Vasilis Ntziachristos

Summary

Country: Germany

Publications

  1. doi request reprint Going deeper than microscopy: the optical imaging frontier in biology
    Vasilis Ntziachristos
    Institute for Biological and Medical Imaging, Helmholtz Zentrum München und Technische Universität München, Munich, Germany
    Nat Methods 7:603-14. 2010
  2. doi request reprint Optoacoustic imaging for clinical applications: devices and methods
    Alexander Dima
    Institute for Biological and Medical Imaging, Chair for Biological Imaging, Technische Univeristät München and Helmholtz Zentrum München, Munich, Germany
    Expert Opin Med Diagn 5:263-72. 2011
  3. doi request reprint Optical and opto-acoustic imaging
    Vasilis Ntziachristos
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Munich, Germany
    Recent Results Cancer Res 187:133-50. 2013
  4. ncbi request reprint Opto-acoustic imaging of drug discovery biomarkers
    Bohumil Bednar
    Department of Imaging, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486 0004, USA
    Curr Pharm Biotechnol 13:2117-27. 2012
  5. pmc Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging
    Sonu Bhaskar
    Comprehensive Pneumology Centre, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Part Fibre Toxicol 7:3. 2010
  6. doi request reprint Current concepts and future perspectives on surgical optical imaging in cancer
    Vasilis Ntziachristos
    Institute for Biological and Medical Imaging, Munich, Germany
    J Biomed Opt 15:066024. 2010
  7. doi request reprint Clinical translation of optical and optoacoustic imaging
    Vasilis Ntziachristos
    Biological Imaging and Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Munich, Germany
    Philos Trans A Math Phys Eng Sci 369:4666-78. 2011
  8. pmc Optical imaging of molecular signatures in pulmonary inflammation
    Vasilis Ntziachristos
    Institute for Biological and Medical Imaging, Helmholtz Zentrum München and Technische Universität München, Munich, Germany
    Proc Am Thorac Soc 6:416-8. 2009
  9. doi request reprint Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography
    Eva Herzog
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Neuherberg, Germany
    Radiology 263:461-8. 2012
  10. doi request reprint Fast automatic segmentation of anatomical structures in x-ray computed tomography images to improve fluorescence molecular tomography reconstruction
    Marcus Freyer
    Technical University Munich, Biological Imaging, Munich, Germany
    J Biomed Opt 15:036006. 2010

Collaborators

Detail Information

Publications67

  1. doi request reprint Going deeper than microscopy: the optical imaging frontier in biology
    Vasilis Ntziachristos
    Institute for Biological and Medical Imaging, Helmholtz Zentrum München und Technische Universität München, Munich, Germany
    Nat Methods 7:603-14. 2010
    ..Key characteristics associated with different imaging implementations are described and the potential of these technologies in biological applications is discussed...
  2. doi request reprint Optoacoustic imaging for clinical applications: devices and methods
    Alexander Dima
    Institute for Biological and Medical Imaging, Chair for Biological Imaging, Technische Univeristät München and Helmholtz Zentrum München, Munich, Germany
    Expert Opin Med Diagn 5:263-72. 2011
    ..These up-and-coming features offer a wider variety of optoacoustic approaches that are likely to be clinically deployed in the near future...
  3. doi request reprint Optical and opto-acoustic imaging
    Vasilis Ntziachristos
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Munich, Germany
    Recent Results Cancer Res 187:133-50. 2013
    ..These new-found imaging abilities directly relate to preclinical screening applications in animal models and are foreseen to significantly impact clinical decision making as well...
  4. ncbi request reprint Opto-acoustic imaging of drug discovery biomarkers
    Bohumil Bednar
    Department of Imaging, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486 0004, USA
    Curr Pharm Biotechnol 13:2117-27. 2012
    ....
  5. pmc Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging
    Sonu Bhaskar
    Comprehensive Pneumology Centre, Institute of Lung Biology and Disease, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Part Fibre Toxicol 7:3. 2010
    ....
  6. doi request reprint Current concepts and future perspectives on surgical optical imaging in cancer
    Vasilis Ntziachristos
    Institute for Biological and Medical Imaging, Munich, Germany
    J Biomed Opt 15:066024. 2010
    ..Key future directions that have the potential to shift the paradigm of surgical health care are also discussed...
  7. doi request reprint Clinical translation of optical and optoacoustic imaging
    Vasilis Ntziachristos
    Biological Imaging and Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Munich, Germany
    Philos Trans A Math Phys Eng Sci 369:4666-78. 2011
    ..This performance is showcased herein and examples are given to illustrate how it is possible to shift the paradigm of optical clinical translation...
  8. pmc Optical imaging of molecular signatures in pulmonary inflammation
    Vasilis Ntziachristos
    Institute for Biological and Medical Imaging, Helmholtz Zentrum München and Technische Universität München, Munich, Germany
    Proc Am Thorac Soc 6:416-8. 2009
    ..Overall, the proposed imaging method can be used with a significantly wider range of possible targets and applications in lung imaging...
  9. doi request reprint Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography
    Eva Herzog
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Neuherberg, Germany
    Radiology 263:461-8. 2012
    ..To investigate whether multispectral optoacoustic tomography (MSOT) can reveal the heterogeneous distributions of exogenous agents of interest and vascular characteristics through tumors of several millimeters in diameter in vivo...
  10. doi request reprint Fast automatic segmentation of anatomical structures in x-ray computed tomography images to improve fluorescence molecular tomography reconstruction
    Marcus Freyer
    Technical University Munich, Biological Imaging, Munich, Germany
    J Biomed Opt 15:036006. 2010
    ..The algorithm and its utilization in an inverse FMT scheme that uses priors is demonstrated on mouse images...
  11. doi request reprint Weighted model-based optoacoustic reconstruction in acoustic scattering media
    X Luís Dean-Ben
    Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Ingolstädter Landstraße 1, D 85764 Neuherberg, Germany
    Phys Med Biol 58:5555-66. 2013
    ..The statistically-based weighting is subsequently verified experimentally, attaining quality improvement of the optoacoustic image reconstructions in the presence of acoustic mismatches in tissue phantoms and small animals ex-vivo. ..
  12. doi request reprint In vivo frequency domain optoacoustic tomography
    Stephan Kellnberger
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Neuherberg, Germany
    Opt Lett 37:3423-5. 2012
    ..The method developed demonstrated the ability to produce tomographic images of optical absorbing phantoms and in vivo images, by enabling visualization of the mouse tail following ICG injection...
  13. doi request reprint Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization
    Neal C Burton
    Institute for Biological and Medical Imaging, Helmholtz Center Munich, Neuherberg, Germany
    Neuroimage 65:522-8. 2013
    ..We also demonstrate how MSOT offers several compelling features for brain research and allows time-dependent detection and quantification of brain parameters that are not available using other imaging methods without invasive procedures...
  14. doi request reprint Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography
    X Luís Dean-Ben
    Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Neuherberg, Germany
    IEEE Trans Med Imaging 31:1922-8. 2012
    ..Superior performance versus commonly-used backprojection inversion algorithms is showcased by numerical simulations and phantom experiments...
  15. ncbi request reprint Model-based optoacoustic inversions with incomplete projection data
    Andreas Buehler
    Institute for Biological and Medical Imaging, Technische Universität München und Helmholtz Zentrum München, Ingoldstädter Landstrafsse 1, D 85764 Neuherberg, Germany
    Med Phys 38:1694-704. 2011
    ..In many tomographic imaging scenarios, however, only limited-view or partial projection data are available, which has been shown to generate image artifacts and overall loss of quantification accuracy...
  16. doi request reprint Acceleration of optoacoustic model-based reconstruction using angular image discretization
    X Luís Dean-Ben
    Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    IEEE Trans Med Imaging 31:1154-62. 2012
    ..It is further anticipated that the new approach will greatly facilitate development of high performance 3-D optoacoustic reconstruction methods...
  17. pmc Fast multispectral optoacoustic tomography (MSOT) for dynamic imaging of pharmacokinetics and biodistribution in multiple organs
    Adrian Taruttis
    Institute for Biological and Medical Imaging, Helmholtz Zentrum Munich, Technical University Munich, Munich, Germany
    PLoS ONE 7:e30491. 2012
    ..Overall, such imaging performance introduces previously undocumented capabilities of fast, high resolution in vivo imaging of the fate of optical agents for drug discovery and basic biological research...
  18. doi request reprint Fast semi-analytical model-based acoustic inversion for quantitative optoacoustic tomography
    Amir Rosenthal
    Institute for Biological and Medical Imaging, and Chair for Biological Imaging, Technische Universität of München and Helmholtz Zentrum München, 85764 Neuherberg, Germany
    IEEE Trans Med Imaging 29:1275-85. 2010
    ....
  19. doi request reprint Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer
    Angelique Ale
    Technische Universität München and Helmholtz Zentrum München, Institute for Biological and Medical Imaging, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    J Biomed Opt 18:56006. 2013
    ..We conclude with the benefits of employing fluorescence subtraction in hybrid FMT-XCT for early detection studies...
  20. doi request reprint Translational optical imaging
    Adrian Taruttis
    Institute for Biological and Medical Imaging, Helmholtz Zentrum Munchen, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    AJR Am J Roentgenol 199:263-71. 2012
    ....
  21. doi request reprint Real-time intraoperative fluorescence imaging system using light-absorption correction
    George Themelis
    Technische Universitat Munchen, Institute for Biological and Medical Imaging, Arcisstrasse 21, 80333 München, Germany
    J Biomed Opt 14:064012. 2009
    ....
  22. ncbi request reprint Imaging performance of a hybrid x-ray computed tomography-fluorescence molecular tomography system using priors
    Angelique Ale
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Med Phys 37:1976-86. 2010
    ..The unique data set studied attains accurately registered data of high spatially sampled photon fields propagating through tissue along 360 degrees projections...
  23. doi request reprint Multispectral optoacoustic tomography by means of normalized spectral ratio
    Thomas Jetzfellner
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Ingolstaedter Landstr 1, 85764 Neuherberg, Germany
    Opt Lett 36:4176-8. 2011
    ..Herein we introduce a spectral ratio approach that accounts for photon fluence variations. The performance and imaging improvement achieved with the proposed method is showcased both numerically and experimentally in phantoms and mice...
  24. doi request reprint Enhancing surgical vision by using real-time imaging of αvβ3-integrin targeted near-infrared fluorescent agent
    George Themelis
    Institute for Biological and Medical Imaging IBMI, Technische Universität München and Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, Neuherberg, Germany
    Ann Surg Oncol 18:3506-13. 2011
    ..Via the use of targeted probes it also becomes highly tumor-specific and can lead to significant improvements in surgical procedures and outcome...
  25. doi request reprint Ex-vivo assessment and non-invasive in vivo imaging of internal hemorrhages in Aga2/+ mutant mice
    Vladimir Ermolayev
    Institute for Biological and Medical Imaging, Helmholtz Zentrum Munchen, Building 56, Ingolstädter Landstraße 1, D 85764 Neuherberg, Germany
    Biochem Biophys Res Commun 432:389-93. 2013
    ..The disease phenotype was characterized on Aga2/+ vs. wild type mice between 6 and 9 days postnatal. Anatomical and functional findings obtained in-vivo were contrasted to the ex-vivo appearance of the same tissues under cryo-slicing...
  26. doi request reprint Improving limited-projection-angle fluorescence molecular tomography using a co-registered x-ray computed tomography scan
    Karin Radrich
    Institute for Biological and Medical Imaging, Helmholtz Zentrum Munchen, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    J Biomed Opt 17:126011. 2012
    ..This work relates to currently disseminated FMT systems, using limited projection scans, and can be employed to enhance their performance...
  27. ncbi request reprint Polarization-sensitive optoacoustic tomography of optically diffuse tissues
    Daniel Razansky
    Institute for Biological and Medical Imaging, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Opt Lett 33:2308-10. 2008
    ..The technique is expected to enable highly accurate imaging of polarization contrast in tissues, far beyond the current capabilities of pure optical polarization-imaging approaches...
  28. doi request reprint Blind source unmixing in multi-spectral optoacoustic tomography
    Jürgen Glatz
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Munich, Germany
    Opt Express 19:3175-84. 2011
    ..We further demonstrate its capacity with temporal unmixing on real-time MSOT data obtained in-vivo for enhancing the visualization of absorber agent flow in the mouse vascular system...
  29. ncbi request reprint Near-field radiofrequency thermoacoustic tomography with impulse excitation
    Daniel Razansky
    Institute for Biological and Medical Imaging IBMI, Technische Universität München and Helmholtz Zentrum München, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
    Med Phys 37:4602-7. 2010
    ..However, existing implementations are based on modulated-carrier-frequency amplification solutions, which are generally costly and cannot achieve ultrahigh-peak-power requirements essential for optimal thermoacoustic signal generation...
  30. doi request reprint Efficient framework for model-based tomographic image reconstruction using wavelet packets
    Amir Rosenthal
    Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Neuherberg, Germany
    IEEE Trans Med Imaging 31:1346-57. 2012
    ..The performance of the new methodology is demonstrated for the case of 2-D optoacoustic tomography for both numerically generated and experimental data...
  31. doi request reprint Near-field thermoacoustic imaging with transmission line pulsers
    Murad Omar
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Ingolstädter Landstr 1, Neuherberg, Germany
    Med Phys 39:4460-6. 2012
    ..This work aimed at investigating transmission lines as a method to generate excitation pulses to improve the NRT resolution over previous implementations without compromising the energy coupled into tissue...
  32. doi request reprint Motion clustering for deblurring multispectral optoacoustic tomography images of the mouse heart
    Adrian Taruttis
    Helmholtz Zentrum München and Technische Universtität München, Institute for Biological and Medical Imaging, 85764 Neuherberg, Germany
    J Biomed Opt 17:016009. 2012
    ..The correction method presented could be generally applied to other MSOT imaging applications prone to motion artifacts, for example, by respiration and heartbeat...
  33. pmc Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques
    Daniel Razansky
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Munich, Germany
    Mol Imaging Biol 14:277-85. 2012
    ..This study is aimed at demonstrating a new method with high potential for noninvasive clinical cardiovascular diagnostics of vulnerable plaques using high-resolution deep-tissue multispectral optoacoustic tomography (MSOT) technology...
  34. doi request reprint Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging
    Rui Ma
    Institute for Biological and Medical Imaging, Technical University of Munich, Neuherberg, Germany
    Opt Express 17:21414-26. 2009
    ..The system performance is determined in phantom experiments involving molecular probes and validated by imaging of small animals of various scales...
  35. doi request reprint Reconstruction of fluorescence distribution hidden in biological tissue using mesoscopic epifluorescence tomography
    Saskia Björn
    Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    J Biomed Opt 16:046005. 2011
    ..Furthermore, we present ex vivo data that show high spatial resolution and quantitative accuracy in heterogeneous tissues using GFP-like fluorescence in B6-albino mice up to a depth of 1100 μm...
  36. doi request reprint The effects of acoustic attenuation in optoacoustic signals
    X Luís Dean-Ben
    Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Phys Med Biol 56:6129-48. 2011
    ..The validity and benefits of the suggested modelling and correction approaches are experimentally validated in phantom measurements...
  37. doi request reprint Statistical approach for optoacoustic image reconstruction in the presence of strong acoustic heterogeneities
    X Luís Dean-Ben
    Institute for Biological and Medical Imaging, Technical University of Munich, Neuherberg, Germany
    IEEE Trans Med Imaging 30:401-8. 2011
    ..This performance is directly related to in vivo small animal imaging applications involving imaging in the presence of bones, lungs, and other highly mismatched organs...
  38. ncbi request reprint Model-based optoacoustic inversion with arbitrary-shape detectors
    Amir Rosenthal
    Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, 85764 Neuherberg, Germany
    Med Phys 38:4285-95. 2011
    ..This effect may lead to attenuation or distortion in the recorded signal and, consequently, in the reconstructed image...
  39. doi request reprint Volumetric real-time multispectral optoacoustic tomography of biomarkers
    Daniel Razansky
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Neuherberg, Germany
    Nat Protoc 6:1121-9. 2011
    ..Overall, the entire protocol can be completed within 15-30 min for acquisition of a whole-body multispectral data set from a living mouse...
  40. doi request reprint Spatiotemporal analysis for indocyanine green-aided imaging of rheumatoid arthritis in hand joints
    Pouyan Mohajerani
    Technische Universität München and Helmholtz Zentrum München, Institute for Biological and Medical Imaging, Ingolstadter Landstrasse 1, Neuherberg 85764, Germany
    J Biomed Opt 18:097004. 2013
    ....
  41. doi request reprint Concurrent video-rate color and near-infrared fluorescence laparoscopy
    Jürgen Glatz
    Technical University Munich, Chair for Biological Imaging, Munich, Germany
    J Biomed Opt 18:101302. 2013
    ....
  42. doi request reprint Enriching the interventional vision of cancer with fluorescence and optoacoustic imaging
    P Beatriz Garcia-Allende
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Munich, Germany
    J Nucl Med 54:664-7. 2013
    ..We present an overview of key recent developments in optical interventional imaging and outline the potential for a paradigm shift in surgical and endoscopic visualization...
  43. doi request reprint Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers
    X Luís Dean-Ben
    Technical University of Munich and Helmholtz Center Munich, Institute for Biological and Medical Imaging, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    J Biomed Opt 17:110504. 2012
    ..Experimental results in a tissue-mimicking phantom clearly demonstrate improved performance as compared to the case in which no information on the distribution of acoustic scatterers is available...
  44. ncbi request reprint Deep tissue optical and optoacoustic molecular imaging technologies for pre-clinical research and drug discovery
    Daniel Razansky
    Institute for Biological and Medical Imaging IBMI, Technische Universität München and Helmholtz Zentrum München, Ingolstädter Landstraβe 1, 85764 Neuherberg, Germany
    Curr Pharm Biotechnol 13:504-22. 2012
    ....
  45. doi request reprint FMT-XCT: in vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography
    Angelique Ale
    Technische Universität München and Helmholtz Zentrum München, Institute for Biological and Medical Imaging, Neuherberg, Germany
    Nat Methods 9:615-20. 2012
    ..These findings indicate that addition of FMT optics into the XCT gantry may be a potent upgrade for small-animal XCT systems...
  46. doi request reprint Revisiting the normalized Born approximation: effects of scattering
    Thomas Pyka
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Neuherberg, Germany
    Opt Lett 36:4329-31. 2011
    ....
  47. doi request reprint In vivo imaging of CT26 mouse tumours by using cmHsp70.1 monoclonal antibody
    Stefan Stangl
    Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universitat Munchen, and Clinical Cooperation Group CCG Innate Immunity in Tumor Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health HMGU, Munich, Germany
    J Cell Mol Med 15:874-87. 2011
    ..The anti-tumoral activity of the cmHsp70.1 mAb is further supported by its capacity to mediate antibody-dependent cytotoxicity...
  48. doi request reprint Near-field thermoacoustic tomography of small animals
    Stephan Kellnberger
    Institute for Biological and Medical Imaging IBMI, Technische Universität München and Helmholtz Zentrum München, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Phys Med Biol 56:3433-44. 2011
    ..The best spatial resolution achieved for those experiments was 150 µm...
  49. doi request reprint Video rate optoacoustic tomography of mouse kidney perfusion
    Andreas Buehler
    Institute for Biological and Medical Imaging, Technische Universität München und Helmholtz Zentrum München, Ingoldstädter Landstrasse 1, 85764 Neuherberg, Germany
    Opt Lett 35:2475-7. 2010
    ..The previously undocumented capacity of whole-body optoacoustic tomography at a video rate has been demonstrated by visualizing mouse kidney perfusion using Indocyanine Green in vivo...
  50. doi request reprint Near-infrared fluorescence cholangiopancreatoscopy: initial clinical feasibility results
    Jürgen Glatz
    Technical University of Munich, Munich, Germany
    Gastrointest Endosc 79:664-8. 2014
    ..The recent clinical propagation of targeted fluorescence agents brings a promising alternative in endoscopy by complementing visual disease detection with molecular biomarkers...
  51. doi request reprint Raster-scan optoacoustic mesoscopy in the 25-125 MHz range
    Murad Omar
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Neuherberg, Germany
    Opt Lett 38:2472-4. 2013
    ..We demonstrate the limits reached due to the width of the laser pulse employed and showcase the technique on drosophila fly and drosophila pupae ex vivo...
  52. doi request reprint Real-time handheld multispectral optoacoustic imaging
    Andreas Buehler
    Institute for Biological and Medical Imaging, Helmholtz Zentrum Munchen, Neuherberg 85764, Germany
    Opt Lett 38:1404-6. 2013
    ..In this Letter, we demonstrate its clinical potential by dynamically resolving multiple disease-relevant tissue chromophores, including oxy-/deoxyhemoglobin, and melanin, in human volunteers...
  53. doi request reprint Non-invasive carotid imaging using optoacoustic tomography
    Alexander Dima
    Institute for Biological and Medical Imaging, Technische Universität München und Helmholtz Zentrum München, Ingoldstädter Landstrasse 1, 85764 Neuherberg, Germany
    Opt Express 20:25044-57. 2012
    ..Instead, feasibility to detect human carotids and carotid-sized vessels in clinically-relevant depths is better demonstrated with curved arrays and tomographic approaches...
  54. pmc High resolution tumor targeting in living mice by means of multispectral optoacoustic tomography
    Andreas Buehler
    Institute for Biological and Medical Imaging, Technische Universität München und Helmholtz Zentrum München, Ingoldstädter Landstraße 1, Neuherberg 85764, Germany
    EJNMMI Res 2:14. 2012
    ..abstract:..
  55. doi request reprint Imaging the bio-distribution of fluorescent probes using multispectral epi-illumination cryoslicing imaging
    Athanasios Sarantopoulos
    Chair for Biological Imaging, Technische Universitat Munchen, Munich, Germany
    Mol Imaging Biol 13:874-85. 2011
    ..However, the validation of probe bio-distribution during their development or the study of different disease models, in support of in vivo imaging studies, is not straightforward...
  56. doi request reprint Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography
    Rui Ma
    Technical University of Munich, Ingolstädter Landstraße 1, Neuherberg, Germany
    Phys Med Biol 57:7227-37. 2012
    ....
  57. doi request reprint Quantitative optoacoustic signal extraction using sparse signal representation
    Amir Rosenthal
    Institute for Biological and Medical Imaging, Helmholtz Center Munich and Technical University of Munich, Neuherberg, D 85764, Germany
    IEEE Trans Med Imaging 28:1997-2006. 2009
    ....
  58. doi request reprint Near-infrared fluorescence catheter system for two-dimensional intravascular imaging in vivo
    R Nika Razansky
    Biological Imaging, Technische Universität München and Institute for Biological and Medical Imaging, IBMI, Helmholtz Zentrum Munchen, Munich, Germany
    Opt Express 18:11372-81. 2010
    ..This imaging approach is geared toward in vivo molecular imaging of atherosclerotic biomarkers and is engineered to allow seamless integration into the cardiac catheterization laboratory...
  59. doi request reprint Real-time imaging of cardiovascular dynamics and circulating gold nanorods with multispectral optoacoustic tomography
    Adrian Taruttis
    Institute for Biological and Medical Imaging, Technical University of Munich, Neuherberg, Germany
    Opt Express 18:19592-602. 2010
    ..We discuss the potential of this imaging ability in cardiovascular disease (CVD) research and clinical applications...
  60. doi request reprint Multimodal molecular imaging of integrin αvβ3 for in vivo detection of pancreatic cancer
    Marija Trajkovic-Arsic
    II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 55:446-51. 2014
    ..Here, we report on so far nonexploited potentials of αvβ3 integrin-targeted molecular imaging technologies for detection of PDAC using genetically engineered mouse models...
  61. pmc Cardioprotective C-kit⁺ bone marrow cells attenuate apoptosis after acute myocardial infarction in mice - in-vivo assessment with fluorescence molecular imaging
    Angelique Ale
    1 Institute for Biological and Medical Imaging, Helmholtz Zentrum München and Technische Universität München, Germany
    Theranostics 3:903-13. 2013
    ....
  62. ncbi request reprint Sensitivity of molecular target detection by multispectral optoacoustic tomography (MSOT)
    Daniel Razansky
    Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Med Phys 36:939-45. 2009
    ..The theoretical predictions are further validated in phantom experiments involving Cy5.5, a common near-infrared fluorescent molecular agent...
  63. doi request reprint Hybrid system for simultaneous fluorescence and x-ray computed tomography
    Ralf B Schulz
    Chair for Biological Imaging, Technical University Munich, 80333 Munich, Germany
    IEEE Trans Med Imaging 29:465-73. 2010
    ..The functional system characteristics are showcased, and images from a brain imaging study are shown, which are reconstructed using XCT-derived priors into the optical forward problem...
  64. doi request reprint Optical and opto-acoustic interventional imaging
    Athanasios Sarantopoulos
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Munich, Germany
    Ann Biomed Eng 40:346-66. 2012
    ..Herein, we outline developments in emerging fluorescence and opto-acoustic sensing and imaging techniques that can lead to practical implementations toward improving interventional vision...
  65. pmc Fast scanning coaxial optoacoustic microscopy
    Rui Ma
    Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    Biomed Opt Express 3:1724-31. 2012
    ..System performance is showcased in phantoms and in vivo imaging of microvasculature, achieving real time operation in two dimensions and penetration of 6 mm into optically dense human tissues...
  66. doi request reprint Compression of Born ratio for fluorescence molecular tomography/x-ray computed tomography hybrid imaging: methodology and in vivo validation
    Pouyan Mohajerani
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Ingolstadter Landstrasse 1, Neuherberg 85764, Germany
    Opt Lett 38:2324-6. 2013
    ..Compression rates of up to two orders of magnitude with minimum distortion of reconstruction have been demonstrated, resulting in large reduction in weight matrix size and reconstruction time. ..
  67. doi request reprint Imaging of mesoscopic-scale organisms using selective-plane optoacoustic tomography
    Daniel Razansky
    Institute for Biological and Medical Imaging, Helmholtz Zentrum Munchen, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Phys Med Biol 54:2769-77. 2009
    ..The utility of the method is demonstrated on several whole-body models and small-animal extremities...