M Mittelbronn

Summary

Country: Germany

Publications

  1. ncbi request reprint Albumin in immunohistochemistry: Foe and friend
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Medical School, D 72076 Tuebingen, Germany
    Appl Immunohistochem Mol Morphol 14:441-4. 2006
  2. ncbi request reprint Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    J Neuroimmunol 189:50-8. 2007
  3. ncbi request reprint De novo erythropoietin receptor (EPO-R) expression in human neoplastic glial cells decreases with grade of malignancy but is favourably associated with patient survival
    M Mittelbronn
    Institute of Brain Research Neuropathology, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 33:299-307. 2007
  4. ncbi request reprint Disseminating anaplastic brainstem oligodendroglioma associated with allelic loss in the tumor suppressor candidate region D19S246 of chromosome 19 mimicking an inflammatory central nervous system disease in a 9-year-old boy
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, D 72076 Tuebingen, Germany
    Hum Pathol 36:854-7. 2005
  5. ncbi request reprint Multiple thromboembolic events in fetofetal transfusion syndrome in triplets contributing to the understanding of pathogenesis of hydranencephaly in combination with polymicrogyria
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Hum Pathol 37:1503-7. 2006
  6. doi request reprint Erythropoietin receptor is expressed in meningiomas and lower levels are associated with tumour recurrence
    O Küster
    Institute of Brain Research, University of Tubingen, Germany
    Neuropathol Appl Neurobiol 35:555-65. 2009
  7. ncbi request reprint Reactive astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tubingen, Germany
    Histopathology 50:897-910. 2007
  8. doi request reprint Diagnostic value of WT1 in neuroepithelial tumours
    J Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 35:69-81. 2009
  9. ncbi request reprint Differential regulation of the monocytic calcium-binding peptides macrophage-inhibiting factor related protein-8 (MRP8/S100A8) and allograft inflammatory factor-1 (AIF-1) following human traumatic brain injury
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 100:627-34. 2000
  10. ncbi request reprint The astrocytic response towards invasive meningiomas
    L Zeltner
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Neuropathol Appl Neurobiol 33:163-8. 2007

Detail Information

Publications69

  1. ncbi request reprint Albumin in immunohistochemistry: Foe and friend
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Medical School, D 72076 Tuebingen, Germany
    Appl Immunohistochem Mol Morphol 14:441-4. 2006
    ..Furthermore, these results imply that in case of a good specific staining pattern, the use of albumin in immunohistochemical solutions merely exerts significant negative background staining effects...
  2. ncbi request reprint Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    J Neuroimmunol 189:50-8. 2007
    ..Further, HLA-E expression levels and immune cell infiltration were significantly correlated in WHO grade IV glioblastomas. Thus, HLA-E overexpression in glioblastomas may be triggered by T and NK cell infiltration...
  3. ncbi request reprint De novo erythropoietin receptor (EPO-R) expression in human neoplastic glial cells decreases with grade of malignancy but is favourably associated with patient survival
    M Mittelbronn
    Institute of Brain Research Neuropathology, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 33:299-307. 2007
    ..Further studies are needed to investigate to what extent the decreased mortality in age-stratified patient groups with high EPO-R levels reflects a direct beneficial role of EPO-R expression...
  4. ncbi request reprint Disseminating anaplastic brainstem oligodendroglioma associated with allelic loss in the tumor suppressor candidate region D19S246 of chromosome 19 mimicking an inflammatory central nervous system disease in a 9-year-old boy
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, D 72076 Tuebingen, Germany
    Hum Pathol 36:854-7. 2005
    ..To our knowledge, this is the first case of a disseminating anaplastic brainstem oligodendroglioma associated with this specific allelic loss occurring in childhood...
  5. ncbi request reprint Multiple thromboembolic events in fetofetal transfusion syndrome in triplets contributing to the understanding of pathogenesis of hydranencephaly in combination with polymicrogyria
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Hum Pathol 37:1503-7. 2006
    ..Polymicrogyria can be considered as postmigratory laminar necrosis. Our findings contribute to the pathogenetic understanding of combined hydranencephaly and polymicrogyria...
  6. doi request reprint Erythropoietin receptor is expressed in meningiomas and lower levels are associated with tumour recurrence
    O Küster
    Institute of Brain Research, University of Tubingen, Germany
    Neuropathol Appl Neurobiol 35:555-65. 2009
    ..As the EpoR status in human meningiomas is unknown, our aim was to characterize EpoR expression in these tumours...
  7. ncbi request reprint Reactive astrocytes and activated microglial cells express EAAT1, but not EAAT2, reflecting a neuroprotective potential following ischaemia
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tubingen, Germany
    Histopathology 50:897-910. 2007
    ..Thus, excitatory amino acid transporters (EAATs) might be a promising therapeutic target. The aim of this study was to investigate glial expression of EAATs following ischaemia...
  8. doi request reprint Diagnostic value of WT1 in neuroepithelial tumours
    J Schittenhelm
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 35:69-81. 2009
    ....
  9. ncbi request reprint Differential regulation of the monocytic calcium-binding peptides macrophage-inhibiting factor related protein-8 (MRP8/S100A8) and allograft inflammatory factor-1 (AIF-1) following human traumatic brain injury
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 100:627-34. 2000
    ..We conclude that the delayed expression of MRP8 and the lack of AIF-1 up-regulation in microglia after TBI is in contrast to ischemic brain lesions and might reflect different activation cascades of microglia...
  10. ncbi request reprint The astrocytic response towards invasive meningiomas
    L Zeltner
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Neuropathol Appl Neurobiol 33:163-8. 2007
    ..This observation might indicate that the survival of subpial astrocytes is dependent on an intact pial-glial basement membrane...
  11. ncbi request reprint Long-term expression of heme oxygenase-1 (HO-1, HSP-32) following focal cerebral infarctions and traumatic brain injury in humans
    R Beschorner
    Institute of Brain Research, University of Tubingen, Germany
    Acta Neuropathol 100:377-84. 2000
    ..Further, HO-1 was weakly expressed in astrocytes in the perifocal penumbra. In contrast to experimental data derived from rat focal ischemia, these results indicate a prolonged HO-1 expression in humans after brain injury...
  12. ncbi request reprint Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo
    M H Deininger
    Institute of Brain Research, University of Tuebingen Medical School, Germany
    Acta Neuropathol 98:240-4. 1999
    ..Further studies are required to determine whether COX-2 is involved in the development of necrosis or, more likely, whether COX-2 is a part of the tumor tissue response to necrosis...
  13. ncbi request reprint Primary anaplastic ganglioglioma with a small-cell glioblastoma component
    J Schittenhelm
    Institute of Brain Research, Eberhard Karls University Tubingen, Germany
    Clin Neuropathol 27:91-5. 2008
    ..To our knowledge, this is the first reported case of a primary anaplastic ganglioglioma with a small-cell glioblastoma component...
  14. doi request reprint Modulation of TGF-beta activity by latent TGF-beta-binding protein 1 in human malignant glioma cells
    Isabel Tritschler
    Department of General Neurology, Laboratory of Molecular Neuro Oncology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Int J Cancer 125:530-40. 2009
    ..Collectively, we identify LTBP-1 as an important modulator of TGF-beta activation in glioma cells, which may contribute to the malignant phenotype of these tumors...
  15. doi request reprint CD8(+)/perforin/granzyme B(+) effector cells infiltrating cerebellum and inferior olives in gluten ataxia
    Michel Mittelbronn
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Neuropathology 30:92-6. 2010
    ....
  16. doi request reprint Spatio-temporal deleted in colorectal cancer (DCC) and netrin-1 expression in human foetal brain development
    P N Harter
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 36:623-35. 2010
    ..So far, little is known about the distribution of those molecules in human CNS development...
  17. ncbi request reprint Spinal cord compression through extraosseous extension of a vertebral low-grade hemangioendothelioma with histiocytoid differentiation
    M Mittelbronn
    Institute of Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Clin Neuropathol 27:351-6. 2008
    ..Furthermore, the clinical course with a progressive development of a paraparesis due to a hemangioendothelioma is very uncommon...
  18. ncbi request reprint Immunohistochemical analysis of CDX2 expression in normal choroid plexus epithelium and choroid plexus tumors
    R Beschorner
    Institute for Brain Research, Eberhard Karls University, Tuebingen, Germany
    Histol Histopathol 24:1507-14. 2009
    ..To date, no data exist on expression of CDX2 in normal and neoplastic choroid plexus epithelium. Aim: To investigate CDX2 expression in normal and neoplastic choroid plexus...
  19. ncbi request reprint Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude
    M Mittelbronn
    Institute of Brain Research, University of Tuebingen, Medical School, Calwer Strasse 3, 72076 Tuebingen, Germany
    Acta Neuropathol 101:249-55. 2001
    ..The brains showed no or a negligible vascular expression of MRP8 and MRP14. Information about the local microglia density in the normal human brain can serve as a reference for the evaluation of pathological microglial responses...
  20. doi request reprint EGR-1 is regulated by N-methyl-D-aspartate-receptor stimulation and associated with patient survival in human high grade astrocytomas
    Michel Mittelbronn
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Brain Pathol 19:195-204. 2009
    ..The NMDA-R-mediated EGR-1 expression, therefore, seems to be a promising target for novel clinical approaches to astrocytoma treatment...
  21. ncbi request reprint Death receptor-mediated apoptosis in human malignant glioma cells: modulation by the CD40/CD40L system
    Jörg Wischhusen
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Medical School, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Neuroimmunol 162:28-42. 2005
    ..Bispecific CD40xCD95 antibodies specifically kill glioma cells, disclosing the property of endogenous CD40 to facilitate death signalling...
  22. ncbi request reprint The clinico-surgico-pathological spectrum of myxopapillary ependymomas--report of four unusal cases and review of the literature
    J Schittenhelm
    Institute of Brain Research, University of Tubingen, Germany
    Clin Neuropathol 27:21-8. 2008
    ..Due to the anatomic complexity of the cauda equina, a complete resection can be technically challenging in this region. However, a gross total resection at the primary surgery is the most predictive factor for the outcome...
  23. ncbi request reprint Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infarction
    J M Schwab
    Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
    Neuropathol Appl Neurobiol 26:434-40. 2000
    ..CTGF can be considered a sensitive marker of early human astrocyte activation and a possible target for pharmacological intervention of aberrant matrix deposition...
  24. ncbi request reprint Rosai-Dorfman disease involving the cranial base, paranasal sinuses and spinal cord
    J Kaminsky
    Department of Neurosurgery, University Hospital of Tubingen, Germany
    Clin Neuropathol 24:194-200. 2005
    ..The individual management of Rosai-Dorfman disease may be challenging due to diffuse involvement of neurovascular structures at the skull base...
  25. ncbi request reprint Atypical teratoid-rhabdoid tumor spreading along the trigeminal nerve
    R Beschorner
    Institute of Brain Research, Tubingen, Germany
    Pediatr Neurosurg 42:258-63. 2006
    ..The origin of the trigeminal tumor as a late metastasis of the former ATRT or as a less likely irradiation-induced secondary ATRT and the operative approach are discussed...
  26. ncbi request reprint Severe hypoxia and multiple infarctions resembling Creutzfeldt-Jakob disease
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Germany
    Folia Neuropathol 46:149-53. 2008
    ..In addition, severe spongiosis can be misleading in the histological examination, suggesting the diagnosis of a prion-induced spongiform encephalopathy...
  27. ncbi request reprint Expression of interleukin-16 by microglial cells in inflammatory, autoimmune, and degenerative lesions of the rat brain
    Liang Hao Guo
    Institute of Brain Research, University of Tuebingen, Calwer Str 3, Tuebingen D 72076, Germany
    J Neuroimmunol 146:39-45. 2004
    ....
  28. doi request reprint Mature cerebellar teratoma in adulthood
    Rudi Beschorner
    Institute for Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Neuropathology 29:176-80. 2009
    ..Late clinical manifestation of the tumor in this case is probably due to an acute late-onset hemorrhage within the tumor...
  29. ncbi request reprint Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    Neuropathology 27:383-9. 2007
    ..Thus, an unusual form of a DNT with multifocal lesions, local regrowth and morphological transformation is supposed...
  30. doi request reprint WT1 expression distinguishes astrocytic tumor cells from normal and reactive astrocytes
    Jens Schittenhelm
    Institute of Brain Research, University Hospital of Tuebingen, Tuebingen, Germany
    Brain Pathol 18:344-53. 2008
    ..68, respectively. Therefore, WT1 expression in astrocytes indicates a neoplastic origin and might represent an important diagnostic tool to differentiate reactive from neoplastic astrocytes by immunohistochemistry...
  31. doi request reprint Growth modelling of non-functioning pituitary adenomas in patients referred for surgery
    Juergen Honegger
    Department of Neurosurgery, University of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Eur J Endocrinol 158:287-94. 2008
    ..However, it is still unknown how individual pituitary adenomas grow over years and whether growth kinetics follow a distinct growth model. The objective of this study was to define a growth model for non-functioning pituitary adenomas...
  32. ncbi request reprint Coincidence of semilobar holoprosencephaly and Chiari II malformation: correlation of prenatal diagnostics and neuropathologic findings
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    J Child Neurol 21:426-9. 2006
    ....
  33. ncbi request reprint HLA-E protects glioma cells from NKG2D-mediated immune responses in vitro: implications for immune escape in vivo
    Jörg Wischhusen
    Laboratory of Molecular Neuro Oncology, Department of General Neurology, Hertie Institute for ClinicaI Brain Research, University of Tubingen Medical School, Tubingen, Germany
    J Neuropathol Exp Neurol 64:523-8. 2005
    ..Thus, our study provides the first evidence that expression and interaction of HLA-E on cancer cells with CD94/NKG2A expressed on lymphocytes compromises innate anti-tumor immune responses...
  34. ncbi request reprint Malignant glioma cells counteract antitumor immune responses through expression of lectin-like transcript-1
    Patrick Roth
    Laboratory of Molecular Neuro Oncology, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Cancer Res 67:3540-4. 2007
    ..Thus, LLT1 acts as a mediator of immune escape and contributes to the immunosuppressive properties of glioma cells...
  35. ncbi request reprint TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells
    Günter Eisele
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Brain 129:2416-25. 2006
    ....
  36. doi request reprint Holocord pilocytic astrocytoma--case report and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tubingen, Calwerstr 3, D 72076 Tubingen, Germany
    Clin Neurol Neurosurg 111:203-7. 2009
    ..Residual parts of the tumor showed progress making additional surgery necessary. Therapy and its consequences are discussed and an overview of the literature of these rare longitudinally extensive intramedullary lesions is given...
  37. ncbi request reprint Gliosarcoma with chondroid and osseous differentiation
    Jens Schittenhelm
    Institute of Brain Research, University Tuebingen, Calwerstr 3, D 72076 Tuebingen, Germany
    Neuropathology 27:90-4. 2007
    ....
  38. doi request reprint Expression of EAAT-1 distinguishes choroid plexus tumors from normal and reactive choroid plexus epithelium
    Rudi Beschorner
    Institute for Brain Research, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 117:667-75. 2009
    ..In conclusion, in contrast to neoplastic CP samples, expression of EAAT-1 is exceptionally rare in non-neoplastic CP. Thus, EAAT-1 is superior to GFAP as a helpful diagnostic tool in CP samples...
  39. ncbi request reprint Regeneration and tolerance factor: a novel mediator of glioblastoma-associated immunosuppression
    Patrick Roth
    Laboratory of Molecular Neuro Oncology, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Medical School, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Cancer Res 66:3852-8. 2006
    ..Depletion of NK cells in these animals abolished this effect. RTF is thus a novel aberrantly expressed molecule which confers immune privilege to human malignant gliomas...
  40. doi request reprint VEGF-dependent induction of CD62E on endothelial cells mediates glioma tropism of adult haematopoietic progenitor cells
    Ghazaleh Tabatabai
    Department of General Neurology, Laboratory of Molecular Neurooncology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Brain 131:2579-95. 2008
    ..Taken together, we identify glioma cell-induced CD62E expression on endothelial cells as one mediator of the glioma tropism of HPC...
  41. doi request reprint Rathke's cleft cyst rupture as potential initial event of a secondary perifocal lymphocytic hypophysitis: proposal of an unusual pathogenetic event and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tuebingen, Calwerstr 3, 72076 Tuebingen, Germany
    Neurosurg Rev 31:157-63. 2008
    ..Our review of the literature provides further insights regarding the clinical behavior and different histological types of the lesions as well as the inflammatory changes that can occur in Rathke's cleft cysts...
  42. doi request reprint Basement membrane remodelling and segmental fibrosis in sporadic inclusion body myositis
    K Doppler
    Institute of Brain Research, University of Tubingen, Calwerstr 3, D 72076 Tubingen, Germany
    Neuromuscul Disord 19:406-11. 2009
    ..In sIBM, basement membrane remodelling and irreversible replacement by fibrosis of myofibers appear to represent the end result of a process in which the balance between injury and repair are disrupted...
  43. doi request reprint Quantitative assessment of postoperative blood collection in brain tumor surgery under valproate medication
    T Psaras
    Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany
    Zentralbl Neurochir 69:165-9. 2008
    ..The aim of the study was to evaluate whether valproate (VPA) increases the risk of bleeding complications in patients undergoing brain tumor surgery...
  44. ncbi request reprint Expression of EAAT1 reflects a possible neuroprotective function of reactive astrocytes and activated microglia following human traumatic brain injury
    R Beschorner
    Institute of Brain Research, Eberhard Karls University, Tuebingen, Germany
    Histol Histopathol 22:515-26. 2007
    ....
  45. ncbi request reprint Differential microglial regulation in the human spinal cord under normal and pathological conditions
    M Stoll
    Institute of Brain Research, University of Tuebingen, Medical School, Tuebingen, Germany
    Neuropathol Appl Neurobiol 32:650-61. 2006
    ..Our results represent important reference values for future neuropathological diagnostic and therapeutical approaches in spinal cord pathologies...
  46. ncbi request reprint Low grade ganglioglioma rapidly progressing to a WHO grade IV tumor showing malignant transformation in both astroglial and neuronal cell components
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathology 27:463-7. 2007
    ....
  47. ncbi request reprint Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival
    Arne Warth
    Institute of Pathology, University of Tuebingen, Tuebingen, Germany
    J Neurosci Res 85:1336-46. 2007
    ..In addition, our results provide unexpectedly high AQP4 levels in pilocytic astrocytomas and present AQP4 as tumor progression marker in WHO grade II-IV astrocytomas...
  48. ncbi request reprint Atypical type II silent corticotrophic adenoma developing into Cushing's disease upon second recurrence
    T Psaras
    Department of Neurosurgery, University of Tuebingen, Germany
    Exp Clin Endocrinol Diabetes 115:610-5. 2007
    ..The combination of an atypical type II adenoma and the switch in the hormone status to an endocrinologically active adenoma makes this case exceedingly rare...
  49. ncbi request reprint Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach
    David Capper
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Acta Neuropathol 115:249-59. 2008
    ....
  50. ncbi request reprint Patterns of SPARC expression and basement membrane intactness at the tumour-brain border of invasive meningiomas
    J Schittenhelm
    Institute of Brain Research, University of Tubingen, Tubingen, Germany
    Neuropathol Appl Neurobiol 32:525-31. 2006
    ..Destruction of the basement membrane and appearance of SPARC+ spindle cells are not coincident during the course of brain invasion by meningiomas...
  51. ncbi request reprint ACTH- and prolactin-producing pituitary gland microadenoma with biphasic features of atypia and intermediate filament expression
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Germany
    Neuro Endocrinol Lett 27:89-92. 2006
    ..To our knowledge, this is the first case of an ACTH- and prolactin-producing pituitary gland adenoma exhibiting biphasic features of atypia...
  52. ncbi request reprint Inflammatory myofibroblastic tumor of the ulnar nerve. Case report and review of the literature
    Jens Schittenhelm
    Institute of Brain Research, University of Tiibingen, Germany
    J Neurosurg 106:1075-9. 2007
    ....
  53. ncbi request reprint Atypical pituitary adenoma exhibiting densely secretory granules and basophilia without hormone production
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Germany
    Neuro Endocrinol Lett 27:93-6. 2006
    ..This discrepancy might be due to a production of unfunctional pre-stages of pituitary gland proteins in this fast growing neoplasm...
  54. ncbi request reprint Lesional expression of RhoA and RhoB following traumatic brain injury in humans
    Christine Brabeck
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    J Neurotrauma 21:697-706. 2004
    ..As the observed upregulation of RhoA and RhoB was still detectable months after TBI, we speculate that even delayed treatment with Rho inhibitors might be a therapeutic option...
  55. ncbi request reprint Effect of focal cerebral infarctions on lesional RhoA and RhoB expression
    Christine Brabeck
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Arch Neurol 60:1245-9. 2003
    ....
  56. ncbi request reprint Ependymoblastomatous exencephaly: a unique fetal malformation
    Michel Mittelbronn
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Pediatr Dev Pathol 11:397-401. 2008
    ..It may be appropriate to regard this as a unique neural tube closure defect that might be termed "ependymoblastomatous exencephaly."..
  57. ncbi request reprint [11C]PIB binding in Parkinson's disease dementia
    Walter Maetzler
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
    Neuroimage 39:1027-33. 2008
    ..Furthermore, we provide evidence that--in addition to nonspecific binding--PIB uptake in the brainstem may also reflect PDD related amyloid...
  58. ncbi request reprint Myogenesis in human denervated muscle biopsies
    Kathrin Doppler
    Institute of Brain Research, University of Tubingen, Calwerstrasse 3, D 72076 Tubingen, Germany
    Muscle Nerve 37:79-83. 2008
    ..A substantial subset of neurogenic biopsies showed small fibers that differ from angular atrophic fibers both in size and expression pattern of MHCn and NCAM. Myogenesis appears to be a frequent finding in neurogenic atrophy...
  59. ncbi request reprint Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription
    Perikles Simon
    Medical Clinic, Department of Sports Medicine, University of Tuebingen, Tuebingen Germany
    Cell Physiol Biochem 20:715-28. 2007
    ..In conclusion, the present observations disclose the transcription of three distinct SGK1 splice variants, which are all markedly upregulated in tumor tissue but differentially upregulated following differentiation or hypoxia...
  60. ncbi request reprint Redistribution of the water channel protein aquaporin-4 and the K+ channel protein Kir4.1 differs in low- and high-grade human brain tumors
    Arne Warth
    Institute of Pathology, University of Tubingen, Liebermeisterstrasse 8, 72076 Tubingen, Germany
    Acta Neuropathol 109:418-26. 2005
    ..The redistribution of AQP4 in glioblastoma cells is discussed as a reaction to the vasogenic edema, as induced by the breakdown of the BBB, to facilitate reabsorption of excess fluid...
  61. ncbi request reprint Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity
    Heinz Wiendl
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Brain 128:2689-704. 2005
    ..This pathway may act as an inhibitory feedback aimed to downregulate the deleterious effects of T-cell infiltration in neuroinflammation...
  62. ncbi request reprint WHO grade associated downregulation of MHC class I antigen-processing machinery components in human astrocytomas: does it reflect a potential immune escape mechanism?
    Matthias Mehling
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    Acta Neuropathol 114:111-9. 2007
    ....
  63. ncbi request reprint A 63-year-old man with dementia, ataxia and VI nerve palsy
    Michel Mittelbronn
    Brain Pathol 17:466-7, 474. 2007
  64. ncbi request reprint Expression of the water channel protein aquaporin-9 in malignant brain tumors
    Arne Warth
    Institutes of Pathology, University of Tubingen, Tubingen, Germany
    Appl Immunohistochem Mol Morphol 15:193-8. 2007
    ..In addition, the increased level of AQP9 immunoreactivity could be involved in the energy metabolism of the glioma and/or surrounding neuronal cells...
  65. ncbi request reprint CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury
    David Kohler
    Department of Anesthesiology and Intensive Care Medicine, University Hospital, Tubingen, Germany
    Circulation 116:1784-94. 2007
    ..In the present study, we studied ecto-enzymatic ATP/ADP-phosphohydrolysis by select members of the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) family during myocardial ischemia...
  66. ncbi request reprint OPA1, associated with autosomal dominant optic atrophy, is widely expressed in the human brain
    Stefanie Bette
    Molecular Genetics Laboratory, University Eye Hospital, Tubingen, Germany
    Acta Neuropathol 109:393-9. 2005
    ....
  67. ncbi request reprint Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors
    Tobias Eckle
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Circulation 115:1581-90. 2007
    ..Once generated, adenosine can activate cell-surface adenosine receptors (A1 AR, A2A AR, A2B AR, A3 AR). In the present study, we define the contribution of adenosine to cardioprotection by ischemic preconditioning...
  68. doi request reprint B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis
    Sonja Ortler
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Eur J Immunol 38:1734-44. 2008
    ..Our findings demonstrate the critical importance of B7-H1 as an immune-inhibitory molecule capable of down-regulating T cell responses thus contributing to the confinement of immunopathological damage...
  69. ncbi request reprint Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury
    Tobias Eckle
    Department of Anesthesiology and Intensive Care Medicine, Center for Biomedical Research, Tubingen University Hospital, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    J Immunol 178:8127-37. 2007
    ..Taken together, these data reveal a previously unrecognized role for CD39 and CD73 in lung protection and suggest treatment with their soluble compounds as a therapeutic strategy for noninfectious ALI...