M A Nitsche

Summary

Country: Germany

Publications

  1. ncbi request reprint GABAergic modulation of DC stimulation-induced motor cortex excitability shifts in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Eur J Neurosci 19:2720-6. 2004
  2. ncbi request reprint A controlled clinical trial of cathodal DC polarization in patients with refractory epilepsy
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, KS 452, Boston, MA 02215, U S A
    Epilepsia 47:335-42. 2006
  3. doi request reprint Transcranial direct current stimulation--update 2011
    Michael A Nitsche
    Georg August University, Department of Clinical Neurophysiology, Robert Koch, Goettingen, Germany
    Restor Neurol Neurosci 29:463-92. 2011
  4. pmc How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?
    Nicolas Lang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom
    Eur J Neurosci 22:495-504. 2005
  5. ncbi request reprint Dopaminergic modulation of long-lasting direct current-induced cortical excitability changes in the human motor cortex
    Michael A Nitsche
    Georg August University, Department for Clinical Neurophysiology, Robert Koch Str 40, 37099 Goettingen, Germany
    Eur J Neurosci 23:1651-7. 2006
  6. pmc Early optimization in finger dexterity of skilled pianists: implication of transcranial stimulation
    Shinichi Furuya
    Institute for Music Physiology and Musicians Medicine, Hannover University of Music, Drama and Media, Hannover, Germany
    BMC Neurosci 14:35. 2013
  7. pmc Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans
    G Batsikadze
    M A Nitsche Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Straße 40, 37075 Gottingen, Germany
    J Physiol 591:1987-2000. 2013
  8. pmc The pharmacology of neuroplasticity induced by non-invasive brain stimulation: building models for the clinical use of CNS active drugs
    Michael A Nitsche
    M A Nitsche Georg August University, University Medical Centre, Dept Clinical Neurophysiology, Robert Koch Str 40, 37099 Gottingen, Germany
    J Physiol 590:4641-62. 2012
  9. pmc Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation
    M A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    J Physiol 527:633-9. 2000
  10. doi request reprint Serotonin affects transcranial direct current-induced neuroplasticity in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, Göttingen 37099, Germany
    Biol Psychiatry 66:503-8. 2009

Detail Information

Publications89

  1. ncbi request reprint GABAergic modulation of DC stimulation-induced motor cortex excitability shifts in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Eur J Neurosci 19:2720-6. 2004
    ..Because intracortical inhibition and facilitation are not changed in this phase compared with pre-tDCS values, excitability changes originating from remote cortical or subcortical areas could be involved...
  2. ncbi request reprint A controlled clinical trial of cathodal DC polarization in patients with refractory epilepsy
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, KS 452, Boston, MA 02215, U S A
    Epilepsia 47:335-42. 2006
    ..To study the effects of cathodal DC polarization in patients with refractory epilepsy and malformations of cortical development (MCDs) as indexed by seizure frequency and epileptiform EEG discharges...
  3. doi request reprint Transcranial direct current stimulation--update 2011
    Michael A Nitsche
    Georg August University, Department of Clinical Neurophysiology, Robert Koch, Goettingen, Germany
    Restor Neurol Neurosci 29:463-92. 2011
    ..This overview will deliver an update of the last two years of research, because especially during this time numerous important studies were published covering the above-mentioned fields...
  4. pmc How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?
    Nicolas Lang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom
    Eur J Neurosci 22:495-504. 2005
    ..The extensive spatial and temporal effects of tDCS need to be taken into account when tDCS is used to modify brain function...
  5. ncbi request reprint Dopaminergic modulation of long-lasting direct current-induced cortical excitability changes in the human motor cortex
    Michael A Nitsche
    Georg August University, Department for Clinical Neurophysiology, Robert Koch Str 40, 37099 Goettingen, Germany
    Eur J Neurosci 23:1651-7. 2006
    ..g. migraine and epilepsy...
  6. pmc Early optimization in finger dexterity of skilled pianists: implication of transcranial stimulation
    Shinichi Furuya
    Institute for Music Physiology and Musicians Medicine, Hannover University of Music, Drama and Media, Hannover, Germany
    BMC Neurosci 14:35. 2013
    ....
  7. pmc Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans
    G Batsikadze
    M A Nitsche Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Straße 40, 37075 Gottingen, Germany
    J Physiol 591:1987-2000. 2013
    ..This should be taken into account for applications of the stimulation technique using different intensities and durations in order to achieve stronger or longer lasting after-effects...
  8. pmc The pharmacology of neuroplasticity induced by non-invasive brain stimulation: building models for the clinical use of CNS active drugs
    Michael A Nitsche
    M A Nitsche Georg August University, University Medical Centre, Dept Clinical Neurophysiology, Robert Koch Str 40, 37099 Gottingen, Germany
    J Physiol 590:4641-62. 2012
    ....
  9. pmc Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation
    M A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    J Physiol 527:633-9. 2000
    ..Transcranial electrical stimulation using weak current may thus be a promising tool to modulate cerebral excitability in a non-invasive, painless, reversible, selective and focal way...
  10. doi request reprint Serotonin affects transcranial direct current-induced neuroplasticity in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, Göttingen 37099, Germany
    Biol Psychiatry 66:503-8. 2009
    ..Here we explore the impact of the serotonin reuptake blocker citalopram on plasticity induced by transcranial direct current stimulation (tDCS) in humans in a single-blinded, placebo-controlled, randomized crossover study...
  11. doi request reprint Treatment of depression with transcranial direct current stimulation (tDCS): a review
    Michael A Nitsche
    Georg August University, Department Clinical Neurophysiology, Robert Koch Strasse 40, 37099 Goettingen, Germany
    Exp Neurol 219:14-9. 2009
    ..Further studies are needed to identify the optimal parameters of stimulation and the clinical and patient characteristics that may condition response to tDCS...
  12. doi request reprint Noninvasive brain stimulation protocols in the treatment of epilepsy: current state and perspectives
    Michael A Nitsche
    Department of Clinical Neurophysiology, Georg August University, 37099 Goettingen, Germany
    Neurotherapeutics 6:244-50. 2009
    ..Clinical studies conducted to date, however, have shown mixed results. Reasons for this, as well as possible optimization strategies that might lead to more efficient future stimulation protocols, will be discussed...
  13. doi request reprint D1-receptor impact on neuroplasticity in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, Georg August University, 37099 Gottingen, Germany
    J Neurosci 29:2648-53. 2009
    ..However, comparison with former results show that an appropriate balance of D(1) and D(2) activity seems necessary to (1) consolidate the respective excitability modifications and (2) to elicit a focusing effect...
  14. ncbi request reprint Catecholaminergic consolidation of motor cortical neuroplasticity in humans
    Michael A Nitsche
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Str 40, 37075 Goettingen, Germany
    Cereb Cortex 14:1240-5. 2004
    ..This result may enable researchers to optimize neuroplastic processes in the human brain on the rational basis of purpose-designed pharmacological interventions...
  15. ncbi request reprint Timing-dependent modulation of associative plasticity by general network excitability in the human motor cortex
    Michael A Nitsche
    Georg August University, Department for Clinical Neurophysiology, 37075 Goettingen, Germany
    J Neurosci 27:3807-12. 2007
    ..These findings might be of importance for the development of plasticity-inducing stimulation protocols supporting information processing in humans...
  16. ncbi request reprint Shaping the effects of transcranial direct current stimulation of the human motor cortex
    M A Nitsche
    Department for Clinical Neurophysiology, Georg August University, Goettingen, Germany
    J Neurophysiol 97:3109-17. 2007
    ..For future applications of tDCS, such paradigms may help to achieve more selective tDCS effects...
  17. ncbi request reprint Consolidation of human motor cortical neuroplasticity by D-cycloserine
    Michael A Nitsche
    Department Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Neuropsychopharmacology 29:1573-8. 2004
    ....
  18. ncbi request reprint MRI study of human brain exposed to weak direct current stimulation of the frontal cortex
    M A Nitsche
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Str 40, 37075 Goettingen, Germany
    Clin Neurophysiol 115:2419-23. 2004
    ....
  19. pmc Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Physiol 568:291-303. 2005
    ..In contrast, the after-effects of tDCS are due to shifts in intracortical inhibition and facilitation, and at least partly also to facilitatory I-wave interaction, which is controlled by synaptic activity...
  20. doi request reprint Transcranial direct current stimulation: State of the art 2008
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Brain Stimul 1:206-23. 2008
    ..Brain stimulation with weak direct currents is a promising tool in human neuroscience and neurobehavioral research. To facilitate and standardize future tDCS studies, we offer this overview of the state of the art for tDCS...
  21. ncbi request reprint Modulation of cortical excitability by weak direct current stimulation--technical, safety and functional aspects
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gotingen, Germany
    Suppl Clin Neurophysiol 56:255-76. 2003
  22. ncbi request reprint [Modulation of cortical excitability by transcranial direct current stimulation]
    M A Nitsche
    Abteilung Klinische Neurophysiolgie, Georg August Universitat Gottingen
    Nervenarzt 73:332-5. 2002
    ....
  23. ncbi request reprint Level of action of cathodal DC polarisation induced inhibition of the human motor cortex
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075, Goettingen, Germany
    Clin Neurophysiol 114:600-4. 2003
    ..To induce prolonged motor cortical excitability reductions by transcranial direct current stimulation in the human...
  24. doi request reprint Contribution of the premotor cortex to consolidation of motor sequence learning in humans during sleep
    Michael A Nitsche
    Georg August University, Department of Clinical Neurophysiology, Gottingen, Germany
    J Neurophysiol 104:2603-14. 2010
    ..In the control experiments, tDCS did not improve performance. We conclude that the premotor cortex is involved in motor memory consolidation during REM sleep...
  25. ncbi request reprint Dopaminergic impact on cortical excitability in humans
    Michael A Nitsche
    Georg August University, Dept Clinical Neurophysiology, Goettingen, Germany
    Rev Neurosci 21:289-98. 2010
    ..Here we review the respective experimental results and derive conclusions about how dopamine might affect the cortical excitability of the human brain...
  26. pmc Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans
    M A Nitsche
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    J Physiol 553:293-301. 2003
    ..The selective elimination of tDCS-driven excitability enhancements by carbamazepine proposes a role for this drug in focussing the effects of cathodal tDCS, which may have important future clinical applications...
  27. ncbi request reprint Facilitation of implicit motor learning by weak transcranial direct current stimulation of the primary motor cortex in the human
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Goettingen, Germany
    J Cogn Neurosci 15:619-26. 2003
    ..We conclude that the primary motor cortex is involved in the acquisition and early consolidation phase of implicit motor learning...
  28. ncbi request reprint Pharmacology of transcranial direct current stimulation: missing effect of riluzole
    D Liebetanz
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Suppl Clin Neurophysiol 56:282-7. 2003
  29. doi request reprint Limited impact of homeostatic plasticity on motor learning in humans
    Min Fang Kuo
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37099 Goettingen, Germany
    Neuropsychologia 46:2122-8. 2008
    ..We conclude that homeostatic plasticity, as tested here, has a limited influence on implicit sequential motor learning...
  30. ncbi request reprint Transcranial direct current stimulation reveals inhibitory deficiency in migraine
    Z Chadaide
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Cephalalgia 27:833-9. 2007
    ..Cathodal stimulation had no significant effect in the patient groups. This result strengthens the notion of deficient inhibitory processes in the cortex of migraineurs, which is selectively revealed by activity-modulating cortical input...
  31. ncbi request reprint Cortical hypoexcitability in chronic smokers? A transcranial magnetic stimulation study
    Nicolas Lang
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Neuropsychopharmacology 33:2517-23. 2008
    ..These changes may form a physiological basis for neurobiological and behavioral variations associated with chronic smoking...
  32. ncbi request reprint Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
    M A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Germany
    Neurology 57:1899-901. 2001
    ..The feasibility of inducing long-lasting excitability modulations in a noninvasive, painless, and reversible way makes this technique a potentially valuable tool in neuroplasticity modulation...
  33. doi request reprint Time course of the induction of homeostatic plasticity generated by repeated transcranial direct current stimulation of the human motor cortex
    K Fricke
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College of London, London, United Kingdom
    J Neurophysiol 105:1141-9. 2011
    ..The results are compatible with a time-dependent "homeostatic-like" rule governing the response of the human motor cortex to plasticity probing protocols...
  34. ncbi request reprint Facilitation of probabilistic classification learning by transcranial direct current stimulation of the prefrontal cortex in the human
    Tamas Z Kincses
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neuropsychologia 42:113-7. 2004
    ..Our results suggest that further studies on the facilitation of learning and memory processes by tDCS are warranted...
  35. doi request reprint Dose-dependent inverted U-shaped effect of dopamine (D2-like) receptor activation on focal and nonfocal plasticity in humans
    Katia Monte-Silva
    Department of Clinical Neurophysiology, Georg August University, 37075 Gottingen, Germany
    J Neurosci 29:6124-31. 2009
    ....
  36. ncbi request reprint External modulation of visual perception in humans
    A Antal
    Department of Clinical Neurophysiology, , Robert Koch Str. 40, , Germany
    Neuroreport 12:3553-5. 2001
    ..The present study also support the view that this method using weak current can be a non-invasive promising tool to induce reversible focal changes in the nervous system...
  37. ncbi request reprint Effects of transcranial direct current stimulation over the human motor cortex on corticospinal and transcallosal excitability
    N Lang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 156:439-43. 2004
    ....
  38. ncbi request reprint Direct current stimulation over MT+/V5 modulates motion aftereffect in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, 37075 Gottingen, Germany
    Neuroreport 15:2491-4. 2004
    ..These results provide evidence that external modulation of neural excitability in human MT+/V5 affects the strength of perceived motion after-effect and support the involvement of MT+/V5 in motion adaptation processes...
  39. ncbi request reprint Transcranial magnetic and direct current stimulation of the visual cortex
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Suppl Clin Neurophysiol 56:291-304. 2003
  40. ncbi request reprint Oscillatory brain activity and transcranial direct current stimulation in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neuroreport 15:1307-10. 2004
    ..Since gamma activity is also related to a higher level of information processing, tDCS might be a suitable method to affect higher order cognitive processes...
  41. ncbi request reprint Direct current stimulation over V5 enhances visuomotor coordination by improving motion perception in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Goettingen, Germany
    J Cogn Neurosci 16:521-7. 2004
    ..The results also raise the possibility of the usefulness of tDCS in rehabilitation strategies for neurological patients with visuomotor disorders...
  42. ncbi request reprint Facilitation of visuo-motor learning by transcranial direct current stimulation of the motor and extrastriate visual areas in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, 37075 Goettingen, Germany
    Eur J Neurosci 19:2888-92. 2004
    ..Also, stimulation of the primary visual cortex was not effective for this kind of task. Our data suggest that the areas V5 and M1 are involved in the early phase of learning of visuo-motor coordination...
  43. ncbi request reprint Can epilepsies be improved by repetitive transcranial magnetic stimulation?--interim analysis of a controlled study
    Frithjof Tergau
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Suppl Clin Neurophysiol 56:400-5. 2003
  44. ncbi request reprint Boosting focally-induced brain plasticity by dopamine
    Min Fang Kuo
    Department of Clinical Neurophysiology, Georg August University Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Cereb Cortex 18:648-51. 2008
    ..Most importantly, it prolongs all of these aftereffects by a factor of about 20. Hereby, DA focuses synapse-specific excitability-enhancing neuroplasticity in human cortical networks...
  45. doi request reprint Safety limits of cathodal transcranial direct current stimulation in rats
    David Liebetanz
    Department of Clinical Neurophysiology, University Medical Center Gottingen, Robert Koch Strasse 40, 37099 Gottingen, Germany
    Clin Neurophysiol 120:1161-7. 2009
    ..tDCS may be of therapeutic value in several neuro-psychiatric disorders. For its clinical applicability, however, more stable effects are required, which may be induced by intensified stimulations...
  46. ncbi request reprint Excitability changes induced in the human primary visual cortex by transcranial direct current stimulation: direct electrophysiological evidence
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Invest Ophthalmol Vis Sci 45:702-7. 2004
    ....
  47. ncbi request reprint Bidirectional modulation of primary visual cortex excitability: a combined tDCS and rTMS study
    Nicolas Lang
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Invest Ophthalmol Vis Sci 48:5782-7. 2007
    ..The authors examined whether tDCS can also prime the cortical response to rTMS in the human visual cortex...
  48. ncbi request reprint No correlation between moving phosphene and motor thresholds: a transcranial magnetic stimulation study
    Andrea Antal
    Department of Clinical Neurophysiology, George August University of Göttingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neuroreport 15:297-302. 2004
    ..Thus, we propose specific measures for cortices of interest: PT for visual experiments and MT for motor experiments...
  49. ncbi request reprint Modulation of moving phosphene thresholds by transcranial direct current stimulation of V1 in human
    Andrea Antal
    Department of Clinical Neurophysiology, George August University of Göttingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Neuropsychologia 41:1802-7. 2003
    ..Our results show that the excitability shifts induced by V1 stimulation can modulate moving phosphene perception. tDCS elicits transient, but yet reversible effects, thus presenting a promising tool for neuroplasticity research...
  50. doi request reprint Modulatory effects of transcranial direct current stimulation on laser-evoked potentials
    Gabor Csifcsak
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Pain Med 10:122-32. 2009
    ..In a separate experiment subjective, pain rating scores of 16 healthy subjects in two perceptual categories (warm sensation, mild pain) were also analyzed...
  51. doi request reprint Transcranial direct current stimulation of the motor cortex induces distinct changes in thermal and mechanical sensory percepts
    Cornelius G Bachmann
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Clin Neurophysiol 121:2083-9. 2010
    ..The aim of this single-blinded, complete crossover study was to evaluate the effects of tDCS on thermal and mechanical perception, as assessed by quantitative sensory testing (QST)...
  52. ncbi request reprint Modulation of motor consolidation by external DC stimulation
    Nicolas Lang
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Suppl Clin Neurophysiol 56:277-81. 2003
  53. ncbi request reprint Anticonvulsant effects of transcranial direct-current stimulation (tDCS) in the rat cortical ramp model of focal epilepsy
    David Liebetanz
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Epilepsia 47:1216-24. 2006
    ..To evaluate its anticonvulsant potential, transcranial direct current stimulation (tDCS) was tested in a modified cortical ramp-stimulation model of focal epilepsy...
  54. ncbi request reprint After-effects of transcranial direct current stimulation (tDCS) on cortical spreading depression
    David Liebetanz
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, 37099 Gottingen, Germany
    Neurosci Lett 398:85-90. 2006
    ....
  55. ncbi request reprint Transcranial direct current stimulation and the visual cortex
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, 37075 Gottingen, Germany
    Brain Res Bull 68:459-63. 2006
    ..Most likely that up- or downregulation of different cortical areas by tDCS will open a new branch in the area of visual psychophysics...
  56. ncbi request reprint Focusing effect of acetylcholine on neuroplasticity in the human motor cortex
    Min Fang Kuo
    Department of Clinical Neurophysiology, Georg August University Gottingen, 37075 Gottingen, Germany
    J Neurosci 27:14442-7. 2007
    ..These findings are in line with a cholinergic focusing effect that optimizes the detection of relevant signals during information processing in humans...
  57. ncbi request reprint Pulse configuration-dependent effects of repetitive transcranial magnetic stimulation on visual perception
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Strasse 40, 37070 Gottingen, Germany
    Neuroreport 13:2229-33. 2002
    ..However the effect of modulation significantly depends on the current waveform and direction...
  58. ncbi request reprint Preconditioning with transcranial direct current stimulation sensitizes the motor cortex to rapid-rate transcranial magnetic stimulation and controls the direction of after-effects
    Nicolas Lang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Biol Psychiatry 56:634-9. 2004
    ....
  59. ncbi request reprint Manipulation of phosphene thresholds by transcranial direct current stimulation in man
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Strasse 40, 37070 Gottingen, Germany
    Exp Brain Res 150:375-8. 2003
    ..Our results show that tDCS elicits a transient, reversible excitability alteration of the visual cortex, thus representing a promising tool for neuroplasticity research...
  60. ncbi request reprint Relationship between lamotrigine oral dose, serum level and its inhibitory effect on CNS: insights from transcranial magnetic stimulation
    Frithjof Tergau
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Strasse 40, D 37075 Goettingen, Germany
    Epilepsy Res 56:67-77. 2003
    ....
  61. doi request reprint Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Gottingen, Germany
    Brain Stimul 3:230-7. 2010
    ..Plasticity induced in the human motor cortex by intermittent theta-burst stimulation (iTBS) was impaired in individuals expressing the Val66Met polymorphism...
  62. doi request reprint Prior state of cortical activity influences subsequent practicing of a visuomotor coordination task
    Andrea Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, 37075 Gottingen, Germany
    Neuropsychologia 46:3157-61. 2008
    ..The results of our study underline the principal functional relevance of the BCM rule for the efficacy of visuomotor practice, but imply that also other mechanisms have to be taken into account...
  63. ncbi request reprint Higher variability of phosphene thresholds in migraineurs than in controls: a consecutive transcranial magnetic stimulation study
    A Antal
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Cephalalgia 26:865-70. 2006
    ..Additionally, both particularly high and low PTs might predict a subsequent headache in some individuals...
  64. ncbi request reprint Altered motion perception in migraineurs: evidence for interictal cortical hyperexcitability
    A Antal
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Cephalalgia 25:788-94. 2005
    ..Thus we conclude that migraineurs display enhanced visual cortical excitability between attacks in V5...
  65. ncbi request reprint Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability
    David Liebetanz
    Department of Clinical Neurophysiology, Georg August University Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    Brain 125:2238-47. 2002
    ....
  66. ncbi request reprint Sex differences in cortical neuroplasticity in humans
    Min Fang Kuo
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Neuroreport 17:1703-7. 2006
    ..These results suggest sex differences, possibly due to the effects of sex hormones, in the modulation of human cortical plasticity...
  67. doi request reprint Electrophysiological correlates of reduced pain perception after theta-burst stimulation
    Gabor Csifcsak
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Neuroreport 20:1051-5. 2009
    ..When compared with sham stimulation, cTBS resulted in a significantly greater diminution of pain ratings and N2-P2 amplitudes on the hand contralateral to the site of motor cortex stimulation...
  68. pmc Effects of frontal transcranial direct current stimulation on emotional state and processing in healthy humans
    M A Nitsche
    Department Clinical Neurophysiology, Georg August University Goettingen, Germany
    Front Psychiatry 3:58. 2012
    ..We conclude that tDCS of the prefrontal cortex improves emotion processing in healthy subjects, but does not influence subjective emotional state...
  69. doi request reprint Diurnal time course of heat pain perception in healthy humans
    C G Bachmann
    Department of Clinical Neurophysiology, University Medical Centre, Georg August University, Robert Koch Strasse 40, D 37075 Goettingen, Germany
    Neurosci Lett 489:122-5. 2011
    ....
  70. doi request reprint Premotor transcranial direct current stimulation (tDCS) affects primary motor excitability in humans
    Klara Boros
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Eur J Neurosci 27:1292-300. 2008
    ..Moreover, this finding indirectly substantiates the efficacy of tDCS to modulate premotor excitability, which might be of interest for applications in diseases accompanied by pathological premotor activity...
  71. doi request reprint H-coil: Induced electric field properties and input/output curves on healthy volunteers, comparison with a standard figure-of-eight coil
    Tommaso Fadini
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Clin Neurophysiol 120:1174-82. 2009
    ..To acquire information about the physical properties and physiological effects of the H-coil...
  72. ncbi request reprint Transcranial direct current stimulation: a new treatment for depression?
    M A Nitsche
    Department Clin Neurophysiology, Georg August University, Goettingen, Germany
    Bipolar Disord 4:98-9. 2002
  73. ncbi request reprint Transcranial direct current stimulation of the unaffected hemisphere in stroke patients
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Neuroreport 16:1551-5. 2005
    ..These results suggest that the appropriate modulation of bihemispheric brain structures can promote motor function recovery...
  74. ncbi request reprint Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease
    Felipe Fregni
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mov Disord 21:1693-702. 2006
    ..These results confirm and extend the notion that cortical brain stimulation might improve motor function in patients with PD...
  75. ncbi request reprint Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression
    Felipe Fregni
    Depress Anxiety 23:482-4. 2006
  76. ncbi request reprint Safety criteria for transcranial direct current stimulation (tDCS) in humans
    Michael A Nitsche
    Clin Neurophysiol 114:2220-2; author reply 2222-3. 2003
  77. ncbi request reprint Transcranial direct current stimulation disrupts tactile perception
    Andreas Rogalewski
    Department of Neurology, University of Muenster, Albert Schweitzer Strasse 33, 48129 Muenster, Germany
    Eur J Neurosci 20:313-6. 2004
    ..This finding offers a new perspective for the treatment of conditions characterized by alterations of cortical excitability...
  78. pmc A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression
    Paulo S Boggio
    Nucleo de Neurociencias, Centro de Ciencias Biologicas e da Saude, Universidade Presbiteriana Mackenzie, Sao Paulo, Brazil
    Int J Neuropsychopharmacol 11:249-54. 2008
    ..Our findings support further investigation on the effects of this novel potential therapeutic approach - tDCS - for the treatment of major depression...
  79. ncbi request reprint Effects of transcranial direct current stimulation coupled with repetitive electrical stimulation on cortical spreading depression
    Felipe Fregni
    Center for Noninvasive Brain Stimulation, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, KS 452, Boston, MA 02215, USA
    Exp Neurol 204:462-6. 2007
    ....
  80. ncbi request reprint Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial direct current stimulation: evidence for homeostatic plasticity in the human motor cortex
    Hartwig R Siebner
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College of London, London WC1N 3BG, United Kingdom
    J Neurosci 24:3379-85. 2004
    ..These preconditioning effects of TDCS suggest the existence of a homeostatic mechanism in the human motor cortex that stabilizes corticospinal excitability within a physiologically useful range...
  81. pmc Transcranial direct current stimulation of the prefrontal cortex modulates the desire for specific foods
    Felipe Fregni
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue KS 454, Boston, MA, 02215, USA
    Appetite 51:34-41. 2008
    ..These changes were not related to mood changes after any type of tDCS treatment. The effects of tDCS on food craving might be related to a modulation of neural circuits associated with reward and decision-making...
  82. ncbi request reprint Cortical stimulation of the prefrontal cortex with transcranial direct current stimulation reduces cue-provoked smoking craving: a randomized, sham-controlled study
    Felipe Fregni
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    J Clin Psychiatry 69:32-40. 2008
    ....
  83. ncbi request reprint Effect of transcranial DC sensorimotor cortex stimulation on somatosensory evoked potentials in humans
    Kaoru Matsunaga
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 8 11 Queen Square, London WC1N 3BG, UK
    Clin Neurophysiol 115:456-60. 2004
    ..To study the after-effect of transcranial direct current stimulation (tDCS) over the sensorimotor cortex on the size of somatosensory evoked potentials (SEPs) in humans...
  84. ncbi request reprint Repeated sessions of noninvasive brain DC stimulation is associated with motor function improvement in stroke patients
    Paulo S Boggio
    Department of Experimental Psychology and Department of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    Restor Neurol Neurosci 25:123-9. 2007
    ..Recent evidence has suggested that a simple technique of noninvasive brain stimulation - transcranial direct current stimulation (tDCS) - is associated with a significant motor function improvement in stroke patients...
  85. ncbi request reprint Treatment of major depression with transcranial direct current stimulation
    Felipe Fregni
    Bipolar Disord 8:203-4. 2006
  86. ncbi request reprint Studying the neurobiology of social interaction with transcranial direct current stimulation--the example of punishing unfairness
    Daria Knoch
    Institute for Empirical Research in Economics, University of Zurich, 8006 Zurich, Switzerland
    Cereb Cortex 18:1987-90. 2008
    ..Here we show that transcranial direct current stimulation (tDCS) can overcome these limits. We apply right prefrontal cathodal tDCS and show that subjects' propensity to punish unfair behavior is reduced significantly...
  87. ncbi request reprint A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Pain 122:197-209. 2006
    ..We discuss potential mechanisms for pain amelioration after tDCS, such as a secondary modulation of thalamic nuclei activity...
  88. ncbi request reprint A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia
    Felipe Fregni
    Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Rheum 54:3988-98. 2006
    ....
  89. ncbi request reprint Transcranial direct stimulation and fluoxetine for the treatment of depression
    Sergio P Rigonatti
    Eur Psychiatry 23:74-6. 2008