Sergej Mironov

Summary

Country: Germany

Publications

  1. pmc Single KATP channel opening in response to stimulation of AMPA/kainate receptors is mediated by Na+ accumulation and submembrane ATP and ADP changes
    R Mollajew
    DFG Center of Molecular Physiology of the Brain, Institute of Neuro and Sensory Physiology, Georg August University, Gottingen 37073, Germany
    J Physiol 591:2593-609. 2013
  2. pmc Calmodulin and calmodulin kinase II mediate emergent bursting activity in the brainstem respiratory network (preBotzinger complex)
    S L Mironov
    S L Mironov Department of Neuro and Sensory Physiology, Georg August University, Humboldtallee 23, 37073 Gottingen, Germany
    J Physiol 591:1613-30. 2013
  3. doi request reprint Stimulation of bursting in pre-Bötzinger neurons by Epac through calcium release and modulation of TRPM4 and K-ATP channels
    Sergej L Mironov
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, Gottingen, Germany
    J Neurochem 117:295-308. 2011
  4. doi request reprint Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome
    S L Mironov
    DFG Center of Molecular Physiology of the Brain, Germany
    Neuropharmacology 60:869-77. 2011
  5. doi request reprint Complexity of mitochondrial dynamics in neurons and its control by ADP produced during synaptic activity
    Sergei L Mironov
    DFG Center of Molecular Physiology of the Brain, Georg August University, Department of Neuro and Sensory Physiology, Humboldtallee 23, Gottingen, 37075, Germany
    Int J Biochem Cell Biol 41:2005-14. 2009
  6. pmc Remodelling of the respiratory network in a mouse model of Rett syndrome depends on brain-derived neurotrophic factor regulated slow calcium buffering
    S L Mironov
    DFG Center of Molecular Physiology of the Brain, Gottingen, Germany
    J Physiol 587:2473-85. 2009
  7. pmc Imaging cytoplasmic cAMP in mouse brainstem neurons
    S L Mironov
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Humboldtallee 23, Georg August University, 37073 Gottingen, Germany
    BMC Neurosci 10:29. 2009
  8. doi request reprint Respiratory circuits: function, mechanisms, topology, and pathology
    Sergej Mironov
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, Gottingen, Germany
    Neuroscientist 15:194-208. 2009
  9. pmc Metabotropic glutamate receptors activate dendritic calcium waves and TRPM channels which drive rhythmic respiratory patterns in mice
    S L Mironov
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, 37073 Gottingen, Germany
    J Physiol 586:2277-91. 2008
  10. pmc ADP regulates movements of mitochondria in neurons
    Sergej L Mironov
    DFG Center Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, Gottingen, Germany
    Biophys J 92:2944-52. 2007

Collaborators

Detail Information

Publications16

  1. pmc Single KATP channel opening in response to stimulation of AMPA/kainate receptors is mediated by Na+ accumulation and submembrane ATP and ADP changes
    R Mollajew
    DFG Center of Molecular Physiology of the Brain, Institute of Neuro and Sensory Physiology, Georg August University, Gottingen 37073, Germany
    J Physiol 591:2593-609. 2013
    ..We propose that KATP channels and GluRs are functionally coupled that can regulate long-lasting changes of neuronal activity in the CNS neurons...
  2. pmc Calmodulin and calmodulin kinase II mediate emergent bursting activity in the brainstem respiratory network (preBotzinger complex)
    S L Mironov
    S L Mironov Department of Neuro and Sensory Physiology, Georg August University, Humboldtallee 23, 37073 Gottingen, Germany
    J Physiol 591:1613-30. 2013
    ..This may find implications in restoration and consolidation of autonomous activity in the respiratory disorders...
  3. doi request reprint Stimulation of bursting in pre-Bötzinger neurons by Epac through calcium release and modulation of TRPM4 and K-ATP channels
    Sergej L Mironov
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, Gottingen, Germany
    J Neurochem 117:295-308. 2011
    ..The data thus indicate a novel pathway of controlling bursting activity in pre-Bötzinger complex neurons through Epac that can involved in reinforcement of the respiratory activity by cAMP...
  4. doi request reprint Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome
    S L Mironov
    DFG Center of Molecular Physiology of the Brain, Germany
    Neuropharmacology 60:869-77. 2011
    ..We propose that disturbances in cAMP homeostasis in MeCP2 -/y mice can lead to inadequate Epac signalling. Concomitant defective development of respiratory circuits may be responsible for irregular breathing activity in RTT...
  5. doi request reprint Complexity of mitochondrial dynamics in neurons and its control by ADP produced during synaptic activity
    Sergei L Mironov
    DFG Center of Molecular Physiology of the Brain, Georg August University, Department of Neuro and Sensory Physiology, Humboldtallee 23, Gottingen, 37075, Germany
    Int J Biochem Cell Biol 41:2005-14. 2009
    ..Finally, the recent views on the mechanisms and possible functional role of mitochondrial network as a whole in neurons are discussed and unresolved issues and future perspectives in this field of research are delineated...
  6. pmc Remodelling of the respiratory network in a mouse model of Rett syndrome depends on brain-derived neurotrophic factor regulated slow calcium buffering
    S L Mironov
    DFG Center of Molecular Physiology of the Brain, Gottingen, Germany
    J Physiol 587:2473-85. 2009
    ....
  7. pmc Imaging cytoplasmic cAMP in mouse brainstem neurons
    S L Mironov
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Humboldtallee 23, Georg August University, 37073 Gottingen, Germany
    BMC Neurosci 10:29. 2009
    ..While imaging of calcium is commonly used in neuroscience applications, probing for cAMP levels has not yet been performed in living vertebrate neuronal tissue before...
  8. doi request reprint Respiratory circuits: function, mechanisms, topology, and pathology
    Sergej Mironov
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, Gottingen, Germany
    Neuroscientist 15:194-208. 2009
    ..These new findings in respiratory neuroscience are further applied to explain modifications in breathing during hypoxia and possible origins of respiratory disorders that may be acquired during neural development and aging...
  9. pmc Metabotropic glutamate receptors activate dendritic calcium waves and TRPM channels which drive rhythmic respiratory patterns in mice
    S L Mironov
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, 37073 Gottingen, Germany
    J Physiol 586:2277-91. 2008
    ..The experimental and theoretical data provide a subcellular basis for a recently proposed group-pacemaker hypothesis and describe a novel mechanism of rhythm generation in neuronal networks...
  10. pmc ADP regulates movements of mitochondria in neurons
    Sergej L Mironov
    DFG Center Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, Gottingen, Germany
    Biophys J 92:2944-52. 2007
    ..We propose that consumption of synaptic ATP can produce local increases in [ADP](i) and facilitate the targeting of mitochondria to synapses...
  11. ncbi request reprint Modulation of synaptic and channel activities in the respiratory network of the mice by NO/cGMP signalling pathways
    Sergej L Mironov
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, Gottingen, Humboldtallee 23, 37073, Germany
    Brain Res 1130:73-82. 2007
    ....
  12. ncbi request reprint ER vesicles and mitochondria move and communicate at synapses
    Sergej L Mironov
    DFG Center Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, Gottingen, Humboldtallee 23, 37073, Germany
    J Cell Sci 119:4926-34. 2006
    ..We propose that communication between perisynaptic ER vesicles and mitochondria can shape intracellular Ca2+ signals and modulate synaptic and integrative neural activities...
  13. ncbi request reprint Spontaneous and evoked neuronal activities regulate movements of single neuronal mitochondria
    S L Mironov
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, Gottingen, Humboldtallee 23, 37073, Germany
    Synapse 59:403-11. 2006
    ..We propose that accumulation and clustering of mitochondria in neurons are caused by interruptions in the directed transport of mitochondria, leading to the inhibition of their movements at the active synapses...
  14. ncbi request reprint Mitochondrial organization and motility probed by two-photon microscopy in cultured mouse brainstem neurons
    Michael Muller
    Zentrum Physiologie und Pathophysiologie, Abteilung Neuro und Sinnesphysiologie, Georg August Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Exp Cell Res 303:114-27. 2005
    ....
  15. ncbi request reprint [Ca2+]i signaling between mitochondria and endoplasmic reticulum in neurons is regulated by microtubules. From mitochondrial permeability transition pore to Ca2+-induced Ca2+ release
    Sergej L Mironov
    Institute for Physiology, Georg August University, Humboldtallee 23, 37073 Gottingen, Germany
    J Biol Chem 280:715-21. 2005
    ..Thus, close positioning of mitochondria to the ER as determined by MT can be essential for the local [Ca](i) signaling in neurons...
  16. pmc Approximate analytical time-dependent solutions to describe large-amplitude local calcium transients in the presence of buffers
    Lidia A Mironova
    DFG Center of Molecular Physiology of the Brain, Department of Neuro and Sensory Physiology, Georg August University, Gottingen, Germany
    Biophys J 94:349-58. 2008
    ..Derived equations can be useful to predict spatiotemporal profiles of large-amplitude [Ca(2+)] transients, which participate in various physiological processes...