Stefan Mohlenkamp

..The effect of aggressive medical therapy on quantitative coronary plaque burden is not generally known, especially in ethnic Chinese...

..The rationale of serial CAC quantification is discussed in this article.The Heinz Nixdorf Recall Study will contribute to the appraisal of new imaging modalities in risk stratification...

..Until then, the repeated radiation exposure cannot be recommended outside of clinical studies...

..The applicability of these results to the general population is currently being investigated in the Heinz-Nixdorf Recall Study...

..We studied the association of CAC with ECG abnormalities in a general population without myocardial infarction or revascularization...

..If CVD risk in the remaining individuals can further be stratified and discriminated by additional risk assessment using coronary artery calcium (CAC) scoring is unknown...

..The predictive value of modern imaging- and non-imaging-based markers of risk that can be used for risk stratification in masters endurance athletes still deserves exploration...

..The resting and the stress ECG provide a number of prognostically relevant indices that can easily be obtained in routine clinical practice, but have thus far found little acceptance for risk stratification of asymptomatic individuals...

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..To quantify the prevalence of coronary artery calcification (CAC) in relation to cardiovascular risk factors in marathon runners, and to study its role for myocardial damage and coronary events...

..His profile suggested a low 10-year cardiovascular risk...

..Little is known, however, whether risk factors have an impact differently on atherosclerosis in these distinct vascular territories in the same individuals...

..The purpose of this study was to determine net reclassification improvement (NRI) and improved risk prediction based on coronary artery calcification (CAC) scoring in comparison with traditional risk factors...

..This marker of target-organ damage might be included, when lifestyle modification and pharmacotherapeutic effects in prehypertensive individuals are tested to avoid exposure to risk and increase benefit...

..In this study, we evaluated the prognostic value of very high coronary CSs in symptomatic males undergoing angiography and analyzed the impact of event definitions on identification of risk predictor's...

..Long-term exposure to particulate air pollution has been associated with increased cardiovascular disease. Biologic pathways for this association are not fully understood...

..We evaluated the sex related cardiovascular risk stratification based on quantification of subclinical atherosclerosis and inflammation...

..The improved technology of BAV makes this technique attractive for elderly patients who are at high operative risk or in cases where valve replacement was refused for any reason...

..This article discusses the present findings of the Heinz Nixdorf Recall Study with respect to the current literature, risk stratification algorithms, and current European guidelines for risk prediction...

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..Special focus is placed on the association of long-term traffic exposure with subclinical atherosclerosis, the major underlying pathology for cardiovascular disease...

..Long-term exposure to urban air pollution may accelerate atherogenesis, but mechanisms are still unclear. The induction of a low-grade systemic inflammatory state is a plausible mechanistic pathway...

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..The aim of this study was to investigate the association of long-term residential exposure to fine particles with carotid intima-media thickness (CIMT)...

..Such acute downstream vascular paralysis could be beneficial in preventing a no-reflow phenomenon in patients undergoing stenting...

..To assess left ventricular volumes and mass by cardiac magnetic resonance imaging in relation to conventional cardiovascular risk factors and coronary atherosclerotic plaque burden in master marathon runners aged > or =50 years...

..SHS increases the risk for acute cardiovascular events and may contribute to the development of atherosclerosis...

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..Further prospective studies are required to establish the clinical value of combined assessment of coronary calcium quantification and CTCA...

..Smoking cessation is a key issue in preventive medicine, but quantitative data on its benefit for the coronary arteries are sparse...

..1% (95%-CI: 1.9, 12.6%) was found for the 21-day average. These results support the hypothesis that short-term exposure to traffic-related particles might lead to detrimental cardiovascular health effects via an inflammatory mechanism...

..Therefore, we examined the relationship between coronary artery calcification as a sign of subclinical coronary atherosclerosis, socio-economic status and established cardiovascular risk factors in a healthy population...

..This report presents population-based estimates of the prevalence of peripheral arterial disease (PAD), chronic critical limb ischemia (CLI), and Moenckeberg's medial calcinosis (MC) in Germany...

..Further, a variety of risk factors are actively evaluated, including markers of the activity of atherosclerotic disease, thrombogenic risk, and genetic polymorphisms...

..An increased rate of progression of coronary calcium seems to indicate a substantially increased risk for adverse cardiac events...

..We aimed to determine, whether the amount of local pericoronary fat volume is associated with the presence of plaque burden in the underlying coronary artery segment...

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..The aim of this study was to investigate the influence of a marathon race on the amount of circulating progenitor cells immediately after the race in advanced-aged runners...

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..0001, PR adjusted for risk factors 1.14 [1.09-1.20], p < 0.0001). In general population, TAC has high prevalence and largely shares cardiovascular risk factors with CAD while being independently associated with present CAC...

..In the present study we aimed to (1) establish age- and gender-specific distribution of thoracic aortic diameters and (2) to determine the prevalence of asymptomatic TAA in a population-based European cohort...

..These findings suggest that inflammation plays an important role in the development and presence of cognitive impairment...

..Here we examine the association between single nucleotide polymorphisms (SNPs) integrated on Metabochip and coronary artery calcification (CAC), a valid risk factor for CHD, in an unselected, population-based German cohort...

..This study sought to determine whether epicardial fat volume predicts coronary events in the general population...

..Objective: To quantify the release of vasoconstrictors and to determine the efficacy of coronary dilators to attenuate their action...

..abstract:..

..Long-term flow adaptation is achieved by an increase in coronary lumen size, whereas short-term myocardial oxygen requirements are met by changes in resting flow velocity...

..This represents the opportunity and the challenge of a proof of principle...

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..Whether drug-eluting stents help to overcome this limitation remains to be shown. Long-term prognosis is good, although previous investigations have been performed in a limited number of cases only...

..Diabetes prevention and smoking prevention and cessation programs need to specifically target individuals of lower income and education. According to our findings, prevention of PAD would benefit extraordinarily...

..The simulation results also indicate that if the vascular diameters change so that the vascular resistance corresponds to the change in flow, then the empirically observed myocardial B(v)-to-F relationship holds well...

..There is a limited association between both parameters and coronary atherosclerosis, so that severity of atherosclerosis in one vascular territory permits no estimate of plaque burden in another vascular territory...

..Moreover, implications for radiation exposure and left ventricular function analysis are discussed...