Research Topics
| Ingo MüllerSummaryCountry: Germany Publications
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Detail Information
Publications
Receptor activator of nuclear factor kappaB ligand plays a nonredundant role in doxorubicin-induced apoptosisIngo Müller
University Children s Hospital Tubingen, Department of General Pediatrics, Hematology and Oncology, 72076 Tuebingen, Germany
Cancer Res 63:1772-5. 2003..This finding suggests improved chemotherapeutic efficiency of the anthracyclin against susceptible malignant cells in the presence with RANKL...- Glycosylation and lectins-examples of immunesurveillance and immune evasionI Muller
University Children s Hospital Tubingen, Germany
Histol Histopathol 19:527-33. 2004..In this review, we focus on recent experimental evidence for regulatory functions of lectins and carbohydrate derivatives in the immune system and tumours... 
Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosisI Muller
Hematology and Oncology, Department of General Pediatrics, University Children s Hospital, Tubingen, Germany
Leukemia 22:2054-61. 2008..Taken together, MSCs display biological properties that may add to the efficiency of surgical treatment in osteonecrosis and should be evaluated in larger patient cohorts...- In vitro analysis of multipotent mesenchymal stromal cells as potential cellular therapeutics in neurometabolic diseases in pediatric patientsIngo Müller
University Children s Hospital, Tubingen, Germany
Exp Hematol 34:1413-9. 2006..Given the plasticity of MSCs, these cells represent an interesting add-on option for cellular therapy in children undergoing bone marrow transplantation for lysosomal storage diseases and other neurometabolic diseases... - Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BMI Muller
University Children s Hospital Tubingen, Tubingen, Germany
Cytotherapy 8:437-44. 2006..Concerns regarding BSE, other infectious complications and host immune reactions have fueled investigation of alternative culture supplements... - Application of multipotent mesenchymal stromal cells in pediatric patients following allogeneic stem cell transplantationIngo Müller
Department of General Pediatrics, Hematology and Oncology, University Children s Hospital Tubingen, Hoppe Seyler St 1, 72076, Tubigen, Germany
Blood Cells Mol Dis 40:25-32. 2008..Transfusion of MSC was safe and encouraging improvements in some patients were observed... 
Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cellsChristina Holzwarth
Department of General Pediatrics, University Children s Hospital, Tubingen, Germany
BMC Cell Biol 11:11. 2010..We analyzed the effect of low oxygen tensions on human MSC cultured with platelet-lysate supplemented media and assessed proliferation, morphology, chromosomal stability, immunophenotype and plasticity...- Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicityPascal David Johann
Department of General Paediatrics, University Children s Hospital, Tubingen, Germany
BMC Cancer 10:501. 2010..Due to phenotypic and morphological similarities of MSC and tumour stromal cells (TStrC), we speculated that immunotherapeutic approaches may be hampered if TStrC may still exhibit immunomodulatory properties of MSC... - WT1 protein expression in slowly proliferating myeloid leukemic cell lines is scarce throughout the cell cycle with a minimum in G0/G1 phaseGunter Kerst
Department of Pediatric Cardiology, University Children s Hospital Tuebingen, Hoppe Seyler Str 1, 72076 Tuebingen, Germany
Leuk Res 32:1393-9. 2008..We conclude that WT1 protein expression is dependent on the cell cycle phase as well as on the proliferation rate. This finding might be relevant for MRD studies and immunotherapeutic strategies targeting WT1... - Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantationMichaela Döring
Department of Pediatric Hematology and Oncology, University Children s Hospital Tubingen, Tubingen, Germany
BMC Infect Dis 12:263. 2012..To address this issue, we retrospectively assessed the safety, feasibility, and initial efficacy of prophylactic posaconazole in children... - Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cellsFriederike Gieseke
University Children s Hospital, Department of General Pediatrics, Hematology and Oncology, Tubingen, Germany
Blood 116:3770-9. 2010..These results identify galectin-1 as the first lectin mediating the immunomodulatory effect of MSCs on allogeneic T cells... - Mesenchymal stem cell therapy for degenerative inflammatory disordersIngo Müller
Department of General Pediatrics, Hematology and Oncology, University Children s Hospital Tubingen, Tubingen, Germany
Curr Opin Organ Transplant 13:639-44. 2008..Here, we review the recent findings supporting the therapeutic use in the clinic and the mechanisms by which MSCs may deliver such an effect... - WT1 protein expression in childhood acute leukemiaGunter Kerst
Department of Pediatric Cardiology, University Children s Hospital, Tuebingen, Germany
Am J Hematol 83:382-6. 2008..The results of this study indicate the following: (i) there are considerable discrepancies between WT1 transcripts and protein expression; (ii) WT1 is not a suitable marker for flow cytometric MRD detection in childhood acute leukemia... - Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1Venkata Lokesh Battula
University of Tubingen, Department of Internal Medicine II, Medical, Otfried Muller Str 10, 72076, Tubingen, Germany
Haematologica 94:173-84. 2009.... - Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNgammaR1 signaling and IDO expressionFriederike Gieseke
University Children s Hospital, Department of General Pediatrics, Hematology and Oncology, Tubingen, Germany
Blood 110:2197-200. 2007..Taken together, human MSCs exert important immunomodulatory functions in the absence of IFNgammaR1 signaling and IDO, partially accounted for by IGF-binding proteins... - Mesenchymal stromal cells: a novel treatment option for steroid-induced avascular osteonecrosisNikolay Tzaribachev
Department of Hematology, Oncology and General Pediatrics, University Children s Hospital, Tuebingen, Germany
Isr Med Assoc J 10:232-4. 2008..Because of their differentiation properties, easy accessibility and proliferative capacity, autologous MSCs could potentially complement AVN treatment by adding fresh "osteogenic cells" to the healing process... - Caspofungin as antifungal prophylaxis in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysisMichaela Döring
Department of Pediatric Hematology Oncology, University Children s Hospital Tubingen, Tubingen, Germany
BMC Infect Dis 12:151. 2012..There are no guidelines for antifungal prophylaxis in children in this situation. Caspofungin (CAS), a broad-spectrum echinocandin, could be an effective alternative with lower nephrotoxicity than L-AmB... - Dendritic cells: functional aspects of glycosylation and lectinsAnnika Erbacher
University Children s Hospital, Department of General Pediatrics, Hematology and Oncology, 72026 Tübingen, Germany
Hum Immunol 70:308-12. 2009..In this review, we focus on glycobiological aspects of antigen uptake and processing, immune modulation, and viral infections in the context of DC biology... - Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in childrenMatthias M Pfeiffer
Department of Pediatric Hematology Oncology, University Children s Hospital, Eberhard Karl s University, Tuebingen, Germany
Haematologica 95:1381-8. 2010.... - Platelet derived bFGF mediates vascular integrative mechanisms of mesenchymal stem cells in vitroHarald F Langer
Medizinische Klinik III, Department of Cardiovascular Medicine, Eberhard Karls Universitat Tubingen, Germany
J Mol Cell Cardiol 47:315-25. 2009..We conclude that platelets may play a critical part in the recruitment of MSCs to the endothelium, influence MSC function and promote integration of MSCs into the endothelium... - Eradication of pulmonary aspergillosis in an adolescent patient undergoing three allogeneic stem cell transplantations for acute lymphoblastic leukemiaMichaela Döring
Department of Pediatric Hematology Oncology, University Children s Hospital Tubingen, Hoppe Seyler Strß 1, 72076 Tubingen, Germany
Case Rep Transplant 2012:672923. 2012.... - Increased alpha2,6-sialylation of surface proteins on tolerogenic, immature dendritic cells and regulatory T cellsJutta Jenner
University Children s Hospital, Department of General Pediatrics, Hematology and Oncology, Tubingen, Germany
Exp Hematol 34:1212-8. 2006..Receptors for sialic acids are expressed on lymphocytes and can generate an inhibitory signal. This study compared the sialic acid expression pattern of tolerogenic cells and effector cells... - Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCRGunter Kerst
Department of Pediatric Haematology and Oncology, University Children s Hospital, D 72076 Tubingen, Germany
Br J Haematol 128:774-82. 2005..We conclude that both MRD assays yield generally concordant results. Their combined use should enable MRD monitoring in virtually all patients and prevent false-negative results due to clonal evolution or phenotypic shifts... - Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro inductionKarin Schilbach
University Children s Hospital Tubingen, Hoppe Seyler Str 1, D 72076 Tubingen, Germany
Blood 106:144-9. 2005..These findings indicate that aAPCs are attractive tools for the ex vivo generation of HA-1H-specific CTLs suitable for immunotherapy of relapsed leukemia... - Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumorsJörg Fuchs
Department of Pediatric Surgery, University Children s Hospital, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
Surg Oncol 17:323-30. 2008..Furthermore, the sensitivity of preoperative imaging (CT) was assessed by intraoperative findings...