R Mischke

Summary

Country: Germany

Publications

  1. ncbi request reprint Acute haemostatic changes in accidentally traumatised dogs
    R Mischke
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany
    Vet J 169:60-4. 2005
  2. doi request reprint Changes of platelet function and blood coagulation during short-term storage of CPDA-1-stabilised ovine blood
    A Baumgarten
    Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany
    Res Vet Sci 91:150-8. 2011
  3. doi request reprint Measurement of platelet function in dogs using a novel impedance aggregometer
    K Kalbantner
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Vet J 185:144-51. 2010
  4. ncbi request reprint Possibilities of flow cytometric analysis for immunophenotypic characterization of canine lymphoma
    K Culmsee
    Department of Small Animal Medicine, School of Veterinary Medicine, University of Hannover, Bischofsholer Damm 15, D 30173 Hannover, Germany
    J Vet Med A Physiol Pathol Clin Med 48:199-206. 2001
  5. ncbi request reprint Detection of fibrin generation alterations in dogs with haemangiosarcoma using resonance thrombography
    R Mischke
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Thromb Res 115:229-38. 2005
  6. ncbi request reprint Incidence of post-anaesthetic arrhythmias in dogs
    K Buhl
    Small Animal Clinic, School of Veterinary Medicine Hannover, Bünteweg 2, 30559, Hannover, Germany
    J Small Anim Pract 46:131-8. 2005
  7. ncbi request reprint Sensitivity of commercial prothrombin time reagents to detect coagulation factor deficiencies in equine plasma
    R Mischke
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Vet J 171:114-9. 2006
  8. ncbi request reprint Immunocytological detection of lymph node metastases in dogs with malignant epithelial tumours
    R Höinghaus
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover
    J Comp Pathol 137:1-8. 2007
  9. doi request reprint Immunocytochemical differentiation of canine mesenchymal tumors in cytologic imprint preparations
    R Höinghaus
    Small Animal Clinic, School of Veterinary Medicine Hannover, Hannover, Germany
    Vet Clin Pathol 37:104-11. 2008
  10. doi request reprint Influence of a cyclic combination chemotherapeutic protocol on primary haemostasis in dogs suffering from malignant lymphoma
    N Eberle
    Small Animal Clinic, Hanover School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hanover, Germany
    Vet J 183:298-304. 2010

Collaborators

  • J Zentek
  • K Culmsee
  • J W Blum
  • Daniela Simon
  • C Jacobs
  • Michael J Day
  • E B Breitschwerdt
  • A Gerhardt
  • R Höinghaus
  • M Hewicker-Trautwein
  • A Baumgarten
  • K Buhl
  • S Kramer
  • K Kalbantner
  • N Eberle
  • A R Günzel-Apel
  • T A Petanides
  • K Rosner
  • I Nolte
  • M Fedrowitz
  • U Kersten
  • S Kubalek
  • C F Bunck
  • M Ganter
  • M Wilhelmi
  • K Rohn
  • M Beyerbach
  • C Urhausen
  • A Seefeldt
  • S J Dieleman
  • M Koivisto
  • F M Eschricht
  • H O Hoppen
  • A F Koutinas
  • S Lekkas
  • C K Koutinas
  • L S Leontides
  • V A Garipidou
  • M N Saridomichelakis
  • P Diniz
  • M Kritsepi
  • M E Mylonakis
  • R von Wasielewski
  • M Freund
  • H J Schuberth
  • M Fehr

Detail Information

Publications35

  1. ncbi request reprint Acute haemostatic changes in accidentally traumatised dogs
    R Mischke
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany
    Vet J 169:60-4. 2005
    ..The results of this study indicate the high frequency of decompensated consumption of haemostatic components in acutely traumatised dogs...
  2. doi request reprint Changes of platelet function and blood coagulation during short-term storage of CPDA-1-stabilised ovine blood
    A Baumgarten
    Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany
    Res Vet Sci 91:150-8. 2011
    ..Functional loss and high percentage of platelets within aggregates which were observed in ovine blood stored at refrigerator temperature have to be considered in blood transfusion in sheep...
  3. doi request reprint Measurement of platelet function in dogs using a novel impedance aggregometer
    K Kalbantner
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Vet J 185:144-51. 2010
    ..05). The findings indicate that the analyser is suitable for the investigation of platelet aggregation in dogs and analysis should be performed on hirudin-anticoagulated blood using optimised agonist concentrations...
  4. ncbi request reprint Possibilities of flow cytometric analysis for immunophenotypic characterization of canine lymphoma
    K Culmsee
    Department of Small Animal Medicine, School of Veterinary Medicine, University of Hannover, Bischofsholer Damm 15, D 30173 Hannover, Germany
    J Vet Med A Physiol Pathol Clin Med 48:199-206. 2001
    ..Flow cytometry is a suitable method for the immunophenotypic analysis of canine lymphoma. Contrary to immunohistochemistry, no surgically produced lymph node biopsy is required and the results are available within a few hours...
  5. ncbi request reprint Detection of fibrin generation alterations in dogs with haemangiosarcoma using resonance thrombography
    R Mischke
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Thromb Res 115:229-38. 2005
    ..The second objective was to evaluate the sensitivity of this method for the detection of hypofibrinogenaemia and/or increased fibrin(ogen) degradation product (FDP) concentration...
  6. ncbi request reprint Incidence of post-anaesthetic arrhythmias in dogs
    K Buhl
    Small Animal Clinic, School of Veterinary Medicine Hannover, Bünteweg 2, 30559, Hannover, Germany
    J Small Anim Pract 46:131-8. 2005
    ..To assess the use of Holter monitoring for evaluating the incidence of post-anaesthetic cardiac arrhythmias and associated anaesthetic risk for two different anaesthetic protocols...
  7. ncbi request reprint Sensitivity of commercial prothrombin time reagents to detect coagulation factor deficiencies in equine plasma
    R Mischke
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Vet J 171:114-9. 2006
    ..The results indicate that adequate sensitivity of PT measurements in equine plasma can be achieved using a standard test procedure as long as a suitable reagent is used...
  8. ncbi request reprint Immunocytological detection of lymph node metastases in dogs with malignant epithelial tumours
    R Höinghaus
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover
    J Comp Pathol 137:1-8. 2007
    ..The study indicated the value of immunocytological labelling for the detection of metastases in cytological specimens of canine lymph node preparations...
  9. doi request reprint Immunocytochemical differentiation of canine mesenchymal tumors in cytologic imprint preparations
    R Höinghaus
    Small Animal Clinic, School of Veterinary Medicine Hannover, Hannover, Germany
    Vet Clin Pathol 37:104-11. 2008
    ..Immunocytochemical techniques are a potentially valuable diagnostic tool to support cytologic diagnosis in dogs. However, detailed studies of staining patterns and intensity in cytologic specimens of mesenchymal tumor types are lacking...
  10. doi request reprint Influence of a cyclic combination chemotherapeutic protocol on primary haemostasis in dogs suffering from malignant lymphoma
    N Eberle
    Small Animal Clinic, Hanover School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hanover, Germany
    Vet J 183:298-304. 2010
    ..05, Friedman-test). The results did not suggest that significant platelet dysfunction was induced by the chemotherapeutic protocol used in the study...
  11. ncbi request reprint Alterations of the global haemostatic function test 'resonance thrombography' in spontaneously traumatised dogs
    R Mischke
    Small Animal Clinic, Hannover School of Veterinary Medicine, Hannover, Germany
    Pathophysiol Haemost Thromb 33:214-20. 2003
    ..Remarkable alterations of fibrin generation as measured by the resonance thrombograph are a rare condition in dogs with acute accidental trauma...
  12. ncbi request reprint Studies on platelet aggregation using the Born method in normal and uraemic dogs
    R Mischke
    Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, Hannover D 30173, Germany
    Vet J 168:270-5. 2004
    ..In contrast, maximum aggregation was increased in uraemic patients compared to reference values using low concentrations of all three agonists (ADP: 1 micromol/L, collagen: 1 microg/mL, and thrombin: 0.1, 0.2 IU/mL)...
  13. ncbi request reprint The correlation between plasma anti-factor Xa activity and haemostatic tests in healthy dogs, following the administration of a low molecular weight heparin
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Res Vet Sci 69:241-7. 2000
    ..The results indicate that measurement of anti-FXa activity with chromogenic substrates is the method of choice to control LMWH therapy in dogs, as is the case in humans...
  14. doi request reprint Effects of gonadectomy on prolactin and LH secretion and the pituitary-thyroid axis in male dogs
    A R Günzel-Apel
    Small Animal Clinic, University of Veterinary Medicine Hannover, PO Box 711180, 30545, Hannover, Germany
    Theriogenology 71:746-53. 2009
    ..Thus, long-term dopamine-2 receptor agonistic treatment may lead to a hypothyroid condition in castrated male dogs...
  15. ncbi request reprint Immunocytochemical differentiation of neoplastic and hyperplastic canine epithelial lesions in cytologic imprint preparations
    R Höinghaus
    Small Animal Clinic, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Vet J 173:79-90. 2007
    ....
  16. ncbi request reprint Immunocytological confirmation of bone marrow metastases in a dog with cholangiocarcinoma
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, D 30173 Hannover, Germany
    J Small Anim Pract 44:411-4. 2003
    ..The authors conclude that cytological and immunocytological examination of bone marrow aspirates should be used more frequently for the detection of distant metastases of carcinomas in small animal medicine...
  17. ncbi request reprint Response of dogs to short-term infusions of carbohydrate- or lipid-based parenteral nutrition
    J Zentek
    Institute of Animal Nutrition, Veterinary School of Hannover, Bischofsholer Damm 15, D 30173 Hannover, Germany
    J Vet Med A Physiol Pathol Clin Med 50:313-21. 2003
    ..In conclusion short infusion periods of 10 h per day were tolerated by healthy dogs without adverse signs, which could improve practicability of PN also in clinical cases...
  18. ncbi request reprint Sensitivity of different prothrombin time assays to factor VII deficiency in canine plasma
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, D 30173, Hannover, Germany
    Vet J 166:79-85. 2003
    ..The results of this study indicate the importance of selecting a sensitive reagent and method for PT measurement and for careful interpretation of PT test results using canine plasma...
  19. doi request reprint Prothrombin time standardisation in canine samples with regard to inter-batch and inter-reagent variability
    R Mischke
    Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany
    Vet J 188:301-6. 2011
    ..In conclusion, standardisation to reduce inter-batch variability seems unnecessary for the studied reagents. Possibilities for PT standardisation in order to achieve a reagent-independent result are limited...
  20. ncbi request reprint Quantification of thrombopoietic activity in bone marrow aspirates of dogs
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Vet J 164:269-74. 2002
    ..84 +/- 2.04, P = 0.0008) as was the number of megakaryocytes. We recommend assessment of thrombopoiesis on the basis of 20-25 fragment-containing low power fields and that age- and sex-related differences should be considered...
  21. ncbi request reprint Changes in C-reactive protein and haptoglobin in dogs with lymphatic neoplasia
    R Mischke
    Small Animal Clinic, Hannover School of Veterinary Medicine, Hannover, Germany
    Vet J 174:188-92. 2007
    ....
  22. doi request reprint G244E in the canine factor IX gene leads to severe haemophilia B in Rhodesian Ridgebacks
    R Mischke
    Small Animal Clinic, University of Veterinary Medicine Hannover, Bünteweg 9, D 30559 Hannover, Germany
    Vet J 187:113-8. 2011
    ..The results of this study suggest that the detected mutation is responsible for a severe form of haemophilia B in Rhodesian Ridgebacks...
  23. ncbi request reprint Commercial variants of the prothrombin time test as a screening test of acquired coagulation factor II, VII, and X deficiencies in dogs
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine, Bischofsholer Damm 15, D 30173 Hannover, Germany
    Res Vet Sci 73:165-70. 2002
    ..001). The results show that, in contrast to the PT(ST), all three tested commercial prothrombin time variants are suitable for the detection of deficiencies of coagulation factors II, VII, and X in canine plasma...
  24. ncbi request reprint Amidolytic heparin activity and values for several hemostatic variables after repeated subcutaneous administration of high doses of a low molecular weight heparin in healthy dogs
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine of Hanover, Germany
    Am J Vet Res 62:595-8. 2001
    ..The screening tests investigated were not suitable for use in monitoring LMWH treatment of dogs. Assays that use chromogenic substrates are necessary to reliably monitor LMWH plasma concentrations in dogs...
  25. ncbi request reprint Optimization of coagulometric tests that incorporate human plasma for determination of coagulation factor activities in canine plasma
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine of Hannover, Germany
    Am J Vet Res 62:625-9. 2001
    ..Differences in activities between human and canine plasma and nonparallelism of the standard curves emphasize the necessity for use of species-specific standard curves for accurate determination of coagulation factor activity...
  26. doi request reprint Factors associated with the occurrence of epistaxis in natural canine leishmaniasis (Leishmania infantum)
    T A Petanides
    Companion Animal Clinic, Veterinary Faculty, Aristotle University of Thessaloniki AUTH, Thessaloniki, Greece
    J Vet Intern Med 22:866-72. 2008
    ..Canine leishmaniasis (CanL) is a common cause of epistaxis in dogs residing in endemic areas. The pathogenesis of CanL-associated epistaxis has not been fully explored because of the limited number of cases reported so far...
  27. ncbi request reprint Investigation of the fibrinolytic system during nonpregnant and pregnant oestrous cycles of bitches
    C F Bunck
    Institute for Reproductive Medicine, School of Veterinary Medicine, , D-30559 Hannover, Germany
    J Reprod Fertil Suppl 57:207-14. 2001
    ..The prolonged euglobulin lysis time, which is indicative of decreased fibrinolytic activity in pregnancy, is thought to be a laboratory artefact caused by increased fibrinogen concentrations...
  28. ncbi request reprint Use of immunocytochemical techniques in canine melanoma
    R Höinghaus
    Clinic for Small Animals, School of Veterinary Medicine Hannover, Germany
    J Vet Med A Physiol Pathol Clin Med 49:198-202. 2002
    ..The specificity of Melan-A was higher compared with S-100. Melan-A, in particular, may be helpful for the cytological diagnosis of canine melanoma...
  29. ncbi request reprint Evaluation of a standard immunofluorescence assay and a new flow cytometric method for the detection of autoreactive antibodies in dogs with tumours
    K Rosner
    Institute for Immunology, University of Veterinary Medicine, D 30173 Hannover, Germany
    Res Vet Sci 82:27-33. 2007
    ..However, this cytometry-based assay makes a more objective and standardized detection of canine autoreactive antibodies possible...
  30. ncbi request reprint Investigations on blood coagulation in the green iguana (Iguana iguana)
    S Kubalek
    Clinic for Small Animals, School of Veterinary Medicine, Hanover, Germany
    J Vet Med A Physiol Pathol Clin Med 49:210-6. 2002
    ..This may be caused by the species specificity of certain components of the reagents used, as well as a less optimal test system, i.e. relationship of test reagent to clotting factor concentrations in iguana plasma...
  31. ncbi request reprint [Preclinical studies for the use of the platelet function analyser PFA-100 with the collagen/ADP cartridge in dogs]
    R Mischke
    Klinik für kleine Haustiere, Tierarztlichen Hochschule Hannover
    Dtsch Tierarztl Wochenschr 109:235-8. 2002
    ..The results of the studies on storage indicated nearly identical recommendations for storage time before measurement of canine (0.5-2 hours) and human (0.5-3 hours) sample material...
  32. ncbi request reprint Blood plasma concentrations of oestradiol-17beta, testosterone and testosterone/oestradiol ratio in dogs with neoplastic and degenerative testicular diseases
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine, Hannover, Germany
    Res Vet Sci 73:267-72. 2002
    ....
  33. ncbi request reprint Reference values for the bone marrow aspirates in adult dogs
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine, Hannover, Germany
    J Vet Med A Physiol Pathol Clin Med 49:499-502. 2002
    ..45 and 2.87. The accurate cytological examination of bone marrow based on the reference ranges presented in this study requires preparation of high-quality bone marrow films with minimal blood contamination...
  34. ncbi request reprint [Comparison of the influence of different anesthetic protocols in the development of post-anesthetic arrhythmia in the dog]
    K Buhl
    Klinik für kleine Haustiere, Tierarztlichen Hochschule Hannover
    Dtsch Tierarztl Wochenschr 110:407-12. 2003
    ..As a comparison a second recording was performed on the 5th post-operative day. The recorded number of arrhythmias was low and no statistical difference was demonstrated between the 2 patient groups...
  35. ncbi request reprint Influence of platelet count, acetylsalicylic acid, von Willebrand's disease, coagulopathies, and haematocrit on results obtained using a platelet function analyser in dogs
    R Mischke
    Clinic for Small Animals, School of Veterinary Medicine Hannover, Hannover, Germany
    Vet J 165:43-52. 2003
    ..0001) will limit the clinical application of the analyser...