Beckmann A, Hainz N, Tschernig T, Meier C. Facets of Communication: Gap Junction Ultrastructure and Function in Cancer Stem Cells and Tumor Cells. Cancers (Basel). 2019;11: pubmed publisher
..In turn, gap junctions also seem to contribute to the unattainability of cancer stem cells by certain treatments and might thus contribute to therapeutic resistance. ..
Beckmann A, Grißmer A, Wolf S, Recktenwald J, Meier C. Oxygen-Glucose Deprivation in Mouse Astrocytes is Associated with Ultrastructural Changes in Connexin 43 Gap Junctions. Neuroscience. 2019;397:67-79 pubmed publisher
Hainz N, Wolf S, Tschernig T, Meier C. Probenecid Application Prevents Clinical Symptoms and Inflammation in Experimental Autoimmune Encephalomyelitis. Inflammation. 2016;39:123-128 pubmed publisher
..Probenecid-treated animals also displayed fewer inflammatory lesions. Microglia activation was not altered by treatment. In conclusion, probenecid prevented the onset of EAE. ..
Beckmann A, Grissmer A, Krause E, Tschernig T, Meier C. Pannexin-1 channels show distinct morphology and no gap junction characteristics in mammalian cells. Cell Tissue Res. 2016;363:751-63 pubmed publisher
..Thus, these results open up new avenues for the detailed analysis of the subcellular localization of Panx1 and of its nearest neighbors such as purinergic receptors in vivo. ..
Raslan A, Hainz N, Beckmann A, Tschernig T, Meier C. Pannexin-1 expression in developing mouse nervous system: new evidence for expression in sensory ganglia. Cell Tissue Res. 2016;364:29-41 pubmed publisher
..The consequences of Panx1 deficiency or inhibition in a number of experimental paradigms might therefore be predicated on changes during early development. ..
Tschernig T, Rabung A, Voss M, Meier C, Bals R, Beisswenger C. Chronic inhalation of cigarette smoke reduces phagocytosis in peripheral blood leukocytes. BMC Res Notes. 2015;8:705 pubmed publisher
..Impaired phagocytosis activity of peripheral blood leukocytes may have a systemic effect and potentially contribute to smoking-associated diseases such as pneumonia and lung cancer. ..
Beckmann A, Schubert M, Hainz N, Haase A, Martin U, Tschernig T, et al
. Ultrastructural demonstration of Cx43 gap junctions in induced pluripotent stem cells from human cord blood. Histochem Cell Biol. 2016;146:529-537 pubmed
..In addition, these gap junctions were shown to contain the gap junction protein Cx43. ..
Wolf S, Hainz N, Beckmann A, Maack C, Menger M, Tschernig T, et al
. Brain damage resulting from postnatal hypoxic-ischemic brain injury is reduced in C57BL/6J mice as compared to C57BL/6N mice. Brain Res. 2016;1650:224-231 pubmed publisher
..These differences might relate to the lack of Nnt, but also to a modified metabolic setting (cardiovascular parameters, oxygen and glucose metabolism, immune function) in C57BL/6J mice. ..
Meier C, Beckmann A. Freeze fracture: new avenues for the ultrastructural analysis of cells in vitro. Histochem Cell Biol. 2018;149:3-13 pubmed publisher
..At the interface of molecular approaches and morphology, the application of FRIL in genetically modified cells provides a novel and intriguing aspect for their analysis. ..