Ulrike Nowak-Gottl

Summary

Country: Germany

Publications

  1. ncbi Risk factors for recurrent venous thromboembolism in the European collaborative paediatric database on cerebral venous thrombosis: a multicentre cohort study
    Gili Kenet
    Israel National Haemophilia Centre, Sheba Medical Centre, Tel Hashomer, Israel
    Lancet Neurol 6:595-603. 2007
  2. ncbi The plasminogen activator inhibitor (PAI)-1 promoter 4G/4G genotype is not associated with ischemic stroke in a population of German children. Childhood Stroke Study Group
    U Nowak-Gottl
    Paediatric Haematology and Oncology, University Hospital Munster, Germany
    Eur J Haematol 66:57-62. 2001
  3. ncbi Interaction of fibrinolysis and prothrombotic risk factors in neonates, infants and children with and without thromboembolism and underlying cardiac disease. a prospective study
    U Nowak-Gottl
    Pediatric Hematology and Oncology, University Hospital Munster, D 48149 Munster, Germany
    Thromb Res 103:93-101. 2001
  4. ncbi Thrombophilia in the young
    U Nowak-Gottl
    Univ Children Hospital, Pediatric Hematology and Oncology, Albert Schweitzer Str 33, 48149 Munster, Germany
    Hamostaseologie 28:16-20. 2008
  5. ncbi Thromboembolism in newborns, infants and children
    U Nowak-Gottl
    Department of Paediatric Haematology Oncology, University of Munster, Germany
    Thromb Haemost 86:464-74. 2001
  6. ncbi Thrombotic events revisited in children with acute lymphoblastic leukemia: impact of concomitant Escherichia coli asparaginase/prednisone administration
    U Nowak-Gottl
    Department of Pediatric Hematology Oncology, University of Münster Children s Hospital, Albert Schweitzerstrasse 33, Munster D 48149, Germany
    Thromb Res 103:165-72. 2001
  7. ncbi Pharmacokinetics, efficacy, and safety of LMWHs in venous thrombosis and stroke in neonates, infants and children
    U Nowak-Gottl
    Department of Paediatric Haematology and Oncology, University of Munster, Munster, Germany
    Br J Pharmacol 153:1120-7. 2008
  8. ncbi Thromboembolism in children
    Ulrike Nowak-Gottl
    Department of Pediatric Hematology Oncology, University of Munster, Germany
    Curr Opin Hematol 9:448-53. 2002
  9. ncbi Haemophilia and thrombophilia. What do we learn about combined inheritance of both genetic variations?
    U Nowak-Gottl
    Pediatric Hematology Oncology, University of Munster, Albert Schweitzer Str 33, 48149 Munster, Germany
    Hamostaseologie 23:36-40. 2003
  10. ncbi Antithrombotic drug treatment of pediatric patients with ischemic stroke
    Ulrike Nowak-Gottl
    Department of Paediatric Haematology and Oncology, University Paediatric Hospital, University of Munster, Albert Schweitzer Strasse 3, 48149 Munster, Germany
    Paediatr Drugs 5:167-75. 2003

Collaborators

Detail Information

Publications53

  1. ncbi Risk factors for recurrent venous thromboembolism in the European collaborative paediatric database on cerebral venous thrombosis: a multicentre cohort study
    Gili Kenet
    Israel National Haemophilia Centre, Sheba Medical Centre, Tel Hashomer, Israel
    Lancet Neurol 6:595-603. 2007
    ....
  2. ncbi The plasminogen activator inhibitor (PAI)-1 promoter 4G/4G genotype is not associated with ischemic stroke in a population of German children. Childhood Stroke Study Group
    U Nowak-Gottl
    Paediatric Haematology and Oncology, University Hospital Munster, Germany
    Eur J Haematol 66:57-62. 2001
    ..To investigate the relationship between an insertion/deletion (4G/5G) polymorphism of the plasminogen activator inhibitor (PAI)-1 gene and childhood patients with a past history of ischemic stroke...
  3. ncbi Interaction of fibrinolysis and prothrombotic risk factors in neonates, infants and children with and without thromboembolism and underlying cardiac disease. a prospective study
    U Nowak-Gottl
    Pediatric Hematology and Oncology, University Hospital Munster, D 48149 Munster, Germany
    Thromb Res 103:93-101. 2001
    ....
  4. ncbi Thrombophilia in the young
    U Nowak-Gottl
    Univ Children Hospital, Pediatric Hematology and Oncology, Albert Schweitzer Str 33, 48149 Munster, Germany
    Hamostaseologie 28:16-20. 2008
    ..Based on these data treatment algorithms have to be discussed...
  5. ncbi Thromboembolism in newborns, infants and children
    U Nowak-Gottl
    Department of Paediatric Haematology Oncology, University of Munster, Germany
    Thromb Haemost 86:464-74. 2001
    ..Thus, recommendations from small-scale studies in paediatric patients and guidelines adapted from adult patient protocols may be helpful in the management of paediatric patients on an individual patient basis...
  6. ncbi Thrombotic events revisited in children with acute lymphoblastic leukemia: impact of concomitant Escherichia coli asparaginase/prednisone administration
    U Nowak-Gottl
    Department of Pediatric Hematology Oncology, University of Münster Children s Hospital, Albert Schweitzerstrasse 33, Munster D 48149, Germany
    Thromb Res 103:165-72. 2001
    ..coli asparaginase concomitantly administered in a leukemic patient suffering from a prothrombotic risk factor to be responsible for the onset of venous thrombosis in the majority of cases...
  7. ncbi Pharmacokinetics, efficacy, and safety of LMWHs in venous thrombosis and stroke in neonates, infants and children
    U Nowak-Gottl
    Department of Paediatric Haematology and Oncology, University of Munster, Munster, Germany
    Br J Pharmacol 153:1120-7. 2008
    ..Further randomized controlled trials are recommended to evaluate the optimum duration and application for different LMWH indications in children...
  8. ncbi Thromboembolism in children
    Ulrike Nowak-Gottl
    Department of Pediatric Hematology Oncology, University of Munster, Germany
    Curr Opin Hematol 9:448-53. 2002
    ..Pediatric treatment protocols for acute thromboembolism, including thrombolytic and anticoagulant therapy, are mainly adapted from adult patient protocols...
  9. ncbi Haemophilia and thrombophilia. What do we learn about combined inheritance of both genetic variations?
    U Nowak-Gottl
    Pediatric Hematology Oncology, University of Munster, Albert Schweitzer Str 33, 48149 Munster, Germany
    Hamostaseologie 23:36-40. 2003
    ..Conclusion: The data of this multicentre cohort study demonstrate that the clinical phenotype of severe haemophilia A in childhood is clearly influenced by the coinheritance of prothrombotic risk factors...
  10. ncbi Antithrombotic drug treatment of pediatric patients with ischemic stroke
    Ulrike Nowak-Gottl
    Department of Paediatric Haematology and Oncology, University Paediatric Hospital, University of Munster, Albert Schweitzer Strasse 3, 48149 Munster, Germany
    Paediatr Drugs 5:167-75. 2003
    ..Alteplase has been used in a few patients within 3 hours of the onset of symptoms. In each patient treated the benefit of anticoagulation has to be weighed up against the individual bleeding risk...
  11. ncbi Arterial ischemic stroke in neonates, infants, and children: an overview of underlying conditions, imaging methods, and treatment modalities
    Ulrike Nowak-Gottl
    Department of Haematology Oncology, University of Münster Münster, Germany
    Semin Thromb Hemost 29:405-14. 2003
    ....
  12. ncbi Thromboembolic diseases in neonates and children
    Ulrike Nowak-Gottl
    Paediatric Haematology Oncology Univ children s hospital Münster, Germany
    Pathophysiol Haemost Thromb 33:269-74. 2003
    ..Data interpretation is based on age-dependent reference ranges or the identification of causative gene mutations/polymorphisms with respect to individual ethnic backgrounds...
  13. ncbi Genetics of hemostasis: differential effects of heritability and household components influencing lipid concentrations and clotting factor levels in 282 pediatric stroke families
    Ulrike Nowak-Gottl
    Department of Pediatric Hematology Oncology, University of Munster, Munster, Germany
    Environ Health Perspect 116:839-43. 2008
    ..Such epidemiologic approaches in families with a first acute ischemic stroke during early childhood are lacking...
  14. ncbi Neonatal thromboembolism
    Ulrike Nowak-Gottl
    Pediatric Hematology Oncology, University Children s Hospital, Munster, Germany
    Semin Thromb Hemost 29:227-34. 2003
    ..Secondary long-term anticoagulation should be administered on an individual basis...
  15. ncbi Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies
    Gili Kenet
    Pediatric Hematology and Oncology, University Hospital of Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Circulation 121:1838-47. 2010
    ..The aim of this study was to estimate the impact of thrombophilia on risk of first childhood stroke through a meta-analysis of published observational studies...
  16. ncbi Thrombolysis in newborns and infants
    U Nowak-Gottl
    Department of Paediatrics, University Children Hospital Münster, Germany
    Thromb Haemost 82:112-6. 1999
    ..Controlled prospective multicentre studies on thrombolytic therapy in neonates and infants are recommended to evaluate patency rates and adverse effects for the different thrombolytic agents used...
  17. ncbi Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood
    U Nowak-Gottl
    Department of Paediatrics, Institute of Clinical Chemistry and Laboratory Medicine and Institute of Arteriosclerosis Research, Westphalian Wilhelms University Münster, Germany
    Blood 94:3678-82. 1999
    ..75/4.7 to 272; P <. 0001). Increased Lp (a) levels, the FV G1691A mutation, protein C deficiency, the prothrombin G20210A variant, and the MTHFR TT677 are important risk factors for spontaneous ischemic stroke in childhood...
  18. ncbi Prospective assessment of risk factors for recurrent stroke during childhood--a 5-year follow-up study
    Ronald Sträter
    Department of Paediatrics, Universität of Münster, Munster, Germany
    Lancet 360:1540-5. 2002
    ..The relevance of these factors to a second ischaemic stroke event is not known...
  19. ncbi Recurrent pulmonary embolism in a 13-year-old male homozygous for the prothrombin G20210A mutation combined with protein S deficiency and increased lipoprotein (a)
    Andrea Kosch
    Department of Pediatric Hematology and Oncology, Westfalische Wilhelms Universitat Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Thromb Res 105:49-53. 2002
    ....
  20. ncbi Role of reduced ADAMTS13 in arterial ischemic stroke: a pediatric cohort study
    Moritz Lambers
    Faculty of Medicine, University of Munster, Germany
    Ann Neurol 73:58-64. 2013
    ..Here we investigated ADAMTS13 in 208 pediatric patients with arterial ischemic stroke (AIS) and 125 population-based control children in a frequency-matched case-control study...
  21. ncbi Role of endogenous testosterone concentration in pediatric stroke
    Sandra Normann
    Department of Pediatric Hematology, University Children s Hospital, University of Munster, Munster, Germany
    Ann Neurol 66:754-8. 2009
    ..98 [1.38-11.45]; AIS = 3.88 [1.13-13.35]; CSVT = 5.50 [1.65-18.32]). Further adjusted analyses revealed that, for each 1nmol/l increase in testosterone in boys, the odds of cerebral thromboembolism were increased 1.3-fold...
  22. ncbi Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up
    Andrea Kosch
    Department of Pediatric Hematology Oncology, Westfalische Wilhelms Universitat Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Blood 104:1356-60. 2004
    ..In conclusion, the present study demonstrates the significance of genetic PR-especially the FV mutation and elevated Lp(a)-for the etiology of neonatal RVT...
  23. ncbi Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children
    Andrea Kosch
    Department of Pediatric Hematology Oncology, University Children s Hospital Munster, Germany
    Thromb Haemost 91:308-14. 2004
    ..Therefore, screening for elevated fasting tHcy levels of patients with thromboembolism is recommended to stratify the risk of thromboembolism...
  24. ncbi Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study. For the Childhood Thrombophilia Study Group
    C Heller
    Department of Paediatrics, University of Frankfurt, Germany
    Br J Haematol 111:534-9. 2000
    ..1; P < 0.0001), PVT (5.47/1.7-17.6; P < 0.0007) and HVT (3.3/0.58-18.7; P = 0.18). The data presented here suggest that genetic prothrombotic risk factors also play an important role in abdominal venous thrombosis during infancy...
  25. ncbi Role of genetic prothrombotic risk factors in childhood caval vein thrombosis
    N Münchow
    Paediatric Haematology and Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur J Pediatr 158:S109-12. 1999
    ..Remarkably, during puberty and adolescence the predominant defect diagnosed was the PT G20210A variant, whereas the FV G1691A mutation had a higher incidence during infancy...
  26. ncbi Inherited thrombophilia in children with venous thromboembolism and the familial risk of thromboembolism: an observational study
    Susanne Holzhauer
    Department of Pediatric Hematology Oncology, Charite, Augustenburger Platz 1, Berlin, Germany
    Blood 120:1510-5. 2012
    ..Interventional studies are required to assess whether thromboembolism can be prevented in this high-risk population...
  27. ncbi Outcome of kidney transplantation in patients with inherited thrombophilia: data of a prospective study
    Stefan Heidenreich
    Department of Medicine, University of Munster, Germany
    J Am Soc Nephrol 14:234-9. 2003
    ..Screening for hypercoagulable states pretransplant is recommended to intensify anticoagulatory treatment posttransplant...
  28. ncbi Symptomatic ischemic stroke in full-term neonates : role of acquired and genetic prothrombotic risk factors
    G Gunther
    Department of Paediatrics, University of Magdeburg, Magdeburg, Germany
    Stroke 31:2437-41. 2000
    ..The present multicenter case-control study was prospectively designed to assess the extent to which single and combined clotting factor abnormalities influence the onset of symptomatic ischemic stroke in full-term neonates...
  29. ncbi Factor VIII, D-Dimer, and thromboembolism in children
    Ulrike Nowak-Gottl
    Department of Pediatric Hematology and Oncology, University Children s Hospital, Muenster, Germany
    N Engl J Med 351:1051-3. 2004
  30. ncbi Thromboembolic events in children with acute lymphoblastic leukemia (BFM protocols): prednisone versus dexamethasone administration
    Ulrike Nowak-Gottl
    Pediatric Hematology Oncology, University Hospital Munster, Germany
    Blood 101:2529-33. 2003
    ..In conclusion, the use of dexamethasone instead of prednisone, administered with CASP, significantly reduced the onset of venous thromboembolism...
  31. ncbi Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies
    Ulrike Nowak-Gottl
    Pediatric Hematology Oncology, University of Muenster, Muenster, Germany
    Blood 114:1947-53. 2009
    ..The observed negative correlation of genetic VT risk with the plasma levels of the fibrinogen gamma' variant suggests that FGG-H2 and -H3 haplotypes modify thrombosis risk by controlling the level of this FGG splice isoform...
  32. ncbi Association of the protein Z ATG haplotype with symptomatic nonvascular stroke or thromboembolism in white children: a family-based cohort study
    Ulrike Nowak-Gottl
    Pediatric Hematology Oncology, University Clinics Münster, Munster, Germany
    Blood 113:2336-41. 2009
    ..4; 95% confidence interval [95% CI] 1.08-1.93). Our results suggest that the ATG haplotype of the PZ gene is a genetic marker for symptomatic TE in white German children...
  33. ncbi In pediatric patients, age has more impact on dosing of vitamin K antagonists than VKORC1 or CYP2C9 genotypes
    Ulrike Nowak-Gottl
    Pediatric Hematology Oncology, University Children s Hospital, University of Munster, Munster, Germany
    Blood 116:6101-5. 2010
    ..3% of VKA dose variations; VKORC1 and CYP2C9 explained only 3.7% and 0.4%, respectively. In children, the most critical factor in determining VKA dose is age. VKORC1/CYP2C9 genotypes only marginally explain dose variations...
  34. ncbi Role of elevated alpha2-macroglobulin revisited: results of a case-control study in children with symptomatic thromboembolism
    A Beheiri
    Department of Paediatric Haematology Oncology, Univ Children s Hospital, Munster, Germany
    J Thromb Haemost 5:1179-84. 2007
    ..The present study was conducted to evaluate the role of alpha2MG in children with venous thromboembolism [VTE: paradoxical embolism causing ischemic stroke (IS) or deep-vein thrombosis (DVT)]...
  35. ncbi Safety and efficacy of low molecular weight heparins in children: a systematic review of the literature and meta-analysis of single-arm studies
    Christoph Bidlingmaier
    Department of Thrombosis and Hemostasis, Dr von Hauner s Children s Hospital, University Children s Hospital, Munich, Germany
    Semin Thromb Hemost 37:814-25. 2011
    ..The present systematic review suggests that use of LMWH in children as primary prophylaxis and in treatment of symptomatic thrombosis is effective and safe. However, properly designed randomized controlled trials are needed...
  36. ncbi Thrombosis in childhood acute lymphoblastic leukaemia: epidemiology, aetiology, diagnosis, prevention and treatment
    Ulrike Nowak-Gottl
    Paediatric Haematology and Oncology, University Hospital Munster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Best Pract Res Clin Haematol 22:103-14. 2009
    ..External CVLs are affected more often than internal CVLs. Evidence-based guidelines on prevention and treatment guidelines for ALL-related VTE are lacking, and carefully designed clinical trials are needed urgently...
  37. ncbi Spectrum of molecular defects and mutation detection rate in patients with severe hemophilia A
    Nadja Bogdanova
    Institut fur Humangenetik, UKM, Munster, Germany
    Hum Mutat 26:249-54. 2005
    ..The newly detected amino acid substitutions were scored for potential gross or local conformational changes and influence on molecular stability for every single F8 domain with available structures, using homology modeling...
  38. ncbi The factor V G1691A mutation is a risk for porencephaly: A case-control study
    Otfried M Debus
    University Children s Hospital Munster, Department of Neuropediatrics, Germany
    Ann Neurol 56:287-90. 2004
    ..003) were significantly associated with porencephaly. These data give evidence that the FV G1691A mutation and a combination of prothromboic factors play a major role in the development of childhood porencephaly...
  39. ncbi Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart disease
    R Junker
    Institute of Clinical Chemistry and Laboratory Medicine and Institute of Atherosclerosis Research, University Hospital Munster, Albert Schweitzer Strasse 33, 48149, Munster, Germany
    Cardiovasc Res 51:251-4. 2001
    ..However, no data are available so far with respect to the MTHFR 677TT genotype in children with underlying structural congenital heart disease (CHD)...
  40. ncbi The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood venous thrombosis
    H G Koch
    Department of Paediatrics, University Hospital, Munster, Germany
    Eur J Pediatr 158:S113-6. 1999
    ..3 micromol/l and the CT genotype of the MTHFR C677T variant are significant risk factors for venous vascular occlusion in children...
  41. ncbi Population pharmacokinetics of enoxaparin in infants, children and adolescents during secondary thromboembolic prophylaxis: a cohort study
    M N Trame
    Department of Pharmaceutical and Medical Chemistry Clinical Pharmacy, University of Munster, Munster, Germany
    J Thromb Haemost 8:1950-8. 2010
    ..In children, it is still used off-label and little is known about the pharmacokinetics in children...
  42. ncbi Prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophilia
    R Junker
    Institute of Clinical Chemistry and Laboratory Medicine, Westfalische Wilhelms Universitat Munster, Germany
    Arterioscler Thromb Vasc Biol 19:2568-72. 1999
    ..In conclusion, the prothrombin G20210A and the FV G1691A mutation, deficiencies of protein C, protein S, and antithrombin are important risk factors for venous thrombosis during childhood and adolescence...
  43. ncbi [Thrombocytic alpha-delta-storage-pool-disease: shortening of bleeding time after infusion of 1-desamino-8-D-arginine vasopressin]
    A Kosch
    Klinik und Poliklinik für Kinderheilkunde, Westfälischen Wilhelms Universität Münster
    Klin Padiatr 211:198-200. 1999
    ..In addition to substitution of platelets, vasopressin is therefore used to prevent bleeding complications...
  44. ncbi Plasminogen activator inhibitor-1 4G/5G-polymorphism and factor V Q506 mutation are not associated with myocardial infarction in young men
    R Junker
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Germany
    Blood Coagul Fibrinolysis 9:597-602. 1998
    ..In conclusion, in the present study neither homozygosity for the 4G allele of the PAI-1 4G/5G-polymorphism nor the FV:Q506 mutation led to an increased risk of myocardial infarction in young men...
  45. ncbi Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system
    R Junker
    Institute of Clinical Chemistry and Laboratory Medicine, University of Munster, Germany
    Thromb Haemost 85:280-6. 2001
    ..Therefore, the clinical significance of the present findings remains to be evaluated...
  46. ncbi Genetic risk factors of thrombophilia in ischaemic childhood stroke of cardiac origin. A prospective ESPED survey
    R Sträter
    Paediatric Haematology and Oncology, University Hospital, Munster
    Eur J Pediatr 158:S122-5. 1999
    ....
  47. ncbi Interferences in coagulation tests--evaluation of the 570-nm method on the Dade Behring BCS analyser
    Ralf Junker
    Institute of Arteriosclerosis Research, University of Munster, Munster, Germany
    Clin Chem Lab Med 43:244-52. 2005
    ..Limitations have to be taken into account regarding lipaemic plasma...
  48. ncbi Health-related quality of life in children and adolescents with stroke, self-reports, and parent/proxies reports: cross-sectional investigation
    Bruno Neuner
    Department of Clinical Epidemiology and Social Medicine, University of Munster, Munster, Germany
    Ann Neurol 70:70-8. 2011
    ..The aim of the present study was to assess HR-QoL by self-assessment and parent/proxy-assessment in children and adolescents who survived a first stroke episode...
  49. ncbi Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in men
    G Benze
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Eur Heart J 23:325-30. 2002
    ..The T807 allele of the GPIa gene alone or in combination with the PlA2 allele had no major effect on premature myocardial infarction risk...
  50. ncbi Testing for lipoprotein(a) concentration and apolipoprotein(a) phenotypes: method standardization and pediatric reference values
    Claus Langer
    Department of Thrombosis and Hemostasis Research, Institute of Clinical Chemistry and Laboratory Medicine, Germany
    Semin Thromb Hemost 37:810-3. 2011
    ..The latter will help to harmonize international pediatric studies and to further evaluate the role of elevated Lp(a) in childhood vascular disease...
  51. ncbi Testing for Apolipoprotein(a) Phenotype Using Isoelectric Focusing and Immunoblotting Technique
    Claus Langer
    Department of Laboratory Medicine, University Hospital, Munster, Germany
    Methods Mol Biol 992:407-12. 2013
    ..The number of Kringle 4 repeats correlates negatively with the level of Lp(a) in plasma. The determination of apo(a) phenotype is able to estimate thromboembolic risk due to this risk factor...
  52. ncbi Post-trauma coagulation and fibrinolysis in children suffering from severe cerebro-cranial trauma
    S Becker
    Department of Paediatrics, University Hospital Frankfurt am Main, Germany
    Eur J Pediatr 158:S197-202. 1999
    ..CONCLUSION: Our data underline the significance of post-trauma disturbances of the haemostatic system for the clinical course and outcome in children with severe cranio-cerebral injuries...
  53. ncbi Resistance to activated protein C (APCR) in children with venous or arterial thromboembolism
    U Nowak-Gottl
    Department of Paediatrics, University Hospital Kiel, Germany
    Br J Haematol 92:992-8. 1996
    ..These data are evidence that APCR combined with exogenous reasons may play an important role in the early manifestation of thromboembolism during infancy and childhood...