking...