F U Muller


Country: Germany


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    Muller F, Boknik P, Knapp J, Linck B, Luss H, Neumann J, et al. Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes. Cardiovasc Res. 2001;52:95-102 pubmed
    ..We suggest that attenuation of the CRE-mediated transcription through chronic stimulation of the cAMP-pathway, e.g. by elevated catecholamines, contributes to the altered expressional regulation in congestive heart failure. ..
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    Müller F, Lewin G, Matus M, Neumann J, Riemann B, Wistuba J, et al. Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2+-ATPase in mice lacking the CREM gene. FASEB J. 2003;17:103-5 pubmed
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    Muller F, Loser K, Kleideiter U, Neumann J, von Wallbrunn C, Dobner T, et al. Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes. Cell Death Differ. 2004;11:485-93 pubmed
    ..We suggest AP-2alpha as a novel cardiac regulator implicated in the activation of apoptosis in IDC. ..
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    Müller F, Lewin G, Baba H, Boknik P, Fabritz L, Kirchhefer U, et al. Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice. J Biol Chem. 2005;280:6906-14 pubmed
    ..Our results indicate that heart-directed expression of CREM-IbDeltaC-X leads to complex cardiac alterations, suggesting CREM as a central regulator of cardiac morphology, function, and gene expression. ..