Thorsten Müller

Summary

Country: Germany

Publications

  1. ncbi request reprint The AICD interacting protein DAB1 is up-regulated in Alzheimer frontal cortex brain samples and causes deregulation of proteins involved in gene expression changes
    T Muller
    Functional Proteomics, Medizinisches Proteom Center, Ruhr University Bochum, D 44780 Bochum, Germany
    Curr Alzheimer Res 8:573-82. 2011
  2. pmc Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)
    Thorsten Müller
    Institute of Pathology and Neuropathology, University Hospital Essen, D 45122 Essen, Germany
    Mol Biol Cell 18:201-10. 2007
  3. doi request reprint The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease
    Thorsten Müller
    Medizinisches Proteom Center, Ruhr University Bochum, Bochum, Germany
    Prog Neurobiol 85:393-406. 2008
  4. pmc Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Cell Biol 14:15. 2013
  5. doi request reprint A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1
    Thorsten Müller
    Functional Proteomics, Medizinisches Proteom Center, Ruhr University Bochum, D 44801 Bochum, Germany
    Biochim Biophys Acta 1834:387-94. 2013
  6. doi request reprint Sense and nonsense of pathway analysis software in proteomics
    Thorsten Müller
    Functional Proteomics, Medizinisches Proteom Center, Ruhr University Bochum, D 44780 Bochum, Germany
    J Proteome Res 10:5398-408. 2011
  7. ncbi request reprint Disease state, age, sex, and post-mortem time-dependent expression of proteins in AD vs. control frontal cortex brain samples
    T Muller
    Funktionelle Proteomik, Medizinisches Proteom Center, Ruhr University Bochum, D 44780 Bochum, Germany
    Curr Alzheimer Res 5:562-71. 2008
  8. pmc The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease
    Andreas Schrötter
    Functional Proteomics, Medizinisches Proteom Center, Ruhr University Bochum, D 44801 Bochum, Germany
    Mol Cell Proteomics 11:1274-88. 2012
  9. doi request reprint FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease
    Andreas Schrötter
    Functional Proteomics, Medizinisches Proteom Center, Ruhr University Bochum, 44801 Bochum, Germany
    J Cell Sci 126:2480-92. 2013
  10. doi request reprint Distinct ubiquitination cascades act on the peroxisomal targeting signal type 2 co-receptor Pex18p
    Fouzi El Magraoui
    Biochemie Intrazellulärer Transportprozesse, Ruhr Universitat Bochum, Bochum, 44780, Germany Systembiochemie, Ruhr Universitat Bochum, Bochum, 44780, Germany Medizinische Proteomik Bioanalytik, AG Neuro Proteomics, Medizinisches Proteom Center, Bochum, 44801, Germany
    Traffic 14:1290-301. 2013

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The AICD interacting protein DAB1 is up-regulated in Alzheimer frontal cortex brain samples and causes deregulation of proteins involved in gene expression changes
    T Muller
    Functional Proteomics, Medizinisches Proteom Center, Ruhr University Bochum, D 44780 Bochum, Germany
    Curr Alzheimer Res 8:573-82. 2011
    ..Our results point to a putative relevance of AICD-dependent mechanisms in AD, caused by protein abundance changes of AICD interacting proteins, as shown for DAB1 in this work...
  2. pmc Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)
    Thorsten Müller
    Institute of Pathology and Neuropathology, University Hospital Essen, D 45122 Essen, Germany
    Mol Biol Cell 18:201-10. 2007
    ..Our data point to a role of AICD in developmental and injury-related cytoskeletal dynamics in the nervous system...
  3. doi request reprint The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease
    Thorsten Müller
    Medizinisches Proteom Center, Ruhr University Bochum, Bochum, Germany
    Prog Neurobiol 85:393-406. 2008
    ....
  4. pmc Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Cell Biol 14:15. 2013
    ..Preliminary results have shown a protein phosphatase inhibitor activity resembling PPP1R2 in bovine and primate spermatozoa...
  5. doi request reprint A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1
    Thorsten Müller
    Functional Proteomics, Medizinisches Proteom Center, Ruhr University Bochum, D 44801 Bochum, Germany
    Biochim Biophys Acta 1834:387-94. 2013
    ..We hypothesize that AICD-dependent deregulation of Stathmin1 causes microtubule disorganization, which might play an important role for the pathophysiology of Alzheimer's disease...
  6. doi request reprint Sense and nonsense of pathway analysis software in proteomics
    Thorsten Müller
    Functional Proteomics, Medizinisches Proteom Center, Ruhr University Bochum, D 44780 Bochum, Germany
    J Proteome Res 10:5398-408. 2011
    ..Next to a general assessment and comparison of the pathway analysis tools, we provide recommendations for users as well as for software developers to improve the added value of a pathway study implementation in proteomic pipelines...
  7. ncbi request reprint Disease state, age, sex, and post-mortem time-dependent expression of proteins in AD vs. control frontal cortex brain samples
    T Muller
    Funktionelle Proteomik, Medizinisches Proteom Center, Ruhr University Bochum, D 44780 Bochum, Germany
    Curr Alzheimer Res 5:562-71. 2008
    ..controls revealed age or sex-dependent regulation. Our analysis suggests the necessity of integrating additionally available covariables in comparative proteome studies of two different sets of human tissue...
  8. pmc The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease
    Andreas Schrötter
    Functional Proteomics, Medizinisches Proteom Center, Ruhr University Bochum, D 44801 Bochum, Germany
    Mol Cell Proteomics 11:1274-88. 2012
    ..In addition, we identified differential gene expression of BACE1 and PSEN1 in the knockdown cells, which is possibly a consequence of MAT2A deregulation and may indicate a self regulatory mechanism...
  9. doi request reprint FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease
    Andreas Schrötter
    Functional Proteomics, Medizinisches Proteom Center, Ruhr University Bochum, 44801 Bochum, Germany
    J Cell Sci 126:2480-92. 2013
    ..Thus, FE65 interactions with BLM and MCM proteins may contribute to the neuronal cell cycle re-entry observed in brains affected by Alzheimer's disease...
  10. doi request reprint Distinct ubiquitination cascades act on the peroxisomal targeting signal type 2 co-receptor Pex18p
    Fouzi El Magraoui
    Biochemie Intrazellulärer Transportprozesse, Ruhr Universitat Bochum, Bochum, 44780, Germany Systembiochemie, Ruhr Universitat Bochum, Bochum, 44780, Germany Medizinische Proteomik Bioanalytik, AG Neuro Proteomics, Medizinisches Proteom Center, Bochum, 44801, Germany
    Traffic 14:1290-301. 2013
    ..Our findings for the PTS2-pathway complement the data on PTS1-receptor ubiquitination and add up to a unified concept of the ubiquitin-based regulation of peroxisomal import. ..
  11. pmc A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients
    Rudolf A Kley
    Department of Neurology, Neuromuscular Center Ruhrgebiet, University Hospital Bergmannsheil, Ruhr University Bochum, Germany
    Mol Cell Proteomics 12:215-27. 2013
    ....
  12. doi request reprint Ultratrace enrichment of tyrosine phosphorylated peptides on an imprinted polymer
    Stefan Helling
    Functional Proteomics, Medizinisches Proteom Center, Ruhr Universität Bochum, Bochum, Germany
    Anal Chem 83:1862-5. 2011
    ..This suggests MIPs as a new tool for affinity-based proteomics...
  13. pmc Multiple phosphorylations of cytochrome c oxidase and their functions
    Stefan Helling
    Medizinisches Proteom Center, Funktionelle Proteomik, Ruhr Universitat Bochum, Bochum, Germany
    Proteomics 12:950-9. 2012
    ..We therefore hypothesize that additional phosphorylation(s) may be required for the "allosteric ATP-inhibition," and that these sites may be easily dephosphorylated or difficult to identify by mass spectrometry...