Anette Melk

Summary

Country: Germany

Publications

  1. ncbi Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
    Anette Melk
    Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 65:510-20. 2004
  2. ncbi Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated kidney graft rejection
    Gunilla Einecke
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 5:1827-36. 2005
  3. ncbi Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney
    Anette Melk
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Transplant 5:1375-82. 2005
  4. ncbi Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling
    Anette Melk
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 68:2667-79. 2005
  5. ncbi Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening
    Anette Melk
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 63:2134-43. 2003
  6. ncbi Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis
    Attapong Vongwiwatana
    Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 5:1367-74. 2005
  7. ncbi Cytokine single nucleotide polymorphisms and intrarenal gene expression in chronic allograft nephropathy in children
    Anette Melk
    Childrens Hospital, Hannover Medical School, Hannover, Germany
    Kidney Int 64:314-20. 2003
  8. ncbi Lesions of T-cell-mediated kidney allograft rejection in mice do not require perforin or granzymes A and B
    Philip F Halloran
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 4:705-12. 2004
  9. ncbi Senescence of renal cells: molecular basis and clinical implications
    Anette Melk
    Division of Nephrology and Immunology, University of Alberta, 250 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada
    Nephrol Dial Transplant 18:2474-8. 2003
  10. ncbi Quantitative gene expression of TGF-beta1, IL-10, TNF-alpha and Fas Ligand in renal cortex and medulla
    Christian von Schnakenburg
    Department of Paediatric Nephrology and Metabolic Diseases, Children s Hospital, Hannover Medical School, D 30623 Hannover, Germany
    Nephrol Dial Transplant 17:573-9. 2002

Collaborators

Detail Information

Publications12

  1. ncbi Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
    Anette Melk
    Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 65:510-20. 2004
    ..In the present study, we evaluated the relationship between renal age in humans and a number of phenomena associated with cellular senescence in vitro...
  2. ncbi Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated kidney graft rejection
    Gunilla Einecke
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 5:1827-36. 2005
    ..Expression of CATs was established before diagnostic lesions and remained remarkably consistent through day 42 despite massive alterations in the pathology, and probably reflects T cells recruited to the graft...
  3. ncbi Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney
    Anette Melk
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Transplant 5:1375-82. 2005
    ..Thus, aging, injury and disease may share common pathways involving somatic cell senescence...
  4. ncbi Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling
    Anette Melk
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 68:2667-79. 2005
    ..The molecular basis of renal aging is not completely understood...
  5. ncbi Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening
    Anette Melk
    Department of Medicine, Division of Nephrology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 63:2134-43. 2003
    ..We previously showed that human kidney cortex displays telomere shortening with age. In this study, we compared the structural and functional changes in rat kidney with age to phenomena associated with cellular senescence in vitro...
  6. ncbi Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis
    Attapong Vongwiwatana
    Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada
    Am J Transplant 5:1367-74. 2005
    ..These findings support a model in which the TEC damage induces loss of epithelial features and expression of fibroblast features, as a common pathway of deterioration by either immunologic or nonimmunologic processes...
  7. ncbi Cytokine single nucleotide polymorphisms and intrarenal gene expression in chronic allograft nephropathy in children
    Anette Melk
    Childrens Hospital, Hannover Medical School, Hannover, Germany
    Kidney Int 64:314-20. 2003
    ....
  8. ncbi Lesions of T-cell-mediated kidney allograft rejection in mice do not require perforin or granzymes A and B
    Philip F Halloran
    Department of Medicine, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 4:705-12. 2004
    ..Together with previous graft survival studies, these results indicate that the granule-associated cytotoxic mechanisms of T cells are not the effectors of T-cell-mediated allograft rejection...
  9. ncbi Senescence of renal cells: molecular basis and clinical implications
    Anette Melk
    Division of Nephrology and Immunology, University of Alberta, 250 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada
    Nephrol Dial Transplant 18:2474-8. 2003
  10. ncbi Quantitative gene expression of TGF-beta1, IL-10, TNF-alpha and Fas Ligand in renal cortex and medulla
    Christian von Schnakenburg
    Department of Paediatric Nephrology and Metabolic Diseases, Children s Hospital, Hannover Medical School, D 30623 Hannover, Germany
    Nephrol Dial Transplant 17:573-9. 2002
    ..With the advent of new quantitative PCR methods results of gene expression are available within few hours after kidney biopsies...
  11. doi Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a
    Jens H Westhoff
    Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    Hypertension 52:123-9. 2008
    ..Thus, hypertension induces cellular senescence via p16(INK4a), possibly through p38, thereby contributing to hypertensive target organ damage. This detrimental effect can be overcome by different therapeutic drug strategies...
  12. ncbi Longitudinal analysis of T-helper cell phenotypes in renal-transplant recipients undergoing growth hormone therapy
    Anette Melk
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 78:1792-801. 2004
    ..We therefore evaluated the immune phenotypes of pediatric renal-transplant recipients and controls in response to rhGH with regard to a possible shift toward a T-helper (TH)1-type response...