F Meier

Summary

Country: Germany

Publications

  1. pmc Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases
    Heike Niessner
    Division of Dermatologic Oncology, Department of Dermatology, University of Tuebingen Germany
    Cancer Med 2:76-85. 2013
  2. ncbi request reprint The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma
    Friedegund Meier
    Department of Dermatology, University of Tuebingen, Tuebingen, Germany
    Front Biosci 10:2986-3001. 2005
  3. ncbi request reprint [An unusual case of pyoderma gangrenosum with necrotizing granulomatous dermatitis]
    Friedegund Meier
    Abteilung für Dermatologie, Universitat Tubingen, Tubingen, Deutschland
    J Dtsch Dermatol Ges 1:302-5. 2003
  4. ncbi request reprint The adhesion molecule L1 (CD171) promotes melanoma progression
    Friedegund Meier
    Department of Dermatology, Section of Dermatologic Oncology, University of Tuebingen, Tuebingen, and Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:549-55. 2006
  5. ncbi request reprint Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma
    Friedegund Meier
    Department of Dermatology, University of Tuebingen, Germany
    Exp Dermatol 12:296-306. 2003
  6. ncbi request reprint Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment
    F Meier
    Division of Dermatological Oncology, Department of Dermatology, University of Tubingen, Tubingen, Germany
    Br J Dermatol 156:1204-13. 2007
  7. doi request reprint Significant response after treatment with the mTOR inhibitor sirolimus in combination with carboplatin and paclitaxel in metastatic melanoma patients
    Friedegund Meier
    Division of Dermatologic Oncology, Department of Dermatology, University of Tuebingen, Liebermeisterstr 25, Tubingen D 72076, Germany
    J Am Acad Dermatol 60:863-8. 2009
  8. ncbi request reprint Metastatic pathways and time courses in the orderly progression of cutaneous melanoma
    F Meier
    Department of Dermatology, Eberhard Karls University, Liebermeisterstr 25, 72076 Tuebingen, Germany
    Br J Dermatol 147:62-70. 2002
  9. ncbi request reprint [Coccidioidomycosis. Two case reports with discussion of current diagnostic and therapeutic issues]
    F Meier
    Universitäts Hautklinik der Eberhard Karls Universität Tübingen
    Hautarzt 55:1143-9. 2004
  10. pmc Serum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasis
    B Weide
    Department of Dermatology, Center for Dermatooncology, University Medical Center, Liebermeisterstrasse 25, Tubingen 72076, Germany
    Br J Cancer 107:422-8. 2012

Collaborators

Detail Information

Publications24

  1. pmc Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases
    Heike Niessner
    Division of Dermatologic Oncology, Department of Dermatology, University of Tuebingen Germany
    Cancer Med 2:76-85. 2013
    ..Thus, inhibition of PI3K-AKT signaling shows potential for enhancing and/or prolonging the antitumor effect of BRAF inhibitors or other anticancer agents in melanoma brain metastases...
  2. ncbi request reprint The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma
    Friedegund Meier
    Department of Dermatology, University of Tuebingen, Tuebingen, Germany
    Front Biosci 10:2986-3001. 2005
    ..The results of the research to date indicate that in melanoma both the MAPK and the AKT signaling pathways may represent promising therapeutic targets...
  3. ncbi request reprint [An unusual case of pyoderma gangrenosum with necrotizing granulomatous dermatitis]
    Friedegund Meier
    Abteilung für Dermatologie, Universitat Tubingen, Tubingen, Deutschland
    J Dtsch Dermatol Ges 1:302-5. 2003
    ....
  4. ncbi request reprint The adhesion molecule L1 (CD171) promotes melanoma progression
    Friedegund Meier
    Department of Dermatology, Section of Dermatologic Oncology, University of Tuebingen, Tuebingen, and Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:549-55. 2006
    ..Altogether, L1 plays a critical role in melanoma invasion and progression and offers therapeutic potential in combination with conventional anticancer agents...
  5. ncbi request reprint Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma
    Friedegund Meier
    Department of Dermatology, University of Tuebingen, Germany
    Exp Dermatol 12:296-306. 2003
    ..The described results of the current and previous studies emphasise the key role of FGF-2 in melanoma development and progression, underscoring the promise of FGF-2 as a target for therapy...
  6. ncbi request reprint Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment
    F Meier
    Division of Dermatological Oncology, Department of Dermatology, University of Tubingen, Tubingen, Germany
    Br J Dermatol 156:1204-13. 2007
    ..Among them, the RAS/RAF/MEK/ERK (MAPK) and PI3K/AKT (AKT) signalling pathways are activated through multiple mechanisms and appear to play a major role in melanoma development and progression...
  7. doi request reprint Significant response after treatment with the mTOR inhibitor sirolimus in combination with carboplatin and paclitaxel in metastatic melanoma patients
    Friedegund Meier
    Division of Dermatologic Oncology, Department of Dermatology, University of Tuebingen, Liebermeisterstr 25, Tubingen D 72076, Germany
    J Am Acad Dermatol 60:863-8. 2009
    ..Our case report, together with the literature discussed, suggests that mTOR inhibition possibly enhances the sensitivity of melanoma cells to chemotherapy and should prompt in-depth and clinical investigation...
  8. ncbi request reprint Metastatic pathways and time courses in the orderly progression of cutaneous melanoma
    F Meier
    Department of Dermatology, Eberhard Karls University, Liebermeisterstr 25, 72076 Tuebingen, Germany
    Br J Dermatol 147:62-70. 2002
    ..However, few reports in the literature give detailed figures on different metastatic pathways in cutaneous melanoma...
  9. ncbi request reprint [Coccidioidomycosis. Two case reports with discussion of current diagnostic and therapeutic issues]
    F Meier
    Universitäts Hautklinik der Eberhard Karls Universität Tübingen
    Hautarzt 55:1143-9. 2004
    ..Since relapses are frequent after discontinuation of the treatment, close clinical, serological and radiological follow-up is required for years...
  10. pmc Serum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasis
    B Weide
    Department of Dermatology, Center for Dermatooncology, University Medical Center, Liebermeisterstrasse 25, Tubingen 72076, Germany
    Br J Cancer 107:422-8. 2012
    ..Established prognostic factors are of limited value to predict long-term survival and benefit from metastasectomy in advanced melanoma. This study aimed to identify prognostic factors in patients with distant metastasis...
  11. ncbi request reprint Dermcidin: a novel human antibiotic peptide secreted by sweat glands
    B Schittek
    Department of Dermatology, Eberhard Karls University Tubingen, Germany
    Nat Immunol 2:1133-7. 2001
    ..This peptide may help limit infection by potential pathogens in the first few hours following bacterial colonization...
  12. pmc Determinants of survival in patients with brain metastases from cutaneous melanoma
    M Staudt
    Department of Dermatology, Eberhard Karls University, Tuebingen, Germany
    Br J Cancer 102:1213-8. 2010
    ..This retrospective study aimed to identify prognostic factors in patients with brain metastases from cutaneous melanoma...
  13. ncbi request reprint [Targeted therapies for melanoma]
    U Leiter
    Zentrum für Dermato Onkologie, Universitäts Hautklinik, Eberhard Karls Universitat Tubingen, Liebermeisterstr 25, 72076, Tubingen, Deutschland
    Hautarzt 65:600-6. 2014
    ..Due to selective kinase inhibitors and immune checkpoint blockade, the therapy of unresectable metastatic melanoma has greatly improved and long-term survival of patients with metastatic melanoma seems a real possibility...
  14. ncbi request reprint Melanoma development and progression: a conspiracy between tumor and host
    Mei Yu Hsu
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104 4283, USA
    Differentiation 70:522-36. 2002
    ..Defining intercellular molecular dialogues in human skin promises to provide key information for the development of novel treatment strategies that target the functional unit of stroma and tumor...
  15. ncbi request reprint Prospective evaluation of a follow-up schedule in cutaneous melanoma patients: recommendations for an effective follow-up strategy
    Claus Garbe
    Department of Dermatology, Skin Cancer Program, Eberhard Karls University of Tuebingen, Germany
    J Clin Oncol 21:520-9. 2003
    ..To prospectively examine and evaluate the results of follow-up procedures in a large cohort of cutaneous melanoma patients...
  16. ncbi request reprint Diagnostic value and prognostic significance of protein S-100beta, melanoma-inhibitory activity, and tyrosinase/MART-1 reverse transcription-polymerase chain reaction in the follow-up of high-risk melanoma patients
    Claus Garbe
    Department of Dermatology, Skin Cancer Program, Eberhard Karls University of Tuebingen, Tuebingen, Germany
    Cancer 97:1737-45. 2003
    ....
  17. doi request reprint Age and gender are significant independent predictors of survival in primary cutaneous melanoma
    Konstantinos Lasithiotakis
    Division of Dermatologic Oncology, Department of Dermatology, University of Tuebingen, Central Malignant Melanoma Registry of the German Dermatological Society, Tuebingen, Germany
    Cancer 112:1795-804. 2008
    ..The aim was to identify age- related and gender-related differences in the clinical presentation and outcome of patients with primary cutaneous melanoma (CM)...
  18. ncbi request reprint The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism
    Katharina Uhlenbrock
    Department of Structural Biology, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    J Cell Sci 117:4863-71. 2004
    ..The reverse transition from mesenchymal invasive to a resident epithelial-like phenotype implicates a role for Tiam1/Rac signaling in the control of cell-cell contacts through a novel ALCAM-mediated mechanism...
  19. ncbi request reprint The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance
    Birgit Schittek
    Division of Dermatologic Oncology, Department of Dermatology, University of Tubingen, Liebermeisterstrasse 25, D 72076 Tubingen, Germany
    Int J Cancer 120:2110-8. 2007
    ..Thus, YB-1 may be a promising molecular target in melanoma therapy...
  20. ncbi request reprint Improvement of overall survival of patients with cutaneous melanoma in Germany, 1976-2001: which factors contributed?
    Konstantinos G Lasithiotakis
    Division of Dermatologic Oncology, Department of Dermatology, Central Malignant Melanoma Registry of the German Dermatological Society, Eberhard Karls University, Tuebingen, Germany
    Cancer 109:1174-82. 2007
    ..A hypothesis generated a retrospective analysis of the improvement of survival over time in patients with cutaneous melanoma (CM) in order to identify factors contributing to this progress...
  21. ncbi request reprint Reciprocal regulation of MelCAM and AKT in human melanoma
    Gang Li
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Oncogene 22:6891-9. 2003
    ..These data link AKT activation with MelCAM expression, and implicate that intervention of MelCAM-AKT signaling axis in melanoma is a potential therapeutical approach...
  22. ncbi request reprint Truncation of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis
    Leon C L T van Kempen
    Department of Biochemistry NCMLS, University of Nijmegen, Nijmegen, The Netherlands
    J Invest Dermatol 122:1293-301. 2004
    ..ALCAM induction could, thus, provide an attractive target for proteolysis as a part of a more complex cellular program that couples growth and migration and facilitates dissemination...
  23. ncbi request reprint The natural course of cutaneous melanoma
    Ulrike Leiter
    Department of Dermatology, Division of Dermatologic Oncology, Eberhard Karls University, Tuebingen, Germany
    J Surg Oncol 86:172-8. 2004
    ....
  24. ncbi request reprint Function and regulation of melanoma-stromal fibroblast interactions: when seeds meet soil
    Gang Li
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Oncogene 22:3162-71. 2003
    ..An understanding of this process and developing new experimental and screening models are of great importance for the development of effective therapeutical strategies to treat melanoma...