Juris J Meier

Summary

Country: Germany

Publications

  1. pmc The role of co-morbidity in the selection of antidiabetic pharmacotherapy in type-2 diabetes
    Diethelm Tschöpe
    Herz und Diabeteszentrum Nordrhein Westfalen in Bad Oeynhausen, Universitätsklinik der Ruhr Universität, Bochum, Germany
    Cardiovasc Diabetol 12:62. 2013
  2. doi request reprint Hyperglycaemia is associated with impaired pulsatile insulin secretion: effect of basal insulin therapy
    J J Meier
    Diabetes Division, Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Diabetes Obes Metab 15:258-63. 2013
  3. doi request reprint GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
    Juris J Meier
    Division of Diabetology, St Josef Hospital, Ruhr University Bochum, Gudrunstraße 56, 44791 Bochum, Germany
    Nat Rev Endocrinol 8:728-42. 2012
  4. doi request reprint Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans
    J J Meier
    Diabetes Division, Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Diabetologia 55:1346-54. 2012
  5. doi request reprint Beta cell mass in diabetes: a realistic therapeutic target?
    J J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University of Bochum, Gudrunstr 56, 44791, Bochum, Germany
    Diabetologia 51:703-13. 2008
  6. ncbi request reprint Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    World J Gastroenterol 12:1874-80. 2006
  7. pmc Waking up the gut in critically ill patients
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstraße 56, 44791 Bochum, Germany
    Crit Care 14:183. 2010
  8. ncbi request reprint Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr Univ of Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Am J Physiol Endocrinol Metab 293:E849-56. 2007
  9. doi request reprint Beta-cell development and turnover during prenatal life in humans
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University of Bochum, Gudrunstrasse 56, Bochum 44791, Germany
    Eur J Endocrinol 162:559-68. 2010
  10. ncbi request reprint The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans
    Juris J Meier
    Dept of Medicine I, St Josef Hospital, Ruhr Univ Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Am J Physiol Endocrinol Metab 290:E1118-23. 2006

Collaborators

Detail Information

Publications81

  1. pmc The role of co-morbidity in the selection of antidiabetic pharmacotherapy in type-2 diabetes
    Diethelm Tschöpe
    Herz und Diabeteszentrum Nordrhein Westfalen in Bad Oeynhausen, Universitätsklinik der Ruhr Universität, Bochum, Germany
    Cardiovasc Diabetol 12:62. 2013
    ..We postulate that differential use of antidiabetic drugs in patients with co-morbid disease constellations will help to reduce treatment related complications and might improve prognosis...
  2. doi request reprint Hyperglycaemia is associated with impaired pulsatile insulin secretion: effect of basal insulin therapy
    J J Meier
    Diabetes Division, Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Diabetes Obes Metab 15:258-63. 2013
    ..whether pulsatile insulin secretion is related to glycaemic control, whether basal insulin supplementation increases postprandial insulin secretion, and if so, is this accomplished by a specific improvement in pulsatile insulin secretion?..
  3. doi request reprint GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
    Juris J Meier
    Division of Diabetology, St Josef Hospital, Ruhr University Bochum, Gudrunstraße 56, 44791 Bochum, Germany
    Nat Rev Endocrinol 8:728-42. 2012
    ..The adverse effect profiles of these compounds also differ. The individual properties of the various GLP-1 receptor agonists might enable incretin-based treatment of type 2 diabetes mellitus to be tailored to the needs of each patient...
  4. doi request reprint Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans
    J J Meier
    Diabetes Division, Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Diabetologia 55:1346-54. 2012
    ..We aimed to determine the lower threshold of beta cell area for diabetes manifestation as well as the impact of insulin sensitivity on glucose homoeostasis in patients with pancreatic diabetes...
  5. doi request reprint Beta cell mass in diabetes: a realistic therapeutic target?
    J J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University of Bochum, Gudrunstr 56, 44791, Bochum, Germany
    Diabetologia 51:703-13. 2008
    ..Finally, the potential effects of current and future treatment regimens on beta cell mass and turnover are considered...
  6. ncbi request reprint Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    World J Gastroenterol 12:1874-80. 2006
    ..While animal experiments suggested a role for GIP as an inhibitor of gastric secretion, the GIP effects on gastric acid output in humans are still controversial...
  7. pmc Waking up the gut in critically ill patients
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstraße 56, 44791 Bochum, Germany
    Crit Care 14:183. 2010
    ..From a pragmatic point of view, the most feasible way towards a restoration of gut hormone secretion in critically ill patients is to provide enteral nutritional supply as soon as possible...
  8. ncbi request reprint Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr Univ of Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Am J Physiol Endocrinol Metab 293:E849-56. 2007
    ..An inverse relationship between insulin concentrations and insulin clearance suggests that the secretion of insulin itself determines the rate of hepatic insulin clearance...
  9. doi request reprint Beta-cell development and turnover during prenatal life in humans
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University of Bochum, Gudrunstrasse 56, Bochum 44791, Germany
    Eur J Endocrinol 162:559-68. 2010
    ..We addressed the following questions in prenatal humans: i) what is the timing of beta-cell occurrence and islet growth? ii) What are the dynamics of beta-cell replication and apoptosis?..
  10. ncbi request reprint The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans
    Juris J Meier
    Dept of Medicine I, St Josef Hospital, Ruhr Univ Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Am J Physiol Endocrinol Metab 290:E1118-23. 2006
    ..Most likely, this is because of direct effects on glucose disposal. However, the glucose-lowering potential of GLP-1-(9-36) amide appears to be small compared with that of intact GLP-1-(7-36) amide...
  11. doi request reprint Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Clin Endocrinol Metab 95:4061-5. 2010
    ..We examined the effects of exogenous glucagon on the release of incretin hormones...
  12. ncbi request reprint [New concepts in the treatment of type 2 diabetes]
    J J Meier
    Medizinische Klinik I, St Josef Hospital, Klinikum der Ruhr Universitat Bochum
    Internist (Berl) 48:698, 700-7. 2007
    ..The long-term effects of these drugs on the development of diabetic complications in long-term trials remains to be awaited...
  13. ncbi request reprint Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects
    J J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791, Bochum, Germany
    Diabetologia 50:806-13. 2007
    ..secretion different after oral and during intravenous glucose administration? (2) If so, is this related to the secretion of incretin hormones? (3) Is glucagon secretion abnormal in first-degree relatives of patients with type 2 diabetes?..
  14. doi request reprint The contribution of incretin hormones to the pathogenesis of type 2 diabetes
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Best Pract Res Clin Endocrinol Metab 23:433-41. 2009
    ....
  15. doi request reprint Excess glycaemic excursions after an oral glucose tolerance test compared with a mixed meal challenge and self-measured home glucose profiles: is the OGTT a valid predictor of postprandial hyperglycaemia and vice versa?
    J J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Diabetes Obes Metab 11:213-22. 2009
    ..We addressed whether (i) glucose concentrations after an oral glucose load are similar to those after a test meal or under daily life conditions and (ii) impaired glucose tolerance (IGT) predicts postprandial hyperglycaemia...
  16. ncbi request reprint Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University, Bochum, Germany
    Gastroenterology 130:44-54. 2006
    ..However, the acute effects of GLP-2 on gastric functions as well as on glucose and lipid homeostasis in humans are less well characterized...
  17. ncbi request reprint The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP)
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Germany
    Regul Pept 113:95-100. 2003
    ..0001), but not the intravenous GIP administration (p=0.18) significantly reduced insulin clearance. Therefore, insulin clearance is reduced after an oral glucose load. This effect does not appear to be mediated by GIP...
  18. ncbi request reprint Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects
    Juris J Meier
    Department of Medicine, Ruhr University, Bochum, Germany
    Diabetes 54:2212-8. 2005
    ....
  19. doi request reprint Hyperglycemia acutely lowers the postprandial excursions of glucagon-like Peptide-1 and gastric inhibitory polypeptide in humans
    Kirsten Vollmer
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Clin Endocrinol Metab 94:1379-85. 2009
    ..We examined whether acute hyperglycemia reduces the postprandial excursions of gastric inhibitory polypeptide (GIP) and GLP-1, and if so, whether this can be attributed to changes in gastric emptying...
  20. ncbi request reprint Gastric inhibitory polypeptide: the neglected incretin revisited
    Juris J Meier
    Medizinische Klinik I, St Josef Hospital, Klinikum der Ruhr Universitat Bochum, Gudrunstrasse 56, 44791, Bochum, Germany
    Regul Pept 107:1-13. 2002
    ..The present work aims to review the physiological functions of GIP, to characterize its role in the pathogenesis of type 2 diabetes, and to discuss possible clinical applications and future perspectives in the light of new findings...
  21. ncbi request reprint Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Germany
    Metabolism 52:1579-85. 2003
    ..Therefore, a reduced GIP-induced insulin secretion in patients with type 2 diabetes and their first-degree relatives at hyperglycemia is more likely due to a general defect of B-cell function than to a specific defect of the GIP action...
  22. doi request reprint Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals
    Stefan Röhrer
    Division of Diabetology and Gastrointestinal Endocrinology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Clin Endocrinol Metab 97:E791-5. 2012
    ..The crosstalk between pulsatile islet hormone secretion in prediabetic individuals has not yet been examined...
  23. pmc Functional assessment of pancreatic beta-cell area in humans
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Germany
    Diabetes 58:1595-603. 2009
    ..However, imaging methods allowing the monitoring of changes in beta-cell mass in vivo have not yet become available. We address whether pancreatic beta-cell area can be assessed by functional test of insulin secretion in humans...
  24. ncbi request reprint Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects
    Juris J Meier
    Department of Medicine, St Josef Hospiital, Ruhr University Bochum, Bochum, Germany
    Diabetes 53:S220-4. 2004
    ..Therefore, the existence of a specific GIP receptor defect in type 2 diabetes appears unlikely...
  25. doi request reprint Impaired glucose-induced glucagon suppression after partial pancreatectomy
    Henning Schrader
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    J Clin Endocrinol Metab 94:2857-63. 2009
    ..We examined whether a partial pancreatectomy in humans would also impair postchallenge glucagon concentrations and, if so, whether this could be attributed to the reduction in insulin levels...
  26. ncbi request reprint Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Diabetes 53:654-62. 2004
    ..Delayed elimination of GLP-1 and GIP in renal insufficiency may influence the pharmacokinetics and pharmacodynamics of dipeptidyl peptidase IV-resistant incretin derivatives to be used for the treatment of patients with type 2 diabetes...
  27. ncbi request reprint Intravenous glucagon-like peptide 1 normalizes blood glucose after major surgery in patients with type 2 diabetes
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Germany
    Crit Care Med 32:848-51. 2004
    ..Therefore, the glucose-lowering effect of the incretin hormone glucagon-like peptide 1 (GLP-1) was investigated in patients with type 2 diabetes after major surgery...
  28. ncbi request reprint Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes
    Juris J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University, 44791 Bochum, Germany
    J Clin Endocrinol Metab 88:2719-25. 2003
    ..4 pmol GLP-1/kg x min. Due to the dose-dependent inhibition of gastric emptying, lower GLP-1 doses than previously used may be as suitable for glucose control in patients with type 2 diabetes...
  29. doi request reprint Reduced pancreatic volume and beta-cell area in patients with chronic pancreatitis
    Henning Schrader
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Germany
    Gastroenterology 136:513-22. 2009
    ....
  30. doi request reprint Long-term recovery of β-cell function after partial pancreatectomy in humans
    Bjoern A Menge
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Metabolism 61:620-4. 2012
    ..05). These findings demonstrate a capacity for recovery of glucose control after partial pancreatectomy and suggest that β-cell function can improve significantly over time even in adult humans...
  31. doi request reprint Proinsulin levels in patients with pancreatic diabetes are associated with functional changes in insulin secretion rather than pancreatic beta-cell area
    Thomas G K Breuer
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    Eur J Endocrinol 163:551-8. 2010
    ..We investigated whether hyperproinsulinaemia is also present in patients with secondary diabetes, and whether proinsulin levels are associated with impaired β-cell area or function...
  32. ncbi request reprint Glucagon-like peptide 1 and gastric inhibitory polypeptide: potential applications in type 2 diabetes mellitus
    Juris J Meier
    Medizinische Klinik I, St Josef Hospital, Klinikum der Ruhr Universitat Bochum, Bochum, Germany
    BioDrugs 17:93-102. 2003
    ..Numerous clinical studies are currently underway to evaluate these approaches. Therefore, an antidiabetic treatment based on incretin hormones may become available within the next 5 years...
  33. doi request reprint Amino acid malnutrition in patients with chronic pancreatitis and pancreatic carcinoma
    Henning Schrader
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Pancreas 38:416-21. 2009
    ..Chronic pancreatitis (CP) and pancreatic cancer (CA) have been associated with intestinal malabsorption and inflammation. However, little is known about the changes in amino acid metabolism in such patients...
  34. doi request reprint Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations
    Mark Ellrichmann
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Clin Endocrinol Metab 93:3995-8. 2008
    ..We addressed whether Orlistat alters the secretion of glucagon-like peptide-1-(7-36)-amide (GLP-1), cholecystokinin (CCK), peptide YY (PYY), and ghrelin as well as postprandial appetite sensations...
  35. ncbi request reprint Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance
    Kirsten Vollmer
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Diabetes 57:678-87. 2008
    ..in GLP-1 levels different after mixed meal or isolated glucose ingestion? 2) Which endogenous factors are associated with the concentrations of GLP-1? In particular, do elevated fasting glucose or glucagon levels diminish GLP-1 responses?..
  36. doi request reprint Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes
    Bjoern A Menge
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, 44791 Bochum, Germany
    Regul Pept 160:75-80. 2010
    ..Amino acids are important modulators of glucose metabolism, insulin secretion and insulin sensitivity. However, little is known about the changes in amino acid metabolism in patients with diabetes...
  37. ncbi request reprint Glucagon-like peptide 2 inhibits ghrelin secretion in humans
    Matthias Banasch
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Regul Pept 137:173-8. 2006
    ..In the present study we addressed, whether (1) exogenous GLP-2 administration decreases ghrelin levels and (2) what other endogenous factors are related to ghrelin secretion under fasting conditions...
  38. ncbi request reprint Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion
    Dirk Hagemann
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Germany
    Regul Pept 143:64-8. 2007
    ..Since meal ingestion also elicits the secretion of the incretin hormone glucagon-like peptide 1 (GLP-1), we examined whether exogenous GLP-1 administration reduces ghrelin secretion in humans...
  39. pmc Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes
    Björn A Menge
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Diabetes 60:2160-8. 2011
    ..In patients with type 2 diabetes, glucagon levels are often increased. Furthermore, pulsatile secretion of insulin is disturbed in such patients. Whether pulsatile glucagon secretion is altered in type 2 diabetes is not known...
  40. pmc Chronic reduction of fasting glycemia with insulin glargine improves first- and second-phase insulin secretion in patients with type 2 diabetes
    Christian Pennartz
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Diabetes Care 34:2048-53. 2011
    ..Insulin secretion is often diminished in hyperglycemic patients with type 2 diabetes. We examined whether chronic basal insulin treatment with insulin glargine improves glucose-induced insulin secretion...
  41. doi request reprint Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas
    Christina U Köhler
    Department of Medicine I, St Josef Hospital, Ruhr University of Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Am J Physiol Endocrinol Metab 300:E221-30. 2011
    ..p16 and p27 appear to restrict β-cell replication with aging. The age dependency of cell cycle regulation in human β-cells might explain the reduced β-cell regeneration in adult humans...
  42. doi request reprint Assessment of pancreatic hardness-surgeon versus durometer
    Orlin Belyaev
    Department of Surgery, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Surg Res 158:53-60. 2010
    ..This study reports the first results of durometrically measured hardness of human pancreas and investigates its correlation to palpatory determined hardness, grade of pancreatic fibrosis, and preoperatively determined radiodensity...
  43. doi request reprint Gastrin stimulates the VEGF-A promotor in a human colon cancer cell line
    Mark Ellrichmann
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum, Germany
    Regul Pept 165:146-50. 2010
    ..Vascular endothelial growth factor (VEGF) is known to play a pivotal role in tumour growth. Therefore, we addressed whether gastrin-17-gly and gastrin-17-amide regulate VEGF-A-gene and protein expression...
  44. doi request reprint Validation of different replication markers for the detection of beta-cell proliferation in human pancreatic tissue
    Christina U Köhler
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum D 44791, Germany
    Regul Pept 162:115-21. 2010
    ..Therefore, the expression of Ki67, PCNA and MCM-7 in human pancreatic tissue was quantified in order to validate their use as beta-cell replication markers...
  45. pmc Diminished glucagon suppression after β-cell reduction is due to impaired α-cell function rather than an expansion of α-cell mass
    Juris J Meier
    Dept of Internal Medicine I, St Josef Hospital, Ruhr University Bochum, Germany
    Am J Physiol Endocrinol Metab 300:E717-23. 2011
    ....
  46. doi request reprint Endogenous hyperinsulinaemia in insulinoma patients is not associated with changes in beta-cell area and turnover in the tumor-adjacent pancreas
    Chiara Montemurro
    Department of Medicine I, St Josef Hospital, Ruhr University of Bochum, Gudrunstrasse 56, Bochum, Germany
    Regul Pept 165:180-5. 2010
    ..However, data about the effects of hyperinsulinism on beta-cell mass and turnover in humans are sparse...
  47. ncbi request reprint Partial pancreatectomy in adult humans does not provoke beta-cell regeneration
    Bjoern A Menge
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Diabetes 57:142-9. 2008
    ..We addressed the following questions: In adult humans: 1) Does partial pancreatectomy provoke new beta-cell formation and increased beta-cell mass? 2) Is beta-cell turnover increased after partial pancreatectomy?..
  48. ncbi request reprint Glucagon like peptide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts
    Kerem Bulut
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Germany
    Eur J Pharmacol 578:279-85. 2008
    ..The mechanisms underlying GLP-2 induced intestinal wound repair seem to involve the secretion of VEGF and, subsequently, TGF-beta from subepithelial fibroblasts, whereas KGF appeared to be less important...
  49. doi request reprint Cell cycle regulation and proliferation in lichen sclerosus
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Regul Pept 167:209-14. 2011
    ..We aimed to investigate the expression pattern of cell cycle regulators, tumour suppressor proteins and proliferation markers in genital LS as compared to extragenital LS (ELS) and healthy controls (HC)...
  50. ncbi request reprint Plasma glucose at hospital admission and previous metabolic control determine myocardial infarct size and survival in patients with and without type 2 diabetes: the Langendreer Myocardial Infarction and Blood Glucose in Diabetic Patients Assessment (LAMBD
    Juris J Meier
    Department of Medicine, Ruhr University, Knappschafts Krankenhaus, Bochum, Germany
    Diabetes Care 28:2551-3. 2005
  51. doi request reprint Sustained partial remission of metastatic pancreatic cancer following systemic chemotherapy with gemcitabine and oxaliplatin plus adjunctive treatment with mistletoe extract
    Peter R Ritter
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Germany
    Onkologie 33:617-9. 2010
    ..The clinical prognosis of metastatic pancreatic cancer is very poor, with a median survival time of such patients ranging from 3 to 6 months. Current chemotherapy regimens include the combination of oxaliplatin and gemcitabine...
  52. pmc Generation of novel single-chain antibodies by phage-display technology to direct imaging agents highly selective to pancreatic beta- or alpha-cells in vivo
    Sandra Ueberberg
    Department of Internal Medicine I, Division of Endocrinology and Metabolism, Berufsgenossenschaftliches University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Diabetes 58:2324-34. 2009
    ..This report outlines an approach for the development of novel ligands homing selectively to islet cells in vivo...
  53. ncbi request reprint Glucagon-like peptide 1 as a regulator of food intake and body weight: therapeutic perspectives
    Juris J Meier
    Medizinische Klinik I, St Josef Hospital, Klinikum der Ruhr Universitat Bochum, Gudrunstr 56, Germany
    Eur J Pharmacol 440:269-79. 2002
    ..The present review aims to describe the role of GLP-1 in the central regulation of feeding and to discuss its possible application in the pharmacotherapy of obesity...
  54. ncbi request reprint Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
    J J Meier
    Medizinische Klinik I, St Josef Hospital, Klinikum der Ruhr Universitat Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Diabetologia 46:798-801. 2003
    ..Therefore, we studied the effect of GIP on glucagon secretion under normoglycaemic conditions...
  55. doi request reprint Metabolic consequences of a 50% partial pancreatectomy in humans
    B A Menge
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Diabetologia 52:306-17. 2009
    ..We examined the effects of approximately 50% partial pancreatectomy on glucose homeostasis and insulin secretion...
  56. ncbi request reprint Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes
    J J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University of Bochum, Bochum, Germany
    Diabetologia 48:1872-81. 2005
    ..The secretion of GIP and GLP-1 was assessed following oral glucose ingestion...
  57. pmc Inpatient treatment of type 2 diabetes
    Thomas G K Breuer
    Division of Diabetology and Gastrointestinal Endocrinology, St Josef Hospital, Ruhr University Bochum, Germany
    Dtsch Arztebl Int 109:466-74. 2012
    ..We discuss the current glucose-lowering strategies and glycemic targets and derive practical recommendations for their application in hospitalized patients...
  58. ncbi request reprint Influence of an antidiabetic treatment with sulfonylurea drugs on long-term survival after acute myocardial infarction in patients with type 2 diabetes. The LAngendreer Myocardial infarction and Blood glucose in Diabetic patients Assessment (LAMBDA)
    J J Meier
    Department of Medicine, Knappschafts Krankenhaus, Ruhr University, Bochum, Germany
    Exp Clin Endocrinol Diabetes 111:344-50. 2003
    ..Patients with type 2 diabetes show a significantly higher mortality after acute myocardial infarction than non-diabetic patients. The influence of sulfonylureas on the survival after acute myocardial infarction is still under debate...
  59. ncbi request reprint [Differences in insulin secretion facilitate the differential diagnosis of insulinoma and factitious hypoglycaemia]
    J J Meier
    Medizinische Universitatsklinik, Knappschaftskrankenhaus, Bochum, Germany
    Dtsch Med Wochenschr 127:375-8. 2002
    ..A 33-year-old female nurse (married; two children; BMI 30.9 kg/m2) had recurrent episodes of symptomatic hypoglycaemia over some months...
  60. ncbi request reprint Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans
    J J Meier
    Department of Medicine I, St Josef Hospital, Ruhr University, Bochum, Germany
    Diabetologia 49:452-8. 2006
    ..Exogenous glucagon-like peptide 1 (GLP-1) lowers postprandial glycaemia predominantly by slowing gastric emptying. Therefore, the effects of GLP-1 on postprandial lipid levels and gastric emptying were assessed...
  61. doi request reprint Determinants of glucose control in patients with chronic pancreatitis
    H Schrader
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Diabetologia 53:1062-9. 2010
    ..We addressed whether the development of diabetes in CP patients is related to pancreatic beta cell area or clinical variables, and which factors predict the diabetes risk after partial pancreatectomy...
  62. ncbi request reprint Glucagon-like peptide 2 improves intestinal wound healing through induction of epithelial cell migration in vitro-evidence for a TGF--beta-mediated effect
    K Bulut
    Department of Medicine I, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, D 44791 Bochum, Germany
    Regul Pept 121:137-43. 2004
    ..We evaluated this potential of GLP-2 after epithelial trauma by using two in vitro models measuring intestinal epithelial cell proliferation and cell migration...
  63. ncbi request reprint [Appetite regulation by ghrelin - a novel neuro-endocrine gastric peptide hormone in the gut-brain-axis]
    D Hagemann
    Medizinische Klinik I, St Josef Hospital Bochum, Klinikum der Ruhr Universitat Bochum, Germany
    Z Gastroenterol 41:929-36. 2003
    ..The discovery of ghrelin definitely contributes to the understanding of the growth-hormone secretion and of the regulation of appetite and food intake...
  64. ncbi request reprint Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes
    Michael A Nauck
    Medizinische Klinik 1, St Josef Hospital, Ruhr Universitat Bochum, Bochum D 44791, Germany
    Regul Pept 122:209-17. 2004
    ....
  65. ncbi request reprint The potential role of glucagon-like peptide 1 in diabetes
    Juris J Meier
    Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 24 130 Warren Hill, 900 Veteran Avenue, Los Angeles, CA 90095, USA
    Curr Opin Investig Drugs 5:402-10. 2004
    ..The physiological effects of GLP-1 and its pharmacokinetic limitations will be reviewed here, and the current therapeutic approaches based on GLP-1 discussed...
  66. ncbi request reprint Gastric inhibitory polypeptide does not inhibit gastric emptying in humans
    Juris J Meier
    Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, 1333 San Pablo St, BMT BII, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 286:E621-5. 2004
    ..The secretion of GIP after meal ingestion is not suppressed by its exogenous administration. The lack of effect of GIP on gastric emptying underlines the differences between GIP and the second incretin glucagon-like peptide 1...
  67. ncbi request reprint Clinical endocrinology and metabolism. Glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide
    Juris J Meier
    Larry Hillblom Islet Research Center, UCLA School of Medicine, Los Angeles, CA, USA
    Best Pract Res Clin Endocrinol Metab 18:587-606. 2004
    ..This review will summarize the actions of GIP in human physiology and discuss its role in the pathogenesis of type 2 diabetes, as well as the therapeutic options derived from these findings...
  68. ncbi request reprint Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes
    Michael A Nauck
    Diabeteszentrum Bad Lauterberg, Kirchberg 21, D 37431 Bad Lauterberg im Harz
    Diabetes 53:S190-6. 2004
    ..On the other hand, this provides a basis to use incretin hormones, especially GLP-1 and its derivatives, to replace a deficiency in incretin-mediated insulin secretion in the treatment of type 2 diabetes...
  69. ncbi request reprint Incretins and their analogues as new antidiabetic drugs
    Michael A Nauck
    Diabeteszentrum Bad Lauterberg, Bad Lauterberg im Harz, Germany
    Drug News Perspect 16:413-22. 2003
    ..GLP-1 derivatives (receptor agonists) with prolonged pharmacokinetics that promise a potential for clinical use in the near future are being developed...
  70. ncbi request reprint Glucagon-like peptide 1(GLP-1) in biology and pathology
    Juris J Meier
    Larry L Hillblom Islet Research Center, UCLA School of Medicine, Los Angeles, USA
    Diabetes Metab Res Rev 21:91-117. 2005
    ..This review will summarize the biological effects of GLP-1, characterize its role in human biology and pathology, and discuss potential clinical applications as well as current clinical studies...
  71. ncbi request reprint Rimonabant as a novel therapeutic option for nonalcoholic steatohepatitis
    Matthias Banasch
    Liver Int 27:1152-5. 2007
  72. ncbi request reprint Incretins and the development of type 2 diabetes
    Juris J Meier
    Curr Diab Rep 6:194-201. 2006
    ..Therefore, although there are hints of early abnormalities in incretin secretion and action in prediabetic populations, it has not been proven that such phenomena are central to the pathogenesis of type 2 diabetes...
  73. ncbi request reprint Intrahepatic transplanted islets in humans secrete insulin in a coordinate pulsatile manner directly into the liver
    Juris J Meier
    Larry Hillblom Islet Research Center, University of California Los Angeles David Geffen School of Medicine, 24 130 Warren Hall, 900 Veteran Ave, 90095 7073, USA
    Diabetes 55:2324-32. 2006
    ..In conclusion, intrahepatic islet transplantation effectively restores the liver to pulsatile insulin delivery...
  74. ncbi request reprint Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis
    Juris J Meier
    Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 24 130 Warren Hall, 900 Veteran Ave, Los Angeles, CA 90095 7073, USA
    Diabetes 55:1051-6. 2006
    ..We conclude that postprandial hyperglucagonemia in type 2 diabetes is likely due to loss of intraislet postprandial suppression of glucagon secretion by insulin...
  75. ncbi request reprint Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans
    Juris J Meier
    Larry L Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 900A Weyburn Place North, Los Angeles, CA 90095 7073, USA
    Diabetes 54:1649-56. 2005
    ..These findings emphasize the dual role of the liver and pancreas and their relationship mediated through magnitude of insulin pulse mass in regulating the quantity and pattern of systemic insulin delivery...
  76. ncbi request reprint Glucagon-like peptide 1 and its derivatives in the treatment of diabetes
    Michael A Nauck
    Diabeteszentrum Bad Lauterberg Kirchberg 21 D 37431 Bad Lauterberg im Harz, Germany
    Regul Pept 128:135-48. 2005
    ..It is hoped that this new class of drugs interacting with the GLP-1 or other incretin receptors, the so-called "incretin mimetics", will broaden our armamentarium of antidiabetic medications in the nearest future...
  77. ncbi request reprint Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover
    Juris J Meier
    Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 24 130 Warren Hall, 900 Veteran Ave, Los Angeles, CA 90095 7073, USA
    Diabetes Care 29:1554-9. 2006
    ..The purpose of this study was to establish whether hypoglycemia after gastric bypass surgery (GBS) for morbid obesity is due to increased fractional beta-cell area or inappropriately increased insulin secretion...
  78. ncbi request reprint Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets
    Robert A Ritzel
    Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, 24 130 Warren Hall, 900 Veteran Ave, Los Angeles, CA 90095 7073, USA
    Diabetes 56:65-71. 2007
    ....
  79. ncbi request reprint The replication of beta cells in normal physiology, in disease and for therapy
    Peter C Butler
    Larry Hillblom Islet Research Center, University of California at Los Angeles UCLA, David Geffen School of Medicine, Los Angeles, CA 90095 7073, USA
    Nat Clin Pract Endocrinol Metab 3:758-68. 2007
    ....
  80. ncbi request reprint Increased expression of nuclear factor-kappaB/RelA is correlated with tumor angiogenesis in human colorectal cancer
    Hong Gang Yu
    Department of Gastroenterology, Renmin Hospital of Wuhan Univeristy, Jiefang Road 238, 430060, Wuhan, China
    Int J Colorectal Dis 19:18-22. 2004
    ..This study examined whether NF-kappa B/RelA expression is associated with vascular endothelial growth factor (VEGF) expression and microvessel density in human colorectal cancer...
  81. ncbi request reprint The potential for stem cell therapy in diabetes
    Juris J Meier
    Larry Hillblom Islet Research Center, University of California Los Angeles, David Geffen School of Medicine, 90095, USA
    Pediatr Res 59:65R-73R. 2006
    ..In this article recent progress in the generation, culture and targeted differentiation of human embryonic stem (ES) cells is reviewed, and some of the issues surrounding their use as a source of beta-cells are discussed...