Horst Neubauer

Summary

Country: Germany

Publications

  1. doi request reprint Newly diagnosed depression is associated with increased beta-thromboglobulin levels and increased expression of platelet activation markers and platelet derived CD40-CD40L
    Horst Neubauer
    Cardiovascular Center, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    J Psychiatr Res 47:865-71. 2013
  2. doi request reprint Pantoprazole does not influence the antiplatelet effect of clopidogrel-a whole blood aggregometry study after coronary stenting
    Horst Neubauer
    Ruhr University Bochum, Cardiovascular Center, St Josef Hospital, Bochum, Germany
    J Cardiovasc Pharmacol 56:91-7. 2010
  3. doi request reprint How to optimise clopidogrel therapy? Reducing the low-response incidence by aggregometry-guided therapy modification
    Horst Neubauer
    Clinic of Cardiology and Angiology, St Josef Hospital BG Kliniken Bergmannsheil, University Hospitals, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Thromb Haemost 99:357-62. 2008
  4. doi request reprint Comparing the antiplatelet effect of clopidogrel hydrogensulfate and clopidogrel besylate: a crossover study
    Horst Neubauer
    Cardiovascular Center, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany
    Clin Res Cardiol 98:533-40. 2009
  5. doi request reprint Upregulation of platelet CD40, CD40 ligand (CD40L) and P-Selectin expression in cigarette smokers: a flow cytometry study
    Horst Neubauer
    Cardiovascular Center, Ruhr University Bochum, Germany
    Blood Coagul Fibrinolysis 20:694-8. 2009
  6. doi request reprint Influence of glycaemic control on platelet bound CD40-CD40L system, P-selectin and soluble CD40 ligand in Type 2 diabetes
    H Neubauer
    Medical Clinic II, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Diabet Med 27:384-90. 2010
  7. pmc Tailored antiplatelet therapy can overcome clopidogrel and aspirin resistance--the BOchum CLopidogrel and Aspirin Plan (BOCLA-Plan) to improve antiplatelet therapy
    Horst Neubauer
    Cardiovascular Center, Ruhr University Bochum, St, Josef Hospital, Gudrunstr, 56, D 44791 Bochum, Germany
    BMC Med 9:3. 2011
  8. doi request reprint New pathways of increased cardiovascular risk in depression: a pilot study on the association of high-sensitivity C-reactive protein with pro-atherosclerotic markers in patients with depression
    Daniela Zahn
    Dept of Psychosomatic Medicine and Psychotherapy, Ruhr University Bochum, LWL University Hospital Bochum, Ruhr University Bochum, Bochum, Germany
    J Affect Disord 146:420-5. 2013
  9. doi request reprint Cytochrome P450 2B6 and 2C9 genotype polymorphism--a possible cause of prasugrel low responsiveness
    Cora C Franken
    Cardiovascular Center, St Josef Hospital, Gudrunstrasse 56, D 44791 Bochum, Germany
    Thromb Haemost 110:131-40. 2013
  10. ncbi request reprint Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study
    Horst Neubauer
    Clinic of Cardiology and Angiology, Ruhr University, Bochum, Germany
    Eur Heart J 24:1744-9. 2003

Collaborators

Detail Information

Publications21

  1. doi request reprint Newly diagnosed depression is associated with increased beta-thromboglobulin levels and increased expression of platelet activation markers and platelet derived CD40-CD40L
    Horst Neubauer
    Cardiovascular Center, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    J Psychiatr Res 47:865-71. 2013
    ..The present study was designed to evaluate the extent of platelet activation and platelet-derived markers of atherosclerotic disease in patients with newly diagnosed depression...
  2. doi request reprint Pantoprazole does not influence the antiplatelet effect of clopidogrel-a whole blood aggregometry study after coronary stenting
    Horst Neubauer
    Ruhr University Bochum, Cardiovascular Center, St Josef Hospital, Bochum, Germany
    J Cardiovasc Pharmacol 56:91-7. 2010
    ..Therefore, the use of pantoprazole seems preferable in patients treated with clopidogrel when a concomitant medication with a PPI is indicated...
  3. doi request reprint How to optimise clopidogrel therapy? Reducing the low-response incidence by aggregometry-guided therapy modification
    Horst Neubauer
    Clinic of Cardiology and Angiology, St Josef Hospital BG Kliniken Bergmannsheil, University Hospitals, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Thromb Haemost 99:357-62. 2008
    ..6% to 5.0%. Our aggregometer-guided therapeutic algorithm reduced the relative percentage of clopidogrel LR by 78.9%. This approach could prove to be helpful in achieving a further decrease in the incidence of clopidogrel resistance...
  4. doi request reprint Comparing the antiplatelet effect of clopidogrel hydrogensulfate and clopidogrel besylate: a crossover study
    Horst Neubauer
    Cardiovascular Center, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany
    Clin Res Cardiol 98:533-40. 2009
    ....
  5. doi request reprint Upregulation of platelet CD40, CD40 ligand (CD40L) and P-Selectin expression in cigarette smokers: a flow cytometry study
    Horst Neubauer
    Cardiovascular Center, Ruhr University Bochum, Germany
    Blood Coagul Fibrinolysis 20:694-8. 2009
    ..These findings emphasize that cigarette smoking leads to a proinflammatory and prothrombotic state thus contributing to accelerated atherosclerosis...
  6. doi request reprint Influence of glycaemic control on platelet bound CD40-CD40L system, P-selectin and soluble CD40 ligand in Type 2 diabetes
    H Neubauer
    Medical Clinic II, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Diabet Med 27:384-90. 2010
    ..The purpose of this study was to investigate whether platelet-bound CD40-CD40L signalling, P-selectin expression and soluble CD40L were increased in patients with diabetes mellitus and can be normalized by improving glycaemic control...
  7. pmc Tailored antiplatelet therapy can overcome clopidogrel and aspirin resistance--the BOchum CLopidogrel and Aspirin Plan (BOCLA-Plan) to improve antiplatelet therapy
    Horst Neubauer
    Cardiovascular Center, Ruhr University Bochum, St, Josef Hospital, Gudrunstr, 56, D 44791 Bochum, Germany
    BMC Med 9:3. 2011
    ..The aim of this single-center prospective study was to reduce the low response incidence of dual antiplatelet therapy with ASA and clopidogrel according to a prespecified therapy algorithm...
  8. doi request reprint New pathways of increased cardiovascular risk in depression: a pilot study on the association of high-sensitivity C-reactive protein with pro-atherosclerotic markers in patients with depression
    Daniela Zahn
    Dept of Psychosomatic Medicine and Psychotherapy, Ruhr University Bochum, LWL University Hospital Bochum, Ruhr University Bochum, Bochum, Germany
    J Affect Disord 146:420-5. 2013
    ..The present study aimed at comparing hs-CRP and its relationship with atherogenic platelet markers in patients with type 2 diabetes (TD2) and/or newly diagnosed major depression (MD)...
  9. doi request reprint Cytochrome P450 2B6 and 2C9 genotype polymorphism--a possible cause of prasugrel low responsiveness
    Cora C Franken
    Cardiovascular Center, St Josef Hospital, Gudrunstrasse 56, D 44791 Bochum, Germany
    Thromb Haemost 110:131-40. 2013
    ..Also, there is a trend to an increased frequency of CYP2B6*6 in PLR. In conclusion, CYP2B6 and CYP2C9 polymorphisms seem to be associated with prasugrel low-response. ..
  10. ncbi request reprint Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study
    Horst Neubauer
    Clinic of Cardiology and Angiology, Ruhr University, Bochum, Germany
    Eur Heart J 24:1744-9. 2003
    ..Since certain lipophilic statins (i.e. simvastatin, atorvastatin, lovastatin) are a substrate of CYP3A4, we were interested in potential drug interactions between clopidogrel and statins...
  11. doi request reprint Which is the best anticoagulant for whole blood aggregometry platelet function testing? Comparison of six anticoagulants and diverse storage conditions
    Andreas Friedrich Christoph Kaiser
    Cardiovascular Center, Ruhr University Bochum, St Josef Hospital, Gudrunstraße 56, Bochum, Germany
    Platelets 23:359-67. 2012
    ..In conclusion, sodium heparin and 45 µg/mL r-hirudin as anticoagulants guarantee the longest storage time for impedance aggregometry...
  12. doi request reprint Dose-dependent effect of early antiplatelet therapy in acute ischaemic stroke
    Saskia H Meves
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Thromb Haemost 107:69-79. 2012
    ..Our findings suggest using a loading dose of 500 mg ASA intravenously as this seems to be favourable when a sufficient early platelet inhibitory effect is wanted...
  13. doi request reprint Cortisol, platelet serotonin content, and platelet activity in patients with major depression and type 2 diabetes: an exploratory investigation
    Daniela Zahn
    From the Department of Health Psychology Zahn, Institute of Psychology, Johannes Gutenberg University Mainz, Germany Departments of Psychosomatic Medicine and Psychotherapy Petrak, Hägele, Herpertz and Psychiatry, Psychotherapy, and Preventive Medicine Juckel, Norra, UHL, LWL University Hospital Bochum, Ruhr University Bochum, Germany Department of Psychiatry and Psychotherapy Franke, Charite Universitatsmedizin Berlin, Germany Central Institute of Mental Health Lederbogen, Medical Faculty, University of Heidelberg, Mannheim, Germany and Cardiovascular Centre Neubauer, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Psychosom Med 77:145-55. 2015
    ....
  14. pmc The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile
    Jan Borgel
    Department of Cardiology, St, Josef Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    BMC Cardiovasc Disord 8:41. 2008
    ..In the present study, we investigated the influence of this polymorphism on survived myocardial infarction in two study groups of patients with on average high cardiovascular risk profile...
  15. doi request reprint Clopidogrel high-on-treatment platelet reactivity in acute ischemic stroke patients
    Saskia H Meves
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany Electronic address
    Thromb Res 133:396-401. 2014
    ..We investigated the prevalence and risk factors for clopidogrel high-on-treatment platelet reactivity (clopidogrel-HTPR) in acute ischemic stroke patients...
  16. doi request reprint BAPA, a synthetic dual inhibitor of Factor Xa and Thrombin, extends the storage-time to a maximum of 12 hours in ADP- and 24 hours in arachidonic acid-induced impedance aggregometry
    Andreas F C Kaiser
    Cardiovascular Center, St Josef Hospital, Ruhr University, Bochum, Germany
    Scand J Clin Lab Invest 71:253-6. 2011
    ..Further studies including blood samples of patients and the comparison of BAPA to other anticoagulants are necessary to define the potential role of BAPA anticoagulated samples...
  17. doi request reprint Effectiveness of antiplatelet therapy in atherosclerotic disease: comparing the ASA low-response prevalence in CVD, CAD and PAD
    Saskia H Meves
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstraße 56, 44791, Bochum, Germany
    J Thromb Thrombolysis 37:190-201. 2014
    ..Our findings may explain, at least in part, the high rates of cardiovascular events observed in the course of atherothrombotic disease and support the need to improve antiplatelet therapy. ..
  18. doi request reprint Unrecognized secondary causes of hypertension in patients with hypertensive urgency/emergency: prevalence and co-prevalence
    Jan Borgel
    Department of Cardiology and Angiology, University Clinic St Josef Hospital, Heart Center, University of Bochum, Germany
    Clin Res Cardiol 99:499-506. 2010
    ..Hypertensive urgency/emergency occurs frequently, yet no prospective data on common secondary causes, including sleep apnea (SA), renal artery stenosis (RAS), and hyperaldosteronism, are available...
  19. doi request reprint Safety and effectiveness of a novel vascular closure device: a prospective study of the ExoSeal compared to the Angio-Seal and ProGlide
    Kaffer Kara
    1 Cardiovascular Center, St Josef Hospital, Ruhr University Bochum, Germany
    J Endovasc Ther 21:822-8. 2014
    ....
  20. pmc Ventricular tachycardia during basilar-type migraine attack
    Kalliopi Pitarokoili
    Department of Neurology, Ruhr University, St Josef Hospital, Bochum, Germany
    Ther Adv Neurol Disord 6:35-40. 2013
    ..The therapeutic implications of such a co-occurrence as well as a possible relationship between ventricular tachycardia and the underlying biology of basilar-type migraine are discussed...
  21. pmc Is there an ideal way to initiate antiplatelet therapy with aspirin? A crossover study on healthy volunteers evaluating different dosing schemes with whole blood aggregometry
    Saskia H Meves
    Ruhr University Bochum, Department of Neurology, St, Josef Hospital, Gudrunstrasse 56, D 44791 Bochum, Germany
    BMC Res Notes 4:106. 2011
    ..This study evaluated the platelet inhibitory effect in healthy volunteers by using three different aspirin loading doses to gain a model for initiating antiplatelet treatment in acute strokes patients...