Vladimir Kirkin

Summary

Affiliation: Merck KGaA
Country: Germany

Publications

  1. doi request reprint A role for ubiquitin in selective autophagy
    Vladimir Kirkin
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Mol Cell 34:259-69. 2009
  2. ncbi request reprint NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets
    Vladimir Kirkin
    Institute of Biochemistry II, Goethe University, Frankfurt Main, Germany
    Autophagy 5:732-3. 2009
  3. ncbi request reprint A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
    Vladimir Kirkin
    Institute of Biochemistry II, Goethe University, Frankfurt Main, Germany
    Mol Cell 33:505-16. 2009
  4. doi request reprint Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy
    Vladimir Rogov
    Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Marie Curie Strasse 9, 60439 Frankfurt am Main, Germany
    Mol Cell 53:167-78. 2014
  5. doi request reprint Selective autophagy in cancer development and therapy
    Ivan Dikic
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University, Frankfurt, Main, Germany
    Cancer Res 70:3431-4. 2010
  6. ncbi request reprint Role of ubiquitin- and Ubl-binding proteins in cell signaling
    Vladimir Kirkin
    Institute of Biochemistry II, Goethe University Hospital, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Curr Opin Cell Biol 19:199-205. 2007
  7. pmc CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
    Noriaki Shimokawa
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt Main, Germany
    EMBO J 29:2421-32. 2010

Collaborators

Detail Information

Publications7

  1. doi request reprint A role for ubiquitin in selective autophagy
    Vladimir Kirkin
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Mol Cell 34:259-69. 2009
    ..This review explores the hypothesis that ubiquitin represents a selective degradation signal suitable for targeting various types of cargo, ranging from protein aggregates to membrane-bound organelles and microbes...
  2. ncbi request reprint NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets
    Vladimir Kirkin
    Institute of Biochemistry II, Goethe University, Frankfurt Main, Germany
    Autophagy 5:732-3. 2009
    ..We propose that NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited...
  3. ncbi request reprint A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
    Vladimir Kirkin
    Institute of Biochemistry II, Goethe University, Frankfurt Main, Germany
    Mol Cell 33:505-16. 2009
    ..We propose that NBR1 and p62 act as receptors for selective autophagosomal degradation of ubiquitinated targets...
  4. doi request reprint Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy
    Vladimir Rogov
    Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Marie Curie Strasse 9, 60439 Frankfurt am Main, Germany
    Mol Cell 53:167-78. 2014
    ..Recently, it was found that UBLs can directly engage the autophagosome nucleation machinery. Here, we review recent findings on selective autophagy and propose a model for selective autophagosome formation in close proximity to cargo...
  5. doi request reprint Selective autophagy in cancer development and therapy
    Ivan Dikic
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University, Frankfurt, Main, Germany
    Cancer Res 70:3431-4. 2010
    ..We discuss the emerging principles of selective autophagy in cancer pathogenesis and treatment...
  6. ncbi request reprint Role of ubiquitin- and Ubl-binding proteins in cell signaling
    Vladimir Kirkin
    Institute of Biochemistry II, Goethe University Hospital, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Curr Opin Cell Biol 19:199-205. 2007
    ....
  7. pmc CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice
    Noriaki Shimokawa
    Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt Main, Germany
    EMBO J 29:2421-32. 2010
    ..These findings indicate an important function of CIN85 in the regulation of dopamine receptor functions and provide a molecular explanation for the hyperactive behaviour of CIN85(Deltaex2) mice...