Jerzy Roch Nofer

Summary

Country: Germany

Publications

  1. doi request reprint Estrogens and atherosclerosis: insights from animal models and cell systems
    Jerzy Roch Nofer
    Center for Laboratory Medicine, University Hospital Munster, Albert Schweizer Campus 1, Gebäude A1, 48129 Munster, Germany
    J Mol Endocrinol 48:R13-29. 2012
  2. doi request reprint Sphingosine kinase inhibition exerts both pro- and anti-atherogenic effects in low-density lipoprotein receptor-deficient (LDL-R(-/-)) mice
    Francesco Poti
    Department of Medicine, Endocrinology, Metabolism and Geriatrics, University of Modena and Reggio Emilia, Modena, Italy
    Thromb Haemost 107:552-61. 2012
  3. ncbi request reprint Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    J Lipid Res 47:794-803. 2006
  4. ncbi request reprint Low density lipoproteins inhibit the Na+/H+ antiport in human platelets via activation of p38MAP kinase
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Albert Schweizer Str 33, D 48129 Munster, Germany
    Biochem Biophys Res Commun 340:751-7. 2006
  5. doi request reprint HDL scavenger receptor class B type I and platelet function
    Jerzy Roch Nofer
    Center for Laboratory Medicine, University Hospital Munster, Munster, Germany
    Curr Opin Lipidol 22:277-82. 2011
  6. ncbi request reprint FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Albert Schweizer Str 33, D 48129 Munster, Germany
    Circulation 115:501-8. 2007
  7. ncbi request reprint Current understanding of the role of high-density lipoproteins in atherosclerosis and senescence
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Albert Schweizer Str 33 D 48129, Munster, Germany
    Expert Rev Cardiovasc Ther 3:1071-86. 2005
  8. ncbi request reprint Atheroprotective effects of high-density lipoprotein-associated lysosphingolipids
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
    Trends Cardiovasc Med 15:265-71. 2005
  9. ncbi request reprint Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease)
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, D 48129 Munster, Germany
    J Biol Chem 279:34032-7. 2004
  10. ncbi request reprint D609-phosphatidylcholine-specific phospholipase C inhibitor attenuates thapsigargin-induced sodium influx in human lymphocytes
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat, A Schweitzer Str 33, 48 149, Munster, Germany
    Cell Signal 12:289-96. 2000

Collaborators

Detail Information

Publications33

  1. doi request reprint Estrogens and atherosclerosis: insights from animal models and cell systems
    Jerzy Roch Nofer
    Center for Laboratory Medicine, University Hospital Munster, Albert Schweizer Campus 1, Gebäude A1, 48129 Munster, Germany
    J Mol Endocrinol 48:R13-29. 2012
    ..The present review summarizes the results of these studies and assesses their contribution toward better understanding of molecular mechanisms underlying anti- and/or pro-atherogenic effects of estrogens in humans...
  2. doi request reprint Sphingosine kinase inhibition exerts both pro- and anti-atherogenic effects in low-density lipoprotein receptor-deficient (LDL-R(-/-)) mice
    Francesco Poti
    Department of Medicine, Endocrinology, Metabolism and Geriatrics, University of Modena and Reggio Emilia, Modena, Italy
    Thromb Haemost 107:552-61. 2012
    ..In conclusion, treatment with SphK inhibitor leads to both pro- and anti-atherogenic effects in LDL-R(-/-) mice. As a consequence, SphK inhibition fails to affect atherosclerosis despite significant S1P reduction in plasma...
  3. ncbi request reprint Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    J Lipid Res 47:794-803. 2006
    ..We conclude that ABCA1 transduces signals from apoA-I by complexing and activating Cdc42 and downstream kinases and, therefore, acts as a full apoA-I receptor...
  4. ncbi request reprint Low density lipoproteins inhibit the Na+/H+ antiport in human platelets via activation of p38MAP kinase
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Albert Schweizer Str 33, D 48129 Munster, Germany
    Biochem Biophys Res Commun 340:751-7. 2006
    ..We conclude that activation of p38MAPK is required for the inhibitory effect of LDL on Na+/H+ antiport and thereby for LDL-dependent sensitization in human platelets...
  5. doi request reprint HDL scavenger receptor class B type I and platelet function
    Jerzy Roch Nofer
    Center for Laboratory Medicine, University Hospital Munster, Munster, Germany
    Curr Opin Lipidol 22:277-82. 2011
    ..The present review summarizes the recent advancements in understanding the role played by scavenger receptor class B type I (SR-BI) - an HDL receptor - in modulating platelet function and mediating platelet-HDL interactions...
  6. ncbi request reprint FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat Munster, Albert Schweizer Str 33, D 48129 Munster, Germany
    Circulation 115:501-8. 2007
    ..The present study was undertaken to investigate whether modulation of S1P signaling would affect atherosclerosis in a murine model of disease...
  7. ncbi request reprint Current understanding of the role of high-density lipoproteins in atherosclerosis and senescence
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Albert Schweizer Str 33 D 48129, Munster, Germany
    Expert Rev Cardiovasc Ther 3:1071-86. 2005
    ..The purpose of this review is to summarize the novel functions of HDL that may protect from atherosclerosis and senescence...
  8. ncbi request reprint Atheroprotective effects of high-density lipoprotein-associated lysosphingolipids
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
    Trends Cardiovasc Med 15:265-71. 2005
    ..In this review, we discuss the latest developments concerning the potential atheroprotective role of HDL-associated lysosphingolipids...
  9. ncbi request reprint Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease)
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, D 48129 Munster, Germany
    J Biol Chem 279:34032-7. 2004
    ..The impaired release of the content of dense bodies may explain the defective activation of Tangier platelets by collagen and low concentrations of thrombin, but not by ADP...
  10. ncbi request reprint D609-phosphatidylcholine-specific phospholipase C inhibitor attenuates thapsigargin-induced sodium influx in human lymphocytes
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Zentrallaboratorium, Westfalische Wilhelms Universitat, A Schweitzer Str 33, 48 149, Munster, Germany
    Cell Signal 12:289-96. 2000
    ..In conclusion, our results suggest that diacylglycerol released due to the PC-PLC activation contributes to the thapsigargin-induced Na(+) entry...
  11. ncbi request reprint Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, D 48129 Munster, Germany
    J Biol Chem 278:53055-62. 2003
    ..These results for the first time demonstrate activation of Rho family G proteins and stress kinases by apoA-I and implicate the involvement of Cdc42 and JNK in the apoA-I-induced cholesterol efflux...
  12. doi request reprint High-density lipoproteins, platelets and the pathogenesis of atherosclerosis
    Jerzy Roch Nofer
    Center for Laboratory Medicine, University Hospital Munster, Munster, Germany
    Clin Exp Pharmacol Physiol 37:726-35. 2010
    ..5. The present review summarizes recent advances in understanding HDL-platelet interactions and discusses the potential use of HDL-like particles in the therapy of thrombosis...
  13. ncbi request reprint High density lipoproteins induce cell cycle entry in vascular smooth muscle cells via mitogen activated protein kinase-dependent pathway
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Thromb Haemost 85:730-5. 2001
    ..The strong and specific mitogenic effect of HDL should be taken into account, when therapeutic strategies to elevate the plasma level of these lipoproteins are developed...
  14. ncbi request reprint Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfälische Wilhelms Universität and the Institut für Arterioskleroseforschung an der Universität Münster, 48129 Munster, Germany
    J Biol Chem 276:34480-5. 2001
    ....
  15. ncbi request reprint HDL and arteriosclerosis: beyond reverse cholesterol transport
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Albert Schweitzer Str 33, 48129 Munster, Germany
    Atherosclerosis 161:1-16. 2002
    ..This complexity further emphasizes that changes in the functionality of HDL rather than changes of plasma HDL-cholesterol levels determine the anti-atherogenicity of therapeutic alterations of HDL metabolism...
  16. ncbi request reprint High density lipoprotein-associated lysosphingolipids reduce E-selectin expression in human endothelial cells
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Biochem Biophys Res Commun 310:98-103. 2003
    ....
  17. pmc HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    J Clin Invest 113:569-81. 2004
    ..This mechanism may contribute to the vasoactive effect of HDL and represent a novel aspect of its antiatherogenic function...
  18. ncbi request reprint Branched chain fatty acids induce nitric oxide-dependent apoptosis in vascular smooth muscle cells
    Susanne Idel
    Institute for Arteriosclerosis Research, Central Laboratory, University of Munster, Domagkstrasse 3, 48129 Munster, Germany
    J Biol Chem 277:49319-25. 2002
    ..These results establish a new signaling cascade in which natural BCFA induced NO-dependent apoptosis, which is apparently triggered by autocrine secretion of TNFalpha in cultured VSMCs...
  19. pmc Apolipoprotein E induces antiinflammatory phenotype in macrophages
    Daniel Baitsch
    Center for Laboratory Medicine, University Hospital Munster, and Leibniz Institute for Arteriosclerosis Research, University of Munster, Albert Schweizer Strasse 33, 48129 Munster, Germany
    Arterioscler Thromb Vasc Biol 31:1160-8. 2011
    ..Apolipoprotein E (apoE) exerts potent antiinflammatory effects. Here, we investigated the effect of apoE on the functional phenotype of macrophages...
  20. ncbi request reprint Atheroprotective effects of high-density lipoproteins
    Gerd Assmann
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Annu Rev Med 54:321-41. 2003
    ..This review summarizes current views on the molecular mechanism underlying these atheroprotective effects of HDL...
  21. ncbi request reprint Expression and functional characterization of ABCG1 splice variant ABCG1(666)
    Thomas Engel
    Leibniz Institute of Arteriosclerosis Research, Westphalian Wilhelms University, Domagkstr 3, 48149 Muenster, Germany
    FEBS Lett 580:4551-9. 2006
    ..Our results support that ABCG1(666) may in fact be the most prominent form of functional ABCG1 expressed in the human...
  22. ncbi request reprint Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol
    Thomas Engel
    Leibniz Institute for Arteriosclerosis Research, Westphalian Wilhelms University, 48149 Muenster, Germany
    FEBS Lett 581:1673-80. 2007
    ..Our study points to detoxification as one of potential cellular functions of ABCG1. We assume that ABCG1 protects against 7beta-HC-induced cell death, an important role in prevention of neurodegenerative and cardiovascular disease...
  23. ncbi request reprint Nicotinamide increases systemic vascular resistance in ovine endotoxemia
    Marion Scharte
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Munster, Albert Schweitzer Strasse 33, 48149, Munster, Germany
    Intensive Care Med 29:989-94. 2003
    ..Here, we investigated the effect of the PARP inhibitor nicotinamide on cardiovascular and liver function in healthy and chronically endotoxemic sheep...
  24. ncbi request reprint Mycophenolic acid counteracts B cell proliferation and plasmablast formation in patients with systemic lupus erythematosus
    Sebastian Eickenberg
    Rheumatology and Clinical Immunology Unit of the Department of Internal Medicine D, University Hospital Munster, Albert Schweitzer Str 33, 48149 Munster, Germany
    Arthritis Res Ther 14:R110. 2012
    ..Also extrarenal manifestations respond to MMF treatment. However, few attempts have been undertaken to delineate its mechanism of action in systemic lupus erythematosus (SLE) a disease characterized by enhanced B cell activation...
  25. doi request reprint Everolimus therapy is associated with reduced lipoprotein-associated phospholipase A2 (Lp-Pla2) activity and oxidative stress in heart transplant recipients
    Katharina Rosing
    Center for Laboratory Medicine, University Hospital Munster, Munster, Germany
    Atherosclerosis 230:164-70. 2013
    ..We here systematically evaluated cardiovascular risk factors in heart transplanted patients, who underwent conversion to everolimus or were maintained on conventional therapy with calcineurin inhibitors (CNI)...
  26. ncbi request reprint Cardiovascular risk assessment in metabolic syndrome: view from PROCAM
    Gerd Assmann
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfäliche Wilhelms Universität, Muenster, Germany
    Endocrinol Metab Clin North Am 33:377-92, table of contents. 2004
    ..This article reviews the progress that has been made toward reaching these goals based on the results of the PROspective Cardiovascular Münster (PROCAM) study...
  27. ncbi request reprint Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice
    Roland Klingenberg
    Department of Cardiology, University Hospital Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 27:2392-9. 2007
    ..The sphingolipid analogue drug FTY720 mediates retrafficking of immune cells and inhibits their homing to inflammatory sites. We have evaluated the effect of FTY720 on atherogenesis and lipid metabolism...
  28. pmc HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production
    Markus Tölle
    Charite Campus Benjamin Franklin, Medizinische Klinik, Berlin, Germany
    Arterioscler Thromb Vasc Biol 28:1542-8. 2008
    ..Here we investigated the influence of HDL on MCP-1 production in vascular smooth muscle cells (VSMCs) and rat aortic explants...
  29. ncbi request reprint Normal platelet reactivity in apolipoprotein E (apo E)-deficient mouse
    Jerzy Roch Nofer
    Platelets 17:498-500. 2006
  30. ncbi request reprint Follicular fluid high density lipoprotein-associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis
    Soren von Otte
    Klinik fur Frauenheilkunde und Geburtshilfe, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Biol Chem 281:5398-405. 2006
    ..We conclude that FF-HDL represents a novel mitogenic and angiogenic factor present in follicular fluid and that S1P is one of the FF-HDL lipid components accounting for this activity...
  31. ncbi request reprint Apolipoprotein E interrupts interleukin-1beta signaling in vascular smooth muscle cells
    Akira Kawamura
    Department of Lipid Metabolism, Leibniz Institut für Arterioskleroseforschung an der Universität Münster, Germany
    Arterioscler Thromb Vasc Biol 27:1610-7. 2007
    ..We here investigated the effect of apoE on intracellular signaling by interleukin-1beta (IL-1beta), a proinflammatory cytokine present in atherosclerotic lesions...
  32. ncbi request reprint Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR
    Thomas Dittmar
    Institute of Immunology, University of Witten Herdecke, Stockumer Str 10, 58448 Witten, Germany
    FASEB J 16:1823-5. 2002
    ..In summary, c-erbB-2 up-regulation switches on the cell migration program by modulating the time course of PLC-gamma1 activation...
  33. ncbi request reprint Increased oxidative stress in subjects exposed to carbon disulfide (CS2)--an occupational coronary risk factor
    Teresa Wronska-Nofer
    Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Teresy Str 8, POBox 199, 90 950 Lodz, Poland
    Arch Toxicol 76:152-7. 2002
    ..It is concluded, that occupational exposure to CS2 produces oxidative stress in plasma. This may favor the development of atherosclerosis and increase the incidence of CHD in workers exposed to CS2...