Ingo Müller

Summary

Country: Germany

Publications

  1. ncbi request reprint Receptor activator of nuclear factor kappaB ligand plays a nonredundant role in doxorubicin-induced apoptosis
    Ingo Müller
    University Children s Hospital Tubingen, Department of General Pediatrics, Hematology and Oncology, 72076 Tuebingen, Germany
    Cancer Res 63:1772-5. 2003
  2. doi request reprint Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis
    I Muller
    Hematology and Oncology, Department of General Pediatrics, University Children s Hospital, Tubingen, Germany
    Leukemia 22:2054-61. 2008
  3. ncbi request reprint Application of multipotent mesenchymal stromal cells in pediatric patients following allogeneic stem cell transplantation
    Ingo Müller
    Department of General Pediatrics, Hematology and Oncology, University Children s Hospital Tubingen, Hoppe Seyler St 1, 72076, Tubigen, Germany
    Blood Cells Mol Dis 40:25-32. 2008
  4. ncbi request reprint Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM
    I Muller
    University Children s Hospital Tubingen, Tubingen, Germany
    Cytotherapy 8:437-44. 2006
  5. ncbi request reprint In vitro analysis of multipotent mesenchymal stromal cells as potential cellular therapeutics in neurometabolic diseases in pediatric patients
    Ingo Müller
    University Children s Hospital, Tubingen, Germany
    Exp Hematol 34:1413-9. 2006
  6. ncbi request reprint Glycosylation and lectins-examples of immunesurveillance and immune evasion
    I Muller
    University Children s Hospital Tubingen, Germany
    Histol Histopathol 19:527-33. 2004
  7. pmc Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells
    Christina Holzwarth
    Department of General Pediatrics, University Children s Hospital, Tubingen, Germany
    BMC Cell Biol 11:11. 2010
  8. pmc Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity
    Pascal David Johann
    Department of General Paediatrics, University Children s Hospital, Tubingen, Germany
    BMC Cancer 10:501. 2010
  9. doi request reprint WT1 protein expression in slowly proliferating myeloid leukemic cell lines is scarce throughout the cell cycle with a minimum in G0/G1 phase
    Gunter Kerst
    Department of Pediatric Cardiology, University Children s Hospital Tuebingen, Hoppe Seyler Str 1, 72076 Tuebingen, Germany
    Leuk Res 32:1393-9. 2008
  10. pmc Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation
    Michaela Döring
    Department of Pediatric Hematology and Oncology, University Children s Hospital Tubingen, Tubingen, Germany
    BMC Infect Dis 12:263. 2012

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Receptor activator of nuclear factor kappaB ligand plays a nonredundant role in doxorubicin-induced apoptosis
    Ingo Müller
    University Children s Hospital Tubingen, Department of General Pediatrics, Hematology and Oncology, 72076 Tuebingen, Germany
    Cancer Res 63:1772-5. 2003
    ..This finding suggests improved chemotherapeutic efficiency of the anthracyclin against susceptible malignant cells in the presence with RANKL...
  2. doi request reprint Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis
    I Muller
    Hematology and Oncology, Department of General Pediatrics, University Children s Hospital, Tubingen, Germany
    Leukemia 22:2054-61. 2008
    ..Taken together, MSCs display biological properties that may add to the efficiency of surgical treatment in osteonecrosis and should be evaluated in larger patient cohorts...
  3. ncbi request reprint Application of multipotent mesenchymal stromal cells in pediatric patients following allogeneic stem cell transplantation
    Ingo Müller
    Department of General Pediatrics, Hematology and Oncology, University Children s Hospital Tubingen, Hoppe Seyler St 1, 72076, Tubigen, Germany
    Blood Cells Mol Dis 40:25-32. 2008
    ..Transfusion of MSC was safe and encouraging improvements in some patients were observed...
  4. ncbi request reprint Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM
    I Muller
    University Children s Hospital Tubingen, Tubingen, Germany
    Cytotherapy 8:437-44. 2006
    ..Concerns regarding BSE, other infectious complications and host immune reactions have fueled investigation of alternative culture supplements...
  5. ncbi request reprint In vitro analysis of multipotent mesenchymal stromal cells as potential cellular therapeutics in neurometabolic diseases in pediatric patients
    Ingo Müller
    University Children s Hospital, Tubingen, Germany
    Exp Hematol 34:1413-9. 2006
    ..Given the plasticity of MSCs, these cells represent an interesting add-on option for cellular therapy in children undergoing bone marrow transplantation for lysosomal storage diseases and other neurometabolic diseases...
  6. ncbi request reprint Glycosylation and lectins-examples of immunesurveillance and immune evasion
    I Muller
    University Children s Hospital Tubingen, Germany
    Histol Histopathol 19:527-33. 2004
    ..In this review, we focus on recent experimental evidence for regulatory functions of lectins and carbohydrate derivatives in the immune system and tumours...
  7. pmc Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells
    Christina Holzwarth
    Department of General Pediatrics, University Children s Hospital, Tubingen, Germany
    BMC Cell Biol 11:11. 2010
    ..We analyzed the effect of low oxygen tensions on human MSC cultured with platelet-lysate supplemented media and assessed proliferation, morphology, chromosomal stability, immunophenotype and plasticity...
  8. pmc Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity
    Pascal David Johann
    Department of General Paediatrics, University Children s Hospital, Tubingen, Germany
    BMC Cancer 10:501. 2010
    ..Due to phenotypic and morphological similarities of MSC and tumour stromal cells (TStrC), we speculated that immunotherapeutic approaches may be hampered if TStrC may still exhibit immunomodulatory properties of MSC...
  9. doi request reprint WT1 protein expression in slowly proliferating myeloid leukemic cell lines is scarce throughout the cell cycle with a minimum in G0/G1 phase
    Gunter Kerst
    Department of Pediatric Cardiology, University Children s Hospital Tuebingen, Hoppe Seyler Str 1, 72076 Tuebingen, Germany
    Leuk Res 32:1393-9. 2008
    ..We conclude that WT1 protein expression is dependent on the cell cycle phase as well as on the proliferation rate. This finding might be relevant for MRD studies and immunotherapeutic strategies targeting WT1...
  10. pmc Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation
    Michaela Döring
    Department of Pediatric Hematology and Oncology, University Children s Hospital Tubingen, Tubingen, Germany
    BMC Infect Dis 12:263. 2012
    ..To address this issue, we retrospectively assessed the safety, feasibility, and initial efficacy of prophylactic posaconazole in children...
  11. doi request reprint Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells
    Friederike Gieseke
    University Children s Hospital, Department of General Pediatrics, Hematology and Oncology, Tubingen, Germany
    Blood 116:3770-9. 2010
    ..These results identify galectin-1 as the first lectin mediating the immunomodulatory effect of MSCs on allogeneic T cells...
  12. doi request reprint Mesenchymal stem cell therapy for degenerative inflammatory disorders
    Ingo Müller
    Department of General Pediatrics, Hematology and Oncology, University Children s Hospital Tubingen, Tubingen, Germany
    Curr Opin Organ Transplant 13:639-44. 2008
    ..Here, we review the recent findings supporting the therapeutic use in the clinic and the mechanisms by which MSCs may deliver such an effect...
  13. ncbi request reprint WT1 protein expression in childhood acute leukemia
    Gunter Kerst
    Department of Pediatric Cardiology, University Children s Hospital, Tuebingen, Germany
    Am J Hematol 83:382-6. 2008
    ..The results of this study indicate the following: (i) there are considerable discrepancies between WT1 transcripts and protein expression; (ii) WT1 is not a suitable marker for flow cytometric MRD detection in childhood acute leukemia...
  14. pmc Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1
    Venkata Lokesh Battula
    University of Tubingen, Department of Internal Medicine II, Medical, Otfried Muller Str 10, 72076, Tubingen, Germany
    Haematologica 94:173-84. 2009
    ....
  15. ncbi request reprint Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNgammaR1 signaling and IDO expression
    Friederike Gieseke
    University Children s Hospital, Department of General Pediatrics, Hematology and Oncology, Tubingen, Germany
    Blood 110:2197-200. 2007
    ..Taken together, human MSCs exert important immunomodulatory functions in the absence of IFNgammaR1 signaling and IDO, partially accounted for by IGF-binding proteins...
  16. ncbi request reprint Mesenchymal stromal cells: a novel treatment option for steroid-induced avascular osteonecrosis
    Nikolay Tzaribachev
    Department of Hematology, Oncology and General Pediatrics, University Children s Hospital, Tuebingen, Germany
    Isr Med Assoc J 10:232-4. 2008
    ..Because of their differentiation properties, easy accessibility and proliferative capacity, autologous MSCs could potentially complement AVN treatment by adding fresh "osteogenic cells" to the healing process...
  17. pmc Caspofungin as antifungal prophylaxis in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis
    Michaela Döring
    Department of Pediatric Hematology Oncology, University Children s Hospital Tubingen, Tubingen, Germany
    BMC Infect Dis 12:151. 2012
    ..There are no guidelines for antifungal prophylaxis in children in this situation. Caspofungin (CAS), a broad-spectrum echinocandin, could be an effective alternative with lower nephrotoxicity than L-AmB...
  18. doi request reprint Dendritic cells: functional aspects of glycosylation and lectins
    Annika Erbacher
    University Children s Hospital, Department of General Pediatrics, Hematology and Oncology, 72026 Tübingen, Germany
    Hum Immunol 70:308-12. 2009
    ..In this review, we focus on glycobiological aspects of antigen uptake and processing, immune modulation, and viral infections in the context of DC biology...
  19. pmc Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children
    Matthias M Pfeiffer
    Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karl s University, Tuebingen, Germany
    Haematologica 95:1381-8. 2010
    ....
  20. doi request reprint Platelet derived bFGF mediates vascular integrative mechanisms of mesenchymal stem cells in vitro
    Harald F Langer
    Medizinische Klinik III, Department of Cardiovascular Medicine, Eberhard Karls Universitat Tubingen, Germany
    J Mol Cell Cardiol 47:315-25. 2009
    ..We conclude that platelets may play a critical part in the recruitment of MSCs to the endothelium, influence MSC function and promote integration of MSCs into the endothelium...
  21. doi request reprint One goal, different strategies--molecular and cellular approaches for the treatment of inherited skin fragility disorders
    Christian Hünefeld
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    Exp Dermatol 22:162-7. 2013
    ..In this review, we summarize current concepts of how inherited blistering diseases might be treated in the future and discuss the opportunities, promises, concerns and risks of these innovative approaches...
  22. pmc Eradication of pulmonary aspergillosis in an adolescent patient undergoing three allogeneic stem cell transplantations for acute lymphoblastic leukemia
    Michaela Döring
    Department of Pediatric Hematology Oncology, University Children s Hospital Tubingen, Hoppe Seyler Strß 1, 72076 Tubingen, Germany
    Case Rep Transplant 2012:672923. 2012
    ....
  23. ncbi request reprint Increased alpha2,6-sialylation of surface proteins on tolerogenic, immature dendritic cells and regulatory T cells
    Jutta Jenner
    University Children s Hospital, Department of General Pediatrics, Hematology and Oncology, Tubingen, Germany
    Exp Hematol 34:1212-8. 2006
    ..Receptors for sialic acids are expressed on lymphocytes and can generate an inhibitory signal. This study compared the sialic acid expression pattern of tolerogenic cells and effector cells...
  24. doi request reprint Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors
    Jörg Fuchs
    Department of Pediatric Surgery, University Children s Hospital, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Surg Oncol 17:323-30. 2008
    ..Furthermore, the sensitivity of preoperative imaging (CT) was assessed by intraoperative findings...
  25. ncbi request reprint Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction
    Karin Schilbach
    University Children s Hospital Tubingen, Hoppe Seyler Str 1, D 72076 Tubingen, Germany
    Blood 106:144-9. 2005
    ..These findings indicate that aAPCs are attractive tools for the ex vivo generation of HA-1H-specific CTLs suitable for immunotherapy of relapsed leukemia...
  26. ncbi request reprint Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCR
    Gunter Kerst
    Department of Pediatric Haematology and Oncology, University Children s Hospital, D 72076 Tubingen, Germany
    Br J Haematol 128:774-82. 2005
    ..We conclude that both MRD assays yield generally concordant results. Their combined use should enable MRD monitoring in virtually all patients and prevent false-negative results due to clonal evolution or phenotypic shifts...