U Mengs

Summary

Country: Germany

Publications

  1. ncbi request reprint [Value of mistletoe lectin standardized mistletoe extract for evaluating antitumor properties]
    U Mengs
    Forschung und Entwicklung, Madaus AG, Koln, Deutschland
    Wien Med Wochenschr 149:262-4. 1999
  2. ncbi request reprint Antitumoral effects of an intravesically applied aqueous mistletoe extract on urinary bladder carcinoma MB49 in mice
    U Mengs
    Madaus AG, Ostmerheimer Strasse 198, D 51109 Köln, Germany
    Anticancer Res 20:3565-8. 2000
  3. ncbi request reprint No induction of chromosomal aberrations in Chinese hamster ovary cells by chrysophanol
    U Mengs
    Madaus AG, Ostmerheimer Strasse 198, D 51109, Cologne, Germany
    Mutat Res 492:69-72. 2001
  4. ncbi request reprint A 13-week oral toxicity study of senna in the rat with an 8-week recovery period
    U Mengs
    Madaus AG, 51101, Cologne, Germany
    Arch Toxicol 78:269-75. 2004
  5. ncbi request reprint Mistletoe extracts standardized to mistletoe lectins in oncology: review on current status of preclinical research
    U Mengs
    Madaus AG, Koln, Germany
    Anticancer Res 22:1399-407. 2002
  6. ncbi request reprint No clastogenic activity of a senna extract in the mouse micronucleus assay
    U Mengs
    Madaus, Ostmerheimer Strasse 198, D 51109, Cologne, Germany
    Mutat Res 444:421-6. 1999
  7. ncbi request reprint Light and electron-microscopic changes in the colon of the guinea pig after treatment with anthranoid and non-anthranoid laxatives
    U Mengs
    Madaus AG, Koln, FRG
    Pharmacology 47:172-7. 1993
  8. ncbi request reprint An oral carcinogenicity and toxicity study of senna (Tinnevelly senna fruits) in the rat
    J M Mitchell
    Purdue Pharma, Ardsley, NY, USA
    Arch Toxicol 80:34-44. 2006
  9. ncbi request reprint No evidence of stimulation of human tumor cell proliferation by a standardized aqueous mistletoe extract in vitro
    A M Burger
    Sunnybrook and Women s College Health Science Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
    Anticancer Res 23:3801-6. 2003
  10. ncbi request reprint Anticancer activity of rViscumin (recombinant mistletoe lectin) in tumor colonization models with immunocompetent mice
    B Schaffrath
    MEMOREC Stoffel GmbH, , Germany
    Anticancer Res 21:3981-7. 2001

Collaborators

  • Josef Beuth
  • A M Burger
  • H H Fiebig
  • J M Mitchell
  • V F Semiglazov
  • V V Stepula
  • A Dudov
  • W Dohmen
  • V F Semiglasov
  • B Schaffrath
  • J C Tigner
  • J Zijlstra
  • P Dettmar
  • J Schnitker
  • S McPherson
  • R Gregson
  • W Lehmacher
  • M Breier
  • G Kelter
  • J B Schüler
  • H Lentzen
  • R D Hilgers
  • T Schwarz
  • B Gerstmayer

Detail Information

Publications15

  1. ncbi request reprint [Value of mistletoe lectin standardized mistletoe extract for evaluating antitumor properties]
    U Mengs
    Forschung und Entwicklung, Madaus AG, Koln, Deutschland
    Wien Med Wochenschr 149:262-4. 1999
    ..The quality of this preparation has also been shown in several animal models to demonstrate antitumoral potencies...
  2. ncbi request reprint Antitumoral effects of an intravesically applied aqueous mistletoe extract on urinary bladder carcinoma MB49 in mice
    U Mengs
    Madaus AG, Ostmerheimer Strasse 198, D 51109 Köln, Germany
    Anticancer Res 20:3565-8. 2000
    ....
  3. ncbi request reprint No induction of chromosomal aberrations in Chinese hamster ovary cells by chrysophanol
    U Mengs
    Madaus AG, Ostmerheimer Strasse 198, D 51109, Cologne, Germany
    Mutat Res 492:69-72. 2001
    ..We conclude that chrysophanol had no clastogenic activity under the conditions described...
  4. ncbi request reprint A 13-week oral toxicity study of senna in the rat with an 8-week recovery period
    U Mengs
    Madaus AG, 51101, Cologne, Germany
    Arch Toxicol 78:269-75. 2004
    ..Thus, the biochemical and morphological changes seen following 13 weeks of treatment of senna significantly reversed following 8 weeks of recovery...
  5. ncbi request reprint Mistletoe extracts standardized to mistletoe lectins in oncology: review on current status of preclinical research
    U Mengs
    Madaus AG, Koln, Germany
    Anticancer Res 22:1399-407. 2002
    ..The objective of this review is to present the current state of preclinical research on standardized mistletoe extracts which hence may be included in the category of rationalphytotherapy...
  6. ncbi request reprint No clastogenic activity of a senna extract in the mouse micronucleus assay
    U Mengs
    Madaus, Ostmerheimer Strasse 198, D 51109, Cologne, Germany
    Mutat Res 444:421-6. 1999
    ..Together with further negative in vivo genotoxicity studies with anthranoids, the conclusion can be drawn that there is no indication so far demonstrating a genotoxic risk for patients taking senna laxatives...
  7. ncbi request reprint Light and electron-microscopic changes in the colon of the guinea pig after treatment with anthranoid and non-anthranoid laxatives
    U Mengs
    Madaus AG, Koln, FRG
    Pharmacology 47:172-7. 1993
    ....
  8. ncbi request reprint An oral carcinogenicity and toxicity study of senna (Tinnevelly senna fruits) in the rat
    J M Mitchell
    Purdue Pharma, Ardsley, NY, USA
    Arch Toxicol 80:34-44. 2006
    ..Based upon these data, it is concluded that senna is not carcinogenic even after daily administration for 2 years at dosages of up to 300 mg/kg/day in Sprague-Dawley rats...
  9. ncbi request reprint No evidence of stimulation of human tumor cell proliferation by a standardized aqueous mistletoe extract in vitro
    A M Burger
    Sunnybrook and Women s College Health Science Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
    Anticancer Res 23:3801-6. 2003
    ..Our data clearly demonstrate that, by applying scientifically valid methods and procedures, the standardized AME did not stimulate tumor cell proliferation but showed time- and concentration-dependent antiproliferative effects...
  10. ncbi request reprint Anticancer activity of rViscumin (recombinant mistletoe lectin) in tumor colonization models with immunocompetent mice
    B Schaffrath
    MEMOREC Stoffel GmbH, , Germany
    Anticancer Res 21:3981-7. 2001
    ..The results indicate that rViscumin has antineoplastic properties and might therefore be a promising candidate in cancer therapy...
  11. ncbi request reprint Antiproliferative activity of an aqueous mistletoe extract in human tumor cell lines and xenografts in vitro
    A M Burger
    Tumor Biology Center, University of Freiburg, Freiburg, Germany
    Arzneimittelforschung 51:748-57. 2001
    ..Experiments with sensitive tumor types identified in these in vitro studies are currently ongoing in order to demonstrate the anticancer activity of AME in different animal tumor models...
  12. ncbi request reprint Anticancer activity of an aqueous mistletoe extract (AME) in syngeneic murine tumor models
    A M Burger
    Tumor Biology Center, University of Freiburg, Germany
    Anticancer Res 21:1965-8. 2001
    ..In view of the low dose levels used, the effects are most likely due to the immunostimulatory rather than to the cytotoxic potencies of AME...
  13. ncbi request reprint Cellular immunomodulation and safety of standardized aqueous mistletoe extract PS76A2 in tumor patients treated for 48 weeks
    W Dohmen
    Academical Practice of General Medicine, Medical Faculty, RWTH Aachen, Thomashofstrasse 3, D 52070 Aachen, Germany
    Anticancer Res 24:1231-7. 2004
    ..Summarizing, it can be stated that the standardized mistletoe extract PS76A2 significantly improved the immune status of tumor patients and was administered safely over a long period...
  14. ncbi request reprint The standardised mistletoe extract PS76A2 improves QoL in patients with breast cancer receiving adjuvant CMF chemotherapy: a randomised, placebo-controlled, double-blind, multicentre clinical trial
    V F Semiglasov
    Scientific Research Oncological Institute, St Petersburg, Russia
    Anticancer Res 24:1293-302. 2004
    ..05). Overall, PS76A2 was well tolerated. Local reactions at the injection sites occurred dose-dependently, but were mild at the low and medium dose levels...
  15. ncbi request reprint Quality of life is improved in breast cancer patients by Standardised Mistletoe Extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial
    V F Semiglazov
    Petrov Research Institute of Oncology, St Petersburg, Russia
    Anticancer Res 26:1519-29. 2006
    ..6% of the PS76A2 group. In conclusion, PS76A2 (15 ng mistletoe lectin/0.5 ml twice weekly) was shown to be safe and effective in improving QoL in breast cancer patients during chemotherapy and follow-up...