Chris G Parsons
Affiliation: Merz Pharmaceuticals
Parsons C, Ruitenberg M, Freitag C, Sroka Saidi K, Russ H, Rammes G. MRZ-99030 - A novel modulator of AÎ² aggregation: I - Mechanism of action (MoA) underlying the potential neuroprotective treatment of Alzheimer's disease, glaucoma and age-related macular degeneration (AMD). Neuropharmacology. 2015;92:158-69 pubmed publisher
..Moreover, in vivo studies demonstrate the neuroprotective potential of MRZ-99030 after systemic and topical administration in animal models of Alzheimer's disease and glaucoma/AMD respectively. ..
Rammes G, Gravius A, Ruitenberg M, Wegener N, Chambon C, Sroka Saidi K, et al
. MRZ-99030 - A novel modulator of AÎ² aggregation: II - Reversal ofÂ AÎ² oligomer-induced deficits in long-term potentiation (LTP) andÂ cognitive performance in rats and mice. Neuropharmacology. 2015;92:170-82 pubmed publisher
..c.v. application of AÎ²1-42 and 7PA2 conditioned medium, respectively. Altogether, these results demonstrate the potential therapeutic benefit of MRZ-99030 in AD. ..