Bodo C Melnik

Summary

Country: Germany

Publications

  1. pmc Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1?
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 22:502-4. 2013
  2. pmc Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood Obesity
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, 49090 Osnabrück, Germany
    J Obes 2012:197653. 2012
  3. pmc Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet
    Bodo Melnik
    Department of Dermatology Environmental Medicine and Health Theory University of Osnabrück Osnabrück, Germany
    Dermatoendocrinol 4:20-32. 2012
  4. pmc The structures of mutant forms of Hfq from Pseudomonas aeruginosa reveal the importance of the conserved His57 for the protein hexamer organization
    Olga Moskaleva
    Institute of Protein Research, RAS, Russia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:760-4. 2010
  5. doi request reprint Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, D 49090 Osnabrück, Germany
    J Transl Med 12:43. 2014
  6. ncbi request reprint Acne: risk indicator for increased body mass index and insulin resistance
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, DE 49076 Osnabrück, Germany
    Acta Derm Venereol 93:644-9. 2013
  7. pmc Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, D 49090, Osnabruck, Germany
    Nutr J 12:103. 2013
  8. pmc Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 22:311-5. 2013
  9. doi request reprint Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 22:172-7. 2013
  10. doi request reprint [Acne and diet]
    B C Melnik
    Dermatologie, Umweltmedizin und Gesundheitstheorie, Universitat Osnabruck
    Hautarzt 64:252, 254-8, 260-2. 2013

Collaborators

Detail Information

Publications31

  1. pmc Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1?
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 22:502-4. 2013
    ..This hypothesis unmasks a common mode of action of antiacne agents as either FoxO enhancers or mTORC1 inhibitors and thus provides a rational approach for the development of new antiacne agents. ..
  2. pmc Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood Obesity
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, 49090 Osnabrück, Germany
    J Obes 2012:197653. 2012
    ..Attenuation of mTORC1 signalling of infant formula by leucine restriction to physiologic lower levels of human milk offers a great chance for the prevention of childhood obesity and obesity-related metabolic diseases...
  3. pmc Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet
    Bodo Melnik
    Department of Dermatology Environmental Medicine and Health Theory University of Osnabrück Osnabrück, Germany
    Dermatoendocrinol 4:20-32. 2012
    ....
  4. pmc The structures of mutant forms of Hfq from Pseudomonas aeruginosa reveal the importance of the conserved His57 for the protein hexamer organization
    Olga Moskaleva
    Institute of Protein Research, RAS, Russia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:760-4. 2010
    ..The results obtained demonstrate the great importance of solvent-inaccessible conserved hydrogen bonds between the Hfq monomers in stabilization of the hexamer structure...
  5. doi request reprint Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, D 49090 Osnabrück, Germany
    J Transl Med 12:43. 2014
    ..The presented concept offers a new option for the prevention of atopic diseases by the addition of physiological amounts of miR-155-enriched exosomes to infant formula for mothers incapable of breastfeeding. ..
  6. ncbi request reprint Acne: risk indicator for increased body mass index and insulin resistance
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, DE 49076 Osnabrück, Germany
    Acta Derm Venereol 93:644-9. 2013
    ....
  7. pmc Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, D 49090, Osnabruck, Germany
    Nutr J 12:103. 2013
    ....
  8. pmc Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 22:311-5. 2013
    ....
  9. doi request reprint Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 22:172-7. 2013
    ..All major therapeutic interventions in HS appear to attenuate increased MAPK activation of innate immune cells due to impaired Notch-mediated feedback regulation of innate immunity...
  10. doi request reprint [Acne and diet]
    B C Melnik
    Dermatologie, Umweltmedizin und Gesundheitstheorie, Universitat Osnabruck
    Hautarzt 64:252, 254-8, 260-2. 2013
    ..A suitable diet attenuating increased mTORC1 activity is a Palaeolithic-like diet with reduced intake of sugar, hyperglycaemic grains, milk and milk products but enriched consumption of vegetables and fish...
  11. pmc The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, Osnabruck, D 49090, Germany
    Nutr Metab (Lond) 9:74. 2012
    ....
  12. doi request reprint Diet in acne: further evidence for the role of nutrient signalling in acne pathogenesis
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Acta Derm Venereol 92:228-31. 2012
    ....
  13. pmc Over-stimulation of insulin/IGF-1 signaling by western diet may promote diseases of civilization: lessons learnt from laron syndrome
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, D 49090 Osnabrück, Germany
    Nutr Metab (Lond) 8:41. 2011
    ....
  14. doi request reprint Milk signalling in the pathogenesis of type 2 diabetes
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Med Hypotheses 76:553-9. 2011
    ..Furthermore, the presented milk hypothesis of T2D is compatible with the concept of high ER stress in T2D and the toxic oligomer hypothesis of T2D and may explain the high association of T2D and Alzheimer disease...
  15. ncbi request reprint The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action
    B C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Germany
    G Ital Dermatol Venereol 145:559-71. 2010
    ....
  16. doi request reprint FoxO1 - the key for the pathogenesis and therapy of acne?
    Bodo C Melnik
    Department of Dermatology, Enviromental Medicine and Health Theory, University of Osnabruck, Germany
    J Dtsch Dermatol Ges 8:105-14. 2010
    ..Various receptor-mediated growth factor signals are integrated at the level of PI3K/Akt activation which finally results in nuclear FoxO1 deficiency...
  17. ncbi request reprint [Disturbances of antimicrobial lipids in atopic dermatitis]
    Bodo Melnik
    Dermatologie, Umweltmedizin und Gesundheitstheorie, Fachbereich Humanwissenshaften, Universität of Osnabrück, Germany
    J Dtsch Dermatol Ges 4:114-23. 2006
    ..The killing of superantigen-secreting bacterial strains with topically applied antimicrobial lipids offers new antiseptic and immunomodulatory options for the treatment and secondary prevention of atopic dermatitis...
  18. ncbi request reprint Abuse of anabolic-androgenic steroids and bodybuilding acne: an underestimated health problem
    Bodo Melnik
    Department of Dermatology, Environmental Medicine and Health Science, Division of Human Sciences, University of OsnabrYck, Germany
    J Dtsch Dermatol Ges 5:110-7. 2007
    ..Both acne conglobata and acne fulminans can be induced by AAS abuse. The dermatologist should recognize bodybuilding acne, address the AAS abuse, and warn the patient about other potential hazards...
  19. doi request reprint FGFR2 signaling and the pathogenesis of acne
    Bodo Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Germany
    J Dtsch Dermatol Ges 6:721-8. 2008
    ....
  20. doi request reprint Anti-acne agents attenuate FGFR2 signal transduction in acne
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    J Invest Dermatol 129:1868-77. 2009
    ....
  21. doi request reprint Milk--the promoter of chronic Western diseases
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Sedanstrasse 115, D 49090 Osnabrück, Germany
    Med Hypotheses 72:631-9. 2009
    ..An accumulated body of evidence for the adverse effects of cow's milk consumption from fetal life to childhood, adolescence, adulthood and senescence will be provided which strengthens the presented hypothesis...
  22. doi request reprint Milk consumption: aggravating factor of acne and promoter of chronic diseases of Western societies
    Bodo Melnik
    Department of Dermatology, Environmental Medicine, and Health Theory, University of Osnabruck, Germany
    J Dtsch Dermatol Ges 7:364-70. 2009
    ..Observations of molecular biology are supported by epidemiologic data and unmask milk consumption as a promoter of chronic diseases of Western societies...
  23. doi request reprint Androgen abuse in the community
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, Division of Human Sciences, University of Osnabruck, Germany
    Curr Opin Endocrinol Diabetes Obes 16:218-23. 2009
    ..To provide information of the current prevalence of illicit use of androgens by individuals of the community...
  24. doi request reprint Permanent impairment of insulin resistance from pregnancy to adulthood: the primary basic risk factor of chronic Western diseases
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, Division of Human Sciences, University of Osnabruck, Sedanstrasse 115, D 49090 Osnabrück, Germany
    Med Hypotheses 73:670-81. 2009
    ..An all-encompassing consideration of IR-inducing risk factors from the beginning of life to adulthood appears to be of crucial importance for the prevention and treatment of chronic Western diseases...
  25. doi request reprint Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 18:833-41. 2009
    ..Persistent acne in adulthood with high IGF-1 levels may be considered as an indicator for increased risk of cancer, which may require appropriate dietary intervention as well as treatment with insulin-sensitizing agents...
  26. doi request reprint [Acne vulgaris. Role of diet]
    B Melnik
    Fachgebiet Dermatologie, Umweltmedizin und Gesundheitstheorie, Universitat Osnabruck, Sedanstr 115, 49090 Osnabrück
    Hautarzt 61:115-25. 2010
    ....
  27. ncbi request reprint [Malignant atrophic papulosis (Köhlmeier-Degos disease). Failure to respond to interferon alpha-2a, pentoxifylline and aspirin]
    B Melnik
    Dermatologie, Umweltmedizin und Gesundheitstheorie, Universitat Osnabruck, Germany
    Hautarzt 53:618-21. 2002
    ..Furthermore, we could not confirm the effectiveness of a recently reported treatment modality with pentoxifylline and aspirin administered to our patient over a period of 5 months...
  28. doi request reprint Evidence for acne-promoting effects of milk and other insulinotropic dairy products
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Nestle Nutr Workshop Ser Pediatr Program 67:131-45. 2011
    ..Both, restriction of milk consumption or generation of less insulinotropic milk will have an enormous impact on the prevention of epidemic western diseases like obesity, diabetes mellitus, cancer, neurodegenerative diseases and acne...
  29. doi request reprint Steroid-induced periorificial dermatitis in children--clinical features and response to azelaic acid
    Thomas Jansen
    Department of Dermatology, Venereology and Allergology, University of Essen, Essen, Germany
    Pediatr Dermatol 27:137-42. 2010
    ..4) months. Treatment with 20% azelaic acid cream could provide an effective and safe alternative therapeutic option in children with nongranulomatous periorificial dermatitis...
  30. ncbi request reprint Lipid composition of outer stratum corneum in hereditary palmoplantar keratodermas
    Wolfgang Kuster
    Department of Dermatology, TOMESA Clinics, Bad Salzschlirf, Germany
    Dermatology 206:131-5. 2003
    ..The analysis of lipid composition of the outer stratum corneum is a promising approach to study the pathophysiology of inherited disorders of keratinization...