Research Topics
Species | K M MullerSummaryCountry: Germany Publications
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Publications
[Pleuromesothelioma -- psychology and pathogenesis]K M Muller
Institut fur Pathologie, Kliniken Bergmannsheil, Bochum
Pneumologie 58:670-9. 2004....
[Pulmonary lymphangioleiomyomatosis. Morphologic and immunohistochemical findings]C Kuhnen
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil Ruhr Universität Bochum, Burkle de la Camp Platz 1, 44789 Bochum
Pathologe 22:197-204. 2001..Using the concept of a melanomyopericyte, pulmonary LAM could be classified as a hamartomatous interstitial lung disease showing perivascular smooth muscle and partial melanocytic differentiation...
Pigmented (melanotic) neurofibroma. Report of an unusual case with immunohistochemical, ultrastructural and cytogenetic analysesCornelius Kuhnen
Institute of Pathology, Limb tumor registry, University Hospital Bergmannsheil, Bochum, Germany
Pathol Res Pract 198:125-31. 2002..However, smaller chromosomal defects might have been overlooked by the limited resolution of this screening method. Therefore, other mechanisms up-regulating melanogenesis, such as mutations in regulatory genes, have to be considered...
Impact of c-Met expression on angiogenesis in soft tissue sarcomas: correlation to microvessel-densityCornelius Kuhnen
Institute for Pathology, Limb tumor registry, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, 44789, Bochum, Germany
J Cancer Res Clin Oncol 129:415-22. 2003..The aim of this study was the analysis of c-Met immunoexpression/-synthesis and microvessel density as parameters for angiogenesis and prognosis in 115 soft tissue sarcomas...
Black spots of the parietal pleura: morphology and formal pathogenesisK M Muller
Institute of Pathology, BG Clinics Bergmannsheil, University Clinic, Bochum, Germany
Respiration 69:261-7. 2002..They represent areas of coal dust accumulation. An increased incorporation of asbestos fibres has been described in these areas, causing them to be seen as potential starting points for malignant mesotheliomas...
Atypical lipomatous tumor in a 14-year-old patient: distinction from lipoblastoma using FISH analysisCornelius Kuhnen
Institute for Pathology, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum, Germany
Virchows Arch 441:299-302. 2002..This case shows that FISH can serve as a decisive tool in the differential diagnosis of lipoblastoma and lipoma-like liposarcoma apart from its role in distinction between lipoblastoma and myxoid/round cell liposarcoma...
[Myofibroblastic sarcoma of the thoracic wall. Change in appearance in tumour recurrence]C Kuhnen
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
Pathologe 24:128-35. 2003....
[Recurrent tumor--pathologic-anatomic findings]K M Muller
Institut fur Pathologie, Berufsgenossenschaftlichen Kliniken Bergmannsheil, Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789 Bochum
Kongressbd Dtsch Ges Chir Kongr 119:779-84. 2002....
[Neuroendocrine tumors of the lung]K M Muller
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Klinikum der Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789 Bochum
Pathologe 24:297-302. 2003..These complex questions can only be answered by studies targeting the course of the disease and the results of therapy...
[Morphological findings after stent implantation in the carotid artery]K M Muller
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Universitätsklinik der Ruhruniversität, Bürkel de la Camp Platz 1, 44789 Bochum, Germany
Pathologe 25:108-15. 2004..In addition, individually differing reaction patterns ranging from discrete inflammatory changes to massive stenoses were identified and documented...
[Pathology, classification, and staging of malignant lung tumors]K M Muller
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil der Ruhr Universität Bochum
Radiologe 44:415-26. 2004..At the present time, the validity of individual findings for a correlation between operability, tumor progress, chemotherapy and prognosis is not sufficiently elucidated by investigations nor secured...
[Pleura: non-neoplastic disorders]K M Muller
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil, Bochum, Ruhruniversitat
Pneumologie 58:516-24. 2004
[Pneumopathy of drug addicts]K M Muller
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil Ruhruniversität Bochum
Pneumologie 58:552. 2004
[Congenital pulmonary fibrosarcoma. Differential diagnosis of infantile pulmonary spindle cell tumors]C Kuhnen
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil Ruhr Universität Bochum, Burkle de la Camp Platz 1, 44789 Bochum
Pathologe 22:151-6. 2001..Especially in congenital lesions a favorable clinical course is to be expected after complete surgical resection. Additional radio- and/or chemotherapy is not recommended...
Beta-catenin in soft tissue sarcomas: expression is related to proliferative activity in high-grade sarcomasC Kuhnen
Institute for Pathology, Limb tumor registry, University Hospital Bergmannsheil, Bochum, Germany
Mod Pathol 13:1005-13. 2000..Mutations of the beta-catenin gene are probably of lesser importance for the accumulation of beta-catenin in soft tissue sarcomas...
Expression and localization of vascular endothelial growth factor and its receptor flt in pulmonary sarcoidosisE Tolnay
Department of Pulmonology, Semmelweis Medical School, Budapest, Hungary
Virchows Arch 432:61-5. 1998..We found an increased transcription and protein production of VEGF and an overexpression of flt in activated alveolar macrophages, in epitheloid cells, and in multinuclear giant cells of pulmonary sarcoid granulomas...
Patterns of chromosomal imbalances in benign solitary fibrous tumours of the pleuraM Krismann
Institute of Pathology, University Clinic, Bochum, Germany
Virchows Arch 437:248-55. 2000..Further molecular characterisation of this rare tumour entity will be necessary to elucidate possible genes involved in early tumorigenesis...
APC and beta-catenin in alveolar soft part sarcoma (ASPS)--immunohistochemical and molecular genetic analysisC Kuhnen
Institute of Pathology, University Hospital Bergmannsheil, Bochum, Germany
Pathol Res Pract 196:299-304. 2000..A nuclear function of APC in ASPS in down-regulating nuclear transcription processes linked to overexpression of beta-catenin, as is known in colorectal carcinogenesis, may be hypothesized...
Severe chromosomal aberrations in pleural mesotheliomas with unusual mesodermal features. Comparative genomic hybridization evidence for a mesothelioma subgroupM Krismann
Institute of Pathology, Professional Associations Clinic Bergmannsheil Bochum, University Clinic, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
J Mol Diagn 2:209-16. 2000..Therefore, we propose to use the term mesodermoma for this subgroup...
Pathology of small-cell lung cancerK Junker
Institute of Pathology, Bergmannsheil University Hospital, Ruhr University of Bochum, Germany
J Cancer Res Clin Oncol 126:361-8. 2000....
Patterns of expression and secretion of vascular endothelial growth factor in malignant soft-tissue tumoursC Kuhnen
Institute of Pathology, University Hospital Bergmannsheil, Bochum, Germany
J Cancer Res Clin Oncol 126:219-25. 2000..Further long-term follow-up studies are needed, which should include patients with tumour recurrences...
Benign solitary fibrous tumour of the thigh: morphological, chromosomal and differential diagnostic aspectsM Krismann
Institute of Pathology, Professional Associations Clinic, Bergmannsheil Bochum, University Clinic, Germany
Langenbecks Arch Surg 385:521-5. 2000..Immunohistochemically, the tumour stained positively for vimentin, CD34, CD99, and focally for actin and desmin. No reaction occurred with keratin or S100 protein antibodies. CGH detected a single loss on chromosome 13q...
[CGH findings in neuroendocrine tumours of the lung]G Johnen
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Universitatsklinik, Bochum
Pathologe 24:303-7. 2003..In conclusion, the CGH results support the classification of typical carcinoid tumors as a separate entity in clear distinction from the NE carcinomas...
[Mesothelioma in academics. German Bochum mesothelioma register]K M Muller
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhruniversität Bochum, Bochum
Chirurg . 2008
[Apoptosis and tumor regression in locally advanced non-small cell lung cancer with neoadjuvant therapy]K Junker
Institut fur Pathologie, Universitätsklinik Bergmannsheil, Bochum
Pathologe 24:214-9. 2003..Only a few weeks after the completion of the neoadjuvant chemoradiotherapy this contributes to a net proliferation of the residual tumour tissue which is largely equivalent to that of the untreated tumour...
Acute and chronic tissue response to coronary stent implantation: pathologic findings in human specimenP H Grewe
Department of Cardiology and Angiology, University Hospital Bergmannsheil, Bochum, Germany
J Am Coll Cardiol 35:157-63. 2000..The aim of our study was to analyze the cellular components of neointimal tissue regeneration after coronary stenting...
[A rare case of a neuroendocrine carcinoma of the esophagus. Intermediate between a well-differentiated neuroendocrine carcinoma and a low-differentiated neuroendocrine carcinoma]T Gumprich
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Universitätsklinik der Ruhr Universität, Bochum
Pathologe 25:229-34. 2004..According to the new WHO classification of neuroendocrine tumors the described tumor was identified as an intermediate between a well-differentiated neuroendocrine carcinoma and a low-differentiated neuroendocrine carcinoma...
[liposarcoma. Aspects of pathomorphology--an analysis of 209 tumos]C Kuhnen
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
Chirurg 75:1151-8. 2004..Among the heterogeneous group of adult soft tissue sarcomas, liposarcomas represent the largest entity along with malignant fibrous histiocytomas (MFH)...
[Virtual multislice-CT-bronchoscopy as a diagnostic tool in patients with endobronchial tumors: case report of a carcinoid tumor]C M Heyer
Institut für Radiologie und Nuklearmedizin, Berufsgenossenschaftliche Kliniken Bergmannsheil, Klinikum der Ruhr Universitat Bochum
Pneumologie 57:272-7. 2003..Multislice-CT generated three-dimensional virtual bronchoscopy enables non-invasive and detailed view of the tracheobronchial system...
[Tenosynovial giant cell tumor]C Kuhnen
Institut fur Pathologie, Register für Gliedmassentumoren, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
Pathologe 26:96-110. 2005..Immunohistochemically, the diffuse-type exhibited focal expression of CD31 (in 75% of tumors) and calretinin (in 63%) besides CD68-staining...
[Pathology and molecular biology of lung cancer]T Wiethege
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Klinikum der Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789 Bochum
Pathologe 21:404-23. 2000..Histological and cytological findings are still the decisive basis for the primary diagnosis of the pathologist in any given case...
Surfactant proteins in pulmonary alveolar proteinosis in adultsF Brasch
Institute of Pathology, University Hospital Bergmannsheil, Buerkle de la Camp Platz 1, D 44789, Bochum, Germany
Eur Respir J 24:426-35. 2004....
[Cellular changes in non-small cell lung cancer after neoadjuvant therapy]K Junker
Institut fur Pathologie, Universitätsklinik Bergmannsheil, Bochum
Pathologe 25:193-201. 2004..Based on these results, grading of non-small cell lung cancer is not recommended after neoadjuvant therapy and the diagnosis of "large cell anaplastic" carcinoma should be made with reservation...
Adult polyglucosan body disease: a postmortem correlation studyE Sindern
Department of Neurology, BG Kliniken Bergmannsheil, Ruhr University, Bochum, Germany
Neurology 61:263-5. 2003..GBE activity was decreased in the morphologically affected tissues but was normal in unaffected tissues. GBE mRNA transcripts were similar in all tissues and in controls, which confirms the lack of tissue-specific GBE isoforms...
[Angiotensin converting enzyme (ACE, CD143) in the regular pulmonary vasculature]A M Muller
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil Universitätsklinik, Bergmannsheil der Ruhr Universität Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
Pathologe 25:141-6. 2004..The nearly exclusive endothelial ACE expression in capillaries and arterial vessels points to ACE as an immunohistochemical marker for these vessels in normal lung tissue...
Scanning electron microscopical investigations of broncho-alveolar casts after intratracheal asbestos fibre instillationB Voss
Professionals Associations Research Institute for Occupational Medicine, Bochum, Germany
Int J Hyg Environ Health 203:127-34. 2000..The question if the migration of fibres is a mechanical movement or an active transport is still under discussion...
[Mesotheliomas with leucocytic infiltration]P Dorfmuller
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil Bochum Universitätsklinik, Bochum
Pathologe 25:349-55. 2004..We therefore studied two rare cases, a mesothelioma with parallel lymphoma and a lymphohistiocytoid mesothelioma, and compared them to a third more common case of mesothelioma with inflammatory tissue-reaction...
Interstitial lung disease in a baby with a de novo mutation in the SFTPC geneF Brasch
Institute of Pathology, University Hospital Bergmannsheil, Bochum, Germany
Eur Respir J 24:30-9. 2004..This report heralds the emerging diversity of phenotypes associated with the expression of mutant surfactant C proteins...
Overlap syndrome between autoimmune hepatitis and primary sclerosing cholangitis in two casesT Griga
Department of Gastroenterology and Hepatology, University Hospital Bergmannsheil, Bochum, Germany
Eur J Gastroenterol Hepatol 12:559-64. 2000..We report two additional cases, one case showing an association with Crohn's disease...
[Therapy-induced tumor regression in adult soft tissue sarcomas-morphological findings]C Kuhnen
Institut für Pathologie der Ruhr Universität Bochum an den BG Kliniken Bergmannsheil
Pathologe 25:437-44. 2004..g. according to the grading scheme for osteosarcomas following chemotherapy of Salzer-Kuntschik). A report of sarcoma resection specimens should include the percentage of vital tumor tissue...
[Classification of pulmonary alveolar proteinosis in newborns, infants, and children]F Brasch
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil Bochum
Pathologe 25:299-309. 2004....
[Leiomyosarcoma of the inferior vena cava. Review of a rare disease]A M Muller
Institut für Pathologie der Ruhr Universität Bochum an den Berufgenossenschaftlichen Kliniken Bergmannsheil
Pathologe 26:153-8. 2005..The resected tumour showed the histological signs of a well differentiated, progesterone positive leiomyosarcoma. The case is discussed on the data of the reviewed literature...
[Inflammatory pseudopapilloma after recurring aspiration of fruit stones as rare differential diagnosis of bronchogenic cancer]J W Walther
Berufsgenossenschaftliche Kliniken Bergmannsheil Bochum, Klinikum der Ruhr Universitat Bochum, Medizinische Klinik und Poliklinik, Abteilung fur Pneumologie, Allergologie und Schlafmedizin
Pneumologie 56:438-42. 2002..Bronchoscopy is mandatory and may obviate misdiagnosis and thoracotomy. The use of inhaled and systemic steroids can be used to facilitate successful endoscopic extraction...
[Association of primary sclerosing cholangitis and sarcoidosis]B Scherr
Abteilung für Gastroenterologie und Hepatologie, Universitatsklinik, Ruhr Universitat Bochum
Med Klin (Munich) 96:550-4. 2001..Primary sclerosing cholangitis and sarcoidosis are rarely associated diseases...
Saline-irrigated, cooled-tip radiofrequency ablation is an effective technique to perform the maze procedureK Khargi
Department of Cardiothoracic Surgery, Berufsgenossenschaftliche, Kliniken Bergmannnsheil University Hospital Bochum, Germany
Ann Thorac Surg 72:S1090-5. 2001..We evaluated the effectiveness of the saline-irrigated-cooled-tip-radiofrequency ablation (SICTRA) to produce linear intraatrial lesions...
[Thoracic aortic aneurysm in the setting of metastatic mediastinitis]E Harrer
Institut für Pathologie an der BG Klinik Bergmannsheil Universitätsklinik, Ruhr Universitat Bochum
Pathologe 24:146-9. 2003..The development of this unusual thoracic aortic aneurysm is shown from impending rupture to successful vascular graft implantation...
[Differential diagnosis of saccular aneurysms of the isthmus aortae: example of a penetrating atherosclerotic ulcer. Case-report and review of the literature]A M Muller
Institut fur Pathologie, Universitätsklinik Bergmannsheil der Ruhr Universität Bochum
Chirurg 75:713-8. 2004....
[Immunohistochemical markers in lung tumors--a status evaluation]K M Muller
Institut fur Pathologie, Berufsgenossenschaftlichen Krankenanstalten Bergmannsheil, Universitatsklinik, Bochum
Pneumologie 45:140-6. 1991....
[Reaction patterns to cutaneous particulate and ornamental tattoos]K M Muller
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Universitatsklinik, Ruhr Universitat Bochum
Pathologe 23:46-53. 2002..A clear correlation between subcutaneous incorporated quartz particles and progressive systemic sclerosis was not found in this study...
[Elemental analysis of tattoo dyes-is there a potential risk from tattoo dyes?]I Schmitz
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Universitatsklinik, Ruhr Universitat Bochum
J Dtsch Dermatol Ges 2:350-3. 2004..Tattoo dyes in current use can cause foreign body reactions...
[Complex pulmonary vessel alterations in an aorto-pulmonary window in adulthood]A M Muller
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil Universitätsklinik, Burkle de la Camp Platz 1, 44789 Bochum
Pathologe 22:349-53. 2001..All these varying findings in the pulmonary arteries emphasise the fact that the pathomorphological findings in lung biopsies might not be representative of the whole lung...
[Cell reactions to amber: amber lung in experimental animals]E Kaiserling
Institut fur Pathologie, Universitatsklinikum Tubingen, Germany
Pathologe 27:188-92. 2006....
[Desmoid-type fibromatosis (aggressive fibromatosis)]C Kuhnen
Institut fur Pathologie, Register für Gliedmassentumoren, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum
Pathologe 26:117-26. 2005....
Ossification in atherosclerotic carotid arteriesT Deneke
Department of Cardiology, Berufsgenossenschaftliche Kliniken, Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum, Germany
Z Kardiol 90:106-15. 2001..The exact mechanisms and development of bone formation in regard to late stage calcified atherosclerosis still remains under debate...
[Drug-induced pulmonary damage]K M Muller
Institut für Pathologie der Ruhr Universität Bochum, Berufsgenossenschaftliche Kliniken, Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum
Pathologe 27:19-26. 2006..Differentiation from pulmonary alterations due to the underlying disease is often difficult. In daily routine diagnostics, it is important to consider iatrogenic causal factors in cases of "undetermined pulmonary disease"...
Bronchioloalveolar carcinoma: a new cancer in Peutz-Jeghers syndromeA von Herbay
Institute of Pathology, University of Heidelberg, Heidelberg, Germany
Lung Cancer 47:283-8. 2005..3. This observation supports the hypothesis that STK11 is a tumour suppressor gene which is involved in the development of lung adenocarcinoma...
[Morphological changes after lung trauma]K M Muller
Institut fur Pathologie, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789 Bochum
Kongressbd Dtsch Ges Chir Kongr 118:576-9. 2001..Inflammatory complications and development of ARDS with subsequent complications in the traumatically pre-damaged pulmonary organ...
Coronary morphologic findings after stent implantationP H Grewe
Department of Cardiology, Institute of Pathology, University Hospital Bergmannsheil, Bochum, Germany
Am J Cardiol 85:554-8. 2000..Morphometric analysis of stents implanted postmortemly and intravitally revealed comparable results. Postmortem stenting seems to be an appropriate model for studying stent expansion and stenting results in human coronary arteries...
Anti-proliferative activity of protein kinase C in apical compartments of human colonic crypts: evidence for a less activated protein kinase C in small adenomasR Assert
Department of Internal Medicine, Berufsgenossenschaftliche Kliniken Bergmannsheil, University of Bochum, Germany
Int J Cancer 80:47-53. 1999..Changes in the regulation patterns of PKC isoforms suggest a decreased activation state of PKC even in small adenomas. This is compatible with an anti-proliferative function of PKC serving to protect mucosa from expanding mutated cells...
Tuberculous involvement of the oesophagus with oesophagobroncheal fistulaT Griga
Department of Gastroenterology and Hepatology, University Hospital Bergmannsheil, Bochum, Germany
Dig Liver Dis 34:528-31. 2002..The patient was immunocompromised due to treatment with azathioprine that she was receiving for multiple sclerosis. The fistula was successfully treated by antituberculous chemotherapy alone...
[Aneurysms in arterio-venous synthetic shunts after dialysis therapy. Morphology and pathogenesis]K M Muller
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Universitatsklinik, Ruhr Universitat Bochum
Pathologe 24:480-6. 2003..Prosthetic aneurysms up to diameters of 3,2 cm were seen. Suitable choice of puncturing sites and puncturing technique can help to avoid destruction of the synthetic material...
[Intraoperative cooled-tip radiofrequency ablation in patients with atrial fibrillation undergoing open heart surgery]B Lemke
Klinik für Kardiologie und Angiologie, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
Z Kardiol 92:1008-17. 2003..Postoperative complications and conversions to sinus rhythm were followed up (mean follow-up duration 17+/-14 months)...
[Fatal cardiomyopathy in adult in polyglucosan body disease]E Postler
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil, Burkle de la Camp Platz 1, 44789 Bochum
Pathologe 23:229-34. 2002..This observation shows that in addition to the known deposition of PGBs in nervous system and skeletal muscle, an involvement of the heart has to be considered in APBD as well...
