Eberhard Nieschlag

Summary

Country: Germany

Publications

  1. ncbi request reprint Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men
    E Nieschlag
    Institute of Reproductive Medicine of the University, Munster, Germany
    Clin Endocrinol (Oxf) 51:757-63. 1999
  2. ncbi request reprint Androgens shorten the longevity of women: sopranos last longer
    E Nieschlag
    Institute of Reproductive Medicine of the Westphalian Wilhelms University, Munster, Germany
    Exp Clin Endocrinol Diabetes 111:230-1. 2003
  3. ncbi request reprint Testosterone replacement therapy: current trends and future directions
    E Nieschlag
    Institute of Reproductive Medicine of the University Domagkstr 11, D 48129 Munster, Germany
    Hum Reprod Update 10:409-19. 2004
  4. ncbi request reprint Lack of effect of a single i.v. dose of oxytocin on sperm output in severely oligozoospermic men
    Maria M Byrne
    Institute of Reproductive Medicine, University of Munster, Domagkstrasse 11, D 48129 Munster, Germany
    Hum Reprod 18:2098-102. 2003
  5. ncbi request reprint Use of progestins in male contraception
    Eberhard Nieschlag
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Muenster, Germany
    Steroids 68:965-72. 2003
  6. ncbi request reprint Case report: natural transmission of an AZFc Y-chromosomal microdeletion from father to his sons
    B Kuhnert
    Institute of Reproductive Medicine of the University, D 48129 Muenster, Germany
    Hum Reprod 19:886-8. 2004
  7. doi request reprint Experimental endocrine manipulation by contraceptive regimen in the male marmoset (Callithrix jacchus)
    Joachim Wistuba
    Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University of Munster, Albert Schweitzer Campus 1, 48129 Munster, Germany
    Reproduction 145:439-51. 2013
  8. ncbi request reprint Norethisterone enanthate has neither a direct effect on the testis nor on the epididymis: a study in adult male cynomolgus monkeys (Macaca fascicularis)
    Aris Junaidi
    Institute of Reproductive Medicine of the University, Munster, Germany
    Eur J Endocrinol 152:655-61. 2005
  9. ncbi request reprint Mouse models of infertility due to swollen spermatozoa
    Trevor G Cooper
    Institute of Reproductive Medicine of the University, Domagkstr 11, D 48129 Munster, Germany
    Mol Cell Endocrinol 216:55-63. 2004
  10. ncbi request reprint Changes in endocrine profile and reproductive organs during puberty in the male marmoset monkey (Callithrix jacchus)
    Ramesh K Chandolia
    Institute for Reproductive Medicine of the University, Domagkstr 11, D 48129 Muenster, Germany
    Reproduction 132:355-63. 2006

Detail Information

Publications140 found, 100 shown here

  1. ncbi request reprint Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men
    E Nieschlag
    Institute of Reproductive Medicine of the University, Munster, Germany
    Clin Endocrinol (Oxf) 51:757-63. 1999
    ..To investigate the suitability of intramuscular testosterone undecanoate (TU) injections for substitution therapy in hypogonadal men...
  2. ncbi request reprint Androgens shorten the longevity of women: sopranos last longer
    E Nieschlag
    Institute of Reproductive Medicine of the Westphalian Wilhelms University, Munster, Germany
    Exp Clin Endocrinol Diabetes 111:230-1. 2003
    ....
  3. ncbi request reprint Testosterone replacement therapy: current trends and future directions
    E Nieschlag
    Institute of Reproductive Medicine of the University Domagkstr 11, D 48129 Munster, Germany
    Hum Reprod Update 10:409-19. 2004
    ....
  4. ncbi request reprint Lack of effect of a single i.v. dose of oxytocin on sperm output in severely oligozoospermic men
    Maria M Byrne
    Institute of Reproductive Medicine, University of Munster, Domagkstrasse 11, D 48129 Munster, Germany
    Hum Reprod 18:2098-102. 2003
    ..The aim of this randomized single-blind cross-over study was to establish the effects of oxytocin on sperm output in severely oligozoospermic men...
  5. ncbi request reprint Use of progestins in male contraception
    Eberhard Nieschlag
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Muenster, Germany
    Steroids 68:965-72. 2003
    ..Acute side-effects of these combinations appear to be minimal and tolerable, long-term effects need to be investigated...
  6. ncbi request reprint Case report: natural transmission of an AZFc Y-chromosomal microdeletion from father to his sons
    B Kuhnert
    Institute of Reproductive Medicine of the University, D 48129 Muenster, Germany
    Hum Reprod 19:886-8. 2004
    ..Thus, other genes or environmental factors must modify spermatogenesis in men with identical Y-chromosomal microdeletions...
  7. doi request reprint Experimental endocrine manipulation by contraceptive regimen in the male marmoset (Callithrix jacchus)
    Joachim Wistuba
    Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University of Munster, Albert Schweitzer Campus 1, 48129 Munster, Germany
    Reproduction 145:439-51. 2013
    ..In conclusion, marmosets showed a different response to regimens of male contraception from macaques or men and have to be considered as a problematic model for preclinical trials of male hormonal contraception...
  8. ncbi request reprint Norethisterone enanthate has neither a direct effect on the testis nor on the epididymis: a study in adult male cynomolgus monkeys (Macaca fascicularis)
    Aris Junaidi
    Institute of Reproductive Medicine of the University, Munster, Germany
    Eur J Endocrinol 152:655-61. 2005
    ..If NETE has a direct effect on spermatogenesis and/or epididymal function, some changes in testicular histology, sperm motility and/or morphology should occur soon after exposure to NETE...
  9. ncbi request reprint Mouse models of infertility due to swollen spermatozoa
    Trevor G Cooper
    Institute of Reproductive Medicine of the University, Domagkstr 11, D 48129 Munster, Germany
    Mol Cell Endocrinol 216:55-63. 2004
    ..Further analysis could pinpoint genes essential for epididymal regulation of sperm volume, explain infertility and suggest modes of male contraception...
  10. ncbi request reprint Changes in endocrine profile and reproductive organs during puberty in the male marmoset monkey (Callithrix jacchus)
    Ramesh K Chandolia
    Institute for Reproductive Medicine of the University, Domagkstr 11, D 48129 Muenster, Germany
    Reproduction 132:355-63. 2006
    ....
  11. doi request reprint Polymorphisms of the luteinizing hormone/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility
    Manuela Simoni
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, Munster, Germany
    Pharmacogenet Genomics 18:193-200. 2008
    ....
  12. ncbi request reprint A clinical trial of 7 alpha-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men
    Sigrid von Eckardstein
    Institute of Reproductive Medicine, University of Munster, Munster, Germany
    J Clin Endocrinol Metab 88:5232-9. 2003
    ....
  13. ncbi request reprint Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation
    Hermann M Behre
    Andrology Unit, Department of Urology, University Hospital, Halle, University Hospital, Munster, Germany
    Pharmacogenet Genomics 15:451-6. 2005
    ..In women undergoing controlled ovarian hyperstimulation, the p.N680S sequence variation results in lower oestradiol levels following FSH stimulation. This lower FSH receptor sensitivity can be overcome by higher FSH doses...
  14. ncbi request reprint X-chromosome inactivation patterns and androgen receptor functionality influence phenotype and social characteristics as well as pharmacogenetics of testosterone therapy in Klinefelter patients
    Michael Zitzmann
    Institute of Reproductive Medicine, University of Munster, D 48129 Munster, Germany
    J Clin Endocrinol Metab 89:6208-17. 2004
    ..The effects of T substitution are pharmacogenetically modified. This finding is magnified by preferential inactivation of the more functional short CAGn allele...
  15. ncbi request reprint Targeted expression of human FSH receptor Asp567Gly mutant mRNA in testis of transgenic mice: role of human FSH receptor promoter
    Verena Nordhoff
    Institute of Reproductive Medicine, University of Munster, Domagkstr 11, D 48149 Munster, Germany
    Asian J Androl 5:267-75. 2003
    ..To specifically express the Asp567Gly human follicle-stimulating hormone receptor (FSHR) under the control of its promoter to evaluate the phenotypic consequences in the presence of normal pituitary function...
  16. ncbi request reprint Elevated follicle-stimulating hormone levels and the chances for azoospermic men to become fathers after retrieval of elongated spermatids from cryopreserved testicular tissue
    Michael Zitzmann
    Institute of Reproductive Medicine of the University, University of Munster, Munster, Germany
    Fertil Steril 86:339-47. 2006
    ..To assess individual chances for a live-born child in azoospermic men by performance of testicular sperm extraction (TESE) followed by intracytoplasmatic sperm injection (ICSI)...
  17. ncbi request reprint Pharmacokinetics and pharmacodynamics of injectable testosterone undecanoate in castrated cynomolgus monkeys (Macaca fascicularis) are independent of different oil vehicles
    Joachim Wistuba
    Institute of Reproductive Medicine of the University, Munster, Germany
    J Med Primatol 34:178-87. 2005
    ..The results suggest that TU in soybean oil produces similar effects as TU in the other vehicles. This study in non-human primates provides no objection to testing of this new preparation in humans...
  18. ncbi request reprint Clinical consequences of microdeletions of the Y chromosome: the extended Münster experience
    Manuela Simoni
    Institute of Reproductive Medicine, University Hospital, Domagkstr 11, D 48149 Munster, Germany
    Reprod Biomed Online 16:289-303. 2008
    ....
  19. ncbi request reprint Male congenital hypothyroid Pax8-/- mice are infertile despite adequate treatment with thyroid hormone
    Joachim Wistuba
    Institute of Reproductive Medicine of the University, Domagkstr 11, 48149 Munster, Germany
    J Endocrinol 192:99-109. 2007
    ..It remains to be elucidated whether congenital hypothyroid male patients with mutations in the Pax8 gene are similarly affected...
  20. doi request reprint Sex hormone levels, genetic androgen receptor polymorphism, and anxiety in ≥50-year-old males
    Gudrun Schneider
    Department of Psychosomatics and Psychotherapy, University of Munster, Munster, Germany
    J Sex Med 8:3452-64. 2011
    ....
  21. ncbi request reprint Follicle-stimulating hormone receptor gene haplotype distribution in normozoospermic and azoospermic men
    Yuni Ahda
    Institute of Reproductive Medicine of the University, Domagkstr 11, D 48129 Munster, Germany
    J Androl 26:494-9. 2005
    ..The A-Ala-Ser and the G-Thr-Asn allele might represent genetic factors contributing to phenotypic expression of severe spermatogenetic impairment...
  22. ncbi request reprint Single-nucleotide polymorphisms in the promoter region influence the expression of the human follicle-stimulating hormone receptor
    Alain Wunsch
    Institute of Reproductive Medicine, University Hospital, Munster, Germany
    Fertil Steril 84:446-53. 2005
    ..To characterize novel single-nucleotide polymorphisms (SNPs) in the human FSH receptor (FSHR) promoter region...
  23. ncbi request reprint No association of the A260G and A386G DAZL single nucleotide polymorphisms with male infertility in a Caucasian population
    Petra Tschanter
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
    Hum Reprod 19:2771-6. 2004
    ..These single nucleotide polymorphisms (SNPs) have been described previously to be associated with spermatogenic failure...
  24. ncbi request reprint Endogenous progesterone and the exogenous progestin norethisterone enanthate are associated with a proinflammatory profile in healthy men
    Michael Zitzmann
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
    J Clin Endocrinol Metab 90:6603-8. 2005
    ..Inflammatory processes are related to atherosclerosis. Identification of inflammation triggers may furnish new therapeutic pathways. In women, progestins can have a marked inflammatory capacity...
  25. doi request reprint Impaired recognition memory in male mice with a supernumerary X chromosome
    Lars Lewejohann
    Department of Behavioural Biology, University of Munster, Munster, Germany
    Physiol Behav 96:23-9. 2009
    ..We suggest that the altered endocrine state and/or changes in the dosage of X-linked genes in the XX(Y*) mouse model affect brain function, in particular those regions responsible for cognition and learning behavior...
  26. doi request reprint Depressive symptoms in men aged 50 years and older and their relationship to genetic androgen receptor polymorphism and sex hormone levels in three different samples
    Gudrun Schneider
    Department of Psychosomatics and Psychotherapy, University of Munster, Germany
    Am J Geriatr Psychiatry 19:274-83. 2011
    ..The aim of this study was to determine how sex hormone levels and the AR polymorphism relate to depressive symptoms in aging men...
  27. doi request reprint Complete spermatogenesis in orthotopic but not in ectopic transplants of autologously grafted marmoset testicular tissue
    C Marc Luetjens
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, Munster, Germany
    Endocrinology 149:1736-47. 2008
    ..Autologous grafting of nonhuman primate testicular tissues can result in complete spermatogenesis. Our findings indicate that transplantation site and developmental age of the tissue play a role more important than the endocrine milieu...
  28. ncbi request reprint Prostate volume and growth in testosterone-substituted hypogonadal men are dependent on the CAG repeat polymorphism of the androgen receptor gene: a longitudinal pharmacogenetic study
    Michael Zitzmann
    Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
    J Clin Endocrinol Metab 88:2049-54. 2003
    ..This first pharmacogenetic study on androgen substitution in hypogonadal men demonstrates a marked influence of the AR gene (CAG)n polymorphism on prostate growth...
  29. ncbi request reprint Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice
    Trevor G Cooper
    Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
    Biol Reprod 69:1750-62. 2003
    ..The changes in these genes could affect sperm function by modifying the composition of epididymal fluid and explain the infertility of the KO males. These genes may be targets for a posttesticular contraceptive...
  30. doi request reprint Aging males' symptoms in relation to the genetically determined androgen receptor CAG polymorphism, sex hormone levels and sample membership
    Gudrun Schneider
    Department of Psychosomatics and Psychotherapy, University of Munster, Domagkstrasse 22, 48149 Munster, Germany
    Psychoneuroendocrinology 35:578-87. 2010
    ..Our results suggest that the so-called aging male symptoms show a certain association to androgenicity, but that they are rather unspecific and of multifactorial origin. Other factors contributing to AMS need further clarification...
  31. ncbi request reprint Coculture of spermatogonia with somatic cells in a novel three-dimensional soft-agar-culture-system
    Jan Bernd Stukenborg
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, 48129 Munster, Germany
    J Androl 29:312-29. 2008
    ..We conclude that our enrichment and culture approach is highly useful for exploration of SSC expansion and have found indications that the system supports differentiation up to the level of postmeiotic germ cells...
  32. ncbi request reprint The presence of germ cells in the semen of azoospermic, cryptozoospermic and severe oligozoospermic patients: stringent flow cytometric analysis and correlations with hormonal status
    C H Yeung
    Institute of Reproductive Medicine, University of Munster, Munster, Germany
    Clin Endocrinol (Oxf) 67:767-75. 2007
    ..Cells from each ejaculate were stained for DNA and mitochondria and analysed as spermatozoa (HC), round spermatids (1N), primary spermatocytes (4N) or diploid cells (2N)...
  33. ncbi request reprint Testosterone-induced inhibition of spermatogenesis is more closely related to suppression of FSH than to testicular androgen levels in the cynomolgus monkey model (Macaca fascicularis)
    G F Weinbauer
    Institute of Reproductive Medicine, , Domagkstrasse 11, , Germany
    J Endocrinol 168:25-38. 2001
    ..For the purpose of male contraception, FSH inhibition appears mandatory...
  34. ncbi request reprint Minutes of the 14th European workshop on molecular and cellular endocrinology of the testis
    Jorg Gromoll
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
    Mol Cell Endocrinol 257:1-5. 2006
  35. ncbi request reprint Tissue expression of the nuclear progesterone receptor in male non-human primates and men
    C Marc Luetjens
    Institute of Reproductive Medicine, University Hospitals, Domagk Strasse 11, D 48149 Munster, Germany
    J Endocrinol 189:529-39. 2006
    ..These data exclude direct genomic effects of gestagens at the spermatogenic level but indicate that a male contraceptive based on gestagens might have some effects on other tissues, such as the epididymis, prostate and mammary gland...
  36. ncbi request reprint Differences in serum LH and FSH levels using depot or daily GnRH agonists in controlled ovarian stimulation: influence on ovarian response and outcome of ART
    Barbara Sonntag
    Assisted Reproduction Unit, Department of Obstetrics and Gynaecology, Munster, Germany
    J Assist Reprod Genet 22:277-83. 2005
    ..To study effects of endogenous LH levels on ovarian response and outcome in ART cycles a controlled study was performed with two patient groups differing in the intensity of pituitary downregulation...
  37. ncbi request reprint Meiosis in autologous ectopic transplants of immature testicular tissue grafted to Callithrix jacchus
    Joachim Wistuba
    Institute of Reproductive Medicine, University Munster, 48129 Munster, Germany
    Biol Reprod 74:706-13. 2006
    ..Further studies have to be performed to overcome the meiotic arrest to explore the model further and to develop therapeutic options...
  38. ncbi request reprint Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men
    Michael Zitzmann
    Institute of Reproductive Medicine, University Clinics, Muenster D 48149, Germany
    J Clin Endocrinol Metab 92:3844-53. 2007
    ..Intramuscular injection of the long-acting ester testosterone undecanoate (TU) offers a new modality...
  39. ncbi request reprint Pharmacokinetics and degree of aromatization rather than total dose of different preparations determine the effects of testosterone: a nonhuman primate study in Macaca fascicularis
    Gerhard F Weinbauer
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
    J Androl 24:765-74. 2003
    ..These results have to be considered in men receiving treatment for hypogonadism or regimens for hormonal contraception...
  40. ncbi request reprint Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: a phase II study
    Sigrid von Eckardstein
    Institute of Reproductive Medicine of the University, Munster, Germany
    J Androl 23:419-25. 2002
    ....
  41. doi request reprint Body fat content and testosterone pharmacokinetics determine gonadotropin suppression after intramuscular injections of testosterone preparations in normal men
    Britta Kornmann
    Centre of Reproductive Medicine and Andrology of the University, Munster, Germany
    J Androl 30:602-13. 2009
    ..We conclude that overweight reduces the chance of rapid and profound gonadotropin suppression during treatment with TU. Body weight needs to be considered to avoid failure of hormonal male contraception...
  42. doi request reprint Anti-Müllerian hormone in men with normal and reduced sperm concentration and men with maldescended testes
    Frank Tüttelmann
    Institute of Reproductive Medicine of the University, Munster, Germany
    Fertil Steril 91:1812-9. 2009
    ....
  43. doi request reprint The struggle for male hormonal contraception
    Eberhard Nieschlag
    Centre of Reproductive Medicine and Andrology CeRA, University of Munster, Domagkstr 11, D 48149 Munster, Germany
    Best Pract Res Clin Endocrinol Metab 25:369-75. 2011
    ..An ongoing large multicenter trial launched by WHO and the US CONRAD Programme will decide about the future of male hormonal contraception...
  44. ncbi request reprint Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone
    Marion Depenbusch
    Institute of Reproductive Medicine of the University, Domagkstr 11, Munster D 48149, Germany
    Eur J Endocrinol 147:617-24. 2002
    ..It is generally accepted that both gonadotropins LH and FSH are necessary for initiation and maintenance of spermatogenesis. We investigated the relative importance of FSH for the maintenance of spermatogenesis in hypogonadotropic men...
  45. ncbi request reprint Association of meiotic arrest with lack of BOULE protein expression in infertile men
    C Marc Luetjens
    Institute of Reproductive Medicine, Westphalian Wilhelms University, D 48129 Muenster, Germany
    J Clin Endocrinol Metab 89:1926-33. 2004
    ..Thus, the spermatogenic damage leading to meiotic arrest is independent of the etiology and indicates that BOULE is a possible fundamental mediator of meiotic transition in the human...
  46. ncbi request reprint Epidermal growth factor receptor pathway substrate 8 (Eps8) expression in maturing testis
    Alain Wunsch
    Institute of Reproductive Medicine of the University, Domagkstr 11, D 48129 Munster, Germany
    Asian J Androl 6:195-203. 2004
    ..Here we evaluated the expression pattern of Eps8 in the maturing testis...
  47. ncbi request reprint Relationship of cytoplasmic droplets to motility, migration in mucus, and volume regulation of human spermatozoa
    Sabina Fetic
    Institute of Reproductive Medicine, University of Munster, Germany
    J Androl 27:294-301. 2006
    ..Therefore, cytoplasmic droplets are not deleterious to sperm motility and may be related to physiological volume regulation, which may be predictive of some forms of human male infertility...
  48. ncbi request reprint Androgen receptor gene CAG and GGN polymorphisms in infertile Nigerian men
    O Akinloye
    Institute of Reproductive Medicine of the University, Munster, Germany
    J Endocrinol Invest 32:797-804. 2009
    ..The functional relevance of this variance to male fertility warrants in-depth elucidation...
  49. ncbi request reprint Clinical, endocrinological, and epigenetic features of the 46,XX male syndrome, compared with 47,XXY Klinefelter patients
    Elena Vorona
    Institute of Reproductive Medicine, University Clinics of Münster, D 48129 Munster, Germany
    J Clin Endocrinol Metab 92:3458-65. 2007
    ..The 46,XX male syndrome represents a rare, poorly characterized form of male hypogonadism...
  50. ncbi request reprint Clinical and diagnostic features of patients with suspected Klinefelter syndrome
    Axel Kamischke
    Institute of Reproductive Medicine and the Institute of Human Genetics of the University, Munster, Germany
    J Androl 24:41-8. 2003
    ..Barr body analysis provides a quick and reliable screening test, which, however, must be confirmed by karyotyping...
  51. ncbi request reprint Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism
    Fabio Lanfranco
    Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
    Eur J Endocrinol 153:845-52. 2005
    ..To determine the frequency of mutations of the gonadotropin-releasing hormone receptor (GnRHR) and of the G protein-coupled receptor 54 (GPR54) genes in normosmic idiopathic hypogonadotropic hypogonadism (IHH)...
  52. ncbi request reprint Male contraception: a realistic option?
    Melanie Wenk
    Institute of Reproductive Medicine, University of Munster, Domagkstr 11, 48149, Munster, Germany
    Eur J Contracept Reprod Health Care 11:69-80. 2006
    ..Further large multi-centre studies are required to establish the contraceptive efficacy of the most promising steroid combinations...
  53. ncbi request reprint Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy
    Fabio Lanfranco
    Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
    Clin Endocrinol (Oxf) 60:500-7. 2004
    ..This study aimed to evaluate adiponectin levels in hypogonadal men prior to and during testosterone replacement therapy...
  54. ncbi request reprint [Hormonal contraception for males--an option for adolescents?]
    Axel Kamischke
    Institut für Reproduktionsmedizin des Universitätsklinikums Münster, Domagkstrasse 11, DE 48129 Münster, Germany
    Gynakol Geburtshilfliche Rundsch 45:241-6. 2005
    ..Special attention will need to be given to bone maturation as androgens at the prescribed doses might induce premature closure of the epiphyseal joints...
  55. ncbi request reprint Quantification of seminal germ cells in azoospermia: correlations with testicular histology and TESE outcome
    C H Yeung
    Institute of Reproductive Medicine, University of Munster, Munster, Germany
    Int J Androl 32:242-54. 2009
    ..In conclusion, seminal germ cells cannot provide good prognosis for TESE, although their presence could indicate the spermatogenic activity in the testis...
  56. ncbi request reprint Regulation of the initial segment of the murine epididymis by dihydrotestosterone and testicular exocrine secretions studied by expression of specific proteins and gene expression
    C Avram
    Institut für Reproduktionsmedizin, Universitat Munster, Domagkstrasse 11, 48149, Germany
    Cell Tissue Res 317:13-22. 2004
    ..The maintenance of the full complement of epithelia in the murine caput epididymidis in the adult thus requires a combination of luminal fluid from the testis, tissue DHT and the presence of the c-ros oncogene...
  57. ncbi request reprint Intramuscular testosterone undecanoate and norethisterone enanthate in a clinical trial for male contraception
    A Kamischke
    Institute of Reproductive Medicine, , , Germany
    J Clin Endocrinol Metab 86:303-9. 2001
    ..Because of its long-lasting, profound suppression of spermatogenesis and the absence of serious side-effects, the combination of TU and NETE can be considered a first choice for further studies of hormonal male contraception...
  58. ncbi request reprint Klinefelter's syndrome
    Fabio Lanfranco
    Institute of Reproductive Medicine of the University of Munster, Domagkstrasse 11, D 48129 Munster, Germany
    Lancet 364:273-83. 2004
    ..The genetic implications of the fertilisation procedures, including pretransfer or prenatal genetic assessment, must be explained to patients and their partners...
  59. ncbi request reprint Gene expression profiling of mouse Sertoli cell lines
    Kai Strothmann
    Institute of Reproductive Medicine, Munster University, Domagkstrasse 11, 48149 Munster, Germany
    Cell Tissue Res 315:249-57. 2004
    ..These results provide a platform for the further investigation of selected candidate genes in primary cultures and/or in vivo...
  60. ncbi request reprint Gene polymorphisms and male infertility--a meta-analysis and literature review
    Frank Tüttelmann
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
    Reprod Biomed Online 15:643-58. 2007
    ..The genetic studies performed so far emphasize the complexity of male infertility as a presumably polygenetic trait amended by environmental, lifestyle or occupational factors...
  61. ncbi request reprint Association of specific symptoms and metabolic risks with serum testosterone in older men
    Michael Zitzmann
    Institute of Reproductive Medicine of the University, Domagkstr 11, D 48129 Munster, Germany
    J Clin Endocrinol Metab 91:4335-43. 2006
    ....
  62. ncbi request reprint Contraceptive steroids influence the hemostatic activation state in healthy men
    Michael Zitzmann
    Institute of Reproductive Medicine of the University, Munster, Germany
    J Androl 23:503-11. 2002
    ..Down-regulation of the hemostatic system with testosterone alone may indicate an antithrombotic effect, whereas clinical consequences of an additional gestagen compound cannot be derived...
  63. ncbi request reprint Testosterone substitution with a new transdermal, hydroalcoholic gel applied to scrotal or non-scrotal skin: a multicentre trial
    B Kuhnert
    Institute of Reproductive Medicine, Munster, Germany
    Eur J Endocrinol 153:317-26. 2005
    ..Therefore, we tested a new hydroalcoholic 2.5% testosterone gel (TGW), which was removed by washing 10 min after administration...
  64. ncbi request reprint Distribution and function of FSH receptor genetic variants in normal men
    K Asatiani
    Institute of Reproductive Medicine of the University, Munster, Germany
    Andrologia 34:172-6. 2002
    ..This clinical finding demonstrates that, differently from females, in whom a significant correlation between FSHR polymorphism and basal FSH levels was found, the FSHR genotype has no influence on clinical parameters in males...
  65. ncbi request reprint Gonadal protection from radiation by GnRH antagonist or recombinant human FSH: a controlled trial in a male nonhuman primate (Macaca fascicularis)
    A Kamischke
    Institute of Reproductive Medicine of the University, Domagkstr 11, D 48129 Munster, Germany
    J Endocrinol 179:183-94. 2003
    ..FSH treatment resulted in slightly better recovery of spermatogenesis, which appears to be of no or only little clinical relevance...
  66. ncbi request reprint Cytoplasmic droplets are normal structures of human sperm but are not well preserved by routine procedures for assessing sperm morphology
    Trevor G Cooper
    Institute of Reproductive Medicine of the University Clinic, Domagkstrasse 11, D 48129 Munster, Germany
    Hum Reprod 19:2283-8. 2004
    ..Most clinicians consider their presence on sperm to be indicative of abnormal sperm, whereas basic scientists consider them to be attributes of normal sperm...
  67. ncbi request reprint Lack of glutamate transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice
    Andrea Wagenfeld
    Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
    J Androl 23:772-82. 2002
    ....
  68. doi request reprint 7α-methyl-19-nortestosterone (MENTR): the population council's contribution to research on male contraception and treatment of hypogonadism
    Eberhard Nieschlag
    Centre of Reproductive Medicine and Andrology, University Hospitals of Münster, Munster, Germany
    Contraception 87:288-95. 2013
    ....
  69. ncbi request reprint Vascular reactivity in hypogonadal men is reduced by androgen substitution
    Michael Zitzmann
    Institute of Reproductive Medicine, University of Munster, Domagkstrasse 11, D 48129 Munster, Germany
    J Clin Endocrinol Metab 87:5030-7. 2002
    ....
  70. ncbi request reprint The CAG repeat polymorphism within the androgen receptor gene and maleness
    Michael Zitzmann
    Institute of Reproductive Medicine of the University, Munster, Germany
    Int J Androl 26:76-83. 2003
    ..It remains to be elucidated whether these insights are important enough to become part of individually useful laboratory assessments...
  71. ncbi request reprint Reproductive functions of the ageing male
    Bianca Kühnert
    Institute of Reproductive Medicine of the University, Domagkstr 11, D 48129 Muenster, Germany
    Hum Reprod Update 10:327-39. 2004
    ..However, even if the genetic risk for progeny from older fathers is slightly increased, the risk to the individual is low...
  72. ncbi request reprint Testosterone treatment comes of age: new options for hypogonadal men
    Eberhard Nieschlag
    Institute of Reproductive Medicine of the University of Münster WHO Collaboration Centre for Research in Male Reproduction, Munster, Germany
    Clin Endocrinol (Oxf) 65:275-81. 2006
    ..Based on pharmacogenetic considerations taking the androgen receptor polymorphism into account, treatment may be individualized for each patient in the future...
  73. ncbi request reprint A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle
    R R Greb
    Department of Obstetrics and Gynecology, Munster University Hospital, Domagkstrasse 11, D 48149 Munster, Germany
    J Clin Endocrinol Metab 90:4866-72. 2005
    ..FSH is essential for follicular maturation. Data from ovarian hyperstimulation cycles suggest that FSH action is attenuated by a frequent single nucleotide polymorphism of the FSH receptor gene exchanging Asn for Ser at codon 680...
  74. doi request reprint Testosterone-induced prostate growth is blocked by co- and preadministration of norethisterone enanthate in castrated cynomolgus monkeys
    Joachim Wistuba
    Centre of Reproductive Medicine and Andrology, University Hospital, Munster, Germany joachim wistuba ukmuenster de
    Urol Int 88:358-64. 2012
    ..Examining the role of progestins, we studied the effects of norethisterone (NET) on testosterone undecanoate (TU)-induced prostate growth in castrated macaques...
  75. ncbi request reprint 10th Summit Meeting consensus: recommendations for regulatory approval for hormonal male contraception. October 22-23, 2006
    Eberhard Nieschlag
    Institute of Reproductive Medicine of the University, WHO Collaboration Centre for Research in Male Reproduction, Domagk Strasse 11, D48149, Munster, Germany
    Contraception 75:166-7. 2007
  76. ncbi request reprint An effective hormonal male contraceptive using testosterone undecanoate with oral or injectable norethisterone preparations
    Axel Kamischke
    Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
    J Clin Endocrinol Metab 87:530-9. 2002
    ..The contraceptive efficacy of this combination of TU and NETE should be evaluated in further clinical trials...
  77. ncbi request reprint Fertility control in wildlife: humans as a model
    Jennifer P Barfield
    Institute of Reproductive Medicine, University of Munster, D 48129 Munster, Germany
    Contraception 73:6-22. 2006
    ..This review compares and contrasts the range of contraceptive methods used in both wildlife and humans...
  78. ncbi request reprint Intrauterine bisphenol A exposure leads to stimulatory effects on Sertoli cell number in rats
    Joachim Wistuba
    Institute of Reproductive Medicine of the University, Domagkstrasse11, 48149 Munster, Germany
    Environ Res 91:95-103. 2003
    ....
  79. ncbi request reprint Sperm volume regulation: maturational changes in fertile and infertile transgenic mice and association with kinematics and tail angulation
    Ching Hei Yeung
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
    Biol Reprod 67:269-75. 2002
    ....
  80. ncbi request reprint Semen analysis and external quality control schemes for semen analysis need global standardization
    T G Cooper
    Institute of Reproductive Medicine of the University, Munster, Germany
    Int J Androl 25:306-11. 2002
    ..Until this is achieved, EQC programmes should develop an internal programme to monitor their materials and methods for assessment...
  81. doi request reprint A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts
    F Tüttelmann
    Institute of Human Genetics, University of Munster, Munster, Germany
    Int J Androl 33:e240-8. 2010
    ..In conclusion, for the first time we describe an association of a common haplotype formed by PRM1 and PRM2 with sperm output in a large group of men...
  82. ncbi request reprint Germ cell transplantation into X-irradiated monkey testes
    S Schlatt
    Institute of Reproductive Medicine of the University, Munster, Germany
    Hum Reprod 17:55-62. 2002
    ..Germ cell transplantation has been applied to restore mouse spermatogenesis. Here, an attempt to apply autologous germ cell transplantation to a primate animal model is described...
  83. ncbi request reprint [Germ cell transplantation as a tool for fertility preservation of oncological patients]
    S Schlatt
    Institut für Reproduktionsmedizin der Westfälischen Wilhelms Universität Münster, Germany
    Klin Padiatr 213:250-4. 2001
    ....
  84. ncbi request reprint Association of three isoforms of the meiotic BOULE gene with spermatogenic failure in infertile men
    E Kostova
    Institute of Reproductive Medicine of the University, Domagkstrasse, Muenster, Germany
    Mol Hum Reprod 13:85-93. 2007
    ..Among the three isoforms, B2 might have the major role for meiotic completion...
  85. ncbi request reprint The cause of infertility of male c-ros tyrosine kinase receptor knockout mice
    C H Yeung
    Institute of Reproductive Medicine of the University D 48129 Münster, Germany
    Biol Reprod 63:612-8. 2000
    ..The infertility of c-ros knockout male mice can be explained by the sperm's inability to enter the oviduct, as a result of their bent tails forming the entangled sperm mass and their compromised flagellar vigor within the uterus...
  86. ncbi request reprint Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction
    M Simoni
    Institute of Reproductive Medicine of the University, Munster, Germany
    Hum Reprod Update 8:413-21. 2002
    ..The presence of SNPs in the FSH receptor gene capable of modifying FSH action paves the way for future patient-tailored, genotype-based hormone therapies...
  87. ncbi request reprint Prediction of ovulation by urinary hormone measurements with the home use ClearPlan Fertility Monitor: comparison with transvaginal ultrasound scans and serum hormone measurements
    H M Behre
    Assisted Reproduction Unit, Department of Obstetrics and Gynaecology, University of Munster, Germany
    Hum Reprod 15:2478-82. 2000
    ..Ovulation never occurred before CPFM peak fertility or the serum LH surge day. CPFM can help women who desire pregnancy to time intercourse. It may also have potential as a diagnostic aid and for monitoring the treatment of infertility...
  88. ncbi request reprint The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males
    M Zitzmann
    Institute of Reproductive Medicine of the University, Munster, Germany
    Clin Endocrinol (Oxf) 55:649-57. 2001
    ..Testosterone (T) action is exerted through the androgen receptor (AR). We investigated the potential impact of the CAG repeat (CAGR) polymorphism within the AR gene on BD and bone metabolism in healthy younger males...
  89. ncbi request reprint CAG repeat length in the androgen receptor gene and gonadotrophin suppression influence the effectiveness of hormonal male contraception
    Sigrid V Eckardstein
    Institute of Reproductive Medicine of the University, Munster, Germany
    Clin Endocrinol (Oxf) 57:647-55. 2002
    ..The basis for this heterogeneity in response remained unresolved to date; however, the presence of ethnic differences points to an involvement of genetic factors...
  90. ncbi request reprint Progress towards hormonal male contraception
    Axel Kamischke
    Institute of Reproductive Medicine of the University, Domagkstr 11, D 48129, Muenster, Germany
    Trends Pharmacol Sci 25:49-57. 2004
    ..Of these, testosterone administered in combination with either depot medroxyprogesterone acetate, norethisterone enanthate, desogestrel or etonogestrel have shown promising efficacy...
  91. ncbi request reprint Is inhibin B a pharmacodynamic parameter for FSH in normal men?
    A Kamischke
    Institute of Reproductive Medicine of the University, Domagkstrasse 11, D 48129 Munster, Germany
    Eur J Endocrinol 144:629-37. 2001
    ..This study aims to investigate the pharmacodynamic effect of FSH on inhibin B serum levels in normal men in order to elucidate the physiological regulation of inhibin B secretion in more detail...
  92. ncbi request reprint Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor
    J Gromoll
    Institute of Reproductive Medicine of the University, Munster, Germany
    Biochem Biophys Res Commun 188:1077-83. 1992
    ....
  93. ncbi request reprint Reproductive functions, fertility and genetic risks of ageing men
    C Rolf
    Institute of Reproductive Medicine of the University, , Germany
    Exp Clin Endocrinol Diabetes 109:68-74. 2001
    ..Hence even if offspring of older men have a slightly increased incidence of certain genetic diseases, the individual risk of such a new disease must be considered as extremely small, as the incidence of these diseases is very low...
  94. ncbi request reprint Testosterone levels in healthy men and the relation to behavioural and physical characteristics: facts and constructs
    M Zitzmann
    Institute of Reproductive Medicine of the University, D-48129 Munster, Germany
    Eur J Endocrinol 144:183-97. 2001
    ..Results of such studies must be viewed with caution, and over-simplification as well as over-interpretation should be avoided...
  95. ncbi request reprint Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men
    T M Bockers
    Institute of Anatomy, Munster, Germany
    Cell Tissue Res 278:595-600. 1994
    ....
  96. ncbi request reprint Partial deletions in the AZFc region of the Y chromosome occur in men with impaired as well as normal spermatogenesis
    K Hucklenbroich
    Institute of Reproductive Medicine and Institute of Legal Medicine, University of Munster, D 48149 Munster, Germany
    Hum Reprod 20:191-7. 2005
    ..In this study, we assessed the occurrence and frequency of partial AZFc microdeletions in patients with spermatogenic failure and in controls with normal spermatogenesis...
  97. ncbi request reprint Sperm aneuploidy rates in younger and older men
    C M Luetjens
    Institute of Reproductive Medicine, Westphalian Wilhelms University, Domagkstrasse 11, D 48149 Muenster, Germany
    Hum Reprod 17:1826-32. 2002
    ..In order to assess the possible risk of chromosomal abnormalities in offspring from older fathers, we investigated the effects of age on the frequency of chromosomal aneuploidy rates of human sperm...
  98. ncbi request reprint Testosterone replacement therapy in male hypogonadism
    M Byrne
    Institute of Reproductive Medicine, University of Munster, Munster, Germany
    J Endocrinol Invest 26:481-9. 2003
    ..This article reviews the current experience with the use of various forms of testosterone for the treatment of male hypogonadism...
  99. ncbi request reprint Investigation, treatment and monitoring of late-onset hypogonadism in males
    E Nieschlag
    Institute of Reproductive Medicine, University of Munster, Germany
    Aging Male 8:56-8. 2005
  100. ncbi request reprint Mosaic status in lymphocytes of infertile men with or without Klinefelter syndrome
    P Lenz
    Institute of Reproductive Medicine and Institute of Human Genetics, Westphalian Wilhelms University, Munster, Germany
    Hum Reprod 20:1248-55. 2005
    ..To test whether Klinefelter patients with 47,XXY karyotype or infertile men with 46,XY karyotype represent gonosomal mosaicisms, we performed meta- and interphase fluorescence in situ hybridization (FISH) on 45 men...
  101. ncbi request reprint Cryopreservation of sperm from adolescents and adults with malignancies
    Axel Kamischke
    Institute of Reproductive Medicine of the University, D 48129 Muenster, Germany
    J Androl 25:586-92. 2004
    ....