N Miosge

Summary

Country: Germany

Publications

  1. pmc The primary cilium as a dual sensor of mechanochemical signals in chondrocytes
    Hayat Muhammad
    Department of Prosthodontics, Georg August University, Goettingen, Germany
    Cell Mol Life Sci 69:2101-7. 2012
  2. ncbi request reprint Basement membrane composition in the early mouse embryo day 7
    Nikolaus Gersdorff
    Department of Prosthodontics, Georg August Universitat Gottingen, Gottingen, Germany
    Dev Dyn 233:1140-8. 2005
  3. doi request reprint Current concepts in stem cell therapy for articular cartilage repair
    Hayat Muhammad
    Georg August University, Tissue Regeneration Work Group, Department of Prosthodontics, Goettingen, Germany
    Expert Opin Biol Ther 13:541-8. 2013
  4. pmc Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney
    Rainer Girgert
    Department of Nephrology and Rheumatology, Georg August University Goettingen, Goettingen, Germany
    Fibrogenesis Tissue Repair 3:19. 2010
  5. pmc Basement membrane components are key players in specialized extracellular matrices
    Jenny Kruegel
    Tissue Regeneration Work Group, Department of Prosthodontics, Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    Cell Mol Life Sci 67:2879-95. 2010
  6. pmc Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis
    Sebastian Koelling
    Zentrum Anatomie, Abt, Histologie, Georg August Universitaet, Kreuzbergring 36, 37075 Gottingen, Germany
    Arthritis Res Ther 8:R56. 2006
  7. ncbi request reprint The ultrastructural composition of basement membranes in vivo
    N Miosge
    University of Goettingen, Department of Histology, Germany
    Histol Histopathol 16:1239-48. 2001
  8. ncbi request reprint Ultrastructural colocalization of nidogen-1 and nidogen-2 with laminin-1 in murine kidney basement membranes
    N Miosge
    Zentrum Anatomie, Abteilung Histologie, Goettingen, Germany
    Histochem Cell Biol 113:115-24. 2000
  9. ncbi request reprint Expression of collagen type I and type II in consecutive stages of human osteoarthritis
    Nicolai Miosge
    Zentrum Anatomie, Abt Histologie, Georg August Universitaet, Kreuzbergring 36, 37075, Goettingen, Germany
    Histochem Cell Biol 122:229-36. 2004
  10. ncbi request reprint The collagen type XVIII endostatin domain is co-localized with perlecan in basement membranes in vivo
    Nicolai Miosge
    Zentrum Anatomie, Abteilung Histologie, Gottingen, Germany
    J Histochem Cytochem 51:285-96. 2003

Collaborators

Detail Information

Publications55

  1. pmc The primary cilium as a dual sensor of mechanochemical signals in chondrocytes
    Hayat Muhammad
    Department of Prosthodontics, Georg August University, Goettingen, Germany
    Cell Mol Life Sci 69:2101-7. 2012
    ..In this review, we focus on the fundamental functional and structural features of primary cilia in chondrocytes and chondrogenic cells...
  2. ncbi request reprint Basement membrane composition in the early mouse embryo day 7
    Nikolaus Gersdorff
    Department of Prosthodontics, Georg August Universitat Gottingen, Gottingen, Germany
    Dev Dyn 233:1140-8. 2005
    ..In conclusion, laminin-1 might be the only laminin isoform in the early mouse embryo that, together with the other main BM components, nidogens, collagen type IV, and perlecan, is synthesized by all three germ layers...
  3. doi request reprint Current concepts in stem cell therapy for articular cartilage repair
    Hayat Muhammad
    Georg August University, Tissue Regeneration Work Group, Department of Prosthodontics, Goettingen, Germany
    Expert Opin Biol Ther 13:541-8. 2013
    ..Intrinsic repair is compromised, and cartilage tissue regeneration is difficult. However, new options are available to repair cartilage tissue by applying ESCs, MSCs and CPCs...
  4. pmc Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney
    Rainer Girgert
    Department of Nephrology and Rheumatology, Georg August University Goettingen, Goettingen, Germany
    Fibrogenesis Tissue Repair 3:19. 2010
    ..The present study evaluates the role of integrin α2 (ITGA2) in cell-matrix interaction...
  5. pmc Basement membrane components are key players in specialized extracellular matrices
    Jenny Kruegel
    Tissue Regeneration Work Group, Department of Prosthodontics, Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    Cell Mol Life Sci 67:2879-95. 2010
    ..Here, we briefly review the latest research on these unique sECM and their components with a special emphasis on embryonic and adult stem cells and their niches...
  6. pmc Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis
    Sebastian Koelling
    Zentrum Anatomie, Abt, Histologie, Georg August Universitaet, Kreuzbergring 36, 37075 Gottingen, Germany
    Arthritis Res Ther 8:R56. 2006
    ....
  7. ncbi request reprint The ultrastructural composition of basement membranes in vivo
    N Miosge
    University of Goettingen, Department of Histology, Germany
    Histol Histopathol 16:1239-48. 2001
    ..Instead, one and the same molecule, e.g. endostatin, can be a basement membrane component in one organ and a matrix molecule in another...
  8. ncbi request reprint Ultrastructural colocalization of nidogen-1 and nidogen-2 with laminin-1 in murine kidney basement membranes
    N Miosge
    Zentrum Anatomie, Abteilung Histologie, Goettingen, Germany
    Histochem Cell Biol 113:115-24. 2000
    ..The results indicate that nidogen-1 and nidogen-2 could well substitute for one another in some of their biological activities in kidney, for example, stabilizing basement membrane networks in vivo...
  9. ncbi request reprint Expression of collagen type I and type II in consecutive stages of human osteoarthritis
    Nicolai Miosge
    Zentrum Anatomie, Abt Histologie, Georg August Universitaet, Kreuzbergring 36, 37075, Goettingen, Germany
    Histochem Cell Biol 122:229-36. 2004
    ..This supports the conclusion that collagen type I gradually becomes one of the factors involved in the pathogenesis of osteoarthritis...
  10. ncbi request reprint The collagen type XVIII endostatin domain is co-localized with perlecan in basement membranes in vivo
    Nicolai Miosge
    Zentrum Anatomie, Abteilung Histologie, Gottingen, Germany
    J Histochem Cytochem 51:285-96. 2003
    ..At least in part, perlecan appears to be an adaptor molecule for the endostatin domain in basement membranes in vivo...
  11. ncbi request reprint Organization of the myotendinous junction is dependent on the presence of alpha7beta1 integrin
    N Miosge
    Zentrum Anatomie, Abteilung Histologie, Universitat Gottingen, Germany
    Lab Invest 79:1591-9. 1999
    ....
  12. ncbi request reprint Ultrastructural triple localization of laminin-1, nidogen-1, and collagen type IV helps elucidate basement membrane structure in vivo
    N Miosge
    Zentrum Anatomie, Abteilung Histologie, Goettingen, Germany
    Anat Rec 254:382-8. 1999
    ..This is also indicated by a changing structure even in individual segments of one basement membrane type which renders a more flexible basement membrane architecture plausible...
  13. ncbi request reprint Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice
    Nicolai Miosge
    Department of Histology, Georg August Universitat Gottingen, D 37075, Gottingen, Germany
    Matrix Biol 21:611-21. 2002
    ..The data support the nidogen-2 compensation hypothesis to explain the limited phenotype observed following elimination of the nidogen-1 gene...
  14. ncbi request reprint Light and electron microscopic in-situ hybridization of collagen type I and type II mRNA in the fibrocartilaginous tissue of late-stage osteoarthritis
    N Miosge
    Zentrum Anatomie, Abt Histologie, Georg August Universitaet, Goettingen, Germany
    Osteoarthritis Cartilage 6:278-85. 1998
    ..We have attempted to elucidate the type of cell which produces each type of collagen in late-stage osteoarthritis...
  15. ncbi request reprint Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations
    N Miosge
    Abteilung Histologie, Universitat Gottingen, Germany
    Cell Mol Life Sci 54:606-13. 1998
    ....
  16. ncbi request reprint Comparison of lectin binding patterns in malformed and normal human embryos and fetuses
    N Miosge
    Department of Histology, University of Goettingen, Germany
    Teratology 57:85-92. 1998
    ..This might indicate a possible general alteration in the carbohydrate pattern in the course of development of malformations in man...
  17. ncbi request reprint In situ-RT-PCR and immunohistochemistry for the localisation of the mRNA of the alpha 3 chain of laminin and laminin-5 during human organogenesis
    Nicolai Miosge
    Department of Histology, University of Gottingen, Kreuzbergring 36, 37075 Gottingen, Germany
    Anat Embryol (Berl) 205:355-63. 2002
    ..Due to this discrepancy, we postulate a broader role for laminin-5 during human embryogenesis, for example, for epithelial cell development, beyond its involvement in hemidesmosome formation and cell adhesion...
  18. ncbi request reprint Extensive glycosylation changes revealed by lectin histochemistry in morphologically normal prenatal tissues of the mouse mutant undulated (un/un)
    F Quondamatteo
    Department of Histology, University of Goettingen, D 37075 Goettingen, Federal Republic of Germany
    Anat Rec 258:243-51. 2000
    ..Our results show that a defect in a gene with a very restricted expression can cause universal changes in the glycosylation pattern during development...
  19. ncbi request reprint The small proteoglycans decorin and biglycan in human articular cartilage of late-stage osteoarthritis
    H C Bock
    Zentrum Anatomie, Abt. Histologie, Georg-August-Universitaet, Kreuzbergring 36, 37075 Goettingen, Germany
    Osteoarthritis Cartilage 9:654-63. 2001
    ....
  20. ncbi request reprint Nidogen-1. Expression and ultrastructural localization during the onset of mesoderm formation in the early mouse embryo
    N Miosge
    Zentrum Anatomie, Abteilung Histologie, Goettingen, Germany
    J Histochem Cytochem 48:229-38. 2000
    ..J Histochem Cytochem 48:229-237, 2000)..
  21. ncbi request reprint The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo
    N Miosge
    Abt Histologie, Universitat Gottingen, Germany
    Histochem J 28:109-16. 1996
    ..The early embryonic expression of both fibulins indicates specific roles during organ development and, in particular, involvements in the differentiation of heart, skeletal and neuronal structures...
  22. ncbi request reprint Laminin gamma3 chain binds to nidogen and is located in murine basement membranes
    Nikolaus Gersdorff
    Department of Prosthodontics, University of Goettingen, D 37075 Goettingen, Germany
    J Biol Chem 280:22146-53. 2005
    ..Ultrastructural immunogold staining localized the gamma3 chain to basement membranes of these tissues...
  23. ncbi request reprint The absence of one or both nidogens does not alter basement membrane composition in adult murine kidney
    N Gersdorff
    Department of Prosthodontics, Georg August University Goettingen, Goettingen, Germany
    Histol Histopathol 22:1077-84. 2007
    ..The results indicate that the lack of nidogen-1, nidogen-2, or both nidogens, plays no crucial role in the occurrence and localization of laminin-111, collagen type IV, and perlecan in murine tubular renal basement membranes...
  24. ncbi request reprint Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development
    N Miosge
    Zentrum Anatomie, Abteilung Histologie, Goettingen, Germany
    Histochem J 33:523-30. 2001
    ..These two proteins might well be able to fulfil identical functions during human organogenesis...
  25. ncbi request reprint New aspects of the pathogenesis of osteoarthritis: the role of fibroblast-like chondrocytes in late stages of the disease
    F Tesche
    Zentrum Anatomie, Abteilung Histologie, 37075 Gottingen, Germany
    Histol Histopathol 20:329-37. 2005
    ....
  26. ncbi request reprint Immunohistochemical localization of laminin, nidogen, and type IV collagen during the early development of human liver
    F Quondamatteo
    Centre of Anatomy, Department of Histology, University of Gottingen, Germany
    Histochem Cell Biol 111:39-47. 1999
    ..The three glycoproteins occur together only in those areas of the developing liver in which, from the 9th GW onward, the differentiation of immature liver cells into biliary epithelium takes place...
  27. ncbi request reprint Perlecan in late stages of osteoarthritis of the human knee joint
    F Tesche
    Zentrum Anatomie, Abteilung Histologie, Kreuzbergring 36, 37075 Gottingen, Germany
    Osteoarthritis Cartilage 12:852-62. 2004
    ....
  28. ncbi request reprint Expression of the mouse histone gene H1t begins at premeiotic stages of spermatogenesis
    B Drabent
    Division of Molecular Biology, Department of Biochemistry, Georg August Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Cell Tissue Res 291:127-32. 1998
    ..This indicates that the H1t gene is expressed at premeiotic stages, albeit at a low level. In contrast to H1t mRNA, the H1t protein has not been detected in spermatogonia by electron microscopy after immunogold staining...
  29. ncbi request reprint Ultrastructural localization of integrin subunits alpha3 and alpha6 in capillarized sinusoids of the human cirrhotic liver
    F Quondamatteo
    Department of Histology, University of Goettingen, Goettingen, Germany
    Histol Histopathol 19:799-806. 2004
    ..On stellate cells, which are major producers of BM components, both integrins alpha3beta1 and alpha6beta1 were also localized...
  30. doi request reprint Collagen IX in weight-bearing areas of human articular cartilage in late stages of osteoarthritis
    Sebastian Koelling
    Department of Prosthodontics, Work Group Tissue Regeneration, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Arch Orthop Trauma Surg 128:1453-9. 2008
    ..To determine if the amounts of collagen IX mRNA and protein are higher in osteoarthritic cartilage from weight-bearing areas of the knee joint compared to non-weight bearing areas in patients with stage IV osteoarthritis (OA)...
  31. ncbi request reprint Detection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordoma
    W Gotz
    University of Goettingen, Department of Histology, Germany
    Differentiation 62:149-57. 1997
    ..Differences in staining patterns of chordoma cells could not, in general, be correlated to any histological features of these tumors...
  32. ncbi request reprint Secreted modular calcium-binding protein-1 localization during mouse embryogenesis
    Nikolaus Gersdorff
    Department of Prosthodontics, Georg August Universitat Gottingen, 37075 Gottingen, Germany
    Histochem Cell Biol 126:705-12. 2006
    ..This broad and organ-specific distribution suggests multifunctional roles of SMOC-1 during mouse embryogenesis...
  33. ncbi request reprint Collagen types XII and XIV are present in basement membrane zones during human embryonic development
    Laurice Thierry
    Zentrum Anatomie, Abteilung Histologie, Kreuzbergring 36, 37075 Gottingen, Germany
    J Mol Histol 35:803-10. 2004
    ..We conclude that both collagens might well be able to serve different functions during human embryonic development although their structures are highly similar...
  34. ncbi request reprint Hematopoietic cells are a source of nidogen-1 and nidogen-2 during mouse liver development
    Laurice T Tomte
    Department of Histology, University of Goettingen, Goettingen, Germany
    J Histochem Cytochem 54:593-604. 2006
    ..We suggest that nidogens may, to some extent, take part in the regulation of hepatic hematopoiesis...
  35. ncbi request reprint Expression of cadherin-8 in renal cell carcinoma and fetal kidney
    Sabine Blaschke
    Department of Nephrology and Rheumatology, Georg August University, Gottingen, Germany
    Int J Cancer 101:327-34. 2002
    ..These results suggest that alterations of type II cadherin expression may play a role in RCC development. In particular, cadherin-8 may be involved in both kidney morphogenesis as well as tumorigenesis in some types of RCC...
  36. doi request reprint Cell biological and biomechanical evaluation of two different fixation techniques for rotator cuff repair
    H M Klinger
    Department of Orthopedic Surgery, Georg August University, Goettingen, Germany
    Scand J Med Sci Sports 19:329-37. 2009
    ..Therefore, the AAMA technique might also be more appropriate for arthroscopic repair...
  37. doi request reprint Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease
    Oliver Gross
    Department of Nephrology and Rheumatology, University Medicine Goettingen Robert Koch Strasse 40, Goettingen, Germany
    Matrix Biol 29:346-56. 2010
    ..The blockade of collagen-receptor DDR1 might serve as an important new therapeutic concept in progressive fibrotic and inflammatory diseases in the future...
  38. pmc Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activation
    S Schweyer
    Department of Pathology, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    Br J Cancer 91:589-98. 2004
    ..Thus, our data suggest that CDDP mediates its p53-independent apoptosis-inducing effect on the malignant human testicular germ cells--at least partially--through activation of the MEK-ERK signalling pathway. July 2004..
  39. doi request reprint Nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis cartilage
    Jenny Kruegel
    Georg August University, Goettingen, Germany
    Arthritis Rheum 58:1422-32. 2008
    ..To investigate the presence and function of nidogen-1 and nidogen-2 in healthy human cartilage and in late-stage osteoarthritis (OA) cartilage...
  40. doi request reprint Coexpression of osteogenic and adipogenic differentiation markers in selected subpopulations of primary human mesenchymal progenitor cells
    M L Ponce
    Department of Gastroenterology and Endocrinology, Georg August University Goettingen, Goettingen, Germany
    J Cell Biochem 104:1342-55. 2008
    ..Our results suggest that osteogenic and adipogenic differentiation in human mesenchymal progenitor cells might not be exclusively reciprocal, but rather, a parallel event until late during osteoblast development...
  41. doi request reprint Sex differences of chondrogenic progenitor cells in late stages of osteoarthritis
    Sebastian Koelling
    Georg August University Goettingen, Goettingen, Germany
    Arthritis Rheum 62:1077-87. 2010
    ....
  42. doi request reprint Mycophenolic acid predose concentrations and renal function in a mouse model for progressive renal fibrosis
    Gunnar Brandhorst
    Department of Clinical Chemistry, University Hospital Goettingen, Goettingen, Germany
    Ther Drug Monit 32:73-8. 2010
    ..01, r = -0.655, Spearman rank correlation). In conclusion, MMF may be a candidate drug for preserving kidney function in progressive renal fibrosis...
  43. ncbi request reprint Abnormal collagen fibrils in cartilage of matrilin-1/matrilin-3-deficient mice
    Claudia Nicolae
    Department of Molecular Medicine, Max Planck Institute for Biochemistry, Martinsried, Germany
    J Biol Chem 282:22163-75. 2007
    ..Taken together, our results demonstrate that matrilin-1 and matrilin-3 modulate collagen fibrillogenesis in cartilage and provide evidence that biochemical compensation might exist between matrilins...
  44. ncbi request reprint Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice
    Ralph Nawrotzki
    Max Planck Institute for Biochemistry, 82152 Martinsried, Germany
    Hum Mol Genet 12:483-95. 2003
    ..We propose that the persistence of alpha5beta1D in alpha7-deficient mice is not compatible with normal muscle function and leads to muscle wasting...
  45. ncbi request reprint Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils
    Anja Kassner
    Institut für Physiologische Chemie und Pathobiochemie, Universitatsklinikum Munster, Waldeyerstrasse 15, 48129 Munster, Germany
    Matrix Biol 22:131-43. 2003
    ..This suprastructural versatility of a collagen is without precedent and highlights pivotal differences in the tissue-specific organization of matrix aggregate structures...
  46. ncbi request reprint Characterization of SMOC-1, a novel modular calcium-binding protein in basement membranes
    Christian Vannahme
    Institute for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
    J Biol Chem 277:37977-86. 2002
    ..Immunogold electron microscopy confirmed the localization of SMOC-1 within basement membranes in kidney and skeletal muscle as well as its expression in the zona pellucida surrounding the oocyte...
  47. ncbi request reprint Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development
    Michael Willem
    Max Planck Institute for Biochemistry, Department of Protein Chemistry, 82152 Martinsried, Germany
    Development 129:2711-22. 2002
    ..These data demonstrate that an interaction between two basement membrane proteins is required for early kidney morphogenesis in vivo...
  48. ncbi request reprint Endostatin/collagen XVIII--an inhibitor of angiogenesis--is expressed in cartilage and fibrocartilage
    Thomas Pufe
    Department of Anatomy, Christian Albrechts University, Olshausenstrasse 40, D 24098 Kiel, Germany
    Matrix Biol 23:267-76. 2004
    ..We observed a strong endostatin/collagen XVIII production in articular and fibrocartilage and an inhibitory potency concerning the VEGF-signalling pathway...
  49. pmc Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice
    Bernhard L Bader
    Department of Dermatology, University of Cologne, 50924 Cologne, Germany
    Mol Cell Biol 25:6846-56. 2005
    ..However, despite the ubiquitous presence of nidogens in basement membranes, defects do not occur in all tissues or in all basement membranes, suggesting a varying spectrum of roles for nidogens in the basement membrane...
  50. ncbi request reprint Stem cell-coated titanium implants for the partial joint resurfacing of the knee
    Karl Heinz Frosch
    Department of Trauma Surgery, Plastic and Reconstructive Surgery, Georg August University Goettingen, Robert Koch Strasse 40, D 37075 Goettingen, Germany
    Biomaterials 27:2542-9. 2006
    ..To improve our approach and optimize the experimental parameters, further investigations are needed prior to clinical application...
  51. pmc Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor
    Svetlana N Popova
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen, Norway
    Mol Cell Biol 27:4306-16. 2007
    ..Our data show a unique role for alpha11beta1 integrin during tooth eruption...
  52. ncbi request reprint Transgenic mice expressing D469Delta mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformations
    Markus Schmitz
    Center for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, D 50931 Cologne, Germany
    Matrix Biol 27:67-85. 2008
    ..Later in development, the growth plate was irregularly shaped and prematurely invaded by bony tissue. In addition, a fusion of the third and fourth sternebrae was frequently observed...
  53. pmc Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice
    Jurgen Schymeinsky
    Department of Protein Chemistry, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
    Mol Cell Biol 22:6820-30. 2002
    ..Nidogen-2 deficiency does not lead to hemorrhages in mice as one may have expected. Our results show that nidogen-2 is not essential for basement membrane formation or maintenance...
  54. pmc Matrilin-3 is dispensable for mouse skeletal growth and development
    Yaping Ko
    Center for Biochemistry, Medical Faculty, University of Cologne, D 50931 Cologne, Germany
    Mol Cell Biol 24:1691-9. 2004
    ..Altogether, our findings suggest functional redundancy among matrilins and demonstrate that the phenotypes of MED disorders are not caused by the absence of matrilin-3 in cartilage ECM...
  55. ncbi request reprint Domain IV of mouse laminin beta1 and beta2 chains
    Takako Sasaki
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 269:431-42. 2002
    ..Immunogold staining localized both beta chains primarily to basement membranes of kidney, muscle and various other tissues...