Bruno Muller-Oerlinghausen

..They were also more marked in patients as compared to healthy subjects. CONCLUSION: Slow Stroke Massage can be used effectively and safely as a complimentary therapeutic strategy in depressed patients...

..A suicide-preventing effect has not been demonstrated conclusively for antidepressants or non-lithium mood stabilizers...

..S.A. Although there are some pointers to the antidepressive and anxiolytic action of slow-stroke massage in various randoms studies of patient cohorts, there have been no controlled trials of depressed hospitalized patients...

..06% of the population). Rational treatment strategies most likely would demand that prescription rates be about 10 times higher...

..Aim of the present study was to investigate in which way general practitioners (GPs) as well as specialists in internal medicine and cardiologists in private practice are managing treatment of AF in the German capital...

..Guidelines and algorithms for selecting an appropriate prophylactic strategy in affective disorders should take into consideration the suicide risk of an individual patient...

..The evidence that lithium can effectively reduce suicide risk has been integrated into modern algorithms in order to select the optimal maintenance therapy for an individual patient...

..This minireview summarizes the existing evidence from large, international observational studies and RCTs on the suicide preventive effects of lithium as compared to other mood stabilizers and antidepressants...

..Abnormal changes in platelets used as peripheral markers of central serotonergic functions are said to be associated with suicidality and depression, but this association has not been supported by consistent findings...

..Valproate is beneficial because it allows the administration of fewer neuroleptic medications and produces improved and quicker remission of manic symptoms...

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..This project was issued in November 2007 by the Federal Ministry of Health. The Drug Commission will be responsible for the co-ordination of any future actions...

..Several studies indicate that there is no correlation between changes in central and peripheral serotonergic parameters. The mechanism of changes of peripheral serotonergic parameters is not sufficiently understood...

..This effect might be explained by the serotonergic effects of lithium...

..Study data suggest that active medication should be maintained for at least 1 year after successful lithium augmentation in patients with unipolar major depressive disorder...

..This is in contrast to the established decline of HPA system activity during treatment with tricyclic antidepressants...

..Unexpectedly, only minimal side effects have been reported. The goal of the present study was to investigate whether healthy controls and depressed patients differ in their ability to tolerate supraphysiological doses of T(4)...

..8 versus 25.5+/-7.7 versus 24.1+/-5.8 pMol [3H]-5HT/10(9) plat. x 5 min, respectively). The findings indicate that pre-treatment 5HT uptake activity contributes to the individual variability in response time to amitriptyline treatment...

..They also possess well documented antisuicidal effects. Second choice prophylactic treatments are carbamazepine and valproate, although evidence of their effectiveness is weaker...

..Results of this study should be confirmed in a larger study group...

..This was also observed for the combined analysis of both polymorphisms. In conclusion, we found no association between the different genotypes of the 44-bp polymorphism and the 17-bp VNTR and maximum rate of 5-HT uptake into platelets...

..In conclusion, adjunctive treatment with L-thyroxine in supraphysiological doses may be an effective strategy in the maintenance treatment of patients with prophylaxis-resistant affective disorders...

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..More carefully designed studies are required to overcome the existing methodological shortcomings...

..We feel that some specific limitations of the study were related to the inclusion of patients regardless of adequacy of treatment, quality of monitoring, drug combinations, age and sex, and stabilization response...

..The aim of this study is to contribute to this ongoing discussion by taking a heuristic case-based approach to the question...

..The impact of the polymorphism on haloperidol pharmacokinetics, adverse events, and efficacy was prospectively evaluated under naturalistic conditions in 172 unselected psychiatric inpatients with acute psychotic symptoms...

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..For the sake of optimal patient care, "pluralistic" approaches towards setting valid therapeutic rules and standards are no alternative during the periods of basic medical training...