Andrzej Dekundy

Summary

Affiliation: Merz Pharmaceuticals
Country: Germany

Publications

  1. ncbi request reprint Dizocilpine improves beneficial effects of cholinergic antagonists in anticholinesterase-treated mice
    Andrzej Dekundy
    Department of Toxicology, Institute of Agricultural Medicine, 20 950 Lublin, Poland
    Toxicol Sci 72:289-95. 2003
  2. ncbi request reprint Modulation of L-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model
    Andrzej Dekundy
    In Vivo Pharmacology, Preclinical Research and Development, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, D 60318 Frankfurt am Main, Germany
    Behav Brain Res 179:76-89. 2007
  3. doi request reprint Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia
    Andrzej Dekundy
    In Vivo Pharmacology, R D CNS, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318, Frankfurt am Main, Germany
    J Neural Transm 118:1703-16. 2011
  4. ncbi request reprint Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease
    Andrzej Dekundy
    Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstr 100, 60318 Frankfurt am Main, Germany
    Brain Res Bull 69:318-26. 2006
  5. ncbi request reprint NMDA antagonists exert distinct effects in experimental organophosphate or carbamate poisoning in mice
    Andrzej Dekundy
    Department of Toxicology, Institute of Agricultural Medicine, 20 090 Lublin, Poland
    Toxicol Appl Pharmacol 219:114-21. 2007
  6. doi request reprint Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats
    Andreas Gravius
    Department of In Vivo Pharmacology, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318, Frankfurt am Main, Germany
    J Neural Transm 115:1609-19. 2008
  7. doi request reprint Oral creatine supplementation attenuates L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats
    Barbara Valastro
    Preclinical Research and Development, In Vitro Screening, Merz Pharmaceuticals GmbH, Altenhoferallee 3, 60438 Frankfurt am Main, Germany
    Behav Brain Res 197:90-6. 2009
  8. ncbi request reprint Lithium-methomyl induced seizures in rats: a new model of status epilepticus?
    Rafal M Kaminski
    Department of Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20 950 Lublin, Poland
    Toxicol Appl Pharmacol 219:122-7. 2007
  9. doi request reprint Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABAA receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function
    Martine Hofmann
    Departments of In vivo Pharmacology, Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany
    Behav Pharmacol 23:790-801. 2012
  10. doi request reprint Long-term exposure to nicotine markedly reduces kynurenic acid in rat brain--in vitro and ex vivo evidence
    Elzbieta Zielinska
    Department of Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20 950 Lublin, Poland
    Toxicol Appl Pharmacol 240:174-9. 2009

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Dizocilpine improves beneficial effects of cholinergic antagonists in anticholinesterase-treated mice
    Andrzej Dekundy
    Department of Toxicology, Institute of Agricultural Medicine, 20 950 Lublin, Poland
    Toxicol Sci 72:289-95. 2003
    ..The results suggest that combined treatment with cholinergic and NMDA antagonists might be beneficial in anticholinesterase-induced poisonings...
  2. ncbi request reprint Modulation of L-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model
    Andrzej Dekundy
    In Vivo Pharmacology, Preclinical Research and Development, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, D 60318 Frankfurt am Main, Germany
    Behav Brain Res 179:76-89. 2007
    ..Combining tests of general motor performance with AIMs ratings in the same experiment allows for selecting drugs that specifically reduce dyskinesia without diminishing the anti-akinetic effect of L-DOPA...
  3. doi request reprint Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia
    Andrzej Dekundy
    In Vivo Pharmacology, R D CNS, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318, Frankfurt am Main, Germany
    J Neural Transm 118:1703-16. 2011
    ..The drug was demonstrated to possess a superior antidyskinetic efficacy with a sufficient therapeutic window. MRZ-8676 has also therapeutic potential as an anxiolytic and analgesic drug...
  4. ncbi request reprint Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease
    Andrzej Dekundy
    Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstr 100, 60318 Frankfurt am Main, Germany
    Brain Res Bull 69:318-26. 2006
    ..However, mGluR5 antagonists may prove useful for the symptomatic treatment of L-DOPA-induced dyskinesia...
  5. ncbi request reprint NMDA antagonists exert distinct effects in experimental organophosphate or carbamate poisoning in mice
    Andrzej Dekundy
    Department of Toxicology, Institute of Agricultural Medicine, 20 090 Lublin, Poland
    Toxicol Appl Pharmacol 219:114-21. 2007
    ..The data indicate that both muscarinic ACh and NMDA receptor-mediated mechanisms contribute to the acute toxicity of AChE inhibitors, and NMDA receptors seem critical to OP-induced seizures...
  6. doi request reprint Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats
    Andreas Gravius
    Department of In Vivo Pharmacology, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318, Frankfurt am Main, Germany
    J Neural Transm 115:1609-19. 2008
    ..Depending on the indication and model, the amnesic effects of MTEP should be taken into account as a potential limitation, also after repetitive treatment...
  7. doi request reprint Oral creatine supplementation attenuates L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats
    Barbara Valastro
    Preclinical Research and Development, In Vitro Screening, Merz Pharmaceuticals GmbH, Altenhoferallee 3, 60438 Frankfurt am Main, Germany
    Behav Brain Res 197:90-6. 2009
    ..In conclusion, we demonstrated that combining L-DOPA therapy with a diet enriched in creatine could attenuate LID, which may represent a new way to control the motor complications associated with L-DOPA therapy...
  8. ncbi request reprint Lithium-methomyl induced seizures in rats: a new model of status epilepticus?
    Rafal M Kaminski
    Department of Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20 950 Lublin, Poland
    Toxicol Appl Pharmacol 219:122-7. 2007
    ..As such, seizures induced by lithium-methomyl administration may be an alternative to lithium-pilocarpine model of status epilepticus, which is associated with high lethality...
  9. doi request reprint Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABAA receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function
    Martine Hofmann
    Departments of In vivo Pharmacology, Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany
    Behav Pharmacol 23:790-801. 2012
    ..Therefore, the anxiolytic effect and the lack of side-effects of these compounds, as described in the literature, could not be confirmed in the present study...
  10. doi request reprint Long-term exposure to nicotine markedly reduces kynurenic acid in rat brain--in vitro and ex vivo evidence
    Elzbieta Zielinska
    Department of Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20 950 Lublin, Poland
    Toxicol Appl Pharmacol 240:174-9. 2009
    ..The present results provide evidence for the hypothesis of reciprocal interaction between the nicotinic cholinergic system and the kynurenine pathway in the brain...
  11. ncbi request reprint Ethosuximide and valproate display high efficacy against lindane-induced seizures in mice
    Rafal M Kaminski
    Isotope Laboratory, Institute of Agricultural Medicine, Jaczewskiego 8, 20 950 Lublin, Poland
    Toxicol Lett 154:55-60. 2004
    ..Nevertheless, the protective efficacy of ethosuximide and valproate against experimentally induced lindane seizures may suggest possible efficacy of these drugs against seizures in lindane-poisoned patients...
  12. ncbi request reprint Proteomic analysis of striatal proteins in the rat model of L-DOPA-induced dyskinesia
    Barbara Valastro
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Neurochem 102:1395-409. 2007
    ..In conclusion, this study provides new insights into the protein changes occurring in LID...
  13. pmc Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease
    Chris G Parsons
    In Vitro Pharmacology, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318, Frankfurt, Germany
    Neurotox Res 24:358-69. 2013
    ..Preclinical data have shown how these drugs act via two different, but interconnected, pathological pathways, and that their complementary activity may produce greater effects than either drug individually. ..
  14. ncbi request reprint Deficit of endogenous kynurenic acid in the frontal cortex of rats with a genetic form of absence epilepsy
    Rafał M Kamiński
    Department of Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, PL 20 950 Lublin, Poland
    Pol J Pharmacol 55:741-6. 2003
    ..Our data suggest that selective deficits of endogenous KYNA may account for increased excitability in the frontal cortex, which in turn may lead to the development of spontaneous spike-wave discharges in WAG/Rij rats...
  15. ncbi request reprint mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neuropharmacology 50:1006-15. 2006
    ..The present results do not support a significant anticonvulsant potential of group I mGlu receptor antagonists in rodent models of difficult-to-treat partial epilepsy...
  16. ncbi request reprint Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease
    Flora Mela
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Neurochem 101:483-97. 2007
    ..These data demonstrate that mGluR5 antagonism produces strong anti-dyskinetic effects in an animal model of Parkinson's disease through central inhibition of the molecular and neurochemical underpinnings of l-DOPA-induced dyskinesia...
  17. ncbi request reprint Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia
    Christine Konradi
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, MA 02478, USA
    Neurobiol Dis 17:219-36. 2004
    ..Some basic maintenance chores such as ribosome protein biosynthesis were downregulated, possibly a response to expended ATP levels...
  18. ncbi request reprint Carbofuran-induced oxidative stress in slow and fast skeletal muscles: prevention by memantine and atropine
    Dejan Milatovic
    University Washington, Seattle, WA, USA
    Toxicology 208:13-24. 2005
    ..MEM and ATS prevent the carbofuran-induced chain of events involved in oxidative stress...