- Inventory of marine biotest methods for the evaluation of dredged material and sedimentsMonika Nendza
Analytisches Laboratorium für Umweltuntersuchungen und Auftragsforschung, Luhnstedt, Germany
Chemosphere 48:865-83. 2002..The toxicological significance and complexity increases with the tiers: (1) screening and detection of impacts, (2) characterization of toxic effects, (3) verification of in situ alterations...
- Mixture toxicity and its modeling by quantitative structure-activity relationshipsRolf Altenburger
Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Permoserstrasse 15, 04318 Leipzig, Germany
Environ Toxicol Chem 22:1900-15. 2003..In the case of ionogenic compounds, initial results suggest that CA may serve as a first-order approximation for the joint effect of un-ionized and ionized compound portions...
- Hazard assessment of silicone oils (polydimethylsiloxanes, PDMS) used in antifouling-/foul-release-products in the marine environmentMonika Nendza
Analytisches Laboratorium, Bahnhofstrasse 1, 24816 Luhnstedt, Germany
Mar Pollut Bull 54:1190-6. 2007..These 'new' effects are not covered by current assessment schemes. PDMS make the case that very low water solubility and bioavailability do not necessarily preclude damage to marine environments...
- Discriminating toxicant classes by mode of action. 1. (Eco)toxicity profilesMonika Nendza
Analytisches Laboratorium, Luhnstedt, Germany
Environ Sci Pollut Res Int 13:192-203. 2006..identification of chemicals with specific MOAs, (4.) indication of most sensitive species, (5.) identification of chemicals that are outliers in QSARs and (6.) selection of appropriate QSARs for predictions...
- Discriminating toxicant classes by mode of action: 3. Substructure indicatorsM Nendza
Analytisches Laboratorium, Bahnhofstrasse 1, D 24816 Luhnstedt, Germany
SAR QSAR Environ Res 18:155-68. 2007..Major improvements are feasible with combined use of three classification schemes: assignments of baseline toxicants are protective, recognition of excess toxicants is acceptable and applicability range increases favourably...
- A comparative survey of chemistry-driven in silico methods to identify hazardous substances under REACHMonika Nendza
Analytisches Laboratorium, Bahnhofstr 1, 24816 Luhnstedt, Germany
Regul Toxicol Pharmacol 66:301-14. 2013..The inventory is complemented by a brief discussion of socio-economic tools for assessing the potential efficiency gains of using in silico methods compared to traditional in vivo testing of chemical hazards. ..