Jurgen Neesen

Summary

Country: Germany

Publications

  1. ncbi request reprint Tep22, a novel testicular expressed gene, is involved in the biogenesis of the acrosome and the midpiece of the sperm tail
    Jurgen Neesen
    Institute of Human Genetics, University of Gottingen, Heinrich Düker Weg 12, Gottingen 37073, Germany
    Biochem Biophys Res Commun 297:737-48. 2002
  2. ncbi request reprint Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene
    J Neesen
    Institut für Humangenetik der Universität Göttingen, Germany
    Gene 200:193-202. 1997
  3. ncbi request reprint Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia
    J Neesen
    Institute of Human Genetics, University of Gottingen, Germany
    Cytogenet Genome Res 98:38-44. 2002
  4. ncbi request reprint Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency
    J Neesen
    Institute of Human Genetics, University of Goettingen, Heinrich Dueker Weg12, 37073 Goettingen, Germany
    Hum Mol Genet 10:1117-28. 2001
  5. pmc Asthenozoospermia in mice with targeted deletion of the sperm mitochondrion-associated cysteine-rich protein (Smcp) gene
    Karim Nayernia
    Institute of Human Genetics, University of Gottingen, 37073 Gottingen, Germany
    Mol Cell Biol 22:3046-52. 2002
  6. doi request reprint Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene
    Pawel Grzmil
    Institute of Human Genetics, University of Gottingen, Heinrich Düker Weg 12, Gottingen, Germany
    Int J Dev Biol 54:1259-66. 2010
  7. ncbi request reprint Mutation analysis of the spastin gene (SPG4) in patients in Germany with autosomal dominant hereditary spastic paraplegia
    S Sauter
    Institute of Human Genetics, University of Gottingen, Gottingen, Germany
    Hum Mutat 20:127-32. 2002
  8. ncbi request reprint Genomic organisation and chromosomal assignment of ODF2 (outer dense fiber 2), encoding the main component of sperm tail outer dense fibers and a centrosomal scaffold protein
    S Hoyer-Fender
    Zoologisches Institut Entwicklungsbiologie, Institut fur Humangenetik, Universitat Gottingen, Gottingen, Germany
    Cytogenet Genome Res 103:122-7. 2003
  9. ncbi request reprint Novel mutations in the Atlastin gene (SPG3A) in families with autosomal dominant hereditary spastic paraplegia and evidence for late onset forms of HSP linked to the SPG3A locus
    S M Sauter
    Institute of Human Genetics, University of Gottingen, Germany
    Hum Mutat 23:98. 2004
  10. ncbi request reprint Partial trisomy of distal 19q detected by quantitative real-time PCR and FISH in a girl with mild facial dysmorphism, hypotonia and developmental delay
    S M Sauter
    Institut fur Humangenetik, Georg August Universitat Gottingen, Heinrich Düker Weg 12, Gottingen, Germany
    Am J Med Genet A 143:1091-9. 2007

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Tep22, a novel testicular expressed gene, is involved in the biogenesis of the acrosome and the midpiece of the sperm tail
    Jurgen Neesen
    Institute of Human Genetics, University of Gottingen, Heinrich Düker Weg 12, Gottingen 37073, Germany
    Biochem Biophys Res Commun 297:737-48. 2002
    ..Taken together, our results suggest that Tep22 is involved in the biogenesis of the acrosome as well as in the function of the midpiece of murine spermatozoa...
  2. ncbi request reprint Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene
    J Neesen
    Institut für Humangenetik der Universität Göttingen, Germany
    Gene 200:193-202. 1997
    ..Two of these clones, gHDHC7 and gMDHC7, are homologous genes encoding axonemal inner arm dyneins. While the human clone is assigned to 3p21, the mouse gene maps to chromosome 14...
  3. ncbi request reprint Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia
    J Neesen
    Institute of Human Genetics, University of Gottingen, Germany
    Cytogenet Genome Res 98:38-44. 2002
    ..However, this exchange was also detected in one control DNA. Our results indicate that mutations in the TCTE3 gene are not a main cause of primary ciliary dyskinesia...
  4. ncbi request reprint Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency
    J Neesen
    Institute of Human Genetics, University of Goettingen, Heinrich Dueker Weg12, 37073 Goettingen, Germany
    Hum Mol Genet 10:1117-28. 2001
    ..The phenotype of MDHC7(-/-) mice is similar to that observed in some patients suffering from PCD, and our data strongly suggest that in some patients this disease could be due to mutations in the homologous human gene DNAH1 (HDHC7)...
  5. pmc Asthenozoospermia in mice with targeted deletion of the sperm mitochondrion-associated cysteine-rich protein (Smcp) gene
    Karim Nayernia
    Institute of Human Genetics, University of Gottingen, 37073 Gottingen, Germany
    Mol Cell Biol 22:3046-52. 2002
    ..These results indicate that the infertility of the male Smcp(-/-) mice on the 129/Sv background is due to reduced motility of the spermatozoa and decreased capability of the spermatozoa to penetrate oocytes...
  6. doi request reprint Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene
    Pawel Grzmil
    Institute of Human Genetics, University of Gottingen, Heinrich Düker Weg 12, Gottingen, Germany
    Int J Dev Biol 54:1259-66. 2010
    ..This assumption is supported by the failure of Arfgef2-deficient oocytes fertilized with Arfgef2-deficient sperm to develop into 4-cell stage embryos. Our results indicate that murine BIG2 is essential for early embryonic development...
  7. ncbi request reprint Mutation analysis of the spastin gene (SPG4) in patients in Germany with autosomal dominant hereditary spastic paraplegia
    S Sauter
    Institute of Human Genetics, University of Gottingen, Gottingen, Germany
    Hum Mutat 20:127-32. 2002
    ..Frameshift mutations account for the majority of SPG4 mutations in this population. The proportion of splice mutations is considerably lower than reported elsewhere...
  8. ncbi request reprint Genomic organisation and chromosomal assignment of ODF2 (outer dense fiber 2), encoding the main component of sperm tail outer dense fibers and a centrosomal scaffold protein
    S Hoyer-Fender
    Zoologisches Institut Entwicklungsbiologie, Institut fur Humangenetik, Universitat Gottingen, Gottingen, Germany
    Cytogenet Genome Res 103:122-7. 2003
    ..ODF2 was mapped to rat chromosome 3 and more specifically by FISH analysis at bands 3q11-->3q12. In addition, we demonstrate that ODF2 is indeed a component of the centrosome and the mitotic spindle poles in mammals...
  9. ncbi request reprint Novel mutations in the Atlastin gene (SPG3A) in families with autosomal dominant hereditary spastic paraplegia and evidence for late onset forms of HSP linked to the SPG3A locus
    S M Sauter
    Institute of Human Genetics, University of Gottingen, Germany
    Hum Mutat 23:98. 2004
    ..481G>C (p.A161P) and c.740A>C (p.H247P). One of the novel mutations was found both in a family with early onset of symptoms and in a late onset family. Furthermore, we report on numerous polymorphisms detected in the SPG3A gene...
  10. ncbi request reprint Partial trisomy of distal 19q detected by quantitative real-time PCR and FISH in a girl with mild facial dysmorphism, hypotonia and developmental delay
    S M Sauter
    Institut fur Humangenetik, Georg August Universitat Gottingen, Heinrich Düker Weg 12, Gottingen, Germany
    Am J Med Genet A 143:1091-9. 2007
    ..The detected chromosomal aberration probably occurred de novo. The clinical features are very likely to be caused solely by the partial trisomy 19q...
  11. ncbi request reprint Tandemly arranged repeats of a novel highly charged 16-amino-acid motif representing the major component of the sperm-tail-specific axoneme-associated protein family Dhmst101 form extended alpha-helical rods within the extremely elongated spermatozoa of D
    J Neesen
    Institute for Human Genetics, University of Gottingen, Germany
    Eur J Biochem 225:1089-95. 1994
    ....
  12. pmc Human cyritestin genes (CYRN1 and CYRN2) are non-functional
    P Grzmil
    Institut fur Humangenetik, Georg August Universitat Gottingen, Heinrich Düker Weg 12, 37073 Gottingen, Germany
    Biochem J 357:551-6. 2001
    ..These results demonstrate clearly that both cyritestin genes are non-functional in humans...
  13. ncbi request reprint Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG)
    A Mannan
    Institute of Human Genetics, University of Gottingen, Gottingen, Germany
    Cytogenet Cell Genet 91:171-9. 2000
    ..These data suggest that both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions...
  14. doi request reprint Valproic acid inhibits the proliferation of cancer cells by re-expressing cyclin D2
    Daria Witt
    Institute of Human Genetics, University Medical Center Gottingen, 37073 Gottingen, Germany
    Carcinogenesis 34:1115-24. 2013
    ..Altogether, our results confirm that VPA is an anticancer therapeutic drug for the treatment of tumors with epigenetically repressed cyclin D2 expression...
  15. ncbi request reprint Analyzes of three common thrombophilic gene mutations in German women with recurrent abortions
    Hans Ulrich Pauer
    Department of Gynecology and Obstetrics, University of Goettingen, Goettingen, Germany
    Acta Obstet Gynecol Scand 82:942-7. 2003
    ..Several etiological factors have been proposed as a cause for recurrent fetal abortions. Changes in blood coagulation during pregnancy may play an important role in the occurrence of recurrent abortions (RA)...