Sven G Meuth

Summary

Country: Germany

Publications

  1. pmc The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice
    Sven G Meuth
    University of Wurzburg, Department of Neurology, Wurzburg, Germany
    Neurobiol Dis 33:1-11. 2009
  2. doi Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death
    Sven G Meuth
    Department of Neurology, University of Wurzburg, D 97070 Wurzburg, Germany
    J Neurosci 29:15397-409. 2009
  3. pmc TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system
    Stefan Bittner
    University of Wuerzburg, Department of Neurology, Josef Schneider Str 11, 97080 Wuerzburg, Germany
    Brain 132:2501-16. 2009
  4. doi Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation
    Sven G Meuth
    Department of Neurology, University of Wurzburg, Josef Schneider Strafe 11, 97080 Wurzburg, Germany
    Neurosci Lett 446:133-8. 2008
  5. doi Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation
    Michael K Schuhmann
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Immunol 184:1536-42. 2010
  6. doi Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-directed CD8(+) T cell attack
    Kerstin Göbel
    Department of Neurology, University of Wurzburg, Germany
    Glia 58:469-80. 2010
  7. doi Upregulation of K2P5.1 potassium channels in multiple sclerosis
    Stefan Bittner
    Department of Neurology, University of Wurzburg, Wurzburg, Munster, Germany
    Ann Neurol 68:58-69. 2010
  8. doi FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection
    Peter Kraft
    From the University Clinic Würzburg, Departments of Neurology P K, E G, M K S, G S, C K and Anesthesiology and Critical Care M B, Rudolf Virchow Center, the Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine C D, I T, B N, Institute of Pharmacology and Toxicology, University of Würzburg K L, Wurzburg, Germany Department of Neurology K G, A M H, S G M, Institute of Physiology and Neuropathophysiology S G M, University of Munster, Germany and University Clinic Frankfurt, Department of Neurology, Frankfurt, Germany W P
    Stroke 44:3202-10. 2013
  9. doi Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 222:153-60. 2010
  10. doi Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking
    Kerstin Göbel
    Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Autoimmun 36:106-14. 2011

Collaborators

Detail Information

Publications47

  1. pmc The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice
    Sven G Meuth
    University of Wurzburg, Department of Neurology, Wurzburg, Germany
    Neurobiol Dis 33:1-11. 2009
    ..In conclusion, our data provide evidence for an important role of functional TASK channels in limiting tissue damage during cerebral ischemia...
  2. doi Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death
    Sven G Meuth
    Department of Neurology, University of Wurzburg, D 97070 Wurzburg, Germany
    J Neurosci 29:15397-409. 2009
    ..Thus, electrical silencing is an immediate consequence of MHC I-restricted interaction of CD8(+) T cells with neurons. This mechanism is clearly perforin-dependent and precedes, but is not causally linked, to neuronal cell death...
  3. pmc TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system
    Stefan Bittner
    University of Wuerzburg, Department of Neurology, Josef Schneider Str 11, 97080 Wuerzburg, Germany
    Brain 132:2501-16. 2009
    ..These data support the identification and characterization of TASK1 as potential molecular target for the therapy of inflammatory and degenerative central nervous system disorders...
  4. doi Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation
    Sven G Meuth
    Department of Neurology, University of Wurzburg, Josef Schneider Strafe 11, 97080 Wurzburg, Germany
    Neurosci Lett 446:133-8. 2008
    ..Thus, regulated expression of TASK channels might contribute to a molecular switch between death and survival of neurons in autoimmune CNS inflammation...
  5. doi Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation
    Michael K Schuhmann
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Immunol 184:1536-42. 2010
    ....
  6. doi Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-directed CD8(+) T cell attack
    Kerstin Göbel
    Department of Neurology, University of Wurzburg, Germany
    Glia 58:469-80. 2010
    ..Collateral neuronal apoptosis could contribute to substantial neuronal loss in gray matter lesions and cause persistent neurological impairment in both acute and chronic gray matter lesions in various inflammatory CNS disorders...
  7. doi Upregulation of K2P5.1 potassium channels in multiple sclerosis
    Stefan Bittner
    Department of Neurology, University of Wurzburg, Wurzburg, Munster, Germany
    Ann Neurol 68:58-69. 2010
    ..1 (KCNK5; TASK2), a member of the 2-pore domain family of potassium channels, on T-cell function and demonstrate its putative relevance in a T-cell-mediated autoimmune disorder, multiple sclerosis (MS)...
  8. doi FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection
    Peter Kraft
    From the University Clinic Würzburg, Departments of Neurology P K, E G, M K S, G S, C K and Anesthesiology and Critical Care M B, Rudolf Virchow Center, the Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine C D, I T, B N, Institute of Pharmacology and Toxicology, University of Würzburg K L, Wurzburg, Germany Department of Neurology K G, A M H, S G M, Institute of Physiology and Neuropathophysiology S G M, University of Munster, Germany and University Clinic Frankfurt, Department of Neurology, Frankfurt, Germany W P
    Stroke 44:3202-10. 2013
    ..We investigated the mode of FTY720 action in models of cerebral ischemia...
  9. doi Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 222:153-60. 2010
    ..Interestingly, mechanical hyperalgesia was more pronounced in the absence of B7-H1. Our study identifies B7-H1 as an important suppressor of the inflammatory response and neuropathic pain occurring after peripheral nerve injury...
  10. doi Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking
    Kerstin Göbel
    Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Autoimmun 36:106-14. 2011
    ..In contrast, blocking B2R had no significant impact on EAE. We conclude that B1R inhibition can reduce BBB damage and cell invasion during autoimmune CNS disease and may offer a novel anti-inflammatory strategy for the treatment of MS...
  11. doi The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis
    Peter Kraft
    University Clinic of Würzburg, Dept of Neurology, Wurzburg, Germany
    Exp Neurol 247:80-90. 2013
    ..Rolipram is a multifaceted antiinflammatory and antithrombotic compound that protects from ischemic neurodegeneration in clinically meaningful settings...
  12. doi Thalamic involvement in patients with neurologic impairment due to Shiga toxin 2
    Sven G Meuth
    Institute of Physiology I, Department of Neurology, University Hospital Munster, Westphalian Wilhelms University, Munster, Germany
    Ann Neurol 73:419-29. 2013
    ..Owing to these observations, we designed a series of experimental studies to evaluate the underlying mechanism of action of this clinical picture...
  13. pmc Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Blood 121:679-91. 2013
    ..6 Tesla. In contrast, established immunoregulatory characteristics of Tregs had no functional relevance. We define herein a novel and unexpected role of Tregs in a primary nonimmunologic disease state...
  14. doi TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions
    Sven G Meuth
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    J Biol Chem 283:14559-70. 2008
    ..These data introduce K(2)P channels as novel potassium conductance on T lymphocytes critically influencing T cell effector function and identify a possible molecular target for immunomodulation in T cell-mediated autoimmune disorders...
  15. pmc Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation
    Friederike Langhauser
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Blood 120:4082-92. 2012
    ..Because KNG appears to be instrumental in pathologic thrombus formation and inflammation but dispensable for hemostasis, KNG inhibition may offer a selective and safe strategy for combating stroke and other thromboembolic diseases...
  16. doi Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of immunomodulatory treatment strategies
    Jochen C Ulzheimer
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    BioDrugs 24:249-74. 2010
    ..Neuroprotective and alternative treatment strategies are presented elsewhere...
  17. pmc Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients
    Stefan Bittner
    Department of Neurology, University of Wuerzburg, Josef Schneider Str 11, Wuerzburg 97080, Germany
    Arthritis Res Ther 13:R21. 2011
    ..1 is upregulated upon (autoimmune) T cell stimulation. The aim of this study was to correlate expression levels of K(2P)5.1 on T cells from patients with rheumatoid arthritis (RA) to disease activity in these patients...
  18. doi CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability
    Nico Melzer
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    FASEB J 23:3659-73. 2009
    ..Moreover, we discuss mechanisms of impaired electrical signaling and cell death of neurons as direct and collateral targets of CD8(+) T cells in the CNS...
  19. doi Antigen-specific blockade of lethal CD8 T-cell mediated autoimmunity in a mouse model of multiple sclerosis
    Shin Young Na
    Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    J Immunol 182:6569-75. 2009
    ..Mechanistic studies performed in vitro and in vivo indicate that it is the low expression of MHC class I on oligodendrocytes, which makes this form of Ag-specific intervention possible...
  20. doi STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death
    Alejandro Berna-Erro
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Strasse 2, D15 97080, Wurzburg, Germany
    Sci Signal 2:ra67. 2009
    ..In vivo, Stim2(-/-) mice were markedly protected from neurological damage in a model of focal cerebral ischemia. These results implicate CCE in ischemic neuronal cell death and establish STIM2 as a critical mediator of this process...
  21. doi The two-pore domain potassium channel TASK3 functionally impacts glioma cell death
    Sven G Meuth
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    J Neurooncol 87:263-70. 2008
    ..This implies that TASK3 channels may possibly represent a novel molecular target for the treatment of this type of cancer...
  22. pmc Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation
    Furat Raslan
    Department of Neurosurgery, University of Wurzburg, Wurzburg, Germany
    J Cereb Blood Flow Metab 30:1477-86. 2010
    ..We conclude that B1R inhibition may offer a novel therapeutic strategy after acute brain injuries...
  23. pmc Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation
    Christiane Albert-Weissenberger
    Department of Neurology, University Clinic of Würzburg, Wurzburg, Germany
    J Cereb Blood Flow Metab 32:1747-56. 2012
    ..Inhibition of B1R may become a novel strategy to counteract trauma-induced neurodegeneration...
  24. ncbi Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels
    Sven G Meuth
    Neurologische Klinik, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    J Neurophysiol 96:1517-29. 2006
    ....
  25. pmc Excitotoxic neuronal cell death during an oligodendrocyte-directed CD8+ T cell attack in the CNS gray matter
    Nico Melzer
    Department of Neurology, University of Munster, Albert Schweitzer Campus 1, Munster 48149, Germany
    J Neuroinflammation 10:121. 2013
    ....
  26. pmc Paraneoplastic and non-paraneoplastic autoimmunity to neurons in the central nervous system
    Nico Melzer
    Department of Neurology, Inflammatory Disorders of the Nervous System and Neurooncology, University of Munster, Albert Schweitzer Campus 1, 48149 Munster, Germany
    J Neurol 260:1215-33. 2013
    ....
  27. doi Glucocorticoid insensitivity at the hypoxic blood-brain barrier can be reversed by inhibition of the proteasome
    Christoph Kleinschnitz
    University of Wurzburg, Department of Neurology, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Stroke 42:1081-9. 2011
    ..The reasons for this discrepancy are unresolved...
  28. doi Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of neuroprotective and alternative treatment strategies
    Sven G Meuth
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    BioDrugs 24:317-30. 2010
    ..In order to maintain clarity, this review focuses on neuroprotective and various other treatment strategies. Clinical trials addressing anti-inflammatory research strategies are presented elsewhere...
  29. doi Intercellular exchanges of membrane fragments (trogocytosis) between human muscle cells and immune cells: a potential mechanism for the modulation of muscular immune responses
    Anne Waschbisch
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    J Neuroimmunol 209:131-8. 2009
    ..Our observations raise the hypothesis that trogocytosis may modulate the outcome of T-T interactions within the micromilieu of skeletal muscle...
  30. pmc CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation
    Tobias Ruck
    Department of Neurology, University of Munster, Munster, Germany
    PLoS ONE 8:e81455. 2013
    ..Taken together, we identify CD4(+)NKG2D(+) cells as a subpopulation of T helper cells with enhanced migratory, encephalitogenic and cytotoxic properties involved in inflammatory CNS lesion development. ..
  31. pmc Temporal pattern of ICAM-I mediated regulatory T cell recruitment to sites of inflammation in adoptive transfer model of multiple sclerosis
    Sebastian Doerck
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 5:e15478. 2010
    ..Therefore it is likely to assume that intervention at the blood brain barrier is time dependent and could result in different therapeutic outcomes depending on the phase of CNS lesion development...
  32. doi CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing
    Sven G Meuth
    University of Wuerzburg, Department of Neurology, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Neuroimmunol 194:62-9. 2008
    ..CD200 and its receptor could also be detected on neurons and macrophages in human MS plaques. Therefore the CD200-CD200R pathway seems of critical relevance for macrophage-mediated damage in autoimmune inflammation of the CNS...
  33. pmc A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis
    Nico Melzer
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 3:e3149. 2008
    ..The mechanisms are reduction of T cell activation by modulation of cellular antigen-presentation and impairment of antigen-specific T cell migration into the CNS rather than or modulation of central glutamate homeostasis...
  34. doi Transient widespread blood-brain barrier alterations after cerebral photothrombosis as revealed by gadofluorine M-enhanced magnetic resonance imaging
    Guido Stoll
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    J Cereb Blood Flow Metab 29:331-41. 2009
    ..The unique properties of Gf hold promise as a more sensitive contrast agent for monitoring BBB disturbances in neurologic disorders, which appear more widespread than anticipated previously...
  35. doi A pure cerebellar syndrome with corresponding ponto-cerebellar atrophy in acquired hepatocerebral degeneration
    Nico Melzer
    Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Neurol Sci 292:96-8. 2010
    ..We report a case of acquired hepatocerebral degeneration (AHCD) presenting as a pure cerebellar syndrome. Magnetic resonance imaging (MRI) showed the typical features of AHCD in conjunction with ponto-cerebellar atrophy...
  36. ncbi T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression
    Christoph Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Exp Neurol 200:480-5. 2006
    ..Our study supports the notion that T cells and T-cell-derived cytokines contribute to the inflammatory response after peripheral nerve injury...
  37. doi From the background to the spotlight: TASK channels in pathological conditions
    Stefan Bittner
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    Brain Pathol 20:999-1009. 2010
    ..Based on these findings TASK channels have evolved from "mere background" channels to key modulators in pathophysiological conditions...
  38. pmc Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9)
    Petra Ehling
    University of Wuerzburg, Department of Neurology, Josef Schneider Str, 11, 97080 Wuerzburg, Germany
    Exp Transl Stroke Med 2:14. 2010
    ..K2P3.1-/- animals showed larger infarct volumes and a worse functional outcome following experimentally induced ischemic stroke. Here, we question the role of the closely related K2P channel K2P9.1...
  39. doi L-selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients
    Nicholas Schwab
    Department of Neurology, University of Munster, Germany
    Neurology 81:865-71. 2013
    ..To find biomarkers identifying patients at risk for the development of progressive multifocal leukoencephalopathy (PML) during natalizumab treatment...
  40. pmc Cytotoxic CD8+ T cells and CD138+ plasma cells prevail in cerebrospinal fluid in non-paraneoplastic cerebellar ataxia with contactin-associated protein-2 antibodies
    Nico Melzer
    Department of Neurology, Inflammatory Disorders of the Nervous System and Neurooncology, University of Munster, Albert Schweitzer Campus 1, Munster 48149, Germany
    J Neuroinflammation 9:160. 2012
    ..CASPR-2 antibodies strongly labeling axons of cerebellar granule neurons have recently been identified in sera from nine patients with otherwise unexplained progressive cerebellar ataxia with mild to severe cerebellar atrophy...
  41. pmc Report on the 3'rd scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Nov. 4'th - Nov. 6'th, 2011
    Christoph Kleinschnitz
    Department of Neurology, University Clinic of Würzburg, Josef Schneider Str, 11, 97080 Wurzburg, Germany
    Exp Transl Stroke Med 4:2. 2012
    ..This first prize award ceremony was a great incentive for the next call for proposals now upcoming in 2012...
  42. pmc Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration
    Christoph Kleinschnitz
    Neurologische Klinik und Poliklinik, Universitat Wurzburg, Wurzburg, Germany
    PLoS Biol 8:. 2010
    ..NOX4 therefore represents a major source of oxidative stress and novel class of drug target for stroke therapy...
  43. doi C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms
    Nadine Heydenreich
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Stroke 43:2457-67. 2012
    ..C1-inhibitor counteracts activation of the contact-kinin system at multiple levels. We investigated the therapeutic potential of C1-inhibitor in models of ischemic stroke...
  44. ncbi The trials and errors in MS therapy
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Int MS J 15:79-90. 2008
    ..Examples include agents that target leukocyte differentiation molecules, co-stimulatory molecules, adhesion molecules and chemotaxis, as well as novel immunomodulators and anti-infective therapies...
  45. doi Multifocal motor neuropathy: update on clinical characteristics, pathophysiological concepts and therapeutic options
    Sven G Meuth
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    Eur Neurol 63:193-204. 2010
    ....
  46. pmc Report on the 1st scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Mittenwalde/Motzen, Germany, Oct. 30th - Nov. 1st, 2009
    Tim Magnus
    Department of Neurology, University Clinic Hamburg Eppendorf, Martinistr, 52, D 20246 Hamburg, Germany
    Exp Transl Stroke Med 2:7. 2010
    ..ABSTRACT: Report on the 1st scientific meeting of the "Verein zur Forderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Mittenwalde/Motzen, Germany, Oct. 30th - Nov. 1st, 2009A scientific meeting report...
  47. ncbi Multiple sclerosis therapy: an update on recently finished trials
    Christoph Kleinschnitz
    Department of Neurology, Bayerische Julius Maximilians Universität Würzburg, Josef Schneider Str 11, 97080, Wurzburg, Germany
    J Neurol 254:1473-90. 2007
    ..Pharmacotherapies include agents that target chemoattraction, cell migration, chemotherapies, and antigen-based therapies...