Volker Meske

Summary

Country: Germany

Publications

  1. ncbi request reprint Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease
    V Meske
    Institute of Anatomy, Charite, Philippstrasse 12, D 10115 Berlin, Germany
    Eur J Neurosci 17:93-102. 2003
  2. ncbi request reprint Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau
    Volker Meske
    Center of Anatomy, Institute of Integrative Neuroanatomy, Department of Clinical Cell and Neurobiology, Charite, Charite Platz 1, 10098 Berlin, Germany
    J Biol Chem 283:100-9. 2008
  3. ncbi request reprint Cholesterol storage and tau pathology in Niemann-Pick type C disease in the brain
    Roland Distl
    Institut fur Anatomie, Charite, Humboldt Universitat, Berlin, Germany
    J Pathol 200:104-11. 2003
  4. ncbi request reprint Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease
    Stephanie Treiber-Held
    Institut fur Anatomie, Charite, Humboldt University, 10098 Berlin, Germany
    J Pathol 200:95-103. 2003
  5. doi request reprint Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice
    Frauke Glöckner
    Institute for Integrative Neuroanatomy, Charite, Universitatsmedizin Berlin, Berlin, Germany
    J Neuropathol Exp Neurol 70:292-301. 2011
  6. ncbi request reprint Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease
    T G Ohm
    Institute of Anatomy, Department of Clinical Cell and Neurobiology, Charite, Humboldt University, Berlin, Germany
    Pharmacopsychiatry 36:S120-6. 2003
  7. ncbi request reprint Cell cultures of autopsy-derived fibroblasts
    Volker Meske
    Department Klinische Zell und Neurobiologie, Institute for Anatomie, Charite, Berlin, Germany
    Methods Mol Med 107:111-23. 2005
  8. ncbi request reprint Cholesterol, statins and tau
    T G Ohm
    Institute of Integrative Neuroanatomy, Department of Clinical Cell and Neurobiology, Charite Universitatsmedizin Berlin, Germany
    Acta Neurol Scand Suppl 185:93-101. 2006
  9. doi request reprint The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability
    Volker Meske
    Center of Anatomy, Institute of Integrative Neuroanatomy, Department of Clinical Cell and Neurobiology, Charite, Charite Platz 1, 10098 Berlin, Germany Electronic address
    Neurobiol Dis 64:88-97. 2014
  10. ncbi request reprint Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons
    R Distl
    Institute of Anatomy, Humboldt University Berlin, Germany
    Acta Neuropathol 101:547-54. 2001

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease
    V Meske
    Institute of Anatomy, Charite, Philippstrasse 12, D 10115 Berlin, Germany
    Eur J Neurosci 17:93-102. 2003
    ....
  2. ncbi request reprint Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau
    Volker Meske
    Center of Anatomy, Institute of Integrative Neuroanatomy, Department of Clinical Cell and Neurobiology, Charite, Charite Platz 1, 10098 Berlin, Germany
    J Biol Chem 283:100-9. 2008
    ....
  3. ncbi request reprint Cholesterol storage and tau pathology in Niemann-Pick type C disease in the brain
    Roland Distl
    Institut fur Anatomie, Charite, Humboldt Universitat, Berlin, Germany
    J Pathol 200:104-11. 2003
    ....
  4. ncbi request reprint Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease
    Stephanie Treiber-Held
    Institut fur Anatomie, Charite, Humboldt University, 10098 Berlin, Germany
    J Pathol 200:95-103. 2003
    ..The NPC mouse model may thus serve as a tool to analyse the role of cholesterol in initial changes of tau that eventually lead to the formation of tangles in both NPC and AD...
  5. doi request reprint Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice
    Frauke Glöckner
    Institute for Integrative Neuroanatomy, Charite, Universitatsmedizin Berlin, Berlin, Germany
    J Neuropathol Exp Neurol 70:292-301. 2011
    ..In htau-ApoE mice on the high cholesterol regimen, brain oxysterol levels were less than in htau-ApoE mice, and the numbers of neurons with pathologically altered tau were similar to those in htau-ApoE mice on the high-cholesterol diet...
  6. ncbi request reprint Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease
    T G Ohm
    Institute of Anatomy, Department of Clinical Cell and Neurobiology, Charite, Humboldt University, Berlin, Germany
    Pharmacopsychiatry 36:S120-6. 2003
    ..In summary, the data showed interesting similarities between NPC and AD suggesting some pathological metabolic pathway in common...
  7. ncbi request reprint Cell cultures of autopsy-derived fibroblasts
    Volker Meske
    Department Klinische Zell und Neurobiologie, Institute for Anatomie, Charite, Berlin, Germany
    Methods Mol Med 107:111-23. 2005
  8. ncbi request reprint Cholesterol, statins and tau
    T G Ohm
    Institute of Integrative Neuroanatomy, Department of Clinical Cell and Neurobiology, Charite Universitatsmedizin Berlin, Germany
    Acta Neurol Scand Suppl 185:93-101. 2006
    ..These changes vary depending on how cholesterol metabolism is manipulated. Effects seem to be either mild and transient, or drastic and related to neurodegeneration, or independent of the mevalonate pathway...
  9. doi request reprint The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability
    Volker Meske
    Center of Anatomy, Institute of Integrative Neuroanatomy, Department of Clinical Cell and Neurobiology, Charite, Charite Platz 1, 10098 Berlin, Germany Electronic address
    Neurobiol Dis 64:88-97. 2014
    ..From our results, we conclude that a pharmacological intervention in the neuropathology of NPC-disease should focus on the restoration of the lysosomal degradation capacity of cells. ..
  10. ncbi request reprint Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons
    R Distl
    Institute of Anatomy, Humboldt University Berlin, Germany
    Acta Neuropathol 101:547-54. 2001
    ....
  11. ncbi request reprint Genotype-related differences of hippocampal apolipoprotein E levels only in early stages of neuropathological changes in Alzheimer's disease
    F Glockner
    Institute of Anatomy, Department of Clinical Cell and Neurobiology, Charite, 10098 Berlin, Germany
    Neuroscience 114:1103-14. 2002
    ..These stages are believed to represent phases of the disease in which the beginning neurodegeneration can be compensated by plastic reorganization...
  12. ncbi request reprint Pathological cholesterol metabolism fails to modify electrophysiological properties of afflicted neurones in Niemann-Pick disease type C
    R A Deisz
    Center of Anatomy, Charite, Institute of Integrative Neuroanatomy, Department of Clinical Cell and Neurobiology, Schumann Strasse 20 21, 10098 Berlin, Germany
    Neuroscience 130:867-73. 2005
    ..We therefore conclude that gross alterations of the electrophysiological properties of neurones will probably not initiate or substantially contribute to the development of the motor impairment or other neurological signs of NPC...
  13. ncbi request reprint Plasticity and the spread of Alzheimer's disease-like changes
    Thomas G Ohm
    Institute for Anatomy, Department Clinical Cell and Neurobiology, Charité Humboldt University 10098 Berlin, Germany
    Neurochem Res 28:1715-23. 2003
    ..Special emphasis is given to some aspects of lipid metabolism, that is, apolipoprotein E polymorphism, statin effects, and lysosomal dysfunction in Alzheimer's and Niemann-Pick C's diseases...