Bodo C Melnik

Summary

Country: Germany

Publications

  1. Melnik B. Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity. Acta Derm Venereol. 2017;97:173-181 pubmed publisher
    ....
  2. Melnik B, Schmitz G. Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. Exp Dermatol. 2009;18:833-41 pubmed publisher
    ..Persistent acne in adulthood with high IGF-1 levels may be considered as an indicator for increased risk of cancer, which may require appropriate dietary intervention as well as treatment with insulin-sensitizing agents. ..
  3. Melnik B, Zouboulis C. Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Exp Dermatol. 2013;22:311-5 pubmed publisher
    ....
  4. Melnik B, John S, Schmitz G. Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutr J. 2013;12:103 pubmed publisher
    ....
  5. request reprint
    Melnik B, Hariry H, Vakilzadeh F, Gropp C, Sitzer G. [Malignant atrophic papulosis (Köhlmeier-Degos disease). Failure to respond to interferon alpha-2a, pentoxifylline and aspirin]. Hautarzt. 2002;53:618-21 pubmed
    ..Furthermore, we could not confirm the effectiveness of a recently reported treatment modality with pentoxifylline and aspirin administered to our patient over a period of 5 months...
  6. Melnik B. Androgen abuse in the community. Curr Opin Endocrinol Diabetes Obes. 2009;16:218-23 pubmed publisher
    ....
  7. Melnik B. FoxO1 - the key for the pathogenesis and therapy of acne?. J Dtsch Dermatol Ges. 2010;8:105-14 pubmed publisher
    ..Various receptor-mediated growth factor signals are integrated at the level of PI3K/Akt activation which finally results in nuclear FoxO1 deficiency. ..
  8. request reprint
    Melnik B. The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action. G Ital Dermatol Venereol. 2010;145:559-71 pubmed
    ....
  9. Melnik B. Olumacostat Glasaretil, a Promising Topical Sebum-Suppressing Agent that Affects All Major Pathogenic Factors of Acne Vulgaris. J Invest Dermatol. 2017;137:1405-1408 pubmed publisher
    ..Olumacostat glasaretil-mediated sebum suppression may reduce Propionibacterium acnes growth and biofilm formation, comedogenesis, and inflammation. ..
  10. Melnik B. p53: key conductor of all anti-acne therapies. J Transl Med. 2017;15:195 pubmed publisher
    ..e., upregulation of the guardian of the genome p53. Immortalized p53-inactivated sebocyte cultures are unfortunate models for studying acne pathogenesis and treatment. ..

Locale

Detail Information

Publications13

  1. Melnik B. Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity. Acta Derm Venereol. 2017;97:173-181 pubmed publisher
    ....
  2. Melnik B, Schmitz G. Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. Exp Dermatol. 2009;18:833-41 pubmed publisher
    ..Persistent acne in adulthood with high IGF-1 levels may be considered as an indicator for increased risk of cancer, which may require appropriate dietary intervention as well as treatment with insulin-sensitizing agents. ..
  3. Melnik B, Zouboulis C. Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Exp Dermatol. 2013;22:311-5 pubmed publisher
    ....
  4. Melnik B, John S, Schmitz G. Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutr J. 2013;12:103 pubmed publisher
    ....
  5. request reprint
    Melnik B, Hariry H, Vakilzadeh F, Gropp C, Sitzer G. [Malignant atrophic papulosis (Köhlmeier-Degos disease). Failure to respond to interferon alpha-2a, pentoxifylline and aspirin]. Hautarzt. 2002;53:618-21 pubmed
    ..Furthermore, we could not confirm the effectiveness of a recently reported treatment modality with pentoxifylline and aspirin administered to our patient over a period of 5 months...
  6. Melnik B. Androgen abuse in the community. Curr Opin Endocrinol Diabetes Obes. 2009;16:218-23 pubmed publisher
    ....
  7. Melnik B. FoxO1 - the key for the pathogenesis and therapy of acne?. J Dtsch Dermatol Ges. 2010;8:105-14 pubmed publisher
    ..Various receptor-mediated growth factor signals are integrated at the level of PI3K/Akt activation which finally results in nuclear FoxO1 deficiency. ..
  8. request reprint
    Melnik B. The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action. G Ital Dermatol Venereol. 2010;145:559-71 pubmed
    ....
  9. Melnik B. Olumacostat Glasaretil, a Promising Topical Sebum-Suppressing Agent that Affects All Major Pathogenic Factors of Acne Vulgaris. J Invest Dermatol. 2017;137:1405-1408 pubmed publisher
    ..Olumacostat glasaretil-mediated sebum suppression may reduce Propionibacterium acnes growth and biofilm formation, comedogenesis, and inflammation. ..
  10. Melnik B. p53: key conductor of all anti-acne therapies. J Transl Med. 2017;15:195 pubmed publisher
    ..e., upregulation of the guardian of the genome p53. Immortalized p53-inactivated sebocyte cultures are unfortunate models for studying acne pathogenesis and treatment. ..
  11. Melnik B, Schmitz G. Milk's Role as an Epigenetic Regulator in Health and Disease. Diseases. 2017;5: pubmed publisher
    ..Commercial interest to enhance dairy lactation performance may further increase the epigenetic miRNA burden for the milk consumer. ..
  12. Melnik B, Schmitz G. MicroRNAs: Milk's epigenetic regulators. Best Pract Res Clin Endocrinol Metab. 2017;31:427-442 pubmed publisher
    ..The deficiency of exosomal miRNAs in infant formula and the persistent uptake of milk miRNAs after the nursing period via consumption of cow's milk are two epigenetic aberrations that may induce adverse long-term effects on human health...
  13. Melnik B. Acne vulgaris: The metabolic syndrome of the pilosebaceous follicle. Clin Dermatol. 2018;36:29-40 pubmed publisher
    ..Acne vulgaris is a family member of mTORC1-driven diseases of civilization and represents the MetS of the sebaceous follicle...