H Murck

Summary

Country: Germany

Publications

  1. ncbi request reprint Hypericum extract in patients with MDD and reversed vegetative signs: re-analysis from data of a double-blind, randomized trial of hypericum extract, fluoxetine, and placebo
    Harald Murck
    Lichtwer Pharma GmbH, Berlin, Germany
    Int J Neuropsychopharmacol 8:215-21. 2005
  2. doi request reprint Ketamine, magnesium and major depression - From pharmacology to pathophysiology and back
    Harald Murck
    Covance Inc, Princeton, USA Clinic of Psychiatry and Psychotherapy of the Philipps University of Marburg, Marburg, Germany Electronic address
    J Psychiatr Res 47:955-65. 2013
  3. ncbi request reprint Hypericum extract reverses S-ketamine-induced changes in auditory evoked potentials in humans - possible implications for the treatment of schizophrenia
    Harald Murck
    Lichtwer Pharma GmbH, Berlin, Germany
    Biol Psychiatry 59:440-5. 2006
  4. ncbi request reprint Effects of Hypericum extract (LI160) on the change of auditory evoked potentials by cortisol administration
    Harald Murck
    Lichtwer Pharma AG, Berlin, Germany
    Neuropsychobiology 50:128-33. 2004
  5. ncbi request reprint Magnesium and affective disorders
    H Murck
    Laxdale Ltd, Stirling, UK
    Nutr Neurosci 5:375-89. 2002
  6. ncbi request reprint [Atypical depression and related illnesses--neurobiological principles for their treatment with Hypericum extract]
    H Murck
    Medizinische Forschung, Lichtwer Pharma AG, Wallenroderstrasse 8 10, D 13435 Berlin, Deutschland
    Wien Med Wochenschr 152:398-403. 2002
  7. ncbi request reprint Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression
    Harald Murck
    Laxdale Ltd, Stirling, Scotland, UK, FK7 9JQ
    Int J Neuropsychopharmacol 7:341-9. 2004
  8. ncbi request reprint Clinical and neurobiological effects of tianeptine and paroxetine in major depression
    Thomas Nickel
    Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Psychopharmacol 23:155-68. 2003
  9. ncbi request reprint Pituitary adenylate cyclase-activating peptide affects homeostatic sleep regulation in healthy young men
    Harald Murck
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 292:E853-7. 2007
  10. ncbi request reprint A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychopharmacol 25:441-7. 2005

Detail Information

Publications25

  1. ncbi request reprint Hypericum extract in patients with MDD and reversed vegetative signs: re-analysis from data of a double-blind, randomized trial of hypericum extract, fluoxetine, and placebo
    Harald Murck
    Lichtwer Pharma GmbH, Berlin, Germany
    Int J Neuropsychopharmacol 8:215-21. 2005
    ..These data are based on a small sample size and must be considered tentative. A characterization of vegetative features of patients with depression could lead to an overall increased effect size in the treatment with HE...
  2. doi request reprint Ketamine, magnesium and major depression - From pharmacology to pathophysiology and back
    Harald Murck
    Covance Inc, Princeton, USA Clinic of Psychiatry and Psychotherapy of the Philipps University of Marburg, Marburg, Germany Electronic address
    J Psychiatr Res 47:955-65. 2013
    ..Overall, any discussion of the glutamatergic system in affective disorders should consider the role of Mg(2+)...
  3. ncbi request reprint Hypericum extract reverses S-ketamine-induced changes in auditory evoked potentials in humans - possible implications for the treatment of schizophrenia
    Harald Murck
    Lichtwer Pharma GmbH, Berlin, Germany
    Biol Psychiatry 59:440-5. 2006
    ..Hypericum extract LI160 has demonstrated a ketamine-antagonising effect. We examined whether LI160 reverses changes of a low dose ketamine on AEP in healthy subjects...
  4. ncbi request reprint Effects of Hypericum extract (LI160) on the change of auditory evoked potentials by cortisol administration
    Harald Murck
    Lichtwer Pharma AG, Berlin, Germany
    Neuropsychobiology 50:128-33. 2004
    ....
  5. ncbi request reprint Magnesium and affective disorders
    H Murck
    Laxdale Ltd, Stirling, UK
    Nutr Neurosci 5:375-89. 2002
    ..e. with respect to kindling, sleep-EEG and endocrine effects. Controlled clinical trials examining the effect of Mg in affective disorder are warranted...
  6. ncbi request reprint [Atypical depression and related illnesses--neurobiological principles for their treatment with Hypericum extract]
    H Murck
    Medizinische Forschung, Lichtwer Pharma AG, Wallenroderstrasse 8 10, D 13435 Berlin, Deutschland
    Wien Med Wochenschr 152:398-403. 2002
    ..Clinical studies with patients with depression with atypical features like the seasonal affective disorder (SAD) and with patients with a depressive syndrome accompanied by somatic complaints or fatigue support this view...
  7. ncbi request reprint Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression
    Harald Murck
    Laxdale Ltd, Stirling, Scotland, UK, FK7 9JQ
    Int J Neuropsychopharmacol 7:341-9. 2004
    ..EPA may, furthermore, enhance the action of antidepressants, like many SSRIs that are p-gp substrates, which are actively transported out of the intracerebral space at the level of the blood-brain barrier...
  8. ncbi request reprint Clinical and neurobiological effects of tianeptine and paroxetine in major depression
    Thomas Nickel
    Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Psychopharmacol 23:155-68. 2003
    ..The normalization of the HPA system as a common mode of action of different antidepressants seems to be of special interest...
  9. ncbi request reprint Pituitary adenylate cyclase-activating peptide affects homeostatic sleep regulation in healthy young men
    Harald Murck
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Am J Physiol Endocrinol Metab 292:E853-7. 2007
    ..Both effects are the opposite of those seen after sleep deprivation but similar to the changes after napping, i.e., a reduced sleep propensity. This implies that PACAP might be involved in homeostatic sleep regulation...
  10. ncbi request reprint A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychopharmacol 25:441-7. 2005
    ..This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John's wort with both placebo and fluoxetine...
  11. ncbi request reprint Neuropeptide Y (NPY) shortens sleep latency but does not suppress ACTH and cortisol in depressed patients and normal controls
    Katja Held
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 31:100-7. 2006
    ..The lack of effects on time awake and HPA hormones may be explained by the higher CRH activity due to age and depression in the investigated samples in comparison to our recent study in young subjects...
  12. ncbi request reprint Alpha-helical CRH exerts CRH agonistic effects on sleep-endocrine activity in humans
    Katja Held
    Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
    Neuropsychobiology 52:62-7. 2005
    ..ACTH (2nd half of the night) and cortisol (total night and 1st half of the night) increased. The results of the present study correspond to a mixture of agonistic and antagonistic effects of alpha-helical CRH...
  13. ncbi request reprint Changes in sleep electroencephalogram and nocturnal hormone secretion after administration of the antidyskinetic agent sarizotan in healthy young male volunteers
    Heike E Kuenzel
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804, Munich, Germany
    Psychopharmacology (Berl) 180:327-32. 2005
    ..Data from an open pilot study in patients with Parkinson's disease show clear indication of a treatment effect against L: -dopa-induced dyskinesia...
  14. ncbi request reprint Nocturnal secretion of TSH and ACTH in male patients with depression and healthy controls
    Christian Peteranderl
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    J Psychiatr Res 36:189-96. 2002
    ..The ratio TSH/ACTH might be a tool to characterize alterations of both the HPT and HPA axis in depression during the first half of the night...
  15. ncbi request reprint Night sleep EEG and daytime sleep propensity in adult hypopituitary patients with growth hormone deficiency before and after six months of growth hormone replacement
    Harald Jorn Schneider
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Psychoneuroendocrinology 30:29-37. 2005
    ..No reports exist about objective measures of daytime sleepiness in GH deficient patients before and during GH-therapy...
  16. pmc The renin-angiotensin-aldosterone system in patients with depression compared to controls--a sleep endocrine study
    Harald Murck
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    BMC Psychiatry 3:15. 2003
    ..angiotensin II (ATII) releases CRH and vasopressin from the hypothalamus. Furthermore renin and aldosterone secretion are synchronized to the rapid eyed movement (REM)-nonREM cycle...
  17. ncbi request reprint Sub-chronic treatment with an extract of Hypericum perforatum (St John's wort) significantly reduces cortisol and corticosterone in the rat brain
    Mike Franklin
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Eur Neuropsychopharmacol 14:7-10. 2004
    ..Results show that HP significantly reduced corticosterone and cortisol in brain frontal cortex tissue. These changes are not reflected in serum. These findings may be important with respect to HPs mode of antidepressant action...
  18. ncbi request reprint Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers
    Ralf Michael Frieboes
    Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Psychoneuroendocrinology 29:851-60. 2004
    ..We hypothesize that sleep is impaired after hexarelin since the GHRH/corticotropin-releasing hormone (CRH) ratio is changed in favour of CRH. There are no hints for an interaction of hexarelin and the immune system...
  19. ncbi request reprint Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG
    Harald Murck
    Department of Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    Psychoneuroendocrinology 29:1205-11. 2004
    ..As this effect could imply an antidepressive potency we studied the effect of intravenous galanin administration on psychopathology and sleep EEG in patients with depression...
  20. ncbi request reprint Treatment of somatoform disorders with St. John's wort: a randomized, double-blind and placebo-controlled trial
    Thomas Muller
    Department of Neurology, St Josef Hospital Bochum, Ruhr University Bochum, Germany
    Psychosom Med 66:538-47. 2004
    ..To investigate efficacy and safety of St. John's wort (SJW) LI 160 in somatoform disorders...
  21. ncbi request reprint St John's wort extract (LI 160) in somatoform disorders: results of a placebo-controlled trial
    Hans Peter Volz
    Psychiatric Department, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Psychopharmacology (Berl) 164:294-300. 2002
    ..Therefore, the efficacy of the Hypericum extract LI 160 in patients with somatoform disorders should be studied in a double-blind placebo-controlled fashion...
  22. ncbi request reprint Increase in amino acids in the pons after sleep deprivation: a pilot study using proton magnetic resonance spectroscopy
    Harald Murck
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychobiology 45:120-3. 2002
    ..These preliminary data support earlier animal data and indirect findings in humans suggesting that GABA and Gln, especially in the pontine structures, may play a key role in the mechanism of TSD...
  23. ncbi request reprint The effects of eicosapentaenoic acid in tardive dyskinesia: a randomized, placebo-controlled trial
    Robin Emsley
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    Schizophr Res 84:112-20. 2006
    ..The primary objective of the present study was to compare the efficacy of EPA versus placebo in reducing symptoms of TD...
  24. ncbi request reprint Ethyl-EPA in Huntington disease: potentially relevant mechanism of action
    Harald Murck
    Amarin Neuroscience Ltd, Laurelhill Business Park, Stirling, UK
    Brain Res Bull 72:159-64. 2007
    ..Further the effects of EPA or Ethyl-EPA in preclinical models of HD are described. The evidence from these studies led to the design of phase III clinical trials, which are ongoing...
  25. ncbi request reprint Magnesium-deficient diet alters depression- and anxiety-related behavior in mice--influence of desipramine and Hypericum perforatum extract
    Nicolas Singewald
    Department of Pharmacology and Toxicology, Institute of Pharmacy and CMBI, Leopold Franzens University of Innsbruck, Peter Mayr Str 1, A 6020 Innsbruck, Austria
    Neuropharmacology 47:1189-97. 2004
    ..Further, the utility of Mg-depletion as a new screening model for clinically active antidepressant and anxiolytic drugs is suggested...